Because of the differences of hydrocarbon accumulation between in-source and out-of-source oil pools, the demand for source kitchen is different. Based on the establishment of source-to-reservoir correlation in the kn...Because of the differences of hydrocarbon accumulation between in-source and out-of-source oil pools, the demand for source kitchen is different. Based on the establishment of source-to-reservoir correlation in the known conventional accumulations, and the characteristics of shale oil source kitchens as well, this paper discusses the differences of source kitchens for the formation of both conventional and shale oils. The formation of conventional oil pools is a process of hydrocarbons enriching from disperse state under the action of buoyancy, which enables most of the oil pools to be formed outside the source kitchens. The source rock does not necessarily have high abundance of organic matter, but has to have high efficiency and enough amount of hydrocarbon expulsion. The TOC threshold of source rocks for conventional oil accumulations is 0.5%, with the best TOC window ranging from 1% to 3%. The oil pools formed inside the source kitchens, mainly shale oil, are the retention of oil and gas in the source rock and there is no large-scale hydrocarbon migration and enrichment process happened, which requires better quality and bigger scale of source rocks. The threshold of TOC for medium to high maturity of shale oil is 2%, with the best range falling in 3%–5%. Medium to low mature shale oil resource has a TOC threshold of 6%, and the higher the better in particular. The most favorable kerogen for both high and low-mature shale oils is oil-prone type of I–II1. Carrying out source rock quality and classification evaluation and looking for large-scale and high-quality source rock enrichment areas are a scientific issue that must be paid attention to when exploration activity changes from out-of-source regions to in-source kitchen areas. The purpose is to provide theoretical guidance for the upcoming shale oil enrichment area selection, economic discovery and objective evaluation of resource potential.展开更多
A simple, sensitive and high throughput ultra performance liquid chromatography tandem mass spectrometry method has been developed for the determination of mycophenolic acid in human plasma. The method involved simple...A simple, sensitive and high throughput ultra performance liquid chromatography tandem mass spectrometry method has been developed for the determination of mycophenolic acid in human plasma. The method involved simple protein precipitation of MPA along with its deuterated analog as an internal standard （IS） from 50 mL of human plasma. The chromatographic analysis was done on Acquity UPLC C18 （100mm×2.1mm,1.7μm） column under isocratic conditions using acetonitrile and 10 mM ammonium formate, pH 3.00 （75：25, v/v） as the mobile phase. A triple quadrupole mass spectrometer operating in the positive ionization mode was used for quantitation. In-source conversion of mycophenolic glucuronide metabolite to the parent drug was selectively controlled by suitable optimization of cone voltage, cone gas flow and desolvation temperature. The method was validated over a wide concentration range of 15-15000 ng/mL. The mean extraction recovery for the analyte and IS was 〉95%. Matrix effect expressed as matrix factors ranged from 0.97 to 1.02. The method was successfully applied to support a bioequivalence study of 500 mg mycophenolate mofetil tablet in 72 healthy subjects.展开更多
With the rapid progress of informatization, the university infonnatization faces the system innovation. The paper mainly discusses the new management model and operation mode of IT department in digital campus time, a...With the rapid progress of informatization, the university infonnatization faces the system innovation. The paper mainly discusses the new management model and operation mode of IT department in digital campus time, as example of the campus card in University of Electronic Science and Technology of China_ The work mode of information center is transformed from cost center to profit center, and the operation mode transform from outsource service to in-sourcing.展开更多
基金Supported by the China National Science and Technology Major Project(2016ZX05046,2017ZX05001)RIPED Scientific Research and Technology Development Project(2018ycq02)。
文摘Because of the differences of hydrocarbon accumulation between in-source and out-of-source oil pools, the demand for source kitchen is different. Based on the establishment of source-to-reservoir correlation in the known conventional accumulations, and the characteristics of shale oil source kitchens as well, this paper discusses the differences of source kitchens for the formation of both conventional and shale oils. The formation of conventional oil pools is a process of hydrocarbons enriching from disperse state under the action of buoyancy, which enables most of the oil pools to be formed outside the source kitchens. The source rock does not necessarily have high abundance of organic matter, but has to have high efficiency and enough amount of hydrocarbon expulsion. The TOC threshold of source rocks for conventional oil accumulations is 0.5%, with the best TOC window ranging from 1% to 3%. The oil pools formed inside the source kitchens, mainly shale oil, are the retention of oil and gas in the source rock and there is no large-scale hydrocarbon migration and enrichment process happened, which requires better quality and bigger scale of source rocks. The threshold of TOC for medium to high maturity of shale oil is 2%, with the best range falling in 3%–5%. Medium to low mature shale oil resource has a TOC threshold of 6%, and the higher the better in particular. The most favorable kerogen for both high and low-mature shale oils is oil-prone type of I–II1. Carrying out source rock quality and classification evaluation and looking for large-scale and high-quality source rock enrichment areas are a scientific issue that must be paid attention to when exploration activity changes from out-of-source regions to in-source kitchen areas. The purpose is to provide theoretical guidance for the upcoming shale oil enrichment area selection, economic discovery and objective evaluation of resource potential.
文摘A simple, sensitive and high throughput ultra performance liquid chromatography tandem mass spectrometry method has been developed for the determination of mycophenolic acid in human plasma. The method involved simple protein precipitation of MPA along with its deuterated analog as an internal standard （IS） from 50 mL of human plasma. The chromatographic analysis was done on Acquity UPLC C18 （100mm×2.1mm,1.7μm） column under isocratic conditions using acetonitrile and 10 mM ammonium formate, pH 3.00 （75：25, v/v） as the mobile phase. A triple quadrupole mass spectrometer operating in the positive ionization mode was used for quantitation. In-source conversion of mycophenolic glucuronide metabolite to the parent drug was selectively controlled by suitable optimization of cone voltage, cone gas flow and desolvation temperature. The method was validated over a wide concentration range of 15-15000 ng/mL. The mean extraction recovery for the analyte and IS was 〉95%. Matrix effect expressed as matrix factors ranged from 0.97 to 1.02. The method was successfully applied to support a bioequivalence study of 500 mg mycophenolate mofetil tablet in 72 healthy subjects.
文摘With the rapid progress of informatization, the university infonnatization faces the system innovation. The paper mainly discusses the new management model and operation mode of IT department in digital campus time, as example of the campus card in University of Electronic Science and Technology of China_ The work mode of information center is transformed from cost center to profit center, and the operation mode transform from outsource service to in-sourcing.
