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Stress signaling caused by mitochondrial import malfunction can be terminated by SIFI:Importance of stress response silencing
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作者 Grace Hohman Michael Shahid Mohamed A.Eldeeb 《Neural Regeneration Research》 2026年第2期673-674,共2页
Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a... Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive. 展开更多
关键词 activation stress pathways neurodegenerative disorders protein aggregatesmitochondrial import stress stress signaling protein aggregates goiran protein aggregates protein aggr neurodegenerative diseasesincluding
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Analysis of Influencing Factors of Academic Warning in Higher Vocational Colleges Based on the Importance of Machine Learning Features and Paths to Improve Learning Ability 被引量:1
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作者 Meimei Huang Lei Zhang Xifeng Fan 《Journal of Contemporary Educational Research》 2025年第5期75-80,共6页
The traditional academic warning methods for students in higher vocational colleges are relatively backward,single,and have many influencing factors,which have a limited effect on improving their learning ability.A da... The traditional academic warning methods for students in higher vocational colleges are relatively backward,single,and have many influencing factors,which have a limited effect on improving their learning ability.A data set was established by collecting academic warning data of students in a certain university.The importance of the school,major,grade,and warning level for the students was analyzed using the Pearson correlation coefficient,random forest variable importance,and permutation importance.It was found that the characteristic of the major has a great impact on the academic warning level.Countermeasures such as dynamic adjustment of majors,reform of cognitive adaptation of courses,full-cycle academic support,and data-driven precise intervention were proposed to provide theoretical support and practical paths for universities to improve the efficiency of academic warning and enhance students’learning ability. 展开更多
关键词 Academic warning Pearson correlation coefficient Random forest variable importance Permutation importance
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家蚕BmNPV多角体蛋白的表达规律及importin α介导的Polh入核转运 被引量:1
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作者 李佳乐 王星洋 吴小锋 《生物工程学报》 北大核心 2025年第7期2647-2657,共11页
家蚕核型多角体病毒(Bombyx mori nucleopolyhedrovirus, BmNPV)对蚕丝业的危害极大。该病毒的多角体蛋白编码基因polyhedrin(polh)能够在病毒感染极晚期超高水平表达,并在细胞核内形成包涵体,多角体蛋白转运到宿主细胞核中的详细机制... 家蚕核型多角体病毒(Bombyx mori nucleopolyhedrovirus, BmNPV)对蚕丝业的危害极大。该病毒的多角体蛋白编码基因polyhedrin(polh)能够在病毒感染极晚期超高水平表达,并在细胞核内形成包涵体,多角体蛋白转运到宿主细胞核中的详细机制目前未知。为阐明病毒蛋白的入核机制,本研究通过分子克隆、免疫共沉淀(co-immunoprecipitation, CO-IP)、免疫荧光等方法,详细分析了多角体蛋白(polyhedrin, Polh)的表达规律,并进一步揭示了宿主蛋白importin α通过蛋白互作的方式参与多角体蛋白的入核转运,为进一步深入阐明包括Polh在内的诸多杆状病毒入核蛋白的入核机制提供了参考。 展开更多
关键词 家蚕核型多角体病毒 多角体蛋白 importinα 入核转运
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Concepts of keystone species and species importance in ecology
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作者 陆兆华 马玲 国庆喜 《Journal of Forestry Research》 SCIE CAS CSCD 2001年第4期250-252,277,共4页
This paper discussed the keystone species concept and introduced the typical characteristics of keystone species and their identification in communities or ecosystems. Based on the research of the keystone species, th... This paper discussed the keystone species concept and introduced the typical characteristics of keystone species and their identification in communities or ecosystems. Based on the research of the keystone species, the concept of species importance (SI) was first advanced in this paper. The species importance can be simply understood as the important value of species in the ecosystem, which consists of three indexes: species structural important value (SIV), functional important value (FIV) and dynamical important value (DIV). With the indexes, the evaluation was also made on species importance of arbor trees in the Three-Hardwood forests (Fraxinus mandshurica, Juglans mandshurica, and Phellodendron amurense) ecosystem. 展开更多
关键词 Species importance Keystone species Structural important value Functional important value Dynamical important value
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基于Null Importance分析慢病人群接受居家药学服务意愿的影响因素
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作者 赵科 杨宏昕 +2 位作者 武明芬 郭浩 赵志刚 《医药导报》 北大核心 2025年第8期1347-1351,共5页
目的探究慢病人群接受居家药学服务意愿的关键影响因素。方法采用中国适老化研究项目中内蒙古自治区及东北地区的调查数据,基于Null Importance方法,筛选影响慢病人群参与居家药学服务意愿的关键因素。构建logistic回归模型,采用5折交... 目的探究慢病人群接受居家药学服务意愿的关键影响因素。方法采用中国适老化研究项目中内蒙古自治区及东北地区的调查数据,基于Null Importance方法,筛选影响慢病人群参与居家药学服务意愿的关键因素。构建logistic回归模型,采用5折交叉验证方法,以准确率及AUC为指标,评价特征选择对模型性能的影响。结果Null Importance方法筛选出10个关键因素,且特征选择后logistic回归模型性能得到提升。显著影响患者对居家药学服务接受意愿的因素包括:获取药品信息途径个数(OR=1.261,95%CI=1.182~1.345),药物适应证认知(OR=1.342,95%CI=1.124~1.603),是否保留药盒(OR=1.218,95%CI=1.015~1.462),用药依从性得分(OR=0.881,95%CI=0.839~0.925),用药素养得分(OR=0.631,95%CI=0.488~0.817),用药指导服务了解程度(OR=1.211,95%CI=1.017~1.442)。结论在Null Importance特征选择方法基础上构建的logistic回归模型,具有良好的性能,有助于慢病人群接受居家药学服务意愿影响因素的分析。 展开更多
关键词 Null importance 居家药学服务 意愿 慢病
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Laboratory Diagnosis and Molecular Epidemiological Characterization of the First Imported Case of Lassa Fever in China 被引量:2
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作者 Yuliang Feng Wei Li +11 位作者 Mingfeng Jiang Hongrong Zhong Wei Wu Lyubo Tian Guo Chen Zhenhua Chen Can Luo Rongmei Yuan Xingyu Zhou Jiandong Li Xiaorong Yang Ming Pan 《Biomedical and Environmental Sciences》 2025年第3期279-289,共11页
Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the preven... Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus. 展开更多
关键词 Lassa fever The first imported case Laboratory diagnosis Epidemiological characterization
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Distribution,species richness,and relative importance of different plant life forms across drylands in China 被引量:1
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作者 Shuran Yao Weigang Hu +16 位作者 Mingfei Ji Abraham Allan Degen Qiajun Du Muhammad Adnan Akram Yuan Sun Ying Sun Yan Deng Longwei Dong Haiyang Gong Qingqing Hou Shubin Xie Xiaoting Wang Jinzhi Ran Bernhard Schmid Qinfeng Guo Karl J.Niklas Jianming Deng 《Plant Diversity》 2025年第2期273-281,共9页
Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmen... Studies on plant diversity are usually based on the total number of species in a community.However,few studies have examined species richness(SR)of different plant life forms in a community along largescale environmental gradients.Particularly,the relative importance(RIV)of different plant life forms in a community and how they vary with environmental variables are still unclear.To fill these gaps,we determined plant diversity of ephemeral plants,annual herbs,perennial herbs,and woody plants from 187 sites across drylands in China.The SR patterns of herbaceous plants,especially perennial herbs,and their RIV in plant communities increased with increasing precipitation and soil nutrient content;however,the RIV of annual herbs was not altered along these gradients.The SR and RIV of ephemeral plants were affected mainly by precipitation seasonality.The SR of woody plants had a unimodal relationship with air temperature and exhibited the highest RIV and SR percentage in plant communities under the harshest environments.An obvious shift emerged in plant community composition,SR and their critical impact factors at 238.5 mm of mean annual precipitation(MAP).In mesic regions(>238.5 mm),herbs were the dominant species,and the SR displayed a relatively slow decreasing rate with increasing aridity,which was mediated mainly by MAP and soil nutrients.In arid regions(<238.5 mm),woody plants were the dominant species,and the SR displayed a relatively fast decreasing rate with increasing aridity,which was mediated mainly by climate variables,especially precipitation.Our findings highlight the importance of comparative life form studies in community structure and biodiversity,as their responses to gradients differed substantially on a large scale. 展开更多
关键词 DRYLANDS Environmental gradients Plant life forms Relative importance Species richness THRESHOLD
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The First Imported Case of Lassa Fever in China-Implications for Global Health Surveillance 被引量:1
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作者 Qiyong Liu 《Biomedical and Environmental Sciences》 2025年第3期277-278,共2页
Lassa fever(LF)is an acute viral hemorrhagic disease caused by Lassa virus(LASV)[1].LASV is transmitted to humans primarily through direct contact with infected Mastomys rodents,or items polluted by infected rodents[2... Lassa fever(LF)is an acute viral hemorrhagic disease caused by Lassa virus(LASV)[1].LASV is transmitted to humans primarily through direct contact with infected Mastomys rodents,or items polluted by infected rodents[2].LF is difficult to diagnose without laboratory tests because of its various symptoms,ranging from no symptoms to multiple organ failure and death[2].West Africa is the traditionally endemic regions for LF,with confirmed and sporadic outbreaks reported in countries,such as Nigeria,Burkina Faso and Guinea[2].LF cases have also been detected in some non-endemic regions due to international travels[3,4],for example,the United Kingdom found LF imported cases from Mali[5].This indicates that the countries are exposed to imported risks of LF due to the globalization.The recent publication[6]reported the first imported cases of LF in China,providing important insights into the understanding and control of the emerging infectious disease. 展开更多
关键词 importED TRAVEL traditionally
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Beyond statistical significance:Embracing minimal clinically important difference for better patient care
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作者 Naveen Jeyaraman Madhan Jeyaraman +2 位作者 Swaminathan Ramasubramanian Sangeetha Balaji Sathish Muthu 《World Journal of Methodology》 2025年第1期33-41,共9页
The minimal clinically important difference(MCID)represents a pivotal metric in bridging the gap between statistical significance and clinical relevance,addressing the direct impact of medical interventions from the p... The minimal clinically important difference(MCID)represents a pivotal metric in bridging the gap between statistical significance and clinical relevance,addressing the direct impact of medical interventions from the patient's perspective.This comprehensive review analyzes the evolution,applications,and challenges of MCID across medical specialties,emphasizing its necessity in ensuring that clinical outcomes not only demonstrate statistical significance but also offer genuine clinical utility that aligns with patient expectations and needs.We discuss the evolution of MCID since its inception in the 1980s,its current applications across various medical specialties,and the methodologies used in its calculation,highlighting both anchor-based and distribution-based approaches.Furthermore,the paper delves into the challenges associated with the application of MCID,such as methodological variability and the interpretation difficulties that arise in clinical settings.Recommendations for the future include standardizing MCID calculation methods,enhancing patient involvement in setting MCID thresholds,and extending research to incorporate diverse global perspectives.These steps are critical to refining the role of MCID in patient-centered healthcare,addressing existing gaps in methodology and interpretation,and ensuring that medical interventions lead to significant,patient-perceived improvements. 展开更多
关键词 Minimal clinically important difference Patient-centered care Clinical relevance Global health
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Exporting Perfumes to China:Key Compliance and Import Requirements
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作者 Jarius Ji 《China Detergent & Cosmetics》 2025年第2期12-15,共4页
China's perfume market has been experiencing significant growth.The “2024 China Perfume and Fragrance White Paper”,jointly published by Eternal Group,DSM-Firmenich,and Ipsos in September 2024,reveals that the ma... China's perfume market has been experiencing significant growth.The “2024 China Perfume and Fragrance White Paper”,jointly published by Eternal Group,DSM-Firmenich,and Ipsos in September 2024,reveals that the market surged from 11.4 billion yuan in 2018 to 22.9 billion yuan in 2023,achieving a compound annual growth rate(CAGR) of 15%.With projections estimating a rise to 44 billion yuan by 2028 at a 14% CAGR,the sector's long-term growth prospects remain strong. 展开更多
关键词 growth prospects white paper China COMPLIANCE perfumes perfume market import requirements
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Proactive detection of imported malaria in malaria-eliminated Sri Lanka
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作者 M K Sampath Indika Kumara Shilanthi Seneviratne 《Asian Pacific Journal of Tropical Medicine》 2025年第6期286-288,共3页
The World Health Organization declared Sri Lanka a malaria eliminated country in 2016[1-3].At present,the country is in the phase of preventing the re-establishment of malaria[4].However,travelers who contract the dis... The World Health Organization declared Sri Lanka a malaria eliminated country in 2016[1-3].At present,the country is in the phase of preventing the re-establishment of malaria[4].However,travelers who contract the disease overseas in malaria endemic countries continue to present a constant risk of re-establishing malaria in Sri Lanka,where malaria-transmitting mosquitos is prevalent.In this context,robust measures are being implemented in the country to prevent re-establishment of malaria and to stop travelers infected with malaria progressing into severe disease and death. 展开更多
关键词 WHO declaration DEATH imported malaria severe disease malaria eliminated Sri Lanka TRAVELERS proactive detection
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Unveiling hidden biases in machine learning feature importance
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作者 Yoshiyasu Takefuji 《Journal of Energy Chemistry》 2025年第3期49-51,共3页
Nirmal et al.presented a machine learning-based design of ternary organic solar cells,utilizing feature importance[1].This paper highlights the alarming potential biases in the use of feature importance in machine lea... Nirmal et al.presented a machine learning-based design of ternary organic solar cells,utilizing feature importance[1].This paper highlights the alarming potential biases in the use of feature importance in machine learning,which can lead to incorrect conclusions and outcomes.Many scientists and researchers including Nirmal et al.are unaware that feature importances in machine learning in general are model-specific and do not necessarily represent true associations between the target and features. 展开更多
关键词 Machine learning Feature importance Potential bias Chi-squared and P-value
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Identifying important nodes of hypergraph:An improved PageRank algorithm
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作者 Yu-Hao Piao Jun-Yi Wang Ke-Zan Li 《Chinese Physics B》 2025年第4期162-171,共10页
Hypergraphs can accurately capture complex higher-order relationships,but it is challenging to identify their important nodes.In this paper,an improved PageRank(ImPageRank)algorithm is designed to identify important n... Hypergraphs can accurately capture complex higher-order relationships,but it is challenging to identify their important nodes.In this paper,an improved PageRank(ImPageRank)algorithm is designed to identify important nodes in a directed hypergraph.The algorithm introduces the Jaccard similarity of directed hypergraphs.By comparing the numbers of common neighbors between nodes with the total number of their neighbors,the Jaccard similarity measure takes into account the similarity between nodes that are not directly connected,and can reflect the potential correlation between nodes.An improved susceptible–infected(SI)model in directed hypergraph is proposed,which considers nonlinear propagation mode and more realistic propagation mechanism.In addition,some important node evaluation methods are transferred from undirected hypergraphs and applied to directed hypergraphs.Finally,the ImPageRank algorithm is used to evaluate the performance of the SI model,network robustness and monotonicity.Simulations of real networks demonstrate the excellent performance of the proposed algorithm and provide a powerful framework for identifying important nodes in directed hypergraphs. 展开更多
关键词 HYPERGRAPH important node PAGERANK susceptible-infected(SI)model centrality index
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Corrigendum to“Meta databases of steel frame buildings for surrogate modelling and machine learning-based feature importance analysis”[Journal of Resilient Cities and Structures Volume 3 Issue 1(2024)20-43]
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作者 Delbaz Samadian Jawad Fayaz +2 位作者 Imrose B.Muhit Annalisa Occhipinti Nashwan Dawood 《Resilient Cities and Structures》 2025年第1期124-124,共1页
The authors regret that the original publication of this paper did not include Jawad Fayaz as a co-author.After further discussions and a thorough review of the research contributions,it was agreed that his significan... The authors regret that the original publication of this paper did not include Jawad Fayaz as a co-author.After further discussions and a thorough review of the research contributions,it was agreed that his significant contributions to the foundational aspects of the research warranted recognition,and he has now been added as a co-author. 展开更多
关键词 machine learning meta databases jawad fayaz surrogate modelling feature importance analysis steel frame buildings
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CHINA’S IMPORT EXPO SHOWS HOW GLOBAL TRADE CAN WORK FOR EVERYONE
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作者 Hannan Hussain 《China Report ASEAN》 2025年第12期64-64,共1页
In the latest show of China’s profound business offerings to countries worldwide,the eighth China International Import Expo(CIIE)occupies center stage.The event brought together over 4,100 foreign exhibitors from doz... In the latest show of China’s profound business offerings to countries worldwide,the eighth China International Import Expo(CIIE)occupies center stage.The event brought together over 4,100 foreign exhibitors from dozens of countries,regions,and global organizations.As this year’s CIIE introduces fresh themes spanning the silver economy,sports economy,and automotive tourism,there is ample latitude for participating entities to benefit from China’s exhibition of new technologies and services. 展开更多
关键词 global trade silver economy automotive tourism new technologies China International import Expo SERVICES technologies services sports economy
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Moderate Deviations for the Optimal Values of Sample Average Approximation with Adaptive Multiple Importance Sampling
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作者 Wenjin ZHANG 《Journal of Mathematical Research with Applications》 2025年第2期275-284,共10页
In this paper, we use sample average approximation with adaptive multiple importance sampling to explore moderate deviations for the optimal values. Utilizing the moderate deviation principle for martingale difference... In this paper, we use sample average approximation with adaptive multiple importance sampling to explore moderate deviations for the optimal values. Utilizing the moderate deviation principle for martingale differences and an appropriate Delta method, we establish a moderate deviation principle for the optimal value. Moreover, for a functional form of stochastic programming, we obtain a functional moderate deviation principle for its optimal value. 展开更多
关键词 adaptive multiple importance sampling martingale difference moderate deviation
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Epidemiological and clinical features of severe imported Plasmodium falciparum malaria among travelers upon hospital admission
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作者 Emerole Karl Tokmalaev Anatoly +1 位作者 Chentsov Vladimir Mvuania Vellynance 《Asian Pacific Journal of Tropical Medicine》 2025年第10期475-476,共2页
Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the... Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the GeoSentinel surveillance network,malaria was the most frequent cause of fever in 21%of returning travelers,followed by dengue,typhoid fever,chikungunya and rickettsiosis[1].Individuals traveling from regions without malaria transmission to areas where it is endemic face a heightened risk of contracting the disease due to their lack of immunity.Despite the official malaria-free status of the Russian Federation since 2010,annual cases of severe Plasmodium(P.)falciparum malaria continue to be reported[2].This underscores the necessity for heightened clinical vigilance and improved preventive strategies especially in non-endemic settings. 展开更多
关键词 epidemiological features geosentinel surveillance networkmalaria denguetyphoid feverchikungunya multicenter study severe imported plasmodium falciparum malaria clinical features non immune travelers endemic regions
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Absence Importance and Its Application to Feature Detection and Matching 被引量:2
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作者 Zhi-Heng Wang Qin-Feng Song +1 位作者 Hong-Min Liu Zhan-Qiang Huo 《International Journal of Automation and computing》 EI CSCD 2016年第5期480-490,共11页
Feature detection and matching play important roles in many fields of computer vision, such as image understanding, feature recognition, 3D-reconstruction, video analysis, etc. Extracting features is usually the first... Feature detection and matching play important roles in many fields of computer vision, such as image understanding, feature recognition, 3D-reconstruction, video analysis, etc. Extracting features is usually the first step for feature detection or matching, and the gradient feature is one of the most used selections. In this paper, a new image feature-absence importance (AI) feature, which can directly characterize the local structure information, is proposed. Greatly different from the most existing features, the proposed absence importance feature is mainly based on the consideration that the absence of the important pixel will have a great effect on the local structure. Two absence importance features, mean absence importance (MAI) and standard deviation absence importance (SDAI), are defined and used subsequently to construct new algorithms for feature detection and matching. Experiments demonstrate that the proposed absence importance features can be used as an important complement of the gradient feature and applied successfully to the fields of feature detection and matching. 展开更多
关键词 Absence importance (AI) feature detection feature matching mean absence importance (MAI) standard deviation absence importance (SDAI).
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Face tracking algorithm based on particle filter with mean shift importance sampling 被引量:2
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作者 高建坡 杨浩 +1 位作者 安国成 吴镇扬 《Journal of Southeast University(English Edition)》 EI CAS 2007年第2期196-201,共6页
The condensation tracking algorithm uses a prior transition probability as the proposal distribution, which does not make full use of the current observation. In order to overcome this shortcoming, a new face tracking... The condensation tracking algorithm uses a prior transition probability as the proposal distribution, which does not make full use of the current observation. In order to overcome this shortcoming, a new face tracking algorithm based on particle filter with mean shift importance sampling is proposed. First, the coarse location of the face target is attained by the efficient mean shift tracker, and then the result is used to construct the proposal distribution for particle propagation. Because the particles obtained with this method can cluster around the true state region, particle efficiency is improved greatly. The experimental results show that the performance of the proposed algorithm is better than that of the standard condensation tracking algorithm. 展开更多
关键词 face tracking particle filter importance sampling CONDENSATION mean shift
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大型过程建模的Import/Export解决方案 被引量:3
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作者 张莉 王文 《计算机工程与应用》 CSCD 北大核心 2001年第12期23-26,共4页
文章分析了大型复杂过程的建模需求,基于已研发的企事业过程建模系统EPMS,提出了将Import/Export技术用于大型过程建模的解决方案,通过过程模型的拆分和组装,从而支持过程模型的多人员、异地并行建模模式和过程重用。
关键词 大型模型建模 import/Export 软件工程 可视化
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