The integrated waveguide polarizer is essential for photonic integrated circuits,and various designs of waveguide polarizers have been developed.As the demand for dense photonic integration increases rapidly,new strat...The integrated waveguide polarizer is essential for photonic integrated circuits,and various designs of waveguide polarizers have been developed.As the demand for dense photonic integration increases rapidly,new strategies to minimize the device size are needed.In this paper,we have inversely designed an integrated transverse electric pass(TE-pass)polarizer with a footprint of 2.88μm×2.88μm,which is the smallest footprint ever achieved.A direct binary search algorithm is used to inversely design the device for maximizing the transverse electric(TE)transmission while minimizing transverse magnetic(TM)transmission.Finally,the inverse-designed device provides an average insertion loss of 0.99 dB and an average extinction ratio of 33 dB over a wavelength range of 100 nm.展开更多
Optical polarizers,which allow the transmission of specific polarization states,are essential components in modern optical systems.Here,we experimentally demonstrate integrated photonic polarizers incorporating reduce...Optical polarizers,which allow the transmission of specific polarization states,are essential components in modern optical systems.Here,we experimentally demonstrate integrated photonic polarizers incorporating reduced graphene oxide(rGO)films.2D graphene oxide(GO)films are integrated onto silicon waveguides and microring resonators(MRRs)with precise control over their thicknesses and sizes,followed by GO reduction via two different methods including uniform thermal reduction and localized photothermal reduction.We measure devices with various lengths,thicknesses,and reduction degrees of GO films.The results show that the devices with rGO exhibit better performance than those with GO,achieving a polarization-dependent loss of~47 dB and a polarization extinction ratio of~16 dB for the hybrid waveguides and MRRs with rGO,respectively.By fitting the experimental results with theory,it is found that rGO exhibits more significant anisotropy in loss,with an anisotropy ratio over 4 times that of GO.In addition,rGO shows higher thermal stability and greater robustness to photothermal reduction than GO.These results highlight the strong potential of rGO films for implementing high-performance polarization selective devices in integrated photonic platforms.展开更多
Hyperpolarization of nuclear spins is crucial for advancing nuclear magnetic resonance and quantum information technologies,as nuclear spins typically exhibit extremely low polarization at room temperature due to thei...Hyperpolarization of nuclear spins is crucial for advancing nuclear magnetic resonance and quantum information technologies,as nuclear spins typically exhibit extremely low polarization at room temperature due to their small gyromagnetic ratios.A promising approach to achieving high nuclear spin polarization is transferring the polarization of electrons to nuclear spins.The nitrogen-vacancy(NV)center in diamond has emerged as a highly effective medium for this purpose,and various hyperpolarization protocols have been developed.Among these,the pulsed polarization(PulsePol)method has been extensively studied due to its robustness against static energy shifts of the electron spin.In this work,we present a novel polarization protocol and uncover a family of magic sequences for hyperpolarizing nuclear spins,with PulsePol emerging as a special case of our general approach.Notably,we demonstrate that some of these magic sequences exhibit significantly greater robustness compared to the PulsePol protocol in the presence of finite half𝜋pulse duration of the protocol,Rabi and detuning errors.This enhanced robustness positions our protocol as a more suitable candidate for hyper-polarizing nuclear spins species with large gyromagnetic ratios and also ensures better compatibility with high-efficiency readout techniques at high magnetic fields.Additionally,the generality of our protocol allows for its direct application to other solid-state quantum systems beyond the NV center.展开更多
Auroral kilometric radiation(AKR),a fundamental plasma emission in Earth's magnetosphere,exhibits three characteristic modes:the right-handed extraordinary(R-X),left-handed ordinary(L-O)and left-handed extraordina...Auroral kilometric radiation(AKR),a fundamental plasma emission in Earth's magnetosphere,exhibits three characteristic modes:the right-handed extraordinary(R-X),left-handed ordinary(L-O)and left-handed extraordinary(L-X)modes.The role of AKR in magnetosphere−ionosphere−atmosphere coupling depends sensitively on its wave mode.While previous studies have primarily focused on the dominant R-X mode,we present the first systematic identification of all three modes using a practical polarization analysis method based on Arase satellite observations.This method employs a spin-axis-relative Ratio:when the satellite's spin axis aligns with the background magnetic field,a positive(negative)Ratio indicates the right-handed(left-handed)polarization,with reversal under anti-parallel conditions.Combined polarization-frequency analysis reveals that R-X,L-O,and L-X modes can exist in both dayside and nightside regions,with power spectral densities up to 10^(-6)mV^(2)m^(-2)Hz^(-1).This study resolves long-standing ambiguities in AKR mode classification and has implications for understanding AKR-induced electron dynamics.展开更多
Repolarizing tumor-associated macrophages(TAMs)toward the proinflammatory M1 phenotype represents a promising strategy to reverse the immunosuppressive tumor microenvironment(TME)and enhance antitumor immunotherapy.Re...Repolarizing tumor-associated macrophages(TAMs)toward the proinflammatory M1 phenotype represents a promising strategy to reverse the immunosuppressive tumor microenvironment(TME)and enhance antitumor immunotherapy.Recent studies have demonstrated that exogenous electrical stimulation can effectively repolarize TAMs toward the M1 phenotype.However,conventional electrical stimulation methods,relying on invasive implanted electrodes,are restricted to targeting localized tumor regions and pose inherent risks to patients.Notably,biological neural networks,distributed systems of interconnected neurons,can naturally permeate tissues and orchestrate cellular activities with high spatial efficiency.Inspired by this natural system,we developed a global in situ electric field network using piezoelectric BaTiO_(3)nanoparticles.Upon ultrasound stimulation,the nanoparticles generate a wireless electric field throughout the TME.In addtion,their nanoscale size enables them to function as synthetic“neurons”,allowing for uniform penetration throughout the tumor tissue and inducing significant repolarization of TAMs via the Ca^(2+)influx-activated nuclear factor-kappa B(NF-κB)signaling pathway.The repolarized M1 TAMs restore anti-tumor immunostimulatory functions and secrete key proinflammatory cytokines(e.g.,tumor necrosis factor-alpha(TNF-α)and interleukin-1 beta(IL-1β)),which enhance immunostimulation within the TME and directly contribute to tumor cell elimination.Remarkably,this strategy achieved robust in vivo tumor growth inhibition with excellent biosafety in a 4T1 breast tumor model.Overall,this work establishes a non-invasive,wireless electric field platform capable of globally repolarizing TAMs,offering a safe and efficient strategy to advance cancer immunotherapy and accelerate the clinical translation of bioelectronic therapies.展开更多
Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease indu...Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.展开更多
In this paper, we propose an ellipsometer using a phase retarder and rotating polarizer and analyzer at a speed ratio I：N. Different ellipsometric configurations are presented by assuming N = 1, 2, and 3. Moreover, t...In this paper, we propose an ellipsometer using a phase retarder and rotating polarizer and analyzer at a speed ratio I：N. Different ellipsometric configurations are presented by assuming N = 1, 2, and 3. Moreover, two values of the offset angle of the retarder are considered for each ellipsometric configuration. The Mueller formalism is employed to extract the Stokes parameters, from which the intensity received by the detector is obtained. The optical properties of c-Si are calculated using all configurations. A comparison between different configurations is carried out considering the effect of the noise on the results and the uncertainties in the ellipsometric parameters as functions of the uncertainties of the Fourier coefficients. It is found that the alignment of the phase retarder has a crucial impact on the results and the ellipsometric configuration with speed ratio 1：1 is preferred over the other configurations.展开更多
An in-fiber Mach-Zehnder interferometer for strain measurement is proposed and experimentally demonstrated. The sensor consists of a taper followed by a short section of a multi-mode fiber （MMF） and a dispersion com...An in-fiber Mach-Zehnder interferometer for strain measurement is proposed and experimentally demonstrated. The sensor consists of a taper followed by a short section of a multi-mode fiber （MMF） and a dispersion com- pensating fiber （DCF）, which is sandwiched between two single mode fibers （SMFs）. The taper is used as a fiber coupler to excite cladding modes in the SMF, and these cladding modes transmit within the MMF and the DCF. The core mode and the cladding modes interfere in the DCF SMF fusion point to form intermodal interference. A well-defined interference spectrum is obtained in the experiment. Selected interference dips are used to measure the strain changes. The experimental results show that this device is sensitive to strain with the wavelength-referenced sensitivity of 2.6 pm/με and the power-referenced sensitivity of 0. 0027 dB/με, respectively.展开更多
A TM-pass polarizer based on multilayer graphene polymer waveguide is proposed and theoretically analyzed.The mode properties,the extinction ratio,the insertion loss and the bandwidth are also discussed.The results sh...A TM-pass polarizer based on multilayer graphene polymer waveguide is proposed and theoretically analyzed.The mode properties,the extinction ratio,the insertion loss and the bandwidth are also discussed.The results show that a TM-pass polarizer,which only guides the TM mode,can be achieved by multilayer graphene polymer waveguide.With length of 150μm,the proposed polarizer can achieve extinction ratio of 33 dB and insertion loss of 0.5 d B at optical wavelength of 1.55μm.This device has an excellent performance,including large extinction ratio and low insertion loss within the spectral range from 1.45μm to 1.6μm.展开更多
Polarimetric imaging enhances the ability to distinguish objects from a bright background by detecting their particular polarization status,which offers another degree of freedom in infrared remote sensing.However,to ...Polarimetric imaging enhances the ability to distinguish objects from a bright background by detecting their particular polarization status,which offers another degree of freedom in infrared remote sensing.However,to scale up by monolithically integrating grating-based polarizers onto a focal plane array(FPA)of infrared detectors,fundamental technical obstacles must be overcome,including reductions of the extinction ratio by the misalignment between the polarizer and the detector,grating line width fluctuations,the line edge roughness,etc.This paper reports the authors’latest achievements in overcoming those problems by solving key technical issues regarding the integration of large-scale polarizers onto the chips of FPAs with individual indium gallium arsenide/indium phosphide(In Ga As/In P)sensors as the basic building blocks.Polarimetric and photovoltaic chips with divisions of the focal plane of 540×4 pixels and 320×256 superpixels have been successfully manufactured.Polarimetric imaging with enhanced contrast has been demonstrated.The progress made in this work has opened up a broad avenue toward industrialization of high quality polarimetric imaging in infrared wavelengths.展开更多
An indium tin oxide(ITO) and silicon nitride(Si_(3)N_(4)) assisted compact TE-pass waveguide polarizer based on lithiumniobate-on-insulator is proposed and numerically analyzed.By properly designing the ITO and Si_(3)...An indium tin oxide(ITO) and silicon nitride(Si_(3)N_(4)) assisted compact TE-pass waveguide polarizer based on lithiumniobate-on-insulator is proposed and numerically analyzed.By properly designing the ITO and Si_(3)N_(4) assisted structure and utilizing the epsilon-near-zero effect of ITO,the TM mode is strongly confined in the ITO layer with extremely high loss,while the TE mode is hardly affected and passes through the waveguide with low loss.The simulation results show that the polarizer has an extinction ratio of 22.5 dB and an insertion loss of 0.8 dB at the wavelength of 1.55 μm,and has an operating bandwidth of about 125 nm(from 1540 nm to 1665 nm) for an extinction ratio of>20 dB and an insertion loss of<0.95 dB.Moreover,the proposed device exhibits large fabrication tolerances.More notably,the device is compact,with a length of only 7.5 μm,and is appropriate for on-chip applications.展开更多
Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modu...Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.展开更多
The temperature-induced complex refractive index（CRI） effect of graphene is demonstrated theoretically and experimentally based on a graphene coated in-fiber MZI（Mach-Zehnder interferometer）. The relationships bet...The temperature-induced complex refractive index（CRI） effect of graphene is demonstrated theoretically and experimentally based on a graphene coated in-fiber MZI（Mach-Zehnder interferometer）. The relationships between real and imaginary parts of the graphene CRI and temperature are obtained through investigating the dip wavelength and intensity of the MZI interference spectrum changing with temperature, respectively. The temperature effect of CRI of the graphene is also analyzed theoretically. Both experimental and theoretical studies show that the real part and imaginary part of the CRI nonlinearly decrease and increase with temperature increasing, respectively. This graphene-coated in-fiber MZI structure also possesses the advantages of easy fabrication, miniaturization, low cost and robustness. It has potential applications in nanomaterial-based optic devices for communication and sensing.展开更多
We theoretically and numerically demonstrate that a transmission-type electrically tunable polarizer can be realized by using graphene ribbons supported on a dielectric film with a graphene sheet behind. The polarizat...We theoretically and numerically demonstrate that a transmission-type electrically tunable polarizer can be realized by using graphene ribbons supported on a dielectric film with a graphene sheet behind. The polarization mechanism originates from the antenna plasmon resonance of graphene stripes. The results of full-wave numerical simulations reveal that transmittance of 0.70 for one polarization and 0.0073 for another polarization can be obtained at normal incidence. The transmission-type electrically tunable polarizer provides and facilitates a variety of applications, including filtering, detecting, and imaging.展开更多
This paper deals with a systematical analysis and an algorithm of attenuation characteristics of a light attenuator combined by n pieces of polarizers （n-LACP） whose extinction ratios are different from each other. ...This paper deals with a systematical analysis and an algorithm of attenuation characteristics of a light attenuator combined by n pieces of polarizers （n-LACP） whose extinction ratios are different from each other. The attenuation ratio expression of a two-LACP is deduced. We find that the monotonic attenuation interval depends on the first polarizer and that the attenuation range depends on the second one. For the three-LACP, a method for obtaining a monotonic attenuation interval is proposed. Moreover, the attenuation ratio expression is demonstrated. Analysis and experiment show that when the initial status of the three-LACP is at the maximum output, if the second or third polarizer rotates alone, the minimum attenuation ratios can reach K2^-1 and K3^-1, respectively, and if the first polarizer rotates, a minimum attenuation ratio of K2^-1K3^-1 can be obtained （K1, K2 and K3 represent the extinction ratios of the three polarizers in turn）. Furthermore, the attenuation ratio expression of n-LACP and the relevant attenuation characteristics are proposed. The minimum attenuation ratio of an n-LACP is （K2K3 ... Kn）-1.展开更多
In this paper, we propose an instantaneous phase-stepping method for determining phase distribution of interference fringes utilizing a camera that is equipped with a micro-polarizer array on the sensor plane. An opti...In this paper, we propose an instantaneous phase-stepping method for determining phase distribution of interference fringes utilizing a camera that is equipped with a micro-polarizer array on the sensor plane. An optical setup of polarization interferometry using a Mach-Zehnder interferometer with two polarizers is constructed. Light emerging from the interferometer is recorded using a camera that has a micro-polarizer array. This micro-polarizer array has four different optical axes. That is, an image obtained by the camera contains four types of information corresponding to four different optical axes of the polarizer. The four images separated from the image recorded by the camera are reconstructed using gray level interpolation. Subsequently, the distributions of the Stokes parameters that represent the state of polarization are calculated from the four images. The phase distribution of the interference fringe pattern produced by the Mach-Zehnder interferometer is then obtained from these Stokes parameters, The effectiveness of the proposed method is demonstrated by measuring a static carrier pattern and time-variant fringe patterns. It is emphasized that this method is applicable to time-variant phenomena because multiple exposures are unnecessary for sufficient data acquisition in the completion of the phase analysis.展开更多
A multi-band circular polarizer using a twisted triple split-ring resonator（TSRR） is presented and studied numerically and experimentally. At four distinct resonant frequencies, the incident linearly polarized wave ...A multi-band circular polarizer using a twisted triple split-ring resonator（TSRR） is presented and studied numerically and experimentally. At four distinct resonant frequencies, the incident linearly polarized wave can be transformed into left/right-handed circularly polarized waves. Numerical simulation results show that a y-polarized wave can be converted into a right-handed circularly polarized wave at 5.738 GHz and 9.218 GHz, while a left-handed circularly polarized wave is produced at 7.292 GHz and 10.118 GHz. The experimental results are in agreement with the numerical results. The surface current distributions are investigated to illustrate the polarization transformation mechanism. Furthermore, the influences of the structure parameters of the circular polarizer on transmission spectra are discussed as well.展开更多
An FSS based circular polarizer for high-speed wireless communication at 75 GHz is presented. It has been designed on a low loss substrate with cross-dipole elements. Both simulation and measured results showed more t...An FSS based circular polarizer for high-speed wireless communication at 75 GHz is presented. It has been designed on a low loss substrate with cross-dipole elements. Both simulation and measured results showed more than 98% circular polarization at 75 GHz. Moreover, 3 dB axial-ratio bandwidth of 6.8 GHz (Simulation) and 7.8 GHz (Measured) has been achieved. The proposed design has many advantages over the recently published research such as simplicity, low-profile, percentage bandwidth, frequency of operation and relative insertion loss.展开更多
基金supported by the National Natural Science Foundation of China(Nos.62175076,62105028,62475085)the Natural Science Foundation of Hubei Province of China(Nos.2024AFA016,2024AFB612)the Open Project Program of Hubei Optical Fundamental Research Center.
文摘The integrated waveguide polarizer is essential for photonic integrated circuits,and various designs of waveguide polarizers have been developed.As the demand for dense photonic integration increases rapidly,new strategies to minimize the device size are needed.In this paper,we have inversely designed an integrated transverse electric pass(TE-pass)polarizer with a footprint of 2.88μm×2.88μm,which is the smallest footprint ever achieved.A direct binary search algorithm is used to inversely design the device for maximizing the transverse electric(TE)transmission while minimizing transverse magnetic(TM)transmission.Finally,the inverse-designed device provides an average insertion loss of 0.99 dB and an average extinction ratio of 33 dB over a wavelength range of 100 nm.
基金supported by the Australian Research Council Centre of Excellence Project in Optical Microcombs for Breakthrough Science(No.CE230100006)the Australian Research Council Discovery Projects Programs(Nos.P190103186 and FT210100806)+4 种基金Linkage Program(Nos.LP210200345 and LP210100467)the Swinburne ECR-SUPRA program,the Industrial Transformation Training Centres scheme(No.IC180100005)the National Natural Science Foundation of China(No.12404375)the Beijing Natural Science Foundation(No.Z180007)the Innovation Program for Quantum Science and Technology(No.2021ZD0300703).
文摘Optical polarizers,which allow the transmission of specific polarization states,are essential components in modern optical systems.Here,we experimentally demonstrate integrated photonic polarizers incorporating reduced graphene oxide(rGO)films.2D graphene oxide(GO)films are integrated onto silicon waveguides and microring resonators(MRRs)with precise control over their thicknesses and sizes,followed by GO reduction via two different methods including uniform thermal reduction and localized photothermal reduction.We measure devices with various lengths,thicknesses,and reduction degrees of GO films.The results show that the devices with rGO exhibit better performance than those with GO,achieving a polarization-dependent loss of~47 dB and a polarization extinction ratio of~16 dB for the hybrid waveguides and MRRs with rGO,respectively.By fitting the experimental results with theory,it is found that rGO exhibits more significant anisotropy in loss,with an anisotropy ratio over 4 times that of GO.In addition,rGO shows higher thermal stability and greater robustness to photothermal reduction than GO.These results highlight the strong potential of rGO films for implementing high-performance polarization selective devices in integrated photonic platforms.
基金supported by the National Natural Science Foundation of China (Grant Nos.12475012,62461160263 for P.W.,and 62276171 for H.L.)Quantum Science and Technology-National Science and Technology Major Project of China (Project No.2023ZD0300600 for P.W.)+3 种基金Guangdong Provincial Quantum Science Strategic Initiative (Grant Nos.GDZX240-3009 and GDZX2303005 for P.W.)Guangdong Basic and Applied Basic Research Foundation (Grant No.2024-A1515011938 for H.L.)Shenzhen Fundamental ResearchGeneral Project (Grant No.JCYJ20240813141503005 for H.L.)the Talents Introduction Foundation of Beijing Normal University (Grant No.310432106 for P.W.)。
文摘Hyperpolarization of nuclear spins is crucial for advancing nuclear magnetic resonance and quantum information technologies,as nuclear spins typically exhibit extremely low polarization at room temperature due to their small gyromagnetic ratios.A promising approach to achieving high nuclear spin polarization is transferring the polarization of electrons to nuclear spins.The nitrogen-vacancy(NV)center in diamond has emerged as a highly effective medium for this purpose,and various hyperpolarization protocols have been developed.Among these,the pulsed polarization(PulsePol)method has been extensively studied due to its robustness against static energy shifts of the electron spin.In this work,we present a novel polarization protocol and uncover a family of magic sequences for hyperpolarizing nuclear spins,with PulsePol emerging as a special case of our general approach.Notably,we demonstrate that some of these magic sequences exhibit significantly greater robustness compared to the PulsePol protocol in the presence of finite half𝜋pulse duration of the protocol,Rabi and detuning errors.This enhanced robustness positions our protocol as a more suitable candidate for hyper-polarizing nuclear spins species with large gyromagnetic ratios and also ensures better compatibility with high-efficiency readout techniques at high magnetic fields.Additionally,the generality of our protocol allows for its direct application to other solid-state quantum systems beyond the NV center.
基金supported by the National Natural Science Foundation of China(Grants 42374215,42230209,42374199,42304183,42422406,42174185,72061147004 and 72342001)the Science and Technology Development Fund,Macao SAR(File no.0042/2024/RIA1 and 0008/2024/AKP)+1 种基金the Natural Science Foundation of Hunan Province(Grant 2023JJ20038)the Research Project of Science and Technology of Hunan Province(2025JJ10009,2022RC4025,2025QK1004,2023JJ50312,2023JJ50010 and 2024RC9012).
文摘Auroral kilometric radiation(AKR),a fundamental plasma emission in Earth's magnetosphere,exhibits three characteristic modes:the right-handed extraordinary(R-X),left-handed ordinary(L-O)and left-handed extraordinary(L-X)modes.The role of AKR in magnetosphere−ionosphere−atmosphere coupling depends sensitively on its wave mode.While previous studies have primarily focused on the dominant R-X mode,we present the first systematic identification of all three modes using a practical polarization analysis method based on Arase satellite observations.This method employs a spin-axis-relative Ratio:when the satellite's spin axis aligns with the background magnetic field,a positive(negative)Ratio indicates the right-handed(left-handed)polarization,with reversal under anti-parallel conditions.Combined polarization-frequency analysis reveals that R-X,L-O,and L-X modes can exist in both dayside and nightside regions,with power spectral densities up to 10^(-6)mV^(2)m^(-2)Hz^(-1).This study resolves long-standing ambiguities in AKR mode classification and has implications for understanding AKR-induced electron dynamics.
基金supported by the National Natural Science Foundation of China(Nos.52373235 and 52573322)the National Natural Science Foundation of Hubei Province of China(No.2024AFB568).
文摘Repolarizing tumor-associated macrophages(TAMs)toward the proinflammatory M1 phenotype represents a promising strategy to reverse the immunosuppressive tumor microenvironment(TME)and enhance antitumor immunotherapy.Recent studies have demonstrated that exogenous electrical stimulation can effectively repolarize TAMs toward the M1 phenotype.However,conventional electrical stimulation methods,relying on invasive implanted electrodes,are restricted to targeting localized tumor regions and pose inherent risks to patients.Notably,biological neural networks,distributed systems of interconnected neurons,can naturally permeate tissues and orchestrate cellular activities with high spatial efficiency.Inspired by this natural system,we developed a global in situ electric field network using piezoelectric BaTiO_(3)nanoparticles.Upon ultrasound stimulation,the nanoparticles generate a wireless electric field throughout the TME.In addtion,their nanoscale size enables them to function as synthetic“neurons”,allowing for uniform penetration throughout the tumor tissue and inducing significant repolarization of TAMs via the Ca^(2+)influx-activated nuclear factor-kappa B(NF-κB)signaling pathway.The repolarized M1 TAMs restore anti-tumor immunostimulatory functions and secrete key proinflammatory cytokines(e.g.,tumor necrosis factor-alpha(TNF-α)and interleukin-1 beta(IL-1β)),which enhance immunostimulation within the TME and directly contribute to tumor cell elimination.Remarkably,this strategy achieved robust in vivo tumor growth inhibition with excellent biosafety in a 4T1 breast tumor model.Overall,this work establishes a non-invasive,wireless electric field platform capable of globally repolarizing TAMs,offering a safe and efficient strategy to advance cancer immunotherapy and accelerate the clinical translation of bioelectronic therapies.
基金supported by grants from the Jiangxi Provincial Natural Science Foundation,No.20242BAB26134(to XF)the National Natural Science Foundation of China,Nos.82060638(to TC),82060222(to XF),82460237(to XF)+1 种基金the Major Disciplines of Academic and Technical Leaders Project of Jiangxi Province,Nos.20194BCJ22032(to TC),20213BCJL22049(to XF)Science and Technology Plan of Jiangxi Health Planning Committee,No.202210390(to XF).
文摘Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.
文摘In this paper, we propose an ellipsometer using a phase retarder and rotating polarizer and analyzer at a speed ratio I：N. Different ellipsometric configurations are presented by assuming N = 1, 2, and 3. Moreover, two values of the offset angle of the retarder are considered for each ellipsometric configuration. The Mueller formalism is employed to extract the Stokes parameters, from which the intensity received by the detector is obtained. The optical properties of c-Si are calculated using all configurations. A comparison between different configurations is carried out considering the effect of the noise on the results and the uncertainties in the ellipsometric parameters as functions of the uncertainties of the Fourier coefficients. It is found that the alignment of the phase retarder has a crucial impact on the results and the ellipsometric configuration with speed ratio 1：1 is preferred over the other configurations.
基金Supported by the National Natural Science Foundation of China under Grant Nos 61077006,60727004,and 61077060the China National Petroleum Corporation Science and Technology Development Projects under Grant No 2014B-4012the Science Research Plan Projects of Shaanxi Education Department under Grant No 14JK1580
文摘An in-fiber Mach-Zehnder interferometer for strain measurement is proposed and experimentally demonstrated. The sensor consists of a taper followed by a short section of a multi-mode fiber （MMF） and a dispersion com- pensating fiber （DCF）, which is sandwiched between two single mode fibers （SMFs）. The taper is used as a fiber coupler to excite cladding modes in the SMF, and these cladding modes transmit within the MMF and the DCF. The core mode and the cladding modes interfere in the DCF SMF fusion point to form intermodal interference. A well-defined interference spectrum is obtained in the experiment. Selected interference dips are used to measure the strain changes. The experimental results show that this device is sensitive to strain with the wavelength-referenced sensitivity of 2.6 pm/με and the power-referenced sensitivity of 0. 0027 dB/με, respectively.
基金supported by the National Natural Science Foundation of China(No.61405083)the Natural Science Foundation of Gansu Province of China(No.17JR5RA197)the Fundamental Research Funds for the Central Universities(No.LZU-JZH1931)
文摘A TM-pass polarizer based on multilayer graphene polymer waveguide is proposed and theoretically analyzed.The mode properties,the extinction ratio,the insertion loss and the bandwidth are also discussed.The results show that a TM-pass polarizer,which only guides the TM mode,can be achieved by multilayer graphene polymer waveguide.With length of 150μm,the proposed polarizer can achieve extinction ratio of 33 dB and insertion loss of 0.5 d B at optical wavelength of 1.55μm.This device has an excellent performance,including large extinction ratio and low insertion loss within the spectral range from 1.45μm to 1.6μm.
基金financially supported by the following projects:Open project of SITP(Project Number:IIMDKFJJ-18-09)National Natural Science Foundation of China(Project Number:61927820)+2 种基金The STCSM2019-11-20 funding(Project Number:19142202700)National Natural Science Foundation of China(Project Number:NSF No.U1732104)Zhejiang Lab’s International Talent Fund for Young Professionals。
文摘Polarimetric imaging enhances the ability to distinguish objects from a bright background by detecting their particular polarization status,which offers another degree of freedom in infrared remote sensing.However,to scale up by monolithically integrating grating-based polarizers onto a focal plane array(FPA)of infrared detectors,fundamental technical obstacles must be overcome,including reductions of the extinction ratio by the misalignment between the polarizer and the detector,grating line width fluctuations,the line edge roughness,etc.This paper reports the authors’latest achievements in overcoming those problems by solving key technical issues regarding the integration of large-scale polarizers onto the chips of FPAs with individual indium gallium arsenide/indium phosphide(In Ga As/In P)sensors as the basic building blocks.Polarimetric and photovoltaic chips with divisions of the focal plane of 540×4 pixels and 320×256 superpixels have been successfully manufactured.Polarimetric imaging with enhanced contrast has been demonstrated.The progress made in this work has opened up a broad avenue toward industrialization of high quality polarimetric imaging in infrared wavelengths.
基金Project supported by the National Natural Science Foundation of China (Grant No. 61875148)。
文摘An indium tin oxide(ITO) and silicon nitride(Si_(3)N_(4)) assisted compact TE-pass waveguide polarizer based on lithiumniobate-on-insulator is proposed and numerically analyzed.By properly designing the ITO and Si_(3)N_(4) assisted structure and utilizing the epsilon-near-zero effect of ITO,the TM mode is strongly confined in the ITO layer with extremely high loss,while the TE mode is hardly affected and passes through the waveguide with low loss.The simulation results show that the polarizer has an extinction ratio of 22.5 dB and an insertion loss of 0.8 dB at the wavelength of 1.55 μm,and has an operating bandwidth of about 125 nm(from 1540 nm to 1665 nm) for an extinction ratio of>20 dB and an insertion loss of<0.95 dB.Moreover,the proposed device exhibits large fabrication tolerances.More notably,the device is compact,with a length of only 7.5 μm,and is appropriate for on-chip applications.
基金supported by the National Natural Science Foundation of China, Nos.82201474 (to GL), 82071330 (to ZT), and 92148206 (to ZT)Key Research and Discovery Program of Hubei Province, No.2021BCA109 (to ZT)。
文摘Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.
基金Project supported by the Shandong Provincial Natural Science Foundation of China(Grant Nos.ZR2009AM017 and ZR2013FM019)the National Postdoctoral Project of China(Grant Nos.200902574 and 20080441150)+2 种基金the Shandong Provincial Education Department Foundation of China(Grant No.J06P14)the Opening Foundation of State Key Lab of Minning Disaster Prevention and Control Co-founded by Shandong Provincethe Ministry of Science and Technology of China(Grant No.MDPC201602)
文摘The temperature-induced complex refractive index（CRI） effect of graphene is demonstrated theoretically and experimentally based on a graphene coated in-fiber MZI（Mach-Zehnder interferometer）. The relationships between real and imaginary parts of the graphene CRI and temperature are obtained through investigating the dip wavelength and intensity of the MZI interference spectrum changing with temperature, respectively. The temperature effect of CRI of the graphene is also analyzed theoretically. Both experimental and theoretical studies show that the real part and imaginary part of the CRI nonlinearly decrease and increase with temperature increasing, respectively. This graphene-coated in-fiber MZI structure also possesses the advantages of easy fabrication, miniaturization, low cost and robustness. It has potential applications in nanomaterial-based optic devices for communication and sensing.
基金Supported by the National Basic Research Program of China under Grant No 2012CB933501the National Natural Science Foundation of China under Grant Nos 61177051,11304389,61404174 and 61205087
文摘We theoretically and numerically demonstrate that a transmission-type electrically tunable polarizer can be realized by using graphene ribbons supported on a dielectric film with a graphene sheet behind. The polarization mechanism originates from the antenna plasmon resonance of graphene stripes. The results of full-wave numerical simulations reveal that transmittance of 0.70 for one polarization and 0.0073 for another polarization can be obtained at normal incidence. The transmission-type electrically tunable polarizer provides and facilitates a variety of applications, including filtering, detecting, and imaging.
基金Project supported by the Technological Innovation Project of Air-to-Air Missile Institute of China (Grant No.5S85000FS)
文摘This paper deals with a systematical analysis and an algorithm of attenuation characteristics of a light attenuator combined by n pieces of polarizers （n-LACP） whose extinction ratios are different from each other. The attenuation ratio expression of a two-LACP is deduced. We find that the monotonic attenuation interval depends on the first polarizer and that the attenuation range depends on the second one. For the three-LACP, a method for obtaining a monotonic attenuation interval is proposed. Moreover, the attenuation ratio expression is demonstrated. Analysis and experiment show that when the initial status of the three-LACP is at the maximum output, if the second or third polarizer rotates alone, the minimum attenuation ratios can reach K2^-1 and K3^-1, respectively, and if the first polarizer rotates, a minimum attenuation ratio of K2^-1K3^-1 can be obtained （K1, K2 and K3 represent the extinction ratios of the three polarizers in turn）. Furthermore, the attenuation ratio expression of n-LACP and the relevant attenuation characteristics are proposed. The minimum attenuation ratio of an n-LACP is （K2K3 ... Kn）-1.
文摘In this paper, we propose an instantaneous phase-stepping method for determining phase distribution of interference fringes utilizing a camera that is equipped with a micro-polarizer array on the sensor plane. An optical setup of polarization interferometry using a Mach-Zehnder interferometer with two polarizers is constructed. Light emerging from the interferometer is recorded using a camera that has a micro-polarizer array. This micro-polarizer array has four different optical axes. That is, an image obtained by the camera contains four types of information corresponding to four different optical axes of the polarizer. The four images separated from the image recorded by the camera are reconstructed using gray level interpolation. Subsequently, the distributions of the Stokes parameters that represent the state of polarization are calculated from the four images. The phase distribution of the interference fringe pattern produced by the Mach-Zehnder interferometer is then obtained from these Stokes parameters, The effectiveness of the proposed method is demonstrated by measuring a static carrier pattern and time-variant fringe patterns. It is emphasized that this method is applicable to time-variant phenomena because multiple exposures are unnecessary for sufficient data acquisition in the completion of the phase analysis.
基金Project supported by the National Natural Science Foundation of China(Grant No.41474117)the Special Funds for Development Scientific Research Unit Projects of Wuhan,China(Grant No.2013BJ004)
文摘A multi-band circular polarizer using a twisted triple split-ring resonator（TSRR） is presented and studied numerically and experimentally. At four distinct resonant frequencies, the incident linearly polarized wave can be transformed into left/right-handed circularly polarized waves. Numerical simulation results show that a y-polarized wave can be converted into a right-handed circularly polarized wave at 5.738 GHz and 9.218 GHz, while a left-handed circularly polarized wave is produced at 7.292 GHz and 10.118 GHz. The experimental results are in agreement with the numerical results. The surface current distributions are investigated to illustrate the polarization transformation mechanism. Furthermore, the influences of the structure parameters of the circular polarizer on transmission spectra are discussed as well.
文摘An FSS based circular polarizer for high-speed wireless communication at 75 GHz is presented. It has been designed on a low loss substrate with cross-dipole elements. Both simulation and measured results showed more than 98% circular polarization at 75 GHz. Moreover, 3 dB axial-ratio bandwidth of 6.8 GHz (Simulation) and 7.8 GHz (Measured) has been achieved. The proposed design has many advantages over the recently published research such as simplicity, low-profile, percentage bandwidth, frequency of operation and relative insertion loss.
