Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a...Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive.展开更多
Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmen...Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale.展开更多
The traditional academic warning methods for students in higher vocational colleges are relatively backward,single,and have many influencing factors,which have a limited effect on improving their learning ability.A da...The traditional academic warning methods for students in higher vocational colleges are relatively backward,single,and have many influencing factors,which have a limited effect on improving their learning ability.A data set was established by collecting academic warning data of students in a certain university.The importance of the school,major,grade,and warning level for the students was analyzed using the Pearson correlation coefficient,random forest variable importance,and permutation importance.It was found that the characteristic of the major has a great impact on the academic warning level.Countermeasures such as dynamic adjustment of majors,reform of cognitive adaptation of courses,full-cycle academic support,and data-driven precise intervention were proposed to provide theoretical support and practical paths for universities to improve the efficiency of academic warning and enhance students’learning ability.展开更多
The authors regret that the original publication of this paper did not include Jawad Fayaz as a co-author.After further discussions and a thorough review of the research contributions,it was agreed that his significan...The authors regret that the original publication of this paper did not include Jawad Fayaz as a co-author.After further discussions and a thorough review of the research contributions,it was agreed that his significant contributions to the foundational aspects of the research warranted recognition,and he has now been added as a co-author.展开更多
Nirmal et al.presented a machine learning-based design of ternary organic solar cells,utilizing feature importance[1].This paper highlights the alarming potential biases in the use of feature importance in machine lea...Nirmal et al.presented a machine learning-based design of ternary organic solar cells,utilizing feature importance[1].This paper highlights the alarming potential biases in the use of feature importance in machine learning,which can lead to incorrect conclusions and outcomes.Many scientists and researchers including Nirmal et al.are unaware that feature importances in machine learning in general are model-specific and do not necessarily represent true associations between the target and features.展开更多
In this paper, we use sample average approximation with adaptive multiple importance sampling to explore moderate deviations for the optimal values. Utilizing the moderate deviation principle for martingale difference...In this paper, we use sample average approximation with adaptive multiple importance sampling to explore moderate deviations for the optimal values. Utilizing the moderate deviation principle for martingale differences and an appropriate Delta method, we establish a moderate deviation principle for the optimal value. Moreover, for a functional form of stochastic programming, we obtain a functional moderate deviation principle for its optimal value.展开更多
The condensation tracking algorithm uses a prior transition probability as the proposal distribution, which does not make full use of the current observation. In order to overcome this shortcoming, a new face tracking...The condensation tracking algorithm uses a prior transition probability as the proposal distribution, which does not make full use of the current observation. In order to overcome this shortcoming, a new face tracking algorithm based on particle filter with mean shift importance sampling is proposed. First, the coarse location of the face target is attained by the efficient mean shift tracker, and then the result is used to construct the proposal distribution for particle propagation. Because the particles obtained with this method can cluster around the true state region, particle efficiency is improved greatly. The experimental results show that the performance of the proposed algorithm is better than that of the standard condensation tracking algorithm.展开更多
Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system.Traditional importance measures mainly concerned the changing value of the system reli...Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system.Traditional importance measures mainly concerned the changing value of the system reliability caused by the change of the reliability of the component,and seldom considered the joint effect of the probability distribution,improvement rate of the object component.This paper studies the rate of the system reliability upgrading with an improvement of the component reliability for the multi-state consecutive k-out-of-n system.To verify the multi-state consecutive k-out-of-n system reliability upgrading by improving one component based on its improvement rate,an increasing potential importance(IPI)and its physical meaning are described at first.Secondly,the relationship between the IPI and Birnbaum importance measures are discussed.And the IPI for some different improvement actions of the component is further discussed.Thirdly,the characteristics of the IPI are analyzed.Finally,an application to an oil pipeline system is given.展开更多
Thorium was discovered in 1828 by the Swedish chemist Jons J.Berzelius.Despite some advantages over uranium for use in nuclear reactors,its main use,in the almost two centuries since its discovery,thorium was restrict...Thorium was discovered in 1828 by the Swedish chemist Jons J.Berzelius.Despite some advantages over uranium for use in nuclear reactors,its main use,in the almost two centuries since its discovery,thorium was restricted to use for gas mantles,especially in the early 20th century.In the beginning of the nuclear era,many countries had interested on thorium,particularly during the 1950-1970 period.There are about 435 nuclear reactors in the world nowadays.They need more than 65,000 tons of uranium yearly.The future world energy needs will increase and,even if we assumed a conservative contribution of nuclear generation,there will be a significant increasing in the uranium prices occur,taking into account that uranium,as used in the present thermal reactors,is a finite resource.Thorium is nearly three times more abundant than uranium in the Earth's crust.Despite thorium is not a fissile material,^232Th can be converted to^233U(fissile)more efficiently than^238U to^239pu.Besides this,since it is possible to convert thorium waste into non-radioactive elements,thorium is an environment-friendly alternative energy source.Thorium fuel cycle is also inherently resistant to proliferation.Some papers evaluate the thorium resources in Brazil over 1,200,000 metric t.Then,the thorium alternative must be seriously considered in Brazil for strategic reasons.In this paper a brief history of thorium is presented,besides a review of the world thorium utilization and a discussion about advantages and restrictions of thorium use.展开更多
The modem times industrial technology and the mathematics mutual promotion, the new technological revolution origins from thecomputation technology improvement, the modem network world is closely linked with the mathe...The modem times industrial technology and the mathematics mutual promotion, the new technological revolution origins from thecomputation technology improvement, the modem network world is closely linked with the mathematics, mathematics development promotedthe technology advancement, the technology advancement also to impetus basic mathematics development, the two promoted the human culturedevelopment together, has brought the modem culture and the civilized unprecedented prosperity, also widely was affecting the modem life andthe thought. This paper analyzed the idea of attaching the importance to the strategy of mathematical culture in the college mathematics teaching.The proposed method is of great importance of enhancing the further direction of the mathematical education paradigms.展开更多
In The Importance of Being Earnest,Oscar Wilde constructs a dandies’world,in which the persons mock at everything and subvert everything.This research analyzes the dandyish features of the character with the aid of C...In The Importance of Being Earnest,Oscar Wilde constructs a dandies’world,in which the persons mock at everything and subvert everything.This research analyzes the dandyish features of the character with the aid of Charles Baudelaire’s definition of dandy and dandyism,and studies Wilde’s subversion of the preexistent binary oppositions by referring to Jonathan Culler’s interpretation of Jacque Derrida’s deconstruction,and points out that Wilde’s writing in Earnest is a deconstructionist writing.He abandons all the so-called essential matters and only focuses on linguistic surface and comic effect.His stance of dandyism challenges the main-stream social norms at his time and foresees the coming artistic trend.展开更多
In a system of systems(SoS),resilience is an important factor in maintaining the functionality,stability,and enhancing the operation effectiveness.From the perspective of resilience,this paper studies the importance o...In a system of systems(SoS),resilience is an important factor in maintaining the functionality,stability,and enhancing the operation effectiveness.From the perspective of resilience,this paper studies the importance of the SoS,and a resilience-based importance measure analysis is conducted to provide suggestions in the design and optimization of the structure of the SoS.In this paper,the components of the SoS are simplified as four kinds of network nodes:sensor,decision point,influencer,and target.In this networked SoS,the number of operation loops is used as the performance indicator,and an approximate algorithm,which is based on eigenvalue of the adjacency matrix,is proposed to calculate the number of operation loops.In order to understand the performance change of the SoS during the attack and defense process in the operations,an integral resilience model is proposed to depict the resilience of the SoS.From different perspectives of enhancing the resilience,different measures,parameters and the corresponding algorithms for the resilience importance of components are proposed.Finally,a case study on an SoS is conducted to verify the validity of the network modelling and the resiliencebased importance analysis method.展开更多
Concerning the issue of high-dimensions and low-failure probabilities including implicit and highly nonlinear limit state function, reliability analysis based on the directional importance sampling in combination with...Concerning the issue of high-dimensions and low-failure probabilities including implicit and highly nonlinear limit state function, reliability analysis based on the directional importance sampling in combination with the radial basis function （RBF） neural network is used, and the RBF neural network based on first-order reliability method （FORM） is to approximate the unknown implicit limit state functions and calculate the most probable point （MPP） with iterative algorithm. For good efficiency, based on the ideas that directional sampling reduces dimensionality and importance sampling focuses on the domain contributing to failure probability, the joint probability density function of importance sampling is constructed, and the sampling center is moved to MPP to ensure that more random sample points draw belong to the failure domain and the simulation efficiency is improved. Then the numerical example of initiating explosive devices for rocket booster explosive bolts demonstrates the applicability, versatility and accuracy of the approach compared with other reliability simulation algorithm.展开更多
文摘Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive.
基金supported by the National Key Research and Development Program of China(2023YFF0805602)National Natural Science Foundation of China(32225032,32001192,32271597)+1 种基金the Innovation Base Project of Gansu Province(2021YFF0703904)the Science and Technology Program of Gansu Province(24JRRA515,22JR5RA525,23JRRA1157).
文摘Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale.
基金supported by the Basic Ability Improvement Project of Young and Middle-Aged Teachers in Colleges and Universities of Guangxi(2022KY1922,2021KY1938).
文摘The traditional academic warning methods for students in higher vocational colleges are relatively backward,single,and have many influencing factors,which have a limited effect on improving their learning ability.A data set was established by collecting academic warning data of students in a certain university.The importance of the school,major,grade,and warning level for the students was analyzed using the Pearson correlation coefficient,random forest variable importance,and permutation importance.It was found that the characteristic of the major has a great impact on the academic warning level.Countermeasures such as dynamic adjustment of majors,reform of cognitive adaptation of courses,full-cycle academic support,and data-driven precise intervention were proposed to provide theoretical support and practical paths for universities to improve the efficiency of academic warning and enhance students’learning ability.
文摘The authors regret that the original publication of this paper did not include Jawad Fayaz as a co-author.After further discussions and a thorough review of the research contributions,it was agreed that his significant contributions to the foundational aspects of the research warranted recognition,and he has now been added as a co-author.
文摘Nirmal et al.presented a machine learning-based design of ternary organic solar cells,utilizing feature importance[1].This paper highlights the alarming potential biases in the use of feature importance in machine learning,which can lead to incorrect conclusions and outcomes.Many scientists and researchers including Nirmal et al.are unaware that feature importances in machine learning in general are model-specific and do not necessarily represent true associations between the target and features.
基金Supported by the National Natural Science Foundation of China(Grant No.12071175)。
文摘In this paper, we use sample average approximation with adaptive multiple importance sampling to explore moderate deviations for the optimal values. Utilizing the moderate deviation principle for martingale differences and an appropriate Delta method, we establish a moderate deviation principle for the optimal value. Moreover, for a functional form of stochastic programming, we obtain a functional moderate deviation principle for its optimal value.
基金The National Natural Science Foundation of China(No60672094)
文摘The condensation tracking algorithm uses a prior transition probability as the proposal distribution, which does not make full use of the current observation. In order to overcome this shortcoming, a new face tracking algorithm based on particle filter with mean shift importance sampling is proposed. First, the coarse location of the face target is attained by the efficient mean shift tracker, and then the result is used to construct the proposal distribution for particle propagation. Because the particles obtained with this method can cluster around the true state region, particle efficiency is improved greatly. The experimental results show that the performance of the proposed algorithm is better than that of the standard condensation tracking algorithm.
基金supported by the National Natural Science Foundation of China(7127117071101116)+1 种基金the National High Technology Research and Development Program of China(863 Progrom)(2012AA040914)the Basic Research Foundation of Northwestern Polytechnical University(JC20120228)
文摘Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system.Traditional importance measures mainly concerned the changing value of the system reliability caused by the change of the reliability of the component,and seldom considered the joint effect of the probability distribution,improvement rate of the object component.This paper studies the rate of the system reliability upgrading with an improvement of the component reliability for the multi-state consecutive k-out-of-n system.To verify the multi-state consecutive k-out-of-n system reliability upgrading by improving one component based on its improvement rate,an increasing potential importance(IPI)and its physical meaning are described at first.Secondly,the relationship between the IPI and Birnbaum importance measures are discussed.And the IPI for some different improvement actions of the component is further discussed.Thirdly,the characteristics of the IPI are analyzed.Finally,an application to an oil pipeline system is given.
文摘Thorium was discovered in 1828 by the Swedish chemist Jons J.Berzelius.Despite some advantages over uranium for use in nuclear reactors,its main use,in the almost two centuries since its discovery,thorium was restricted to use for gas mantles,especially in the early 20th century.In the beginning of the nuclear era,many countries had interested on thorium,particularly during the 1950-1970 period.There are about 435 nuclear reactors in the world nowadays.They need more than 65,000 tons of uranium yearly.The future world energy needs will increase and,even if we assumed a conservative contribution of nuclear generation,there will be a significant increasing in the uranium prices occur,taking into account that uranium,as used in the present thermal reactors,is a finite resource.Thorium is nearly three times more abundant than uranium in the Earth's crust.Despite thorium is not a fissile material,^232Th can be converted to^233U(fissile)more efficiently than^238U to^239pu.Besides this,since it is possible to convert thorium waste into non-radioactive elements,thorium is an environment-friendly alternative energy source.Thorium fuel cycle is also inherently resistant to proliferation.Some papers evaluate the thorium resources in Brazil over 1,200,000 metric t.Then,the thorium alternative must be seriously considered in Brazil for strategic reasons.In this paper a brief history of thorium is presented,besides a review of the world thorium utilization and a discussion about advantages and restrictions of thorium use.
文摘The modem times industrial technology and the mathematics mutual promotion, the new technological revolution origins from thecomputation technology improvement, the modem network world is closely linked with the mathematics, mathematics development promotedthe technology advancement, the technology advancement also to impetus basic mathematics development, the two promoted the human culturedevelopment together, has brought the modem culture and the civilized unprecedented prosperity, also widely was affecting the modem life andthe thought. This paper analyzed the idea of attaching the importance to the strategy of mathematical culture in the college mathematics teaching.The proposed method is of great importance of enhancing the further direction of the mathematical education paradigms.
文摘In The Importance of Being Earnest,Oscar Wilde constructs a dandies’world,in which the persons mock at everything and subvert everything.This research analyzes the dandyish features of the character with the aid of Charles Baudelaire’s definition of dandy and dandyism,and studies Wilde’s subversion of the preexistent binary oppositions by referring to Jonathan Culler’s interpretation of Jacque Derrida’s deconstruction,and points out that Wilde’s writing in Earnest is a deconstructionist writing.He abandons all the so-called essential matters and only focuses on linguistic surface and comic effect.His stance of dandyism challenges the main-stream social norms at his time and foresees the coming artistic trend.
基金supported by the National Natural Science Foundation of China(71571004)
文摘In a system of systems(SoS),resilience is an important factor in maintaining the functionality,stability,and enhancing the operation effectiveness.From the perspective of resilience,this paper studies the importance of the SoS,and a resilience-based importance measure analysis is conducted to provide suggestions in the design and optimization of the structure of the SoS.In this paper,the components of the SoS are simplified as four kinds of network nodes:sensor,decision point,influencer,and target.In this networked SoS,the number of operation loops is used as the performance indicator,and an approximate algorithm,which is based on eigenvalue of the adjacency matrix,is proposed to calculate the number of operation loops.In order to understand the performance change of the SoS during the attack and defense process in the operations,an integral resilience model is proposed to depict the resilience of the SoS.From different perspectives of enhancing the resilience,different measures,parameters and the corresponding algorithms for the resilience importance of components are proposed.Finally,a case study on an SoS is conducted to verify the validity of the network modelling and the resiliencebased importance analysis method.
文摘Concerning the issue of high-dimensions and low-failure probabilities including implicit and highly nonlinear limit state function, reliability analysis based on the directional importance sampling in combination with the radial basis function （RBF） neural network is used, and the RBF neural network based on first-order reliability method （FORM） is to approximate the unknown implicit limit state functions and calculate the most probable point （MPP） with iterative algorithm. For good efficiency, based on the ideas that directional sampling reduces dimensionality and importance sampling focuses on the domain contributing to failure probability, the joint probability density function of importance sampling is constructed, and the sampling center is moved to MPP to ensure that more random sample points draw belong to the failure domain and the simulation efficiency is improved. Then the numerical example of initiating explosive devices for rocket booster explosive bolts demonstrates the applicability, versatility and accuracy of the approach compared with other reliability simulation algorithm.
