The human brain is a complex intelligent system composed of tens of billions of neurons interconnected through synapses,and its intricate network structure has consistently attracted numerous scientists to explore the...The human brain is a complex intelligent system composed of tens of billions of neurons interconnected through synapses,and its intricate network structure has consistently attracted numerous scientists to explore the mysteries of brain functions.However,most existing studies have only verified the biological mimicry characteristics of memristors at the single neuron-synapse level,and there is still a lack of research on memristors simulating synaptic coupling between neurons in multi-neuron networks.Based on this,this paper uses discrete memristors to couple dual discrete Rulkov neurons,and adds synaptic crosstalk between the two discrete memristors to form a neuronal network.A memristor-coupled dual-neuron map,called the Rulkov-memristor-Rulkov(R-M-R)map,is constructed to simulate synaptic connections between neurons in biological tissues.Then,the equilibrium points of the R-M-R map are studied.Subsequently,the effect of parameter variations on the dynamic performance of the R-M-R map is comprehensively analyzed using bifurcation diagram,phase diagram,Lyapunov exponent spectrum(LEs),firing diagram,and spectral entropy(SE)complexity algorithms.In the RM-R map,diverse categories of periodic,chaotic,and hyperchaotic attractors,as well as different states of firing patterns,can be observed.Additionally,different types of state transitions and coexisting attractors are discovered.Finally,the feasibility of the model in digital circuits is verified using a DSP hardware platform.In this study,the coupling principle of biological neurons is simulated,the chaotic dynamic behavior of the R-M-R map is analyzed,and a foundation is laid for deciphering the complex working mechanisms of the brain.展开更多
Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder and the leading cause of dementia worldwide.It is characterized by the accumulation of extracellular amyloid-beta(Aβ)plaques and intracellul...Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder and the leading cause of dementia worldwide.It is characterized by the accumulation of extracellular amyloid-beta(Aβ)plaques and intracellular tau neurofibrillary tangles,leading to synaptic dysfunction,neuronal loss,and cognitive decline.These pathological changes can begin decades before clinical symptoms emerge,highlighting the critical need for early,accessible,and accurate diagnostic tools.展开更多
The vonoprazan(VPZ)triple therapy regimen for Helicobacter pylori(H.pylori)eradication developed by Han et al employs a scientifically rigorous clinical trial design.This multicenter randomized controlled trial establ...The vonoprazan(VPZ)triple therapy regimen for Helicobacter pylori(H.pylori)eradication developed by Han et al employs a scientifically rigorous clinical trial design.This multicenter randomized controlled trial establishes a standardized treatment framework aimed at improving H.pylori eradication rates,focusing on simplifying treatment regimens,shortening therapy duration,and optimizing therapeutic outcomes.The core of clinical translation lies in improving drug accessibility,establishing multidimensional safety evaluation systems,and optimizing cost-effectiveness.Conducting regional adaptability studies and comprehensive safety assessments is crucial for enhancing VPZ regimen effectiveness in China’s diverse healthcare environments.This study provides important evidence-based support for optimizing H.pylori treatment strategies in China,though further validation of universal applicability for nationwide implementation remains necessary.展开更多
Language policies are of great significance to a nation’s stability,unity,and development.Uzbekistan’s language policies have reflected the political,economic,and cultural dynamics of different periods throughout hi...Language policies are of great significance to a nation’s stability,unity,and development.Uzbekistan’s language policies have reflected the political,economic,and cultural dynamics of different periods throughout historical changes,influencing social structures and ethnic relations.This paper summarizes the characteristics of Uzbekistan’s language policies in different eras:During the Tsarist Russian period,the Russification of language policies hindered the development of local languages;in the Soviet era,policies adopted a dual approach,promoting both Russian and prioritizing ethnic languages;after independence,Uzbekistan established Uzbek as the state language and emphasized foreign language education.The current language policy in Uzbekistan presents a complex landscape:While emphasizing the dominant role of the national language helps preserve its heritage,it may easily spark ethnic and political tensions;promoting pluralism and inclusivity brings benefits but faces challenges in balancing language statuses,resource allocation,management,and communication;modernization efforts encounter difficulties in standardizing dialects and foreign loanwords;and in international exchanges,there is a need to balance relations with global lingua francas.In conclusion,Uzbekistan’s language policies have undergone unique transformations and face numerous challenges.In-depth research is crucial for improving the country’s policies and enhancing China-Uzbekistan cooperation.Proactive measures are needed to address these challenges,ensuring the sustainability of language policies and fostering greater national prosperity.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.62571079)the Technological Innovation Projects in the Field of Artificial Intelligence in Liaoning Province(Grant No.2023JH26/10300011)+1 种基金the Basic Scientific Research Projects in the Department of Education of Liaoning Province(Grant No.LJ212410152049)the Liaoning Provincial Science and Technology Plan Joint Project(Grant No.2025-BSLH-041)。
文摘The human brain is a complex intelligent system composed of tens of billions of neurons interconnected through synapses,and its intricate network structure has consistently attracted numerous scientists to explore the mysteries of brain functions.However,most existing studies have only verified the biological mimicry characteristics of memristors at the single neuron-synapse level,and there is still a lack of research on memristors simulating synaptic coupling between neurons in multi-neuron networks.Based on this,this paper uses discrete memristors to couple dual discrete Rulkov neurons,and adds synaptic crosstalk between the two discrete memristors to form a neuronal network.A memristor-coupled dual-neuron map,called the Rulkov-memristor-Rulkov(R-M-R)map,is constructed to simulate synaptic connections between neurons in biological tissues.Then,the equilibrium points of the R-M-R map are studied.Subsequently,the effect of parameter variations on the dynamic performance of the R-M-R map is comprehensively analyzed using bifurcation diagram,phase diagram,Lyapunov exponent spectrum(LEs),firing diagram,and spectral entropy(SE)complexity algorithms.In the RM-R map,diverse categories of periodic,chaotic,and hyperchaotic attractors,as well as different states of firing patterns,can be observed.Additionally,different types of state transitions and coexisting attractors are discovered.Finally,the feasibility of the model in digital circuits is verified using a DSP hardware platform.In this study,the coupling principle of biological neurons is simulated,the chaotic dynamic behavior of the R-M-R map is analyzed,and a foundation is laid for deciphering the complex working mechanisms of the brain.
文摘Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder and the leading cause of dementia worldwide.It is characterized by the accumulation of extracellular amyloid-beta(Aβ)plaques and intracellular tau neurofibrillary tangles,leading to synaptic dysfunction,neuronal loss,and cognitive decline.These pathological changes can begin decades before clinical symptoms emerge,highlighting the critical need for early,accessible,and accurate diagnostic tools.
文摘The vonoprazan(VPZ)triple therapy regimen for Helicobacter pylori(H.pylori)eradication developed by Han et al employs a scientifically rigorous clinical trial design.This multicenter randomized controlled trial establishes a standardized treatment framework aimed at improving H.pylori eradication rates,focusing on simplifying treatment regimens,shortening therapy duration,and optimizing therapeutic outcomes.The core of clinical translation lies in improving drug accessibility,establishing multidimensional safety evaluation systems,and optimizing cost-effectiveness.Conducting regional adaptability studies and comprehensive safety assessments is crucial for enhancing VPZ regimen effectiveness in China’s diverse healthcare environments.This study provides important evidence-based support for optimizing H.pylori treatment strategies in China,though further validation of universal applicability for nationwide implementation remains necessary.
基金the 2023 Open Project of the Kazakhstan Research Center at YiIi Normal University,Study on National Language Education Policy in Kazakhstan Under the Belt and Road Initiative(No.2023HSKSTYJYB007).
文摘Language policies are of great significance to a nation’s stability,unity,and development.Uzbekistan’s language policies have reflected the political,economic,and cultural dynamics of different periods throughout historical changes,influencing social structures and ethnic relations.This paper summarizes the characteristics of Uzbekistan’s language policies in different eras:During the Tsarist Russian period,the Russification of language policies hindered the development of local languages;in the Soviet era,policies adopted a dual approach,promoting both Russian and prioritizing ethnic languages;after independence,Uzbekistan established Uzbek as the state language and emphasized foreign language education.The current language policy in Uzbekistan presents a complex landscape:While emphasizing the dominant role of the national language helps preserve its heritage,it may easily spark ethnic and political tensions;promoting pluralism and inclusivity brings benefits but faces challenges in balancing language statuses,resource allocation,management,and communication;modernization efforts encounter difficulties in standardizing dialects and foreign loanwords;and in international exchanges,there is a need to balance relations with global lingua francas.In conclusion,Uzbekistan’s language policies have undergone unique transformations and face numerous challenges.In-depth research is crucial for improving the country’s policies and enhancing China-Uzbekistan cooperation.Proactive measures are needed to address these challenges,ensuring the sustainability of language policies and fostering greater national prosperity.
