Trimethoprim(TMP),as a broad-spectrum bacteriostatic antibiotic,is widely used in clinical anti-infection therapy and livestock breeding.However,its low water solubility leads to insufficient bioavailability,which has...Trimethoprim(TMP),as a broad-spectrum bacteriostatic antibiotic,is widely used in clinical anti-infection therapy and livestock breeding.However,its low water solubility leads to insufficient bioavailability,which has become a key problem restricting its development.Cyclodextrins and their derivatives,with their unique cyclic structures,can form inclusion complexes with TMP to improve its properties.This article reviews the pharmacological characteristics of TMP,the types and properties of common cyclodextrins,focusing on introducing various preparation methods of trimethoprim cyclodextrin inclusion complexes and multiple characterization methods for identifying the inclusion complexes,aiming to provide a reference for further research and development of trimethoprim cyclodextrin inclusion complexes.展开更多
When China launched the Made in China 2025(MIC 2025)program 10 years ago,it stirred global interest,some with admiration,some skeptical and others critical.Yet now,as the initiative approaches its original milestone y...When China launched the Made in China 2025(MIC 2025)program 10 years ago,it stirred global interest,some with admiration,some skeptical and others critical.Yet now,as the initiative approaches its original milestone year,one thing is clear:MIC 2025 has profoundly reshaped China's industrial landscape and generated ripple effects that extend far beyond its borders.From low-end manufacturing to advanced industries,MIC 2025 has elevated China’s position in global value chains while supporting broader global goals,such as clean energy,supply chain resilience and technological inclusivity.展开更多
基金Academic Fund for Students of Foshan University in 2024(Project No.:xsjj202409zrb11)。
文摘Trimethoprim(TMP),as a broad-spectrum bacteriostatic antibiotic,is widely used in clinical anti-infection therapy and livestock breeding.However,its low water solubility leads to insufficient bioavailability,which has become a key problem restricting its development.Cyclodextrins and their derivatives,with their unique cyclic structures,can form inclusion complexes with TMP to improve its properties.This article reviews the pharmacological characteristics of TMP,the types and properties of common cyclodextrins,focusing on introducing various preparation methods of trimethoprim cyclodextrin inclusion complexes and multiple characterization methods for identifying the inclusion complexes,aiming to provide a reference for further research and development of trimethoprim cyclodextrin inclusion complexes.
文摘When China launched the Made in China 2025(MIC 2025)program 10 years ago,it stirred global interest,some with admiration,some skeptical and others critical.Yet now,as the initiative approaches its original milestone year,one thing is clear:MIC 2025 has profoundly reshaped China's industrial landscape and generated ripple effects that extend far beyond its borders.From low-end manufacturing to advanced industries,MIC 2025 has elevated China’s position in global value chains while supporting broader global goals,such as clean energy,supply chain resilience and technological inclusivity.
