Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be considered.In this paper,we establish an HIV infection model with n...Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be considered.In this paper,we establish an HIV infection model with nonlocal dispersal and infection age.Moreover,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and dispersal.The well-posedness,positivity,and boundedness of the solution for the model are studied.展开更多
Introduction: The National Central Cancer Registry(NCCR) of China collected population-based cancer registration data from all cancer registries in China. This study aimed to compile national cancer incidences and mor...Introduction: The National Central Cancer Registry(NCCR) of China collected population-based cancer registration data from all cancer registries in China. This study aimed to compile national cancer incidences and mortalities in 2011 and estimate cancer incident new cases and cancer deaths.Methods: In 2014, there were 234 cancer registries that submitted records of new cancer cases and cancer deaths that occurred in 2011 to the NCCR. All datasets were evaluated based on the criteria of data quality of the NCCR. The data of 177 registries was of suicient quality and was compiled to evaluate cancer statistics in 2011. The pooled data were stratiied by area, sex, age group, and cancer type. Cancer incident cases and deaths were estimated using age-standardized rates(ASR) and the Chinese population. All incidences and mortalities were age-standardized to the 2000 Chinese standard population and Segi's population.Results: The estimates of new cancer incident cases and cancer deaths were 3,372,175 and 2,113,048 in 2011, respectively. The crude incidence was 250.28/1,00,000(277.77/1,00,000 for males and 221.37/1,00,000 for females). The ASRs of incidence by the Chinese standard population(ASRIC) and by the world standard population(ASRIW) were 186.34/1,00,000 and 182.76/1,00,000, respectively, with a cumulative incidence(0–74 years old) of 21.20%. Cancers of the lung, female breast, stomach, liver, colorectum, esophagus, cervix, uterus, prostate, and ovary were the most common cancers, accounting for approximately 75% of all new cancer cases. Lung, liver, gastric, esophageal, colorectal, female breast, pancreatic, brain, and cervical cancers and leukemia were the leading causes of cancer death, accounting for approximately 80% of all cancer deaths. Cancer incidence, mortality, and spectrum were all diferent between urban and rural areas and between males and females.Conclusions: The population covered by the cancer registries greatly increased from 2010 to 2011. The data quality and representativeness of cancer registries have gradually improved. Cancer registries have an irreplaceable role in research on cancer prevention and control. The disease burden of cancer is increasing, and the health department must implement efective measures to contain the increased cancer burden in China.展开更多
To search factors influencing morbidity between coronary heart disease(CHD) and stroke, a longitudinal prospective study was done in a cohort of 1 809 participants aged 3574 at entry of Jiangsu province, China. The av...To search factors influencing morbidity between coronary heart disease(CHD) and stroke, a longitudinal prospective study was done in a cohort of 1 809 participants aged 3574 at entry of Jiangsu province, China. The average annual agedadjusted incidence of stroke was 142.3/\{100 000\}, being over 1315 years more than that of coronary event(CE)(49.1/100 000), the difference of the incidences between the two diseases was very significant(P<0.01). Multivariate regression analysis revealed that the main risk factors of CHD include increase of serum total cholecsterol, hypertension and mental stress, whereas the most important risk factors for stroke consist of elevation of systolic blood pressure(SBP) as well as smoking and alcohol drinking habit. It was noted that these participants in cohort usually had high salt intake, low animal protein diet, and low level of serum cholecsterol with high level of blood presure and smoking and alcohol habit. We suggest that rational dietary food, stopping smoking, limited alcohol and community control of hypertension are the preventive strategy against these diseases.展开更多
Malaria is a major cause of morbidity and mortality in Apac district, Northern Uganda. Hence, the study aimed to model malaria incidences with respect to climate variables for the period 2007 to 2016 in Apac district....Malaria is a major cause of morbidity and mortality in Apac district, Northern Uganda. Hence, the study aimed to model malaria incidences with respect to climate variables for the period 2007 to 2016 in Apac district. Data on monthly malaria incidence in Apac district for the period January 2007 to December 2016 was obtained from the Ministry of health, Uganda whereas climate data was obtained from Uganda National Meteorological Authority. Generalized linear models, Poisson and negative binomial regression models were employed to analyze the data. These models were used to fit monthly malaria incidences as a function of monthly rainfall and average temperature. Negative binomial model provided a better fit as compared to the Poisson regression model as indicated by the residual plots and residual deviances. The Pearson correlation test indicated a strong positive association between rainfall and malaria incidences. High malaria incidences were observed in the months of August, September and November. This study showed a significant association between monthly malaria incidence and climate variables that is rainfall and temperature. This study provided useful information for predicting malaria incidence and developing the future warning system. This is an important tool for policy makers to put in place effective control measures for malaria early enough.展开更多
Purpose: This paper aims to assess the incidences and risk factors for surgical site (ISO) infections in the general surgery department of the Koutiala District Hospital. Patients and Methods: This was a prospective a...Purpose: This paper aims to assess the incidences and risk factors for surgical site (ISO) infections in the general surgery department of the Koutiala District Hospital. Patients and Methods: This was a prospective and descriptive study from August 1, 2017 to October 31, 2020 involving all patients who underwent laparotomy in the general surgery department of the Koutiala District Hospital. Patients who were not operated on and who did not have a laparotomy were not included. Age, sex, frequency, patient history, National Nosocomial Infections Surveillance (NNIS) index, time to occur, bacteriological test results and course of infection were analyzed. Results: Fifty patients were registered. The average age was 34.2 ± 21.2 years old. Eleven patients were 60 years old or older. The hospital incidence rate was 4.3% and the community incidence rate was 6.1 cases per 100,000 population. The concept of smoking was noted in 15 patients. Patients were operated on in emergency 84% of cases. Peritonitis was the most common initial lesion with 32% of cases. Our patients had an NNIS index greater than 0 in 84% of cases. The time to develop infection from the surgical site was less than 3 days in 8 patients (16% of cases). Depending on the depth of the infection, it was superficial (cutaneous) in 39 patients (78%) and deep (subcutaneous and organic) in 11 patients (22%). Escherichia coli was the most common germ with 72% followed by staphylococcus aureus at 24%. We noted 22% morbidity. The median length of hospitalization was 9 ± 2.2 days. Conclusion: ISO is common in our service. Prevention and mastery require knowledge of risk factors.展开更多
Introduction:Measles,mumps,and rubella remain significant global health threats despite being vaccine-preventable diseases.The World Health Organization aims to achieve regional elimination of measles and rubella by 2...Introduction:Measles,mumps,and rubella remain significant global health threats despite being vaccine-preventable diseases.The World Health Organization aims to achieve regional elimination of measles and rubella by 2030,yet substantial disparities in vaccination coverage and disease incidence persist across regions.We analyzed global vaccination and disease data to provide evidence for optimizing immunization strategies.Methods:The study analyzed World Health Organization data on measles,mumps,and rubella from 2014–2023.Our analysis included vaccine types,recommended vaccination schedules,coverage rates,supplemental immunization activities,and disease incidence.We employed descriptive epidemiological methods for data synthesis and analysis.Results:All countries implemented≥1 measlescontaining vaccine dose,with 190(97.9%)countries using a≥2-dose schedule.Global 2nd dose of measlescontaining vaccine coverage increased from 59%to 74%during the study period.High-income regions maintained>90%coverage,while the African Region reported the lowest coverage(70%for the 1st dose and 49%for the 2nd dose of measles-containing vaccine).Supplemental immunization activities helped address coverage gaps but required integration with routine immunization systems.Rubella vaccine was implemented in 90.2%of countries,while mumps vaccine adoption remained lower at 63.9%.The African Region experienced high incidence rates for both measles(551.8 per million)and rubella(21.9 per million).The COVID-19 pandemic disrupted vaccination coverage(3%–5%decline globally),with the African Region experiencing a post-pandemic U-shaped resurgence in cases.China’s transition to the measles,mumps,and rubella vaccine has reduced mumps incidence to below 100 cases per million by 2020.Conclusions:While global control of measles,mumps,and rubella has progressed,inequities in vaccination coverage and pandemic-related disruptions threaten elimination goals.Strengthening routine immunization systems is critical.Achieving the World Health Organization’s 2030 targets will require sustained investment in health systems and implementation of equity-focused innovations.展开更多
The aim of this study was to investigate the combined effects of chitosan oligosaccharide(COS) and a microencapsulated Enterococcus faecalis CG1.0007 probiotic(PRO) on growth performance and diarrhea incidences in ent...The aim of this study was to investigate the combined effects of chitosan oligosaccharide(COS) and a microencapsulated Enterococcus faecalis CG1.0007 probiotic(PRO) on growth performance and diarrhea incidences in enterotoxigenic Escherichia coli(ETEC) K88^+ challenged piglets in a 14-d study. Thirty piglets,7.19 ± 0.52 kg initial BW weaned at 21 ± 1 d.were allotted to 5 treatment groups(n = 6)consisting of a corn-soybean meal diet with no additive(negative control, NC), NC + 0.25% chlortetracycline(positive control, PC), NC + 400 mg/kg COS(COS), NC + 100 mg/kg PRO(PRO) and NC + a combination of COS and PRO(CPRO). Pigs were individually housed in cages, acclimated to treatments for a 7-d period and had ad libitum access to feed and water throughout the study, On d 8, pigs were weighed, blood samples were collected, and then orally challenged with 6 mL(1 ×10^(11) cfu/mL) of freshly grown ETEC inoculum. During post-challenge period, blood was sampled at 24 and 48 h to determine plasma urea nitrogen(PUN), and diarrhea incidences and fecal consistency scores were recorded from d 9 to 12. On d 14, all pigs were weighed and then euthanized to obtain intestinal tissue samples for histomorphometric measurements. Growth performance responses were similar among treatments during the pre-and post-challenge periods. There were no significant differences in PUN content, incidences of diarrhea, and fecal consistency scores among treatments. The intestinal histomorphology results did not differ significantly among treatments except for PC with increased(P = 0.0001) villus:crypt ratio compared with the NC. Under the conditions of the present study, it can be concluded that supplementation of piglet diets with 400 mg/kg COS, 100 mg/kg microencapsulated PRO or their combination did not significantly improve piglet growth performance both during the pre-and post-ETEC K88+ oral inoculation. Also, there were no significant reduction of incidences and severity of diarrhea after challenge compared with the control group.展开更多
This study investigates the reduction in polarization measurement accuracy caused by varying in-cident angles in a liquid crystal variable retarder(LCVR).The phase delay characteristics of the LCVR were examined,with ...This study investigates the reduction in polarization measurement accuracy caused by varying in-cident angles in a liquid crystal variable retarder(LCVR).The phase delay characteristics of the LCVR were examined,with particular emphasis on the influence of different two-dimensional incident angles on phase delay behavior.Building upon the calibration of phase delay under normal incidence,a phase delay calibra-tion model was developed to account for variations in incident angle and driving voltage.A mathematical re-lationship was established between phase delay and the azimuth angle(α)and pitch angle(β).Experimental validation was conducted under three conditions:α=20°,β=0°;α=0°,β=20°;and an arbitrary angle whereα=5°,β=15°.The results demonstrated that the maximum average deviation between theoretical pre-dictions and experimental measurements did not exceed 0.059 rad.The proposed calibration method proved to be both accurate and practical.This approach offers robust support for LCVR parameter calibration and performance optimization in optical systems,particularly in polarization imaging applications.展开更多
The aim was to evaluate the effects of dietary supplementation of spay-dried whole egg containing antiF4 antibodies(SDWE) against recombinantly produced F4 antigens in enterotoxigenic Escherichia coli K88^+(ETEC)-chal...The aim was to evaluate the effects of dietary supplementation of spay-dried whole egg containing antiF4 antibodies(SDWE) against recombinantly produced F4 antigens in enterotoxigenic Escherichia coli K88^+(ETEC)-challenged piglets. Twenty-seven 21-d-old and individually housed piglets were randomly allotted to 3 treatments consisting of a wheat-soybean meal basal diet containing either 0(control egg powder; CEP), 0.1%(SDWE1) or 0.4%(SDWE2) SDWE. After a 7-d adaptation period, blood samples were collected from all pigs,and pigs were weighed and orally challenged with an ETEC inoculum. Blood was sampled at 24 and 48 h post-challenge, and diarrhea incidences and scores were recorded. On d 14, all pigs were weighed and then euthanized to obtain intestinal tissue samples for histomorphology measurement. During the pre-challenge period, pigs fed the SDWE showed a linear improvement(P < 0.05)in average daily gain(ADG) and gain to feed ratio(G:F), but there were no differences among treatments in growth performance during the post-challenge period. Diarrhea incidences and scores, fecal shedding of ETEC, plasma urea nitrogen content and intestinal histo morphology were similar among treatments.The results show that 0.4% SDWE supported greater piglet performance before challenge although such benefits were not evident during the post-challenge period at either 0.1% or 0.4% supplementation.展开更多
Background Military service members routinely participate in combatives training(boxing,judo,martial arts,and hand-to-hand combat)to acquire and maintain mission essential skills.Despite injury mitigation strategies,h...Background Military service members routinely participate in combatives training(boxing,judo,martial arts,and hand-to-hand combat)to acquire and maintain mission essential skills.Despite injury mitigation strategies,high concussion incidence rates of 20.8 concussions per 100 exposures while participating in combative sports have been reported.The purpose of this study was to identify factors potentially associated with greater odds of sustaining a concussion in these combative activities in a military training environment.Methods A retrospective cohort study was conducted with participants enrolled at 4 military service academies participating in the concussion assessment,research,and education consortium from 2014 to 2020.Demographic information(site,varsity status,sport contact level,sex,concussion history,and headache history)and pre-injury baseline assessments(e.g.,Balance Error Scoring System(BESS),Brief Symptom Inventory(BSI))were collected at the time of enrollment.Univariate and multivariable logistic regression models were used to estimate the odds of sustaining a concussion while participating in combatives training during the follow-up period based on these pre-injury characteristics.Results During the study period,17,681 participants(25%female;19.11±1.45 years(mean±SD))completed a baseline assessment and 484(35%female;19.88±1.43 years)sustained a concussion during a combatives training.Univariate logistic regression models revealed females(odds ratio(OR)=1.71;p<0.001;95%confidence interval(95%CI):1.41–2.07),participating in high contact varsity sports(OR=0.52;p<0.001;95%CI:0.38–0.71),BSI total score(OR=1.03;p<0.001;95%CI:1.01–1.04),BESS total score(OR=1.02;p<0.001;95%CI:1.02–1.04),and headache history(OR=1.43;p<0.001;95%CI:1.18–1.73)were associated with greater odds of sustaining a combatives-related concussion.Multivariable models yielded similar results after controlling for significant covariates.Conclusion Females,higher BSI and BESS total scores at baseline,and participants with a history of headaches had greater odds of sustaining a combatives-related concussion during the follow-up period.Conversely,participants in high contact varsity sports had lower odds of sustaining a combatives-related concussion.These different variables should be taken into account when designing combatives training programs in a military setting.展开更多
1.Introduction Injury prevention is an essential element of science and medicine in sports,and it garners attention from stakeholders focused on minimizing athletes’injury risk.Catchy titles including“injury risk”o...1.Introduction Injury prevention is an essential element of science and medicine in sports,and it garners attention from stakeholders focused on minimizing athletes’injury risk.Catchy titles including“injury risk”or“injury prevention”are likely to grab the readers’attention.Meanwhile,studies on injury prevention might assess the impact of interventions on mitigating injury risk factors(e.g.,strength,range of motion(ROM))but fail to report injury data(e.g.,incidence).1,2 Likewise,observational studies may include“injury risk”in their titles,but fail to provide injury data.3 Without injury data.展开更多
Hepatitis B Virus(HBV)infection and heavy alcohol consumption are the two primary pathogenic causes of liver cirrhosis.In this paper,we proposed a deterministic mathematical model and a logistic equation to investigat...Hepatitis B Virus(HBV)infection and heavy alcohol consumption are the two primary pathogenic causes of liver cirrhosis.In this paper,we proposed a deterministic mathematical model and a logistic equation to investigate the dynamics of liver cirrhosis progression as well as to explain the implications of variations in alcohol consumption on chronic hepatitis B patients,respectively.The intricate interactions between liver cirrhosis,recovery,and treatment dynamics are captured by the model.This study aims to show that alcohol consumption by Hepatitis B-infected individuals accelerates liver cirrhosis progression while treatment of acutely infected individuals reduces it.We proved that a unique solution of the proposed model exists,which is positive and bounded.Using the next-generation matrix approach,two basic reproductive numbers R_(A_(0))and R_(A_(max))are calculated to identify future recurrence.The equilibrium points are calculated,and both equilibria are proved locally and globally asymptotically stable when R_(0)is below and above one,respectively.It is shown that bifurcation exists at R_(0)=1 and a detailed proof for forward bifurcation is given.Furthermore,we performed the sensitivity analysis of the model parameters on R_(0).For the confirmation of analytical work,we performed numerical simulations,and the results indicate that the treatment and the inhibitory effects reduce the risk of developing liver cirrhosis in individuals,while heavy alcohol consumption accelerates markedly the liver cirrhosis progression in patients with chronic hepatitis B.展开更多
Reinforced concrete(RC)beams face potential near-field blast threats as key structural components in building structures.To investigate the failure modes and dynamic responses of RC beams subjected to near-field blast...Reinforced concrete(RC)beams face potential near-field blast threats as key structural components in building structures.To investigate the failure modes and dynamic responses of RC beams subjected to near-field blast loading,this paper presents both blast tests and numerical simulation studies on RC beams.First,near-field blast tests were conducted on five RC beam specimens under strong and weak-axis bending loading.Then,a refined finite element model of RC beams was established to verify the applicability of the adopted finite element analysis method.Finally,based on the calibrated finite element model,the failure mechanisms of RC beams were explored,and the influence of blast incidence angle on the failure modes and dynamic responses of RC beams was investigated.The results indicate:(i)Near-field blast loading demonstrates pronounced non-uniform distribution patterns.Under strong-axis incidence,clearing effects beyond the mid-span region are more significant than weak-axis incidence,leading to accelerated impulse attenuation.(ii)Three consecutive developmental stages primarily control the damage mechanism of RC beams:stress wave-induced local damage,local deformation causing plastic hinge propagation,and free vibration of the beam;(iii)As the scaled distance decreases,the failure mode of RC beams under weak-axis blast loading evolves from flexural failure to local failure.The resistance mechanism of RC beams under weak-axis blast loading is more prone to transition from compressive membrane action to tensile membrane action,reducing their blast resistance capacity;(iv)As the explosion incident angleθincreases from 0°to 90°,the blast wave-structure interaction transitions from regular reflection to Mach reflection and back to normal reflection,causing the dynamic response of RC beams to first decrease then increase,with corner concrete spalling damage being the primary failure mode.展开更多
Carfilzomib(CFZ)is an irreversible proteasome inhibitor cur-rently approved for the treatment of relapsed multiple myeloma(MM).It has been implicated as a cause of thrombotic micro-angiopathy(TMA)and mostly occurs aft...Carfilzomib(CFZ)is an irreversible proteasome inhibitor cur-rently approved for the treatment of relapsed multiple myeloma(MM).It has been implicated as a cause of thrombotic micro-angiopathy(TMA)and mostly occurs after two courses of chemotherapy.The incidence,risk factors,and treatment of CFZ-related TMA remain unclear.Here we describe two cases.展开更多
A methodology for the reduction of radar cross section(RCS)of cambered platforms within the target airspace is presented,which utilizes a dual-polarized ultra-wide-angle artificial electromagnetic absorbing surface.By...A methodology for the reduction of radar cross section(RCS)of cambered platforms within the target airspace is presented,which utilizes a dual-polarized ultra-wide-angle artificial electromagnetic absorbing surface.By applying the theory of generalized Brewster complex wave impedance matching,five distinct unit cell designs are developed to attain more than95%absorption rate for dual-polarized incident waves within five angular ranges:0°-30°,30°-50°,50°-60°,60°-70°,and 70°-80°.To optimally reduce the RCS of a cambered platform,the five types of units can be evenly distributed on the surface based on the local incident angles of plane waves originating from the target airspace.As an illustrative example,the leading edge of an airfoil is taken into account,and experimental measurements validate the efficiency of the proposed structure.Specifically,the absorbing surface achieves more than 10 dB of RCS reduction in the frequency ranges from 5-10 GHz(about66.7%relative bandwidth)for dual polarizations.展开更多
According to the 2024 global cancer data from GLOBOCAN,liver cancer ranks the 6th most common malignancy and the 3rd leading cause of cancer-related mortality worldwide[1].Among these cases,hepatocellular carcinoma(HC...According to the 2024 global cancer data from GLOBOCAN,liver cancer ranks the 6th most common malignancy and the 3rd leading cause of cancer-related mortality worldwide[1].Among these cases,hepatocellular carcinoma(HCC)accounts for approximately 85%−90%[2,3].Its incidence and mortality rates remain persistently high worldwide.However,China has the highest incidence and mortality rates of the disease in the world[4].And the majority of patients are diagnosed at intermediate or advanced stages.Thus,identifying novel tumor biomarkers for early detection and implementing precision therapy has long been a key focus of research.展开更多
Tuberculosis(TB),one of the oldest infectious diseases caused by Mycobacterium tuberculosis,poses a considerable challenge to global public health.There are approximately 10 million new TB cases worldwide annually,and...Tuberculosis(TB),one of the oldest infectious diseases caused by Mycobacterium tuberculosis,poses a considerable challenge to global public health.There are approximately 10 million new TB cases worldwide annually,and TB claims the lives of nearly 3 million people each year,making it one of the leading causes of death from a single infectious disease[1].China ranks third globally in terms of TB burden,with approximately 733,000 TB cases reported in 2023[2].Based on the ecological model of health determinants developed by Whitehead and Dahlgren,health determinants can be classified into direct causes.展开更多
The metalens has attracted remarkable attention due to its ultra-thin and ultra-light characteristics,which indicate great potential for compact imaging.However,the limited efficiency at a large angle incidence severe...The metalens has attracted remarkable attention due to its ultra-thin and ultra-light characteristics,which indicate great potential for compact imaging.However,the limited efficiency at a large angle incidence severely hinders the application of wide-angle focusing and imaging,which is pursued in the fast-developing imaging systems.Therefore,new strategies to improve the lens performance at large incident angles are in demand.In this work,we propose tilted structures for largeangle focusing with improved efficiency.Metalenses based on dynamic phase and geometric phase are designed and systematically characterized by numerical simulations.We show that tilted structures of unit cells significantly improve the lens performance at oblique incidences.In detail,the focusing efficiency of the metalens with tilted structures is increased over 25%at 30°incidence,as well as the modulation transfer function.In addition,we develop a hybrid metalens array achieving highly efficient wide-angle imaging up to 120°.We believe this design provides a feasible route toward wide-field and high-performance imaging applications.展开更多
This paper investigates a nonlocal dispersal epidemic model under the multiple nonlocal distributed delays and nonlinear incidence effects.First,the minimal wave speed c*and the basic reproduction number Ro are define...This paper investigates a nonlocal dispersal epidemic model under the multiple nonlocal distributed delays and nonlinear incidence effects.First,the minimal wave speed c*and the basic reproduction number Ro are defined,which determine the existence of traveling wave solutions.Second,with the help of the upper and lower solutions,Schauder's fixed point theorem,and limiting techniques,the traveling waves satisfying some asymptotic boundary conditions are discussed.Specifically,when Ro>1,for every speed c>c^(*) there exists a traveling wave solution satisfying the boundary conditions,and there is no such traveling wave solution for any 0<c<c^(*) when R_(0)>1 or c>0 when R_(0)<1.Finally,we analyze the effects of nonlocal time delay on the minimum wave speed.展开更多
The diagnosis and treatment processes for long COVID have been relatively slow to develop for several reasons,such as a lack of consensus about its definition among medical professionals and researchers,and restricted...The diagnosis and treatment processes for long COVID have been relatively slow to develop for several reasons,such as a lack of consensus about its definition among medical professionals and researchers,and restricted access to knowledge from the relevant pandemics of the past.Legacies of viral pandemics unfortunately do not include sufficient research on how the acute symptoms of infection evolved into chronic health conditions.More so,the idea of surviving a viral pandemic with long-lasting symptoms is not new,yet it is curiously disjointed as a medical concept throughout documented histories on the subject.Individuals with long-term conditions that are rooted in acute viral infections,such as COVID-19,require a coordinated system of care that includes comprehensive rehabilitation.This commentary will discuss the philosophical underpinnings of the historical scarcity of documented incidences of individuals with chronic virus symptoms and the need for a shift in post-viral infection treatment approaches.展开更多
基金Supported by Funding for the National Natural Science Foundation of China(12201557,12001483,61807006)。
文摘Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be considered.In this paper,we establish an HIV infection model with nonlocal dispersal and infection age.Moreover,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and dispersal.The well-posedness,positivity,and boundedness of the solution for the model are studied.
文摘Introduction: The National Central Cancer Registry(NCCR) of China collected population-based cancer registration data from all cancer registries in China. This study aimed to compile national cancer incidences and mortalities in 2011 and estimate cancer incident new cases and cancer deaths.Methods: In 2014, there were 234 cancer registries that submitted records of new cancer cases and cancer deaths that occurred in 2011 to the NCCR. All datasets were evaluated based on the criteria of data quality of the NCCR. The data of 177 registries was of suicient quality and was compiled to evaluate cancer statistics in 2011. The pooled data were stratiied by area, sex, age group, and cancer type. Cancer incident cases and deaths were estimated using age-standardized rates(ASR) and the Chinese population. All incidences and mortalities were age-standardized to the 2000 Chinese standard population and Segi's population.Results: The estimates of new cancer incident cases and cancer deaths were 3,372,175 and 2,113,048 in 2011, respectively. The crude incidence was 250.28/1,00,000(277.77/1,00,000 for males and 221.37/1,00,000 for females). The ASRs of incidence by the Chinese standard population(ASRIC) and by the world standard population(ASRIW) were 186.34/1,00,000 and 182.76/1,00,000, respectively, with a cumulative incidence(0–74 years old) of 21.20%. Cancers of the lung, female breast, stomach, liver, colorectum, esophagus, cervix, uterus, prostate, and ovary were the most common cancers, accounting for approximately 75% of all new cancer cases. Lung, liver, gastric, esophageal, colorectal, female breast, pancreatic, brain, and cervical cancers and leukemia were the leading causes of cancer death, accounting for approximately 80% of all cancer deaths. Cancer incidence, mortality, and spectrum were all diferent between urban and rural areas and between males and females.Conclusions: The population covered by the cancer registries greatly increased from 2010 to 2011. The data quality and representativeness of cancer registries have gradually improved. Cancer registries have an irreplaceable role in research on cancer prevention and control. The disease burden of cancer is increasing, and the health department must implement efective measures to contain the increased cancer burden in China.
文摘To search factors influencing morbidity between coronary heart disease(CHD) and stroke, a longitudinal prospective study was done in a cohort of 1 809 participants aged 3574 at entry of Jiangsu province, China. The average annual agedadjusted incidence of stroke was 142.3/\{100 000\}, being over 1315 years more than that of coronary event(CE)(49.1/100 000), the difference of the incidences between the two diseases was very significant(P<0.01). Multivariate regression analysis revealed that the main risk factors of CHD include increase of serum total cholecsterol, hypertension and mental stress, whereas the most important risk factors for stroke consist of elevation of systolic blood pressure(SBP) as well as smoking and alcohol drinking habit. It was noted that these participants in cohort usually had high salt intake, low animal protein diet, and low level of serum cholecsterol with high level of blood presure and smoking and alcohol habit. We suggest that rational dietary food, stopping smoking, limited alcohol and community control of hypertension are the preventive strategy against these diseases.
文摘Malaria is a major cause of morbidity and mortality in Apac district, Northern Uganda. Hence, the study aimed to model malaria incidences with respect to climate variables for the period 2007 to 2016 in Apac district. Data on monthly malaria incidence in Apac district for the period January 2007 to December 2016 was obtained from the Ministry of health, Uganda whereas climate data was obtained from Uganda National Meteorological Authority. Generalized linear models, Poisson and negative binomial regression models were employed to analyze the data. These models were used to fit monthly malaria incidences as a function of monthly rainfall and average temperature. Negative binomial model provided a better fit as compared to the Poisson regression model as indicated by the residual plots and residual deviances. The Pearson correlation test indicated a strong positive association between rainfall and malaria incidences. High malaria incidences were observed in the months of August, September and November. This study showed a significant association between monthly malaria incidence and climate variables that is rainfall and temperature. This study provided useful information for predicting malaria incidence and developing the future warning system. This is an important tool for policy makers to put in place effective control measures for malaria early enough.
文摘Purpose: This paper aims to assess the incidences and risk factors for surgical site (ISO) infections in the general surgery department of the Koutiala District Hospital. Patients and Methods: This was a prospective and descriptive study from August 1, 2017 to October 31, 2020 involving all patients who underwent laparotomy in the general surgery department of the Koutiala District Hospital. Patients who were not operated on and who did not have a laparotomy were not included. Age, sex, frequency, patient history, National Nosocomial Infections Surveillance (NNIS) index, time to occur, bacteriological test results and course of infection were analyzed. Results: Fifty patients were registered. The average age was 34.2 ± 21.2 years old. Eleven patients were 60 years old or older. The hospital incidence rate was 4.3% and the community incidence rate was 6.1 cases per 100,000 population. The concept of smoking was noted in 15 patients. Patients were operated on in emergency 84% of cases. Peritonitis was the most common initial lesion with 32% of cases. Our patients had an NNIS index greater than 0 in 84% of cases. The time to develop infection from the surgical site was less than 3 days in 8 patients (16% of cases). Depending on the depth of the infection, it was superficial (cutaneous) in 39 patients (78%) and deep (subcutaneous and organic) in 11 patients (22%). Escherichia coli was the most common germ with 72% followed by staphylococcus aureus at 24%. We noted 22% morbidity. The median length of hospitalization was 9 ± 2.2 days. Conclusion: ISO is common in our service. Prevention and mastery require knowledge of risk factors.
基金Supported by the operation of the public health emergency response mechanism of the Chinese Center for Disease Control and Prevention(102393220020010000017-251705)the World Health Organization development for manual of measles elimination.
文摘Introduction:Measles,mumps,and rubella remain significant global health threats despite being vaccine-preventable diseases.The World Health Organization aims to achieve regional elimination of measles and rubella by 2030,yet substantial disparities in vaccination coverage and disease incidence persist across regions.We analyzed global vaccination and disease data to provide evidence for optimizing immunization strategies.Methods:The study analyzed World Health Organization data on measles,mumps,and rubella from 2014–2023.Our analysis included vaccine types,recommended vaccination schedules,coverage rates,supplemental immunization activities,and disease incidence.We employed descriptive epidemiological methods for data synthesis and analysis.Results:All countries implemented≥1 measlescontaining vaccine dose,with 190(97.9%)countries using a≥2-dose schedule.Global 2nd dose of measlescontaining vaccine coverage increased from 59%to 74%during the study period.High-income regions maintained>90%coverage,while the African Region reported the lowest coverage(70%for the 1st dose and 49%for the 2nd dose of measles-containing vaccine).Supplemental immunization activities helped address coverage gaps but required integration with routine immunization systems.Rubella vaccine was implemented in 90.2%of countries,while mumps vaccine adoption remained lower at 63.9%.The African Region experienced high incidence rates for both measles(551.8 per million)and rubella(21.9 per million).The COVID-19 pandemic disrupted vaccination coverage(3%–5%decline globally),with the African Region experiencing a post-pandemic U-shaped resurgence in cases.China’s transition to the measles,mumps,and rubella vaccine has reduced mumps incidence to below 100 cases per million by 2020.Conclusions:While global control of measles,mumps,and rubella has progressed,inequities in vaccination coverage and pandemic-related disruptions threaten elimination goals.Strengthening routine immunization systems is critical.Achieving the World Health Organization’s 2030 targets will require sustained investment in health systems and implementation of equity-focused innovations.
基金funded by Natural Sciences and Engineering Research Council of Canada and Manitoba Pork Council
文摘The aim of this study was to investigate the combined effects of chitosan oligosaccharide(COS) and a microencapsulated Enterococcus faecalis CG1.0007 probiotic(PRO) on growth performance and diarrhea incidences in enterotoxigenic Escherichia coli(ETEC) K88^+ challenged piglets in a 14-d study. Thirty piglets,7.19 ± 0.52 kg initial BW weaned at 21 ± 1 d.were allotted to 5 treatment groups(n = 6)consisting of a corn-soybean meal diet with no additive(negative control, NC), NC + 0.25% chlortetracycline(positive control, PC), NC + 400 mg/kg COS(COS), NC + 100 mg/kg PRO(PRO) and NC + a combination of COS and PRO(CPRO). Pigs were individually housed in cages, acclimated to treatments for a 7-d period and had ad libitum access to feed and water throughout the study, On d 8, pigs were weighed, blood samples were collected, and then orally challenged with 6 mL(1 ×10^(11) cfu/mL) of freshly grown ETEC inoculum. During post-challenge period, blood was sampled at 24 and 48 h to determine plasma urea nitrogen(PUN), and diarrhea incidences and fecal consistency scores were recorded from d 9 to 12. On d 14, all pigs were weighed and then euthanized to obtain intestinal tissue samples for histomorphometric measurements. Growth performance responses were similar among treatments during the pre-and post-challenge periods. There were no significant differences in PUN content, incidences of diarrhea, and fecal consistency scores among treatments. The intestinal histomorphology results did not differ significantly among treatments except for PC with increased(P = 0.0001) villus:crypt ratio compared with the NC. Under the conditions of the present study, it can be concluded that supplementation of piglet diets with 400 mg/kg COS, 100 mg/kg microencapsulated PRO or their combination did not significantly improve piglet growth performance both during the pre-and post-ETEC K88+ oral inoculation. Also, there were no significant reduction of incidences and severity of diarrhea after challenge compared with the control group.
文摘This study investigates the reduction in polarization measurement accuracy caused by varying in-cident angles in a liquid crystal variable retarder(LCVR).The phase delay characteristics of the LCVR were examined,with particular emphasis on the influence of different two-dimensional incident angles on phase delay behavior.Building upon the calibration of phase delay under normal incidence,a phase delay calibra-tion model was developed to account for variations in incident angle and driving voltage.A mathematical re-lationship was established between phase delay and the azimuth angle(α)and pitch angle(β).Experimental validation was conducted under three conditions:α=20°,β=0°;α=0°,β=20°;and an arbitrary angle whereα=5°,β=15°.The results demonstrated that the maximum average deviation between theoretical pre-dictions and experimental measurements did not exceed 0.059 rad.The proposed calibration method proved to be both accurate and practical.This approach offers robust support for LCVR parameter calibration and performance optimization in optical systems,particularly in polarization imaging applications.
基金funded by Natural Sciences and Engineering Research Council of Canada and Zyme Fast System Inc.
文摘The aim was to evaluate the effects of dietary supplementation of spay-dried whole egg containing antiF4 antibodies(SDWE) against recombinantly produced F4 antigens in enterotoxigenic Escherichia coli K88^+(ETEC)-challenged piglets. Twenty-seven 21-d-old and individually housed piglets were randomly allotted to 3 treatments consisting of a wheat-soybean meal basal diet containing either 0(control egg powder; CEP), 0.1%(SDWE1) or 0.4%(SDWE2) SDWE. After a 7-d adaptation period, blood samples were collected from all pigs,and pigs were weighed and orally challenged with an ETEC inoculum. Blood was sampled at 24 and 48 h post-challenge, and diarrhea incidences and scores were recorded. On d 14, all pigs were weighed and then euthanized to obtain intestinal tissue samples for histomorphology measurement. During the pre-challenge period, pigs fed the SDWE showed a linear improvement(P < 0.05)in average daily gain(ADG) and gain to feed ratio(G:F), but there were no differences among treatments in growth performance during the post-challenge period. Diarrhea incidences and scores, fecal shedding of ETEC, plasma urea nitrogen content and intestinal histo morphology were similar among treatments.The results show that 0.4% SDWE supported greater piglet performance before challenge although such benefits were not evident during the post-challenge period at either 0.1% or 0.4% supplementation.
基金supported by the Office of the Assistant Secretary of Defense for Health Affairs,through the Combat Casualty Care Research Program,endorsed by the Department of Defense,through the Joint Program Committee 6/Combat Casualty Care Research Program-Psychological Health and Traumatic Brain Injury Program under Award No.W81XWH1420151 and No.W81XWH1820047.
文摘Background Military service members routinely participate in combatives training(boxing,judo,martial arts,and hand-to-hand combat)to acquire and maintain mission essential skills.Despite injury mitigation strategies,high concussion incidence rates of 20.8 concussions per 100 exposures while participating in combative sports have been reported.The purpose of this study was to identify factors potentially associated with greater odds of sustaining a concussion in these combative activities in a military training environment.Methods A retrospective cohort study was conducted with participants enrolled at 4 military service academies participating in the concussion assessment,research,and education consortium from 2014 to 2020.Demographic information(site,varsity status,sport contact level,sex,concussion history,and headache history)and pre-injury baseline assessments(e.g.,Balance Error Scoring System(BESS),Brief Symptom Inventory(BSI))were collected at the time of enrollment.Univariate and multivariable logistic regression models were used to estimate the odds of sustaining a concussion while participating in combatives training during the follow-up period based on these pre-injury characteristics.Results During the study period,17,681 participants(25%female;19.11±1.45 years(mean±SD))completed a baseline assessment and 484(35%female;19.88±1.43 years)sustained a concussion during a combatives training.Univariate logistic regression models revealed females(odds ratio(OR)=1.71;p<0.001;95%confidence interval(95%CI):1.41–2.07),participating in high contact varsity sports(OR=0.52;p<0.001;95%CI:0.38–0.71),BSI total score(OR=1.03;p<0.001;95%CI:1.01–1.04),BESS total score(OR=1.02;p<0.001;95%CI:1.02–1.04),and headache history(OR=1.43;p<0.001;95%CI:1.18–1.73)were associated with greater odds of sustaining a combatives-related concussion.Multivariable models yielded similar results after controlling for significant covariates.Conclusion Females,higher BSI and BESS total scores at baseline,and participants with a history of headaches had greater odds of sustaining a combatives-related concussion during the follow-up period.Conversely,participants in high contact varsity sports had lower odds of sustaining a combatives-related concussion.These different variables should be taken into account when designing combatives training programs in a military setting.
基金Centre of Research,Education,Innovation,and Intervention in Sport(CIFI2D)is financed by the Portuguese Foundation for Science and Technology,under the DOI https://doi.org/10.54499/UIDB/05913/2020。
文摘1.Introduction Injury prevention is an essential element of science and medicine in sports,and it garners attention from stakeholders focused on minimizing athletes’injury risk.Catchy titles including“injury risk”or“injury prevention”are likely to grab the readers’attention.Meanwhile,studies on injury prevention might assess the impact of interventions on mitigating injury risk factors(e.g.,strength,range of motion(ROM))but fail to report injury data(e.g.,incidence).1,2 Likewise,observational studies may include“injury risk”in their titles,but fail to provide injury data.3 Without injury data.
文摘Hepatitis B Virus(HBV)infection and heavy alcohol consumption are the two primary pathogenic causes of liver cirrhosis.In this paper,we proposed a deterministic mathematical model and a logistic equation to investigate the dynamics of liver cirrhosis progression as well as to explain the implications of variations in alcohol consumption on chronic hepatitis B patients,respectively.The intricate interactions between liver cirrhosis,recovery,and treatment dynamics are captured by the model.This study aims to show that alcohol consumption by Hepatitis B-infected individuals accelerates liver cirrhosis progression while treatment of acutely infected individuals reduces it.We proved that a unique solution of the proposed model exists,which is positive and bounded.Using the next-generation matrix approach,two basic reproductive numbers R_(A_(0))and R_(A_(max))are calculated to identify future recurrence.The equilibrium points are calculated,and both equilibria are proved locally and globally asymptotically stable when R_(0)is below and above one,respectively.It is shown that bifurcation exists at R_(0)=1 and a detailed proof for forward bifurcation is given.Furthermore,we performed the sensitivity analysis of the model parameters on R_(0).For the confirmation of analytical work,we performed numerical simulations,and the results indicate that the treatment and the inhibitory effects reduce the risk of developing liver cirrhosis in individuals,while heavy alcohol consumption accelerates markedly the liver cirrhosis progression in patients with chronic hepatitis B.
基金supported by the National Natural Science Foundation of China(Grant Nos.52178445,52578544)Open Research Fund of State Key Laboratory of Target Vulnerability Assessment,Defense Engineering Institute,AMS(Grant No.YSX2024KFYS002).
文摘Reinforced concrete(RC)beams face potential near-field blast threats as key structural components in building structures.To investigate the failure modes and dynamic responses of RC beams subjected to near-field blast loading,this paper presents both blast tests and numerical simulation studies on RC beams.First,near-field blast tests were conducted on five RC beam specimens under strong and weak-axis bending loading.Then,a refined finite element model of RC beams was established to verify the applicability of the adopted finite element analysis method.Finally,based on the calibrated finite element model,the failure mechanisms of RC beams were explored,and the influence of blast incidence angle on the failure modes and dynamic responses of RC beams was investigated.The results indicate:(i)Near-field blast loading demonstrates pronounced non-uniform distribution patterns.Under strong-axis incidence,clearing effects beyond the mid-span region are more significant than weak-axis incidence,leading to accelerated impulse attenuation.(ii)Three consecutive developmental stages primarily control the damage mechanism of RC beams:stress wave-induced local damage,local deformation causing plastic hinge propagation,and free vibration of the beam;(iii)As the scaled distance decreases,the failure mode of RC beams under weak-axis blast loading evolves from flexural failure to local failure.The resistance mechanism of RC beams under weak-axis blast loading is more prone to transition from compressive membrane action to tensile membrane action,reducing their blast resistance capacity;(iv)As the explosion incident angleθincreases from 0°to 90°,the blast wave-structure interaction transitions from regular reflection to Mach reflection and back to normal reflection,causing the dynamic response of RC beams to first decrease then increase,with corner concrete spalling damage being the primary failure mode.
基金Wuju Innovative Anti-Tumor Research Fund,Grant/Award Number:CFC2023WJZD001National High Level Hospital Clinical Research Funding,Grant/Award Number:2025‐PUMCH‐C‐040。
文摘Carfilzomib(CFZ)is an irreversible proteasome inhibitor cur-rently approved for the treatment of relapsed multiple myeloma(MM).It has been implicated as a cause of thrombotic micro-angiopathy(TMA)and mostly occurs after two courses of chemotherapy.The incidence,risk factors,and treatment of CFZ-related TMA remain unclear.Here we describe two cases.
基金supported by the National Key Research and Development Program of China(2023YFB3907304-3)the National Natural Science Foundation of China(NSFC)(62271050)。
文摘A methodology for the reduction of radar cross section(RCS)of cambered platforms within the target airspace is presented,which utilizes a dual-polarized ultra-wide-angle artificial electromagnetic absorbing surface.By applying the theory of generalized Brewster complex wave impedance matching,five distinct unit cell designs are developed to attain more than95%absorption rate for dual-polarized incident waves within five angular ranges:0°-30°,30°-50°,50°-60°,60°-70°,and 70°-80°.To optimally reduce the RCS of a cambered platform,the five types of units can be evenly distributed on the surface based on the local incident angles of plane waves originating from the target airspace.As an illustrative example,the leading edge of an airfoil is taken into account,and experimental measurements validate the efficiency of the proposed structure.Specifically,the absorbing surface achieves more than 10 dB of RCS reduction in the frequency ranges from 5-10 GHz(about66.7%relative bandwidth)for dual polarizations.
基金supported by a grant from the Central Level Public Welfare Research Institutes Basic Research Expenses of Chinese Academy of Medical Sciences(No.2023-RW320-05)。
文摘According to the 2024 global cancer data from GLOBOCAN,liver cancer ranks the 6th most common malignancy and the 3rd leading cause of cancer-related mortality worldwide[1].Among these cases,hepatocellular carcinoma(HCC)accounts for approximately 85%−90%[2,3].Its incidence and mortality rates remain persistently high worldwide.However,China has the highest incidence and mortality rates of the disease in the world[4].And the majority of patients are diagnosed at intermediate or advanced stages.Thus,identifying novel tumor biomarkers for early detection and implementing precision therapy has long been a key focus of research.
基金supported by the National Natural Science Foundation of China(82574173,82003516)Jiangsu Provincial Natural Science Foundation(BK20251958)+2 种基金Jiangsu Provincial Medical Key Discipline(ZDXK202250)Top Talent Awards Project Fund(RDF-TP-0023,RDF-TP-0030)Postgraduate Research Fund(PGRS2112022)at Xi'an Jiaotong-Liverpool University.
文摘Tuberculosis(TB),one of the oldest infectious diseases caused by Mycobacterium tuberculosis,poses a considerable challenge to global public health.There are approximately 10 million new TB cases worldwide annually,and TB claims the lives of nearly 3 million people each year,making it one of the leading causes of death from a single infectious disease[1].China ranks third globally in terms of TB burden,with approximately 733,000 TB cases reported in 2023[2].Based on the ecological model of health determinants developed by Whitehead and Dahlgren,health determinants can be classified into direct causes.
基金This work was supported by the National Key Research and Development Program of China(No.2022YFA1404301)National Natural Science Foundation of China(Nos.62325504,62305149,92250304,and 62288101).
文摘The metalens has attracted remarkable attention due to its ultra-thin and ultra-light characteristics,which indicate great potential for compact imaging.However,the limited efficiency at a large angle incidence severely hinders the application of wide-angle focusing and imaging,which is pursued in the fast-developing imaging systems.Therefore,new strategies to improve the lens performance at large incident angles are in demand.In this work,we propose tilted structures for largeangle focusing with improved efficiency.Metalenses based on dynamic phase and geometric phase are designed and systematically characterized by numerical simulations.We show that tilted structures of unit cells significantly improve the lens performance at oblique incidences.In detail,the focusing efficiency of the metalens with tilted structures is increased over 25%at 30°incidence,as well as the modulation transfer function.In addition,we develop a hybrid metalens array achieving highly efficient wide-angle imaging up to 120°.We believe this design provides a feasible route toward wide-field and high-performance imaging applications.
基金supported by a grant from the Young Scientist Funds of Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2022D01C63)Natural Science Foundation of China(No.12271421).
文摘This paper investigates a nonlocal dispersal epidemic model under the multiple nonlocal distributed delays and nonlinear incidence effects.First,the minimal wave speed c*and the basic reproduction number Ro are defined,which determine the existence of traveling wave solutions.Second,with the help of the upper and lower solutions,Schauder's fixed point theorem,and limiting techniques,the traveling waves satisfying some asymptotic boundary conditions are discussed.Specifically,when Ro>1,for every speed c>c^(*) there exists a traveling wave solution satisfying the boundary conditions,and there is no such traveling wave solution for any 0<c<c^(*) when R_(0)>1 or c>0 when R_(0)<1.Finally,we analyze the effects of nonlocal time delay on the minimum wave speed.
文摘The diagnosis and treatment processes for long COVID have been relatively slow to develop for several reasons,such as a lack of consensus about its definition among medical professionals and researchers,and restricted access to knowledge from the relevant pandemics of the past.Legacies of viral pandemics unfortunately do not include sufficient research on how the acute symptoms of infection evolved into chronic health conditions.More so,the idea of surviving a viral pandemic with long-lasting symptoms is not new,yet it is curiously disjointed as a medical concept throughout documented histories on the subject.Individuals with long-term conditions that are rooted in acute viral infections,such as COVID-19,require a coordinated system of care that includes comprehensive rehabilitation.This commentary will discuss the philosophical underpinnings of the historical scarcity of documented incidences of individuals with chronic virus symptoms and the need for a shift in post-viral infection treatment approaches.
