The“return to the Asia-Pacific”policy and the“Asia-Pacific rebalancing”policy during the Obama period marked the germination of the Indo-Pacific strategy of the United States,and since then,the Indo-Pacific strate...The“return to the Asia-Pacific”policy and the“Asia-Pacific rebalancing”policy during the Obama period marked the germination of the Indo-Pacific strategy of the United States,and since then,the Indo-Pacific strategy has been continuously strengthened by the two administrations of Trump and Biden(Ling,2023).In order to stop China from rising,the United States has been trying to draw the ten ASEAN countries which are geographically close to China to American side.However,due to the different national conditions and the different needs of the ten countries,it is difficult for the United States to keep ASEAN’s attitude towards China consistent under the frame of Indo-Pacific strategy.Therefore,this paper will analyze the different attitudes of the ten countries towards China respectively,so as to help China formulate better policies and find better ways to cope with America’s containment of China’s rise and maintain regional and world peace.展开更多
The Trump administration of the United States has accelerated the advancement of the‘‘open and free Indo-Pacific’,strategy since 2017.From a geopolitical point of view and in terms of its national interests,Russia ...The Trump administration of the United States has accelerated the advancement of the‘‘open and free Indo-Pacific’,strategy since 2017.From a geopolitical point of view and in terms of its national interests,Russia has generally been critical of this strategy,believing it has posed certain challenges to its“Pivot to the East”strategy.Meanwhile,Russia is rejoicing for not being the primary target of US containment in the region and has sensed a new opportunity for exercising its Asia-Pacific diplomacy in the context of the Indo-Pacific strategy.Based on this situation,Russia has made a flexible and pragmatic policy response to it.However,Russia will inevitably face many restraints.In the future,Russia will seek to maximize its strategic interests on the basis of adhering to its inherent principles of Asia-Pacific diplomacy.展开更多
Japan-UK security cooperation has been deepening as the Indo-Pacific Strategy has converged with Global Britain,which has become strongly Indo-Pacific-oriented.In terms of their cooperation on security,the two countri...Japan-UK security cooperation has been deepening as the Indo-Pacific Strategy has converged with Global Britain,which has become strongly Indo-Pacific-oriented.In terms of their cooperation on security,the two countries have close security interactions,high-level security consultations,numerous mechanisms on security cooperation,frequent defense cooperation and exchanges between forces,and cooperation geared at a response to the Korean nuclear issue.In particular,Japan and the UK regard Indo-Pacific security as the strategic focus of their cooperation,and this underscores the rules-based international order.There are multiple motivations for Japan and the UK to strengthen their security cooperation,and the deepening of their security cooperation in the Indo-Pacific region is to a great extent due to strategic factors,including responding to the US strategic adjustment,Japan and Britain’s respective proactive strategic demands,the improving strategic positions of the Indopacific region,their seeking to shape the regional order in the Indo-Pacific,and so on.Despite facing challenges,Japan-UK security cooperation is continuously strengthening against a background of deepening strategic convergence between the two countries and great power competition.展开更多
In 2017, the Trump administration formally articulated its vision for the Indo-Pacific strategy, replacing "Asia-Pacific" with"Indo-Pacific"in policy papers and taking measures to promote the reali...In 2017, the Trump administration formally articulated its vision for the Indo-Pacific strategy, replacing "Asia-Pacific" with"Indo-Pacific"in policy papers and taking measures to promote the realization of an "Indo-Pacific dream". This represents a significant adjustment in US regional policies. An important power in the Indian Ocean region, India is perceived as key to the successful implementation of this Indo-Pacific strategy. Generally speaking, the current Indian government and strategy circle actively support the upgrading of the"Indo-Pacific"concept from a geographical and academic term to a US vision for foreign strategies, anticipating that India could garner significant strategic benefits from it. Given this, New Delhi will continually adapt its foreign policies to the US Indo-Pacific strategy and may even direct the development of the strategy to counter the Belt and Road Initiative, work with other nations to balance China's influence and finally make the rise of India as a great power a reality. Nonetheless, the Indo-pacific strategy is in its early stages, and the content is not completely pro-India currently. On top of this India is still skeptical of the US and will proceed cautiously, leaving room for maneuver in the future,fully tapping into the benefits of the Indo-Pacific strategy and avoiding direct confrontation with China.展开更多
Since the Trump administration,the national security strategy of the United States has focused on addressing the major power competition and regarded China as its main strategic competitor,which has been profoundly re...Since the Trump administration,the national security strategy of the United States has focused on addressing the major power competition and regarded China as its main strategic competitor,which has been profoundly reflected in its introduction of the Indo-Pacific Strategy.The United States has certain resource advantages in the process of advancing the Indo-Pacific Strategy,and has made some progress of it.Nonetheless,the prospect of the strategy does not entirely depend on the will and action of the United States,but also on the joint action of other elements.展开更多
The Indo-Pacific Strategy Report(IPSR)released by the U.S.Department of Defense on June 1,2019 expounded America’s historic ties to the Indo-Pacific region,looked forward to and established the vision and principles...The Indo-Pacific Strategy Report(IPSR)released by the U.S.Department of Defense on June 1,2019 expounded America’s historic ties to the Indo-Pacific region,looked forward to and established the vision and principles of“One Free and Open Indo-Pacific”,analyzed the strategic picture for the region,and clarified the pluralistic challenges faced by the U.S.and the policy measures to tackle these challenges.Based on the text of IPSR,this essay gives an analysis and study of the historic evolution,policy measurement and restrictive factors of the U.S.“Indo-Pacific Strategy”.展开更多
Nereididae is a prolific annelid family widely distributed in the world oceans,especially in the Indo-Pacific Convergence Zone(IPCZ).However,its biogeographic pattern remains unexplored in IPCZ.To contribute to the un...Nereididae is a prolific annelid family widely distributed in the world oceans,especially in the Indo-Pacific Convergence Zone(IPCZ).However,its biogeographic pattern remains unexplored in IPCZ.To contribute to the understanding of biodiversity and biogeography of Nereididae in the IPCZ,we integrated historical data of species distributions with those of model-predicted ones to determine the biogeographic patterns of nereid species,from which we projected to its future distribution patterns for 2090-2100 under different climate scenarios(SSP1-1.9 and SSP5-8.5).Functional diversity within IPCZ was assessed using functional richness,functional evenness,and functional disparity.Divergence times within Nereididae were estimated using three DNA marker genes(COI,16S,and 18S rRNA),and a time tree was constructed based on a strict molecular clock model.The IPCZ was established as a key Nereididae biodiversity hotspot through distribution modelling of 256 species(44 genera),and temperature emerging as the predominant climatic driver of species distribution patterns.The distribution of species and functional diversity is notable for its non-centralized pattern.We projected that by the end of the century,areas of medium-to-high species richness will expand significantly under the low-emission SSP1-1.9 climate scenario.However,under the high-emission SSP5-8.5 scenario,the suitability of these regions significantly declines,posing an increasingly severe threat to biodiversity.In addition,by molecular clock analysis,we revealed that the evolutionary divergence of extant nereidid species occurred mainly in the Cretaceous and Jurassic,suggesting that paleogeographical and environmental events,such as oceanic anoxic events,might have played a pivotal role in shaping the evolutionary trajectory and ecological adaptations of marine annelids.These findings highlight the importance of considering both current biodiversity patterns and historical contexts in conservation planning,and provided insights into the potential factors on the biogeographic distribution and evolutionary processes of Nereididae.展开更多
In recent years, since the Obama Administration, the policy discussions on the Indo-Pacific region have gradually moved from conceptualization to strategy. The Indo-Pacific strategy is established during the Trump Adm...In recent years, since the Obama Administration, the policy discussions on the Indo-Pacific region have gradually moved from conceptualization to strategy. The Indo-Pacific strategy is established during the Trump Administration, in which, Japan played a leading role. The Indo-Pacific strategy is advanced jointly by the United States and Japan. In this process, the three characteristics of dual ambiguity, dual assurance and dual check are taking shape, which has a compound influence on the Japan-U.S. alliance and showed the interaction between tension and synergy. Compared with the Asia-Pacific strategy, building a huge Indo-Pacific strategy requires more costs, and Indo-Pacific countries are paying close attention to its development trend.展开更多
Introduction Since Japanese Prime Minister Shinzo Abe launched a new foreign policy doctrine at the opening session of the Sixth Tokyo International Conference on African Development(TICADⅥ)on August 27,2016,Japan’s...Introduction Since Japanese Prime Minister Shinzo Abe launched a new foreign policy doctrine at the opening session of the Sixth Tokyo International Conference on African Development(TICADⅥ)on August 27,2016,Japan’s"Free and Open Indo-Pacific"strategy,or FOIP,has stimulated a broader debate on the future Indo-Pacific regional order.展开更多
Introduced by the late Prime Minister Shinzo Abe and inherited and developed by Fumio Kishida,Japan's“Indo–Pacific”strategy has gradually taken shape.This strategy can be deemed a broad vision,covering a wide r...Introduced by the late Prime Minister Shinzo Abe and inherited and developed by Fumio Kishida,Japan's“Indo–Pacific”strategy has gradually taken shape.This strategy can be deemed a broad vision,covering a wide range of topics and an extensive network of partners,with a strong trend of pan-securitization.It is a comprehensive inter national st rateg y based on Japan's alliance policy and China containment strategy,following a global,security-oriented approach.Driven by considerations such as maintaining its economic status,realizing its long-cherished dream of becoming a political powerhouse,and containing China,Japan has stepped up its“Indo–Pacific”strategy,which may influence global development,undermine regional maritime security,and impede China's reunification process.Meanwhile,Japan's“Indo–Pacific”strategy faces the triple challenge of a strategic overdraft,the unstable economic foundations,and the weak external support.These constraints may not suffice to reverse the direction of Japan's“Indo–Pacific”strategy in the short term but will limit its effectiveness.展开更多
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.展开更多
This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although ...This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.展开更多
India's eastward advancement began in the early 1990s. It was then called the"Look East"policy, and was later upgraded in name to the"Act East"policy in 2014. Over the past 25 years, India'...India's eastward advancement began in the early 1990s. It was then called the"Look East"policy, and was later upgraded in name to the"Act East"policy in 2014. Over the past 25 years, India's"Advance East"strategy has continued to expand, undergoing a compound evolution and upgrade from economy to security, from bilateral to multilateral, from the ASEAN region to East Asia and further onto the Asia-Pacific region,which has been reflected in the rise in India's national strength and regional influence, more and more become an important pillar in India's diplomatic strategy. Nonetheless, the traditional development trends of India's eastward advancement are being affected by the newly emerging Indo-Pacific diplomacy strategies and achievements. India's Indo-Pacific diplomacy was born out of its Advance East strategy, though not limited to advancement east; the core demand of India has always been to merge into the Asia-Pacific region. In other words, India's Advance East strategy is an important pivot for its Indo-Pacific diplomacy. The reliance of India's Indo-Pacific diplomacy on major power diplomacy has impacted the core position of ASEAN in its Advance East strategy, while the element of containing China in India's Indo-Pacific diplomacy will dilute its intention to cooperate with China. This is also manifested in its Advance East strategy.展开更多
Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,thi...Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.展开更多
Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employe...Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employed to fabricate a multi-layer PENG based on a cellulose/polyvinylidene fluoride(PVDF)blend film matrix,incorporating multi-phase BCZT(0.1BaZr_(0.2)Ti_(0.8)O_(3)-0.9Ba_(0.7)Ca_(0.3)TiO_(3))ceramic fillers.Structural characterization via SEM and TEM revealed that an intricate hydrogen-bond network facilitated the uniform dispersion of ceramic fillers within the composite film’s sub-layers.In order to study the effect of filler distribution on piezoelectric performance,the single-and double-layer composite films with varying BCZT configurations were produced and evaluated.The results demonstrated that double-layer PENGs exhibit significantly enhanced electrical output compared to their single-layer counterparts,with the D-L_(3)H_(7) configuration achieving an open circuit voltage(V_(OC))of 23.13 V and a short circuit current(I_(SC))of 8.32μA.This enhancement is attributed to increased inter-layer interfaces,which effectively suppressed charge injection and migration,leading to improved charge density.Additionally,the presence of sharp tipped hexagonal tetragonal phase nanoparticles induced an electric field enhancement effect,further optimizing performance.展开更多
Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practic...Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.展开更多
Since the Trump administration put forward the concept of Indo-Pacific,and even before the recent release of the Indo-Pacific Strategy Report,the United States’Indo-Pacific strategy has consistently been a hotly disc...Since the Trump administration put forward the concept of Indo-Pacific,and even before the recent release of the Indo-Pacific Strategy Report,the United States’Indo-Pacific strategy has consistently been a hotly discussed and heavily researched topic in the strategic and academic communities of China and abroad.Various works have investigated the background of Washington’s proposal and its underlying intention,as well as the geopolitical connotations and future prospects of the strategy.展开更多
The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by the...The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by their interdisciplinary nature,regulatory constraints,and function-oriented definitions.Based on real-world translation examples,this paper analyzes the challenges in translating cosmetics ingredient terminology for international trade and proposes targeted translation strategies.The study aims to facilitate the global marketing of cosmetic products while ensuring consumers can accurately understand product ingredient information.展开更多
Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomed...Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.展开更多
With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitiv...With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitive impairment is characterized by chronicity,which not only seriously threatens the health of the elderly and reduces their quality of life,but also imposes a heavy burden on families and society due to its long course.Attaching importance to and strengthening the chronic disease management of elderly cognitive impairment has profound significance for delaying disease progression,improving patients’quality of life,and reducing the burden of family care.Therefore,this paper first comprehensively understands elderly cognitive impairment by briefly elaborating on its definition and characteristics;on this basis,it focuses on exploring effective strategies for the chronic disease management of elderly cognitive impairment,hoping to provide new ideas and methods for the management of this condition and offer useful references for relevant clinical research and practice.展开更多
文摘The“return to the Asia-Pacific”policy and the“Asia-Pacific rebalancing”policy during the Obama period marked the germination of the Indo-Pacific strategy of the United States,and since then,the Indo-Pacific strategy has been continuously strengthened by the two administrations of Trump and Biden(Ling,2023).In order to stop China from rising,the United States has been trying to draw the ten ASEAN countries which are geographically close to China to American side.However,due to the different national conditions and the different needs of the ten countries,it is difficult for the United States to keep ASEAN’s attitude towards China consistent under the frame of Indo-Pacific strategy.Therefore,this paper will analyze the different attitudes of the ten countries towards China respectively,so as to help China formulate better policies and find better ways to cope with America’s containment of China’s rise and maintain regional and world peace.
文摘The Trump administration of the United States has accelerated the advancement of the‘‘open and free Indo-Pacific’,strategy since 2017.From a geopolitical point of view and in terms of its national interests,Russia has generally been critical of this strategy,believing it has posed certain challenges to its“Pivot to the East”strategy.Meanwhile,Russia is rejoicing for not being the primary target of US containment in the region and has sensed a new opportunity for exercising its Asia-Pacific diplomacy in the context of the Indo-Pacific strategy.Based on this situation,Russia has made a flexible and pragmatic policy response to it.However,Russia will inevitably face many restraints.In the future,Russia will seek to maximize its strategic interests on the basis of adhering to its inherent principles of Asia-Pacific diplomacy.
基金This article is a phased outcome of the National Social Sciences Foundation project:“Japan’s Adjustment of China Strategy in the Context of Belt and Road Initiative and China’s Response”(Project Number:18BGJ056).
文摘Japan-UK security cooperation has been deepening as the Indo-Pacific Strategy has converged with Global Britain,which has become strongly Indo-Pacific-oriented.In terms of their cooperation on security,the two countries have close security interactions,high-level security consultations,numerous mechanisms on security cooperation,frequent defense cooperation and exchanges between forces,and cooperation geared at a response to the Korean nuclear issue.In particular,Japan and the UK regard Indo-Pacific security as the strategic focus of their cooperation,and this underscores the rules-based international order.There are multiple motivations for Japan and the UK to strengthen their security cooperation,and the deepening of their security cooperation in the Indo-Pacific region is to a great extent due to strategic factors,including responding to the US strategic adjustment,Japan and Britain’s respective proactive strategic demands,the improving strategic positions of the Indopacific region,their seeking to shape the regional order in the Indo-Pacific,and so on.Despite facing challenges,Japan-UK security cooperation is continuously strengthening against a background of deepening strategic convergence between the two countries and great power competition.
文摘In 2017, the Trump administration formally articulated its vision for the Indo-Pacific strategy, replacing "Asia-Pacific" with"Indo-Pacific"in policy papers and taking measures to promote the realization of an "Indo-Pacific dream". This represents a significant adjustment in US regional policies. An important power in the Indian Ocean region, India is perceived as key to the successful implementation of this Indo-Pacific strategy. Generally speaking, the current Indian government and strategy circle actively support the upgrading of the"Indo-Pacific"concept from a geographical and academic term to a US vision for foreign strategies, anticipating that India could garner significant strategic benefits from it. Given this, New Delhi will continually adapt its foreign policies to the US Indo-Pacific strategy and may even direct the development of the strategy to counter the Belt and Road Initiative, work with other nations to balance China's influence and finally make the rise of India as a great power a reality. Nonetheless, the Indo-pacific strategy is in its early stages, and the content is not completely pro-India currently. On top of this India is still skeptical of the US and will proceed cautiously, leaving room for maneuver in the future,fully tapping into the benefits of the Indo-Pacific strategy and avoiding direct confrontation with China.
文摘Since the Trump administration,the national security strategy of the United States has focused on addressing the major power competition and regarded China as its main strategic competitor,which has been profoundly reflected in its introduction of the Indo-Pacific Strategy.The United States has certain resource advantages in the process of advancing the Indo-Pacific Strategy,and has made some progress of it.Nonetheless,the prospect of the strategy does not entirely depend on the will and action of the United States,but also on the joint action of other elements.
文摘The Indo-Pacific Strategy Report(IPSR)released by the U.S.Department of Defense on June 1,2019 expounded America’s historic ties to the Indo-Pacific region,looked forward to and established the vision and principles of“One Free and Open Indo-Pacific”,analyzed the strategic picture for the region,and clarified the pluralistic challenges faced by the U.S.and the policy measures to tackle these challenges.Based on the text of IPSR,this essay gives an analysis and study of the historic evolution,policy measurement and restrictive factors of the U.S.“Indo-Pacific Strategy”.
基金Supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB42000000)the National Natural Science Foundation of China(No.42376092)the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(No.2022QNLM030004)。
文摘Nereididae is a prolific annelid family widely distributed in the world oceans,especially in the Indo-Pacific Convergence Zone(IPCZ).However,its biogeographic pattern remains unexplored in IPCZ.To contribute to the understanding of biodiversity and biogeography of Nereididae in the IPCZ,we integrated historical data of species distributions with those of model-predicted ones to determine the biogeographic patterns of nereid species,from which we projected to its future distribution patterns for 2090-2100 under different climate scenarios(SSP1-1.9 and SSP5-8.5).Functional diversity within IPCZ was assessed using functional richness,functional evenness,and functional disparity.Divergence times within Nereididae were estimated using three DNA marker genes(COI,16S,and 18S rRNA),and a time tree was constructed based on a strict molecular clock model.The IPCZ was established as a key Nereididae biodiversity hotspot through distribution modelling of 256 species(44 genera),and temperature emerging as the predominant climatic driver of species distribution patterns.The distribution of species and functional diversity is notable for its non-centralized pattern.We projected that by the end of the century,areas of medium-to-high species richness will expand significantly under the low-emission SSP1-1.9 climate scenario.However,under the high-emission SSP5-8.5 scenario,the suitability of these regions significantly declines,posing an increasingly severe threat to biodiversity.In addition,by molecular clock analysis,we revealed that the evolutionary divergence of extant nereidid species occurred mainly in the Cretaceous and Jurassic,suggesting that paleogeographical and environmental events,such as oceanic anoxic events,might have played a pivotal role in shaping the evolutionary trajectory and ecological adaptations of marine annelids.These findings highlight the importance of considering both current biodiversity patterns and historical contexts in conservation planning,and provided insights into the potential factors on the biogeographic distribution and evolutionary processes of Nereididae.
文摘In recent years, since the Obama Administration, the policy discussions on the Indo-Pacific region have gradually moved from conceptualization to strategy. The Indo-Pacific strategy is established during the Trump Administration, in which, Japan played a leading role. The Indo-Pacific strategy is advanced jointly by the United States and Japan. In this process, the three characteristics of dual ambiguity, dual assurance and dual check are taking shape, which has a compound influence on the Japan-U.S. alliance and showed the interaction between tension and synergy. Compared with the Asia-Pacific strategy, building a huge Indo-Pacific strategy requires more costs, and Indo-Pacific countries are paying close attention to its development trend.
文摘Introduction Since Japanese Prime Minister Shinzo Abe launched a new foreign policy doctrine at the opening session of the Sixth Tokyo International Conference on African Development(TICADⅥ)on August 27,2016,Japan’s"Free and Open Indo-Pacific"strategy,or FOIP,has stimulated a broader debate on the future Indo-Pacific regional order.
文摘Introduced by the late Prime Minister Shinzo Abe and inherited and developed by Fumio Kishida,Japan's“Indo–Pacific”strategy has gradually taken shape.This strategy can be deemed a broad vision,covering a wide range of topics and an extensive network of partners,with a strong trend of pan-securitization.It is a comprehensive inter national st rateg y based on Japan's alliance policy and China containment strategy,following a global,security-oriented approach.Driven by considerations such as maintaining its economic status,realizing its long-cherished dream of becoming a political powerhouse,and containing China,Japan has stepped up its“Indo–Pacific”strategy,which may influence global development,undermine regional maritime security,and impede China's reunification process.Meanwhile,Japan's“Indo–Pacific”strategy faces the triple challenge of a strategic overdraft,the unstable economic foundations,and the weak external support.These constraints may not suffice to reverse the direction of Japan's“Indo–Pacific”strategy in the short term but will limit its effectiveness.
基金supported by the National Natural Science Foundation of China,82471345(to LC)the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
文摘Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.
文摘This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.
文摘India's eastward advancement began in the early 1990s. It was then called the"Look East"policy, and was later upgraded in name to the"Act East"policy in 2014. Over the past 25 years, India's"Advance East"strategy has continued to expand, undergoing a compound evolution and upgrade from economy to security, from bilateral to multilateral, from the ASEAN region to East Asia and further onto the Asia-Pacific region,which has been reflected in the rise in India's national strength and regional influence, more and more become an important pillar in India's diplomatic strategy. Nonetheless, the traditional development trends of India's eastward advancement are being affected by the newly emerging Indo-Pacific diplomacy strategies and achievements. India's Indo-Pacific diplomacy was born out of its Advance East strategy, though not limited to advancement east; the core demand of India has always been to merge into the Asia-Pacific region. In other words, India's Advance East strategy is an important pivot for its Indo-Pacific diplomacy. The reliance of India's Indo-Pacific diplomacy on major power diplomacy has impacted the core position of ASEAN in its Advance East strategy, while the element of containing China in India's Indo-Pacific diplomacy will dilute its intention to cooperate with China. This is also manifested in its Advance East strategy.
文摘Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.
基金National Natural Science Foundation of China(52472132)Opening Project of Engineering Research Center of Eco-friendly Polymeric Materials,Ministry of Education(EFP-KF2403)Innovation Service Capability Support Plan of Xianyang(Science and Technology Innovation Talents)。
文摘Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employed to fabricate a multi-layer PENG based on a cellulose/polyvinylidene fluoride(PVDF)blend film matrix,incorporating multi-phase BCZT(0.1BaZr_(0.2)Ti_(0.8)O_(3)-0.9Ba_(0.7)Ca_(0.3)TiO_(3))ceramic fillers.Structural characterization via SEM and TEM revealed that an intricate hydrogen-bond network facilitated the uniform dispersion of ceramic fillers within the composite film’s sub-layers.In order to study the effect of filler distribution on piezoelectric performance,the single-and double-layer composite films with varying BCZT configurations were produced and evaluated.The results demonstrated that double-layer PENGs exhibit significantly enhanced electrical output compared to their single-layer counterparts,with the D-L_(3)H_(7) configuration achieving an open circuit voltage(V_(OC))of 23.13 V and a short circuit current(I_(SC))of 8.32μA.This enhancement is attributed to increased inter-layer interfaces,which effectively suppressed charge injection and migration,leading to improved charge density.Additionally,the presence of sharp tipped hexagonal tetragonal phase nanoparticles induced an electric field enhancement effect,further optimizing performance.
基金the support from Base for Interdisciplinary Innovative Talent Training,Shanghai Jiao Tong UniversityYouth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine。
文摘Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.
文摘Since the Trump administration put forward the concept of Indo-Pacific,and even before the recent release of the Indo-Pacific Strategy Report,the United States’Indo-Pacific strategy has consistently been a hotly discussed and heavily researched topic in the strategic and academic communities of China and abroad.Various works have investigated the background of Washington’s proposal and its underlying intention,as well as the geopolitical connotations and future prospects of the strategy.
基金funded by 2025 Graduate Teaching Construction Project of USST.
文摘The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by their interdisciplinary nature,regulatory constraints,and function-oriented definitions.Based on real-world translation examples,this paper analyzes the challenges in translating cosmetics ingredient terminology for international trade and proposes targeted translation strategies.The study aims to facilitate the global marketing of cosmetic products while ensuring consumers can accurately understand product ingredient information.
基金supported by the National Natural Science Foundation of China[82003956]the National Key Research and Development Program of China[No.2022YFA1205802]+2 种基金financially supported by Henan Province Health Science and Technology Innovation Youth Talent Project(YQRC2023013 and YQRC2024013)the Key Project of Medical Science and Technology of Henan Province(SBGJ202302072)the Science and Technology Research Project of Henan Province(252102311236).
文摘Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.
文摘With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitive impairment is characterized by chronicity,which not only seriously threatens the health of the elderly and reduces their quality of life,but also imposes a heavy burden on families and society due to its long course.Attaching importance to and strengthening the chronic disease management of elderly cognitive impairment has profound significance for delaying disease progression,improving patients’quality of life,and reducing the burden of family care.Therefore,this paper first comprehensively understands elderly cognitive impairment by briefly elaborating on its definition and characteristics;on this basis,it focuses on exploring effective strategies for the chronic disease management of elderly cognitive impairment,hoping to provide new ideas and methods for the management of this condition and offer useful references for relevant clinical research and practice.
