Objective: To observe the therapeutic effect of the integrated acupuncture-moxibustio n and herbal therapies for facial paralysis. Methods: A total of 68 cases of facial paralysis were treated by integration of acupun...Objective: To observe the therapeutic effect of the integrated acupuncture-moxibustio n and herbal therapies for facial paralysis. Methods: A total of 68 cases of facial paralysis were treated by integration of acupunct ure-moxibustion and herbal therapies. For acu-moxibustion, Yifeng (翳风 TE 17) , Dicang (地仓 ST 4), Jiache (颊车 ST 6), Yangbai (阳白 GB 14), Hegu (合谷 LI 4), etc. were used. In addition, for facial palsy patients with wind-phlegm blockin g meridian-collaterals and wind-stirring due to yin defi ciency types in the acute stage, Modified Qian Zheng San (牵正散 Powder for Treating Wry-mouth) and Modi f ied Zhen Gan Xi Feng Tang (镇肝熄风汤 Tranquilizing Liver-wind Decoction) were u sed respectively; and for those in convalescent stage and sequela stage, Modifie d Danggui Bu Xue Tang (当归补血汤 Ghinese Angelica Decoction for Replenishing Bl ood) + Qian Zheng San (Powder for Treating Wry-mouth) and Modified Bu Yang Hu an Wu Tang (补阳还五汤 Decoction Invigorating Yang for Recuperation) were employed. Results: After the treatment, the curative rate of the 68 cases a ccounted for 90 % of the total cases, the remarkably effective 6%, the improved 3% and the poor 1% respectively. Conclusion: The therapeutic effectiveness of the integrated tre atment of acupuncture-moxibustion and herbal therapies for facial paralysis is certain.展开更多
It was in the 1980s that research on somatostatin(SST)in Alzheimer’s disease(AD)truly gained traction,demonstrating consistent colocalization with amyloid-β(Aβ),along with massive SST/SST cell losses(Almeida,2024)....It was in the 1980s that research on somatostatin(SST)in Alzheimer’s disease(AD)truly gained traction,demonstrating consistent colocalization with amyloid-β(Aβ),along with massive SST/SST cell losses(Almeida,2024).Although the field already had some grasp over the neuroendocrine and hypothalamic functions of the peptide,very little was known about the GABAergic interneurons(SST-INs)that synthesize it in cortical/hippocampal regions.Quite excitingly,over 40 years later,research has grown effervescent.展开更多
The number and diversity of inhibitory neurons(INs)increased substantially during mammalian brain evolution.However,the generative mechanisms of the vast repertoire of human INs remain elusive.We performed spatial and...The number and diversity of inhibitory neurons(INs)increased substantially during mammalian brain evolution.However,the generative mechanisms of the vast repertoire of human INs remain elusive.We performed spatial and single-cell transcriptomics of human medial ganglionic eminence(hMGE),a pivotal source of cortical and subpallial INs,and built the trajectories of hMGE-derived cells during brain development.We identified spatiotemporally and molecularly segregated progenitor cell populations fated to produce distinct IN types.展开更多
Objective Insomnia is a highly prevalent disorder among patients suffering from stroke.The association between insomnia and stroke mortality is less studied,particularly using the latest diagnostic criteria.The curren...Objective Insomnia is a highly prevalent disorder among patients suffering from stroke.The association between insomnia and stroke mortality is less studied,particularly using the latest diagnostic criteria.The current study examined the relationship between insomnia and mortality among patients with first-evonal hazard models were used to calculate HRs for stroke er stroke in China.Methods Patients with acute cerebrovascular diseases(stroke)were recruited from 56 hospitals in China's Mainland.Insomnia was defined as difficulty falling asleep,or difficulty staying asleep or waking up early,for at least two consecutive visits.Demographic data,medical history and clinical data were collected.Four follow-up visits occurred within the first year after stroke,and the last follow-up call was conducted 6 years later.Cox proportional hazard models were used to calculate HRs for stroke mortality.results Insomnia was reported by 38.4%(489/1273)of patients at baseline.During the 6 years of follow-up,after adjusting for all confounders,insomnia was found to be associated with increased mortality(HR=1.66,95%CI 1.10 to 2.48).Old age(HR=1.08,95%CI 1.06 to 1.10),stroke recurrence in the first year of follow-up(HR=2.53,95%CI 1.48 to 4.31)and stroke survivors with hypertension(HR=1.62,95%CI 1.04 to 2.53)had substantially higher risk of mortality.Conclusions Besides old age,stroke recurrence in the first year of follow-up and hypertension,insomnia is associated with increased risk of mortality in patients with first-ever stroke in China.More studies about prompt and efficient interventions for insomnia are expected in the future.Trial registration number rctn62169508.展开更多
The amino acids and the volatile substances in grapes and wines play important roles in their quality,and the concentrations of these substances can be changed by how a vineyard is managed,e.g.,irrigation and fertigat...The amino acids and the volatile substances in grapes and wines play important roles in their quality,and the concentrations of these substances can be changed by how a vineyard is managed,e.g.,irrigation and fertigation regimes.This study aimed to evaluate the effect of fertilizer and water management on the distribution of amino acids,the volatile component profiles,and the sensory characteristics of Cabernet Sauvignon grapes and wines.The results showed that the amino acid concentration in grape berries was the highest under the 100%local fertilizer rate(HF)and 100%water irrigation quota(HW)treatment,and the volatile component concentration in wine was the highest under HF and 80%water irrigation quota(MW)treatment.The effect of irrigation on the amino acid content in grapes was greater than that of fertigation.The synergistic effect of fertilizer and water on arginine,serine,and glutamine in grape berries was significant.The interactive effect of fertigation and irrigation on the volatile substance in grapes was greater than that of fertigation and irrigation alone.The influence of irrigation on volatile substances in wines was greater than that of fertigation.In addition,there was also a correlation between the concentrations of multiple amino acids in grapes and volatile components in wines.Principal component analysis showed that the wine from the HFMW treatment had the best quality among all treatments.展开更多
文摘Objective: To observe the therapeutic effect of the integrated acupuncture-moxibustio n and herbal therapies for facial paralysis. Methods: A total of 68 cases of facial paralysis were treated by integration of acupunct ure-moxibustion and herbal therapies. For acu-moxibustion, Yifeng (翳风 TE 17) , Dicang (地仓 ST 4), Jiache (颊车 ST 6), Yangbai (阳白 GB 14), Hegu (合谷 LI 4), etc. were used. In addition, for facial palsy patients with wind-phlegm blockin g meridian-collaterals and wind-stirring due to yin defi ciency types in the acute stage, Modified Qian Zheng San (牵正散 Powder for Treating Wry-mouth) and Modi f ied Zhen Gan Xi Feng Tang (镇肝熄风汤 Tranquilizing Liver-wind Decoction) were u sed respectively; and for those in convalescent stage and sequela stage, Modifie d Danggui Bu Xue Tang (当归补血汤 Ghinese Angelica Decoction for Replenishing Bl ood) + Qian Zheng San (Powder for Treating Wry-mouth) and Modified Bu Yang Hu an Wu Tang (补阳还五汤 Decoction Invigorating Yang for Recuperation) were employed. Results: After the treatment, the curative rate of the 68 cases a ccounted for 90 % of the total cases, the remarkably effective 6%, the improved 3% and the poor 1% respectively. Conclusion: The therapeutic effectiveness of the integrated tre atment of acupuncture-moxibustion and herbal therapies for facial paralysis is certain.
文摘It was in the 1980s that research on somatostatin(SST)in Alzheimer’s disease(AD)truly gained traction,demonstrating consistent colocalization with amyloid-β(Aβ),along with massive SST/SST cell losses(Almeida,2024).Although the field already had some grasp over the neuroendocrine and hypothalamic functions of the peptide,very little was known about the GABAergic interneurons(SST-INs)that synthesize it in cortical/hippocampal regions.Quite excitingly,over 40 years later,research has grown effervescent.
文摘The number and diversity of inhibitory neurons(INs)increased substantially during mammalian brain evolution.However,the generative mechanisms of the vast repertoire of human INs remain elusive.We performed spatial and single-cell transcriptomics of human medial ganglionic eminence(hMGE),a pivotal source of cortical and subpallial INs,and built the trajectories of hMGE-derived cells during brain development.We identified spatiotemporally and molecularly segregated progenitor cell populations fated to produce distinct IN types.
基金This study was funded by National Key Research&Development Program of China(2016YFC1307200)Beijing excellent talents training Program,the Ministry of Science and Technology and the Ministry of Health of the People’s Republic of China.Individual grants include the National 11th&12th Five-year S&T Major Project(2006BAI01A11,2011BAI08B01,2011BAI08B02,2015BAI13B03)+5 种基金the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2013BAI09B03)the Ministry of Science and Technology of the People’s Republic of China Beijing Institute for Brain Disorders(BIBD-PXM2013_014226_07_000084)the Beijing Biobank of Cerebral Vascular Disease(D131100005313003)the Basic Clinical Research Cooperation Program of Capital Medical University(16JL(TTZX)03)Beijing Brain Research(Z161100000216131)the Beijing Municipal Science&Technology Commission(Z151100004015127 and Z151100003915117)。
文摘Objective Insomnia is a highly prevalent disorder among patients suffering from stroke.The association between insomnia and stroke mortality is less studied,particularly using the latest diagnostic criteria.The current study examined the relationship between insomnia and mortality among patients with first-evonal hazard models were used to calculate HRs for stroke er stroke in China.Methods Patients with acute cerebrovascular diseases(stroke)were recruited from 56 hospitals in China's Mainland.Insomnia was defined as difficulty falling asleep,or difficulty staying asleep or waking up early,for at least two consecutive visits.Demographic data,medical history and clinical data were collected.Four follow-up visits occurred within the first year after stroke,and the last follow-up call was conducted 6 years later.Cox proportional hazard models were used to calculate HRs for stroke mortality.results Insomnia was reported by 38.4%(489/1273)of patients at baseline.During the 6 years of follow-up,after adjusting for all confounders,insomnia was found to be associated with increased mortality(HR=1.66,95%CI 1.10 to 2.48).Old age(HR=1.08,95%CI 1.06 to 1.10),stroke recurrence in the first year of follow-up(HR=2.53,95%CI 1.48 to 4.31)and stroke survivors with hypertension(HR=1.62,95%CI 1.04 to 2.53)had substantially higher risk of mortality.Conclusions Besides old age,stroke recurrence in the first year of follow-up and hypertension,insomnia is associated with increased risk of mortality in patients with first-ever stroke in China.More studies about prompt and efficient interventions for insomnia are expected in the future.Trial registration number rctn62169508.
基金the S&T Program of Hebei,China(Grant No.20327001D)the leading Talent Project of Science and Technology Innovation in Ningxia Hui Autonomous Region(Grant No.2022GKLRLX07).
文摘The amino acids and the volatile substances in grapes and wines play important roles in their quality,and the concentrations of these substances can be changed by how a vineyard is managed,e.g.,irrigation and fertigation regimes.This study aimed to evaluate the effect of fertilizer and water management on the distribution of amino acids,the volatile component profiles,and the sensory characteristics of Cabernet Sauvignon grapes and wines.The results showed that the amino acid concentration in grape berries was the highest under the 100%local fertilizer rate(HF)and 100%water irrigation quota(HW)treatment,and the volatile component concentration in wine was the highest under HF and 80%water irrigation quota(MW)treatment.The effect of irrigation on the amino acid content in grapes was greater than that of fertigation.The synergistic effect of fertilizer and water on arginine,serine,and glutamine in grape berries was significant.The interactive effect of fertigation and irrigation on the volatile substance in grapes was greater than that of fertigation and irrigation alone.The influence of irrigation on volatile substances in wines was greater than that of fertigation.In addition,there was also a correlation between the concentrations of multiple amino acids in grapes and volatile components in wines.Principal component analysis showed that the wine from the HFMW treatment had the best quality among all treatments.
