Objective:To predict the nephrotoxicity mechanism of Lianqiao-4 through network pharmacology and molecular docking methods.Methods:The main chemical components of Lianqiao(Forsythia suspensa),Bistortae rhizoma,Ophiopo...Objective:To predict the nephrotoxicity mechanism of Lianqiao-4 through network pharmacology and molecular docking methods.Methods:The main chemical components of Lianqiao(Forsythia suspensa),Bistortae rhizoma,Ophiopogonis radix,and Clematidis radix et rhizoma,as well as nephrotoxicity-related targets,were screened through databases such as TCMSP,Swiss Target Prediction,GeneCards,and ETCM.Venny 2.1.0 was used to identify the main components of Lianqiao-4 and nephrotoxicity targets.The STRING platform and David database were utilized to construct a protein-protein interaction(PPI)network diagram,while gene function(GO)enrichment analysis and KEGG pathway analysis were conducted.The“Lianqiao-4 active ingredients-nephrotoxicity targets-signaling pathways”network model was constructed using Cytoscape 3.9.1 software.Results:Network pharmacology and molecular docking analysis revealed that the core active ingredients responsible for the nephrotoxicity mechanism of Mongolian medicine Lianqiao-4 include steroidal saponins such as ophiopogonin A,flavonoids like kaempferol and quercetin,steroidal compounds such asβ-sitosterol and sitosterol,and other key regulatory targets including STAT3,ABCG2,HSP90AA1,MMP9,PTGS2,and EGFR.Major pathways involved include lipid and atherosclerosis,chemical carcinogenesis-DNA adducts,and arachidonic acid metabolism.Conclusion:Mongolian medicine Lianqiao-4 exerts its therapeutic effect on nephrotoxicity through multiple components,targets,and pathways,pending experimental verification.展开更多
The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.H...The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency.展开更多
KTi_(2)(PO_(4))_(3)is a promising anode material for potassium storage,but suffers from low conductivity and difficult balance between high capacity and good structural stability.Herein,the Ti_(3)C_(2)T_(x)MXene is us...KTi_(2)(PO_(4))_(3)is a promising anode material for potassium storage,but suffers from low conductivity and difficult balance between high capacity and good structural stability.Herein,the Ti_(3)C_(2)T_(x)MXene is used as a multifunctional binder to fabricate the KTi_(2)(PO_(4))_(3)electrode by the traditional homogenizing-coating method.The MXene nanosheets,together with the conductive agent super P nanoparticles,construct a multiple conductive network for fast electron/ion transfer and high electrochemical kinet-ics.Moreover,the network ensures the structural stability of the KTi_(2)(PO_(4))_(3)electrode during the de-intercalation/intercalation of 4 K^(+)ions,which is beneficial for simultaneously achieving high capacity and good cycle performance.Therefore,the MXene-bonded KTi_(2)(PO_(4))_(3)electrode delivers a reversible capacity of 255.2 mAh/g at 50 mA/g,outstanding rate capability with 132.3 mAh/g at 2 A/g,and ex-cellent cycle performance with 151.6 mAh/g at 1 A/g after 2000 cycles.This work not only suggests a high-performance anode material for potassium-ion batteries,but also demonstrates that the MXene is a promising binder material for constructing conductive electrodes in rechargeable batteries.展开更多
All-solid-state lithium batteries(ASSLBs)are important for enhancing safety across various applications related to lithium-ion batteries(LIBs).Lithium iron phosphate(LiFePO4)is a widely utilized commercial cathode in ...All-solid-state lithium batteries(ASSLBs)are important for enhancing safety across various applications related to lithium-ion batteries(LIBs).Lithium iron phosphate(LiFePO4)is a widely utilized commercial cathode in LIBs,prized for its stable cycling performance,thermal stability,and low cost.However,low electronic conductivity and slow ion diffusion kinetics limit its application at high rates and low temper-atures.Herein,Ti3C2Tx MXene nanosheets(NSs)are introduced into the LiFePO4 cathode.The continu-ous electron-conducting networks are constructed due to the high electrical conductivity of Ti3C2Tx NSs.Meanwhile,the coordination environment of lithium ions in the cathode is weakened by the oxygenated end groups of Ti3C2Tx NSs,and thus efficient ion-percolating networks are constructed.Therefore,the ionic and electronic conductivities of the modified cathode are significantly improved.Assembled all-solid-state LiFePO4/Li full cells with poly(ethylene oxide)as electrolyte exhibits high initial discharged capacities of 91.5 mAh g^(-1) at 10 C,and capacities of 155.1 mAh g^(-1) after 1000 cycles at 1 C with a re-tention rate of 93.8%.Furthermore,the cells still deliver excellent performance at high loading,room temperature,and low temperature.This work offers a facile and scalable strategy for designing high-performance ASSLBs.展开更多
Salt stress is a global constraint on agricultural production.Therefore,the development of salt tolerant plants has become a current research hotspot.While salt tolerance has evolved more frequently in C_(4) grass lin...Salt stress is a global constraint on agricultural production.Therefore,the development of salt tolerant plants has become a current research hotspot.While salt tolerance has evolved more frequently in C_(4) grass lineages,few studies have explored the molecular bases underlying salt stress tolerance in the C_(4) crop foxtail millet.In this study,we used a multi-pronged approach spanning the omics analyses of transcriptomes and physiological analysis of the C_(3) crop rice and the C_(4) model crop foxtail millet to investigate their responses to salt stress.The results revealed that compared to C_(3) rice,C_(4) foxtail millet has upregulated abscisic acid(ABA)and notably reduced CK biosynthesis and signaling transduction under salt stress.Salt stress in C_(3) rice plants triggered rapid downregulation of photosynthesis related genes,which was coupled with severely reduced net photosynthetic rates.In the salt-treated C_(3) rice and C_(4) foxtail millet,some stress responsive transcription factors(TFs),such as AP2/ERF,WRKY and MYB,underwent strong and distinct transcriptional changes.Based on a weighted gene co-expression network analysis(WGCNA),the AP2/ERF transcription factor Rice Starch Regulator1 SiRSR1(Seita.3G044600)was identified as a key regulator of the salt stress response.To confirm its function,we generated OsRSR1-knockout lines using CRISPR/Cas9 genome editing in rice and its upstream repressor SimiR172a-overexpressing(172a-OE)transgenic plants in foxtail millet,which both showed increased salt tolerance.Overall,this study not only provides new insights into the convergent regulation of the salt stress responses of foxtail millet and rice,but it also sheds light on the divergent signaling networks between them in response to salt stress.展开更多
(±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified co...(±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified compounds(5–7),were isolated from the crude extract of the mangrove-derived fungus Penicillium sp.,guided by heteronuclear single quantum correlation(HSQC)-based small molecule accurate recognition technology(SMART 2.0)and liquid chromatography-tandem mass spectrometry(LC-MS/MS)-based molecular networking.The structural elucidation of new compounds was accomplished through comprehensive spectroscopic analysis,and their absolute configurations were determined using DP4+^(13)C nuclear magnetic resonance(NMR)calculations and electronic circular dichroism(ECD)calculations.Compounds 1a/1b–4a/4b demonstrated moderate cytotoxicity against three human cancer cell lines HeLa,HCT116 and MCF-7 with half maximal inhibitory concentration(IC50)values ranging from 15.95±1.64 to 28.56±2.59μmol·L–1.展开更多
This paper presents an investigation of the tribological performance of AA2024–B_(4)C composites,with a specific focus on the influence of reinforcement and processing parameters.In this study three input parameters ...This paper presents an investigation of the tribological performance of AA2024–B_(4)C composites,with a specific focus on the influence of reinforcement and processing parameters.In this study three input parameters were varied:B_(4)C weight percentage,milling time,and normal load,to evaluate their effects on two output parameters:wear loss and the coefficient of friction.AA2024 alloy was used as the matrix alloy,while B_(4)C particles were used as reinforcement.Due to the high hardness and wear resistance of B_(4)C,the optimized composite shows strong potential for use in aerospace structural elements and automotive brake components.The optimisation of tribological behaviour was conducted using a Taguchi-Grey Relational Analysis(Taguchi-GRA)and the Technique for Order of Preference by Similarity to Ideal Solution(TOPSIS).A total of 27 combinations of input parameters were analysed,varying the B_(4)C content(0,10,and 15 wt.%),milling time(0,15,and 25 h),and normal load(1,5,and 10 N).Wear loss and the coefficient of friction were numerically evaluated and selected as criteria for optimisation.Artificial Neural Networks(ANNs)were also applied for two outputs simultaneously.TOPSIS identified Alternative 1 as the optimal solution,confirming the results obtained using the Taguchi Grey method.The optimal condition obtained(10 wt.%B_(4)C,25 h milling time,10 N load)resulted in a minimum wear loss of 1.7 mg and a coefficient of friction of 0.176,confirming significant enhancement in tribological behaviour.Based on the results,both the B_(4)C content and the applied processing conditions have a significant impact on wear loss and frictional properties.This approach demonstrates high reliability and confidence,enabling the design of future composite materials with optimal properties for specific applications.展开更多
随着网络技术的持续演进,为满足日益增长的通信需求,急需对油气自控网络进行升级。基于虚拟交换实例(Virtual Switching Instance,VSI)/虚拟扩展局域网(Virtual eXtensible Local Area Network,VXLAN)隧道通信技术,开展网际互连协议第4...随着网络技术的持续演进,为满足日益增长的通信需求,急需对油气自控网络进行升级。基于虚拟交换实例(Virtual Switching Instance,VSI)/虚拟扩展局域网(Virtual eXtensible Local Area Network,VXLAN)隧道通信技术,开展网际互连协议第4版/网际互连协议第6版(Internet Protocol Version 4/Internet Protocol Version 6,IPv6)双栈部署与效能评估相关研究。通过确立双栈架构的设计原则与目标,构建分层网络架构,实现VSI/VXLAN隧道与IPv4/IPv6双栈架构的深度融合,完成核心网络设备与接入层网络的双栈部署,并实施安全域划分。基于多维度效能评估指标体系,采集多测点、多负载条件下的性能数据,量化评估网络的安全防护能力。实验结果表明,该方案可显著提升油气自控网络在协议兼容性、传输效率与安全性方面的综合性能,为其数字化升级提供理论支撑与实践路径。展开更多
We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from Drug Bank, SuperT arget, TTD(Therapeutic Targets Database) and other databases and the relevant signali...We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from Drug Bank, SuperT arget, TTD(Therapeutic Targets Database) and other databases and the relevant signaling pathways from the KEGG(Kyoto Encyclopedia of Genes and Genomes) database and established models of the chemical composition-target network and chemical composition-target- disease network using Cytoscape software, the analysis indicated that the chemical composition had at least nine different types of targets that acted together to exert effects on the diseases, suggesting a "multi-component, multi-target" feature of the traditional Mongolian medicine. We also employed the rat model of rheumatoid arthritis induced by Collgen Type II to validate the key targets of the chemical components of Sendeng-4, and three of the key targets were validated through laboratory experiments, further confirming the anti-inflammatory effects of Sendeng-4. In all, this study predicted the active ingredients and targets of Sendeng-4, and explored its mechanism of action, which provided new strategies and methods for further research and development of Sendeng-4 and other traditional Mongolian medicines as well.展开更多
A new three-dimensional supramolecular [Ce2（2,5-pydc）3（H2O）2]（1） has been hydrothermally synthesized at 180 ℃ and characterized by single-crystal X-ray diffraction.X-ray crystal analyses reveal that the compoun...A new three-dimensional supramolecular [Ce2（2,5-pydc）3（H2O）2]（1） has been hydrothermally synthesized at 180 ℃ and characterized by single-crystal X-ray diffraction.X-ray crystal analyses reveal that the compound belongs to the monoclinic system,space group P21/c,C21H13Ce2N3O14,a = 6.561（1）,b = 17.986（5）,c = 9.411（3） ,β = 95.558（5）° and Z = 2.In the structure of 1,each Ce（1） center is surrounded by 2,5-pydc ligands,forming the 6-connected node,and the 2,5-pydc ligand coordinates to the Ce（Ⅲ） in two different coordination modes.In mode 1,the four oxygen atoms of two carboxyl groups connect neighboring Ce（Ⅲ） ions,giving 4-connected（4-c） second building unit（SBU-1）.Furthermore,the structure is extended into a 2-D layer from SBU-1 by sharing Ce（1） atoms.In mode 2,the ligand coordinates to the Ce（Ⅲ） ion from the adjacent chain with the 4-connected（4-c） second building unit（SBU-2）,generating a 1-D ladder from SBU-2 by sharing Ce（1） atoms.Finally,the structure is extended into a 6,4,4-c network.Its photoluminescence property was also investigated.展开更多
文摘Objective:To predict the nephrotoxicity mechanism of Lianqiao-4 through network pharmacology and molecular docking methods.Methods:The main chemical components of Lianqiao(Forsythia suspensa),Bistortae rhizoma,Ophiopogonis radix,and Clematidis radix et rhizoma,as well as nephrotoxicity-related targets,were screened through databases such as TCMSP,Swiss Target Prediction,GeneCards,and ETCM.Venny 2.1.0 was used to identify the main components of Lianqiao-4 and nephrotoxicity targets.The STRING platform and David database were utilized to construct a protein-protein interaction(PPI)network diagram,while gene function(GO)enrichment analysis and KEGG pathway analysis were conducted.The“Lianqiao-4 active ingredients-nephrotoxicity targets-signaling pathways”network model was constructed using Cytoscape 3.9.1 software.Results:Network pharmacology and molecular docking analysis revealed that the core active ingredients responsible for the nephrotoxicity mechanism of Mongolian medicine Lianqiao-4 include steroidal saponins such as ophiopogonin A,flavonoids like kaempferol and quercetin,steroidal compounds such asβ-sitosterol and sitosterol,and other key regulatory targets including STAT3,ABCG2,HSP90AA1,MMP9,PTGS2,and EGFR.Major pathways involved include lipid and atherosclerosis,chemical carcinogenesis-DNA adducts,and arachidonic acid metabolism.Conclusion:Mongolian medicine Lianqiao-4 exerts its therapeutic effect on nephrotoxicity through multiple components,targets,and pathways,pending experimental verification.
基金supported by the National Key Research and Development Program of China under Grant 2022YFB2901501in part by the Science and Technology Innovation leading Talents Subsidy Project of Central Plains under Grant 244200510038.
文摘The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency.
基金support by National Natural Science Foundation of China(No.U2004212).
文摘KTi_(2)(PO_(4))_(3)is a promising anode material for potassium storage,but suffers from low conductivity and difficult balance between high capacity and good structural stability.Herein,the Ti_(3)C_(2)T_(x)MXene is used as a multifunctional binder to fabricate the KTi_(2)(PO_(4))_(3)electrode by the traditional homogenizing-coating method.The MXene nanosheets,together with the conductive agent super P nanoparticles,construct a multiple conductive network for fast electron/ion transfer and high electrochemical kinet-ics.Moreover,the network ensures the structural stability of the KTi_(2)(PO_(4))_(3)electrode during the de-intercalation/intercalation of 4 K^(+)ions,which is beneficial for simultaneously achieving high capacity and good cycle performance.Therefore,the MXene-bonded KTi_(2)(PO_(4))_(3)electrode delivers a reversible capacity of 255.2 mAh/g at 50 mA/g,outstanding rate capability with 132.3 mAh/g at 2 A/g,and ex-cellent cycle performance with 151.6 mAh/g at 1 A/g after 2000 cycles.This work not only suggests a high-performance anode material for potassium-ion batteries,but also demonstrates that the MXene is a promising binder material for constructing conductive electrodes in rechargeable batteries.
基金supported by the Natural Science Foundation of Shandong Province(Nos.ZR2022QE014 and ZR2021QH237)the National Natural Science Foundation of China(Grant Nos.52401221,51971120,and U1902221)the Medical StaffScience and Technology Plan of Shandong Province(No.SDYWZGKCJH2022073).
文摘All-solid-state lithium batteries(ASSLBs)are important for enhancing safety across various applications related to lithium-ion batteries(LIBs).Lithium iron phosphate(LiFePO4)is a widely utilized commercial cathode in LIBs,prized for its stable cycling performance,thermal stability,and low cost.However,low electronic conductivity and slow ion diffusion kinetics limit its application at high rates and low temper-atures.Herein,Ti3C2Tx MXene nanosheets(NSs)are introduced into the LiFePO4 cathode.The continu-ous electron-conducting networks are constructed due to the high electrical conductivity of Ti3C2Tx NSs.Meanwhile,the coordination environment of lithium ions in the cathode is weakened by the oxygenated end groups of Ti3C2Tx NSs,and thus efficient ion-percolating networks are constructed.Therefore,the ionic and electronic conductivities of the modified cathode are significantly improved.Assembled all-solid-state LiFePO4/Li full cells with poly(ethylene oxide)as electrolyte exhibits high initial discharged capacities of 91.5 mAh g^(-1) at 10 C,and capacities of 155.1 mAh g^(-1) after 1000 cycles at 1 C with a re-tention rate of 93.8%.Furthermore,the cells still deliver excellent performance at high loading,room temperature,and low temperature.This work offers a facile and scalable strategy for designing high-performance ASSLBs.
基金supported by the National Natural Science Foundation of China(32241042)the National Key R&D Program of China(2019YFD1000700 and 2019YFD1000703)the Biological Breeding-National Science and Technology Major Project,China(2022ZD04017).
文摘Salt stress is a global constraint on agricultural production.Therefore,the development of salt tolerant plants has become a current research hotspot.While salt tolerance has evolved more frequently in C_(4) grass lineages,few studies have explored the molecular bases underlying salt stress tolerance in the C_(4) crop foxtail millet.In this study,we used a multi-pronged approach spanning the omics analyses of transcriptomes and physiological analysis of the C_(3) crop rice and the C_(4) model crop foxtail millet to investigate their responses to salt stress.The results revealed that compared to C_(3) rice,C_(4) foxtail millet has upregulated abscisic acid(ABA)and notably reduced CK biosynthesis and signaling transduction under salt stress.Salt stress in C_(3) rice plants triggered rapid downregulation of photosynthesis related genes,which was coupled with severely reduced net photosynthetic rates.In the salt-treated C_(3) rice and C_(4) foxtail millet,some stress responsive transcription factors(TFs),such as AP2/ERF,WRKY and MYB,underwent strong and distinct transcriptional changes.Based on a weighted gene co-expression network analysis(WGCNA),the AP2/ERF transcription factor Rice Starch Regulator1 SiRSR1(Seita.3G044600)was identified as a key regulator of the salt stress response.To confirm its function,we generated OsRSR1-knockout lines using CRISPR/Cas9 genome editing in rice and its upstream repressor SimiR172a-overexpressing(172a-OE)transgenic plants in foxtail millet,which both showed increased salt tolerance.Overall,this study not only provides new insights into the convergent regulation of the salt stress responses of foxtail millet and rice,but it also sheds light on the divergent signaling networks between them in response to salt stress.
基金supported by the National Key Research and Development Program of China(No.2022YFC2303100)the National Natural Science Foundation of China(Nos.32022002 and 21977113).
文摘(±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified compounds(5–7),were isolated from the crude extract of the mangrove-derived fungus Penicillium sp.,guided by heteronuclear single quantum correlation(HSQC)-based small molecule accurate recognition technology(SMART 2.0)and liquid chromatography-tandem mass spectrometry(LC-MS/MS)-based molecular networking.The structural elucidation of new compounds was accomplished through comprehensive spectroscopic analysis,and their absolute configurations were determined using DP4+^(13)C nuclear magnetic resonance(NMR)calculations and electronic circular dichroism(ECD)calculations.Compounds 1a/1b–4a/4b demonstrated moderate cytotoxicity against three human cancer cell lines HeLa,HCT116 and MCF-7 with half maximal inhibitory concentration(IC50)values ranging from 15.95±1.64 to 28.56±2.59μmol·L–1.
文摘This paper presents an investigation of the tribological performance of AA2024–B_(4)C composites,with a specific focus on the influence of reinforcement and processing parameters.In this study three input parameters were varied:B_(4)C weight percentage,milling time,and normal load,to evaluate their effects on two output parameters:wear loss and the coefficient of friction.AA2024 alloy was used as the matrix alloy,while B_(4)C particles were used as reinforcement.Due to the high hardness and wear resistance of B_(4)C,the optimized composite shows strong potential for use in aerospace structural elements and automotive brake components.The optimisation of tribological behaviour was conducted using a Taguchi-Grey Relational Analysis(Taguchi-GRA)and the Technique for Order of Preference by Similarity to Ideal Solution(TOPSIS).A total of 27 combinations of input parameters were analysed,varying the B_(4)C content(0,10,and 15 wt.%),milling time(0,15,and 25 h),and normal load(1,5,and 10 N).Wear loss and the coefficient of friction were numerically evaluated and selected as criteria for optimisation.Artificial Neural Networks(ANNs)were also applied for two outputs simultaneously.TOPSIS identified Alternative 1 as the optimal solution,confirming the results obtained using the Taguchi Grey method.The optimal condition obtained(10 wt.%B_(4)C,25 h milling time,10 N load)resulted in a minimum wear loss of 1.7 mg and a coefficient of friction of 0.176,confirming significant enhancement in tribological behaviour.Based on the results,both the B_(4)C content and the applied processing conditions have a significant impact on wear loss and frictional properties.This approach demonstrates high reliability and confidence,enabling the design of future composite materials with optimal properties for specific applications.
文摘随着网络技术的持续演进,为满足日益增长的通信需求,急需对油气自控网络进行升级。基于虚拟交换实例(Virtual Switching Instance,VSI)/虚拟扩展局域网(Virtual eXtensible Local Area Network,VXLAN)隧道通信技术,开展网际互连协议第4版/网际互连协议第6版(Internet Protocol Version 4/Internet Protocol Version 6,IPv6)双栈部署与效能评估相关研究。通过确立双栈架构的设计原则与目标,构建分层网络架构,实现VSI/VXLAN隧道与IPv4/IPv6双栈架构的深度融合,完成核心网络设备与接入层网络的双栈部署,并实施安全域划分。基于多维度效能评估指标体系,采集多测点、多负载条件下的性能数据,量化评估网络的安全防护能力。实验结果表明,该方案可显著提升油气自控网络在协议兼容性、传输效率与安全性方面的综合性能,为其数字化升级提供理论支撑与实践路径。
基金supported by the National Natural Science Foundation of China(No.81160550)Inner Mongolia Natural Science Foundation(No.2013JQ03)2010 Science and Technology Project of social development in Inner Mongolia
文摘We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from Drug Bank, SuperT arget, TTD(Therapeutic Targets Database) and other databases and the relevant signaling pathways from the KEGG(Kyoto Encyclopedia of Genes and Genomes) database and established models of the chemical composition-target network and chemical composition-target- disease network using Cytoscape software, the analysis indicated that the chemical composition had at least nine different types of targets that acted together to exert effects on the diseases, suggesting a "multi-component, multi-target" feature of the traditional Mongolian medicine. We also employed the rat model of rheumatoid arthritis induced by Collgen Type II to validate the key targets of the chemical components of Sendeng-4, and three of the key targets were validated through laboratory experiments, further confirming the anti-inflammatory effects of Sendeng-4. In all, this study predicted the active ingredients and targets of Sendeng-4, and explored its mechanism of action, which provided new strategies and methods for further research and development of Sendeng-4 and other traditional Mongolian medicines as well.
文摘A new three-dimensional supramolecular [Ce2（2,5-pydc）3（H2O）2]（1） has been hydrothermally synthesized at 180 ℃ and characterized by single-crystal X-ray diffraction.X-ray crystal analyses reveal that the compound belongs to the monoclinic system,space group P21/c,C21H13Ce2N3O14,a = 6.561（1）,b = 17.986（5）,c = 9.411（3） ,β = 95.558（5）° and Z = 2.In the structure of 1,each Ce（1） center is surrounded by 2,5-pydc ligands,forming the 6-connected node,and the 2,5-pydc ligand coordinates to the Ce（Ⅲ） in two different coordination modes.In mode 1,the four oxygen atoms of two carboxyl groups connect neighboring Ce（Ⅲ） ions,giving 4-connected（4-c） second building unit（SBU-1）.Furthermore,the structure is extended into a 2-D layer from SBU-1 by sharing Ce（1） atoms.In mode 2,the ligand coordinates to the Ce（Ⅲ） ion from the adjacent chain with the 4-connected（4-c） second building unit（SBU-2）,generating a 1-D ladder from SBU-2 by sharing Ce（1） atoms.Finally,the structure is extended into a 6,4,4-c network.Its photoluminescence property was also investigated.
