BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary app...BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.展开更多
Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immun...Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immune tolerance of cancer cells.The classical theory holds that prostate apoptosis response-4(PAR-4)is a tumor suppressor protein.However,our recent research has found that PAR-4 has a biological function of promoting cancer in hepatocellular carcinoma(HCC),and our analysis shows that PAR-4 can be modified of lactic acid.These research evidences suggest that PAR-4 lactylation modification may drive immune tolerance in HCC.Therefore,inhibiting PAR-4 lactylation modification is very likely to increase the sensitivity of HCC to immunotherapy.展开更多
To investigate the mechanical response during failure and the impact tendency characteristics of gangue-coal combined structure,uniaxial compression tests were conducted on nine groups of combined structures,each with...To investigate the mechanical response during failure and the impact tendency characteristics of gangue-coal combined structure,uniaxial compression tests were conducted on nine groups of combined structures,each with varying gangue thicknesses and positions.The response patterns of compressive strength,elastic modulus,pre-peak accumulated energy,elastic energy index,and impact energy index were systematically analyzed.Furthermore,a new index for evaluating the impact tendency of gangue-containing coal was proposed,and its effectiveness was verified.The findings are as follows:(1)As the gangue thickness increases,both the compressive strength and the pre-peak energy of the combined structure decrease,whereas the elastic modulus increases accordingly.When the gangue is located in the lower middle position,the combined structure exhibits the lowest compressive strength and elastic modulus but the highest pre peak energy.(2)As the gangue shifts toward the middle position of the combined structure,the failure mode gradually transitions from comple te“crushing”failure to an incomplete“point-type”failure.As gangue thickness further increases,the failure region evolves from overall failure to localized failure,with the degree of failure shifting from complete to incomplete.The K_(crc)value corresponding to“crushing”complete failure is higher and has a stronger impact tendency compared to“point-type”incomplete failure.(3)The proposed comprehensive impact instability evaluation index K_(crc)for the gangue-coal combined structure has shown a significant positive correlation with compressive strength(R_(c))and impact energy index(K_(E)),further verifyi ng its rationality in comprehensively assessing the impact tendency of gangue-containing coal bodies.Applying this index to the evaluation of gangue-containing coal seams provides a more accurate reflection of their impact tendency compared with the residual energy index,which has a wide range of potential applications and practical significance.展开更多
Polymethacrylimide(PMI)foam has the highest specific stiffness and strength among polymer foams,with excellent radar-absorbing capabilities,which provide it with broad prospects in underwater ap-plications.To evaluate...Polymethacrylimide(PMI)foam has the highest specific stiffness and strength among polymer foams,with excellent radar-absorbing capabilities,which provide it with broad prospects in underwater ap-plications.To evaluate the impact resistance of PMI foam sandwich structures,the dynamic response and energy absorption characteristics of PMI foam sandwich structures with different core layers under various water impact loads were investigated using combined experimental and numerical methods.A fluid-structure interaction device with a diffusion angle was used for water impact testing of the PMI foam sandwich structures.The 3D-DIC technique was employed to process the deformation images of the sandwich-structure back panel captured by the high-speed cameras.Numerical simulations were performed to analyze the dynamic deformation process of the PMI foam core.The results indicated that the maximum deformation of the back panel exhibited a nonlinear relationship with the impulse.Below the critical impulse,the maximum deformation of the back panel plateaued,which was determined by the core density.Beyond the critical impulse,the rate of deformation increased with the impulse was governed by the core thickness.Compared with different sandwich panels,PMI foam sandwich struc-tures demonstrate significant advantages in terms of impact resistance under high-impulse conditions.展开更多
Infants exhibit diminished susceptibility to external infections,a phenomenon closely linked to the pervasive presence of the bifidobacterial community within their intestinal tract.Nonetheless,a significant knowledge...Infants exhibit diminished susceptibility to external infections,a phenomenon closely linked to the pervasive presence of the bifidobacterial community within their intestinal tract.Nonetheless,a significant knowledge gap remains concerning the distinct species of bifidobacteria initiating anti-infection immune responses during the early developmental stages.In this study,the impact of early intervention with Bifidobacterium bifidum,Bifidobacterium breve,and Bifidobacterium longum on neonatal rats infected with Salmonella enterica serovar Typhimurium SL1344 were compared.The study encompasses various immunity levels,including gut immunity,central immunity(thymus),peripheral immunity(spleen),and brain immunity.Following Salmonella infection,significant alterations in neonatal rats were observed in growth and developmental levels,immune markers,cytokine levels,balance of T lymphocyte subpopulations,intestinal barrier function,and blood-brain barrier integrity.Compared with B.breve and B.longum,B.bifidum demonstrated more pronounced efficacy in regulating these physiological processes.By conducting multi-level analyses of gut microbiota,bifidobacterial community,colonic content metabolomics,and serum metabolomics,the significance of B.bifidum’s role is underscored,and the immune-enhancing function of messenger metabolites is unveiled.Among these metabolites,γ-L-glutamyl-L-glutamic acid and orotic acid were found to be shared by all 3 species,while hippuric acid and 1a,1b-dihomo prostaglandin F2αwere unique to B.bifidum,and DL-arginine was specific to B.longum.Overall,this study has provided novel insights into the intervention and immunomodulation by Bifidobacterium in early-life infections,emphasizing the significant role of B.bifidum.展开更多
During the construction of bank slopes involving pile driving,ensuring slope stability is crucial.This requires the design of appropriate support systems and a thorough evaluation of the failure mechanisms of pile str...During the construction of bank slopes involving pile driving,ensuring slope stability is crucial.This requires the design of appropriate support systems and a thorough evaluation of the failure mechanisms of pile structures under dynamic loading conditions.Based on the Huarong Coal Wharf project,various support schemes are analyzed using numerical simulation methods to calculate and compare slope stability coefficients.The optimal scheme is then identified.Under the selected support scheme,a numerical model of double-row suspended steel sheet piles is developed to investigate the dynamic response of the pile structures under pile driving loads.A time-history analysis is performed to assess the slope’s dynamic stability.The results show that the maximum displacements of the upper and lower steel sheet pile rows are 2.51 and 3.14 cm,respectively.The maximum principal stresses remain below 20 MPa in both rows,while the maximum von Mises stresses are 20.85 MPa for the upper row and 25.40 MPa for the lower row.The dominant frequencies of the steel sheet pile structures fall between 30 and 35 Hz,with a frequency bandwidth ranging from 0 to 500 Hz.The stability coefficient of the pile structures varies over time during the pile driving process,ultimately reaching a value of 1.26—exceeding the required safety threshold.This research provides practical guidance for designing support systems in wharf piling projects and offers a reliable basis for evaluating the safety performance of steel sheet piles in bank slopes.展开更多
Structures modelled with flexible-base assumptions,incorporating soil effects,generally exhibit longer natural periods and higher damping compared to fixed-base models that exclude soil-structure interaction(SSI).Howe...Structures modelled with flexible-base assumptions,incorporating soil effects,generally exhibit longer natural periods and higher damping compared to fixed-base models that exclude soil-structure interaction(SSI).However,the beneficial or detrimental nature of SSI remains contentious in current earthquake damage analyses and research findings.This study introduces a numerical modelling technique,validated by experimental shaking table tests,to examine the effects of SSI on high-rise buildings.The study considers various substructure parameters,including foundation types,soil types,and bedrock depths.Both advantageous and adverse impacts of SSI are identified and analysed.Numerical simulations reveal that increased subsoil stiffness significantly amplifies the base shear of structures compared to bedrock depth effects.Additionally,increased foundation rocking results in higher inter-storey drifts and reduced base shear.Overall,SSI tends to amplify inter-storey drifts,indicating detrimental effects.Specifically,the study found that the inclusion of SSI increased maximum inter-storey drifts by up to 38%,particularly in softer soils,while reducing base shear by up to 44%in structures with classical compensated foundations on D_(e)and E_(e)soil types.In contrast,piled foundation systems experienced an increase in base shear of up to 27%under the same conditions.Conversely,SSI has beneficial impacts on base shear for structures with classical compensated foundations on soil types of D_(e)and E_(e),as it reduces the base shear.For structures with piled foundations and those with classical compensated foundations on C_(e)soil,SSI effects are detrimental.C_(e),D_(e),and E_(e)soils correspond to geotechnical classifications per AS1170,representing stiff,medium,and soft soils respectively.The study also presents minimum base shear ratios considering SSI reduction effects for various foundation types.展开更多
Based on ANSYS/LS-DYNA, the dynamics analysis software, and using nonlinear dynamic finite element method, the process of a submarine pipeline impacted by dropped objects is simulated, Some conclusions are drawn： Fir...Based on ANSYS/LS-DYNA, the dynamics analysis software, and using nonlinear dynamic finite element method, the process of a submarine pipeline impacted by dropped objects is simulated, Some conclusions are drawn： First, the damage depth of suspended pipe is smaller than that of the bare pipe in case of the same fall energy, and with the increase of fall energy, the difference grows; Second, with the falling object＇s speed and mass rising, the deformation of pipeline intensifies at the impact site and the maximum vibration amplitude of submarine pipeline increases; Third, when the fall energy is equal, the smaller the contact area of falling objects and pipeline is, the greater the damage depth of pipeline becomes; Fourth, changes of seabed soil parameters （shear elastic modulus, internal friction angle, density） have less influence on the suspended pipeline＇s dent depths and maximum vibration amplitude,展开更多
To study the response characteristics of the carbon fiber fabric reinforced composites under impact loading, one dimensional strain impact test, multi gauge technique and Lagrange analysis method are used. The decay...To study the response characteristics of the carbon fiber fabric reinforced composites under impact loading, one dimensional strain impact test, multi gauge technique and Lagrange analysis method are used. The decaying rule of the stress σ , strain ε , strain rate ε · and density ρ with time and space is obtained. By the theory of dynamics, the impact response characteristics of the material is analyzed and discussed.展开更多
Objective： To investigate prognostic impact of histopathologic response induced by neoadjuvant chemotherapy in patients with stage ⅢA non-small cell lung cancer （NSCLC）. Methods： Forty patients with stage ⅢA NSC...Objective： To investigate prognostic impact of histopathologic response induced by neoadjuvant chemotherapy in patients with stage ⅢA non-small cell lung cancer （NSCLC）. Methods： Forty patients with stage ⅢA NSCLC underwent two cycles of neoadjuvant chemotherapy with mitomycin, vindosine, and cisplatin followed by surgery. Histopathologic response in resection of the tumor was examined after surgery. Tumor regression was classified as grade Ⅳ, grade Ⅲ, grade Ⅱ, and grade Ⅰ according to the extent of tumor necrosis and the extent of the vital tumor tissues. The tumor regression grading was correlated with the survival time of the patients. Results： After two cycles of chemotherapy, 19 （47.5%） of 40 patients had objective response （2 complete and 17 partial response）. In 40 resected tumor specimens, 2 （5%） were classified as regression grade Ⅳ, 16 （40%） as regression grade Ⅲ, 18 （45%） as regression gradeⅡ, and 4 （10%） as regression grade Ⅰ. The rate of complete surgical resection was significantly higher in patients with tumor regression grade Ⅲ-Ⅳ （〈10% vital tumor tissue）（P〈0.05）. The median survival time in patients classified as having tumor regression grade Ⅲ-Ⅳ was significantly longer than that in patients who had regression grade Ⅰ-Ⅱ （P〈0.05）. The 3-year survival rate in patients with regression grade Ⅲ-Ⅳ was markedly higher than that in patients who had regression grade Ⅰ-Ⅱ （P〈0.05）. Conclusion： The extent of tumor regression induced by neoadjuvant chemotherapy is a critical issue for successful therapeutic approach in patients with stage ⅢA NSCLC. In resected specimens of tumors after chemotherapy, the presence of marked tumor regression （regression grade Ⅲ-Ⅳ） is predictive for superior survival time.展开更多
Aim To study the influence of restraint system performance upon the occupant's response during impact, and provide a scientific base for occupant restraint system design. Methods \ In the light of basic th...Aim To study the influence of restraint system performance upon the occupant's response during impact, and provide a scientific base for occupant restraint system design. Methods \ In the light of basic theory of multibody system dynamics and impact dynamics on the basis of classical theory of impact, R W method is adopted to construct the vehicle occupant system model consisting of fourteen rigid bodies, thirty seven DOFs and slip joints for the simulation. A software named SVC3D(3 dimensional simulation of vehicle crash) is developed in the FORTRAN language. Results\ The results of simulation have a good coincidence with those of tests and the restraint system with low elongation webbing and equipped with pretensioner provides better restraint effect for the occupant. Conclusion\ The model of vehicle occupant multibody system and SVC3D are suitable for use. Occupant should be belted with low elongation webbing to a certain degree and occupant restraint system should be equipped with pretensioner.展开更多
Al-Sc and Al-Ti semi-infinite targets were impacted by high-speed projectiles at velocities of 0.8, 1.0, 1.2 and 1.5 km/s, respectively. It is found that the Al-Sc targets demonstrate more excellent ability to resist ...Al-Sc and Al-Ti semi-infinite targets were impacted by high-speed projectiles at velocities of 0.8, 1.0, 1.2 and 1.5 km/s, respectively. It is found that the Al-Sc targets demonstrate more excellent ability to resist high-speed impact. It is concluded that different microstructures of Al-Sc and Al-Ti alloys, including different grain sizes and secondary particles precipitated in the matrix, result in their greatly different capabilities of resisting impact. Furthermore, the effect of the size range ofnanoscale A13Sc precipitate in A1-Sc alloy on the resistance of high-speed impact was investigated. In addition, computer simulations and validation of these simulations were developed which fairly accurately represented residual crater shapes/geometries. Validated computer simulations allowed representative extrapolations of impact craters well beyond the laboratory where melt and solidification occurred at the crater wall, especially for hypervelocity impact （〉5 km/s）.展开更多
Taylor impact is a widely used strategy in which a flat-nosed projectile is fired onto a rigid anvil directly to determine the dynamic strength of rod specimens. Nowadays, the rigid anvil is often replaced by an outpu...Taylor impact is a widely used strategy in which a flat-nosed projectile is fired onto a rigid anvil directly to determine the dynamic strength of rod specimens. Nowadays, the rigid anvil is often replaced by an output target bar to ensure the accuracy of measurement via recording strain signals in the output bar. For testing the dynamic strength of low-density materials, a low-impedance target bar, which exhibits viscoelastic characteristics is often employed. In this paper, an extended Taylor model is proposed to improve the idealization of treating the target bar as perfectly rigid material in the classic Taylor model, and the viscoelastic effect of the target bar is incorporated. The viscoelastic target bar is depicted by two elastic springs and one dashpot. Based on the plastic shock wave theory in the flat-nosed projectile associated with the viscoelastic wave analysis in the target bar, the viscoelastic effect of the target bar on the impact response of the flat-nosed projectile is investigated. The finite element simulation is also carried out to verify the theoretical model,and good agreement is found. The present theoretical model is also called the Taylor-cylinder Hopkinson impact, which provides a more accurate way to identify the dynamic material parameters. The dynamic responses of the present model are further compared with previous elastic and rigid target bar models. It is found that the viscoelastic effect of the target bar should be taken into consideration in the Taylor-cylinder Hopkinson impact test for low-impedance materials.展开更多
Taking the excellent energy absorption performances of cellular structures into consideration,three beam-column steel joints are proposed to analyze the effect of cellular metallic fillers on impact mechanical respons...Taking the excellent energy absorption performances of cellular structures into consideration,three beam-column steel joints are proposed to analyze the effect of cellular metallic fillers on impact mechanical responses of beam-column joints.Based on the existing experimental results,the finite element models of the associated joints are established by using finite element method software.The deformation mode,the bearing capacity and energy absorption performance of various joints subjected to impact loadings with the loading velocities from 10 to 100 m/s are analyzed,respectively.The dynamic responses of cellular metal-filled beamcolumn joints are quantitatively analyzed by means of displacements of central region,nominal impacting stress and energy absorption efficiency.The results can be concluded that the filling of cellular filler weakens the stress concentration on joints,alleviates the occurrence of tearing in connection region among column and beam,and reduces the displacement caused by impact loading.Energy absorption efficiency of filled joints subjected to impact loading increases as the impacting velocity increases,and the cellular metallic filler improves their impact resistance of beam-column joints.The energy absorption efficiency of fully filled joints is superior to that of others.This study can provide a reference for steel structural design and post-disaster repair under extreme working conditions.展开更多
The impacts of climate change on agriculture are still shadowed with uncertainty. However, climate change is expected to adversely affect Iran＇s agricultural practices through changes in precipitation, temperature an...The impacts of climate change on agriculture are still shadowed with uncertainty. However, climate change is expected to adversely affect Iran＇s agricultural practices through changes in precipitation, temperature and carbon dioxide fertilization. Therefore, adaptation of this sector to the increasing weather events is imperative. This study is aimed to document the likely impacts of climate change on Iran＇s agriculture and the current adaptation efforts made by government and farmers. The review of literature shows that changes in rainfall and water endowments will have significant impacts on crop yield, crops＇ water requirements and income and welfare of farm families. The extent of the changes in yield depends on the crop type, assumptions related to the CO2 fertilization effect, climate scenarios and adaptation abilities. On adaptation, the government＇s efforts have been distinguished in the improving agricultural productivity and irrigation development based on current technology, developing new technologies and policy reforms. Farmers＇ adaptive responses have also been identified. Some conclusions and recommendations are offered to increase the adaptive capacity of farmers and reduce negative impacts of climate change.展开更多
Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommo...Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommodation mechanism of the pre-rolled AZ31 magnesium alloy under high-speed impact loading were investigated.The twin and shear band are prevailing at low temperature,and the coexistence of twins and recrystallized grains is the dominant microstructure at medium temperature,while at high temperature,dynamic recrystallization(DRX)is almost complete.The increment of temperature reduces the critical condition difference between twinning and DRX,and the recrystallized temperature decreases with increasing strain rate.The mechanical response is related to the competition among the shear band strengthen,the twin strengthen and the fine grain strengthen and determined by the prevailing grain structure.The fine grain strengthen could compensate soften caused by the temperature increase and the reduction of twin and shear band.During high-speed deformation,different twin variants,introduced by pre-rolling,induce different deformation mechanism to accommodate plastic deformation and are in favor for non-basal slip.At low temperature,the high-speed deformation is achieved by twinning,dislocation slip and the following deformation shear band at different deformation stages.At high temperature,the high-speed deformation is realized by twinning and dislocation slip of early deformation stage,transition shear band of medium deformation stage and DRX of final deformation stage.展开更多
The dynamic response behaviors of upright breakwaters under broken wave impact are analysed based on the mass-damper-spring dynamic system model. The effects of the mass, damping, stiffness, natural period, and impuls...The dynamic response behaviors of upright breakwaters under broken wave impact are analysed based on the mass-damper-spring dynamic system model. The effects of the mass, damping, stiffness, natural period, and impulse duration (or oscillation period) on the translation, rotation, sliding force, overturning moment, and corresponding dynamic amplifying factors are studied. It is concluded that the ampli-ying factors only depend on the ratio of the system natural period to impulse duration (or oscillation period) under a certain damping ratio. Moreover, the equivalent static approach to breakwater design is also discussed.展开更多
The mechanical behaviors and energy dissipation characteristics of heat-treated granite were investigated under repeated impact loading.The granite samples were firstly heat-treated at the temperature of 20℃,200℃,40...The mechanical behaviors and energy dissipation characteristics of heat-treated granite were investigated under repeated impact loading.The granite samples were firstly heat-treated at the temperature of 20℃,200℃,400℃,and 600℃,respectively.The thermal damage characteristics of these samples were then observed and measured before impact tests.Dynamic impact compression tests finally were carried out using a modified split-Hopkinson pressure bar under three impact velocities of 12 m/s,15 m/s,and 18 m/s.These test results show that the mineral composition and the main oxides of the granite do not change with these treatment temperatures.The number of microcracks and microvoids decreases in the sample after 200℃ treatment.The mechanical properties of a sample after 600℃ treatment were rapidly deteriorated under the same impact velocity.The average of peak stress is much smaller than those after 20℃,200℃ and 400℃ treatments.The heat-treated samples have an energy threshold each.When the dissipated energy of a sample under a single impact is less than this threshold,the repeated impacts hardly lead to further damage accumulation even if its total breakage energy dissipation(BED)density is large.Under the same number of repeated impacts,the cumulative BED density of a sample after 600℃ treatment is the largest and its damage evolves most quickly.The total BED density of the sample after 200℃ treatment is the highest,which implies that this sample has better resistance to repeated impact,thus having less crack initiation and growth.展开更多
The transient response of an unlimited cylindrical cavity buried in the infinite elastic soil subjected to an anti-plane impact load along the cavern axis direction was studied.Using Laplace transform combining with c...The transient response of an unlimited cylindrical cavity buried in the infinite elastic soil subjected to an anti-plane impact load along the cavern axis direction was studied.Using Laplace transform combining with contour integral of the Laplace inverse transform specifically,the general analytical expressions of the soil displacement and stress are obtained in the time domain,respectively.And the numerical solutions of the problem computed by analytical expressions are presented.In the time domain,the dynamic responses of the infinite elastic soil are analyzed,and the calculation results are compared with those from numerical inversion proposed by Durbin and the static results.One observes good agreement between analytical and numerical inversion results,lending the further support to the method presented.Finally,some valuable shear wave propagation laws are gained: the displacement of the soil remains zero before the wave arrival,and after the shear wave arrival,the stress and the displacement at this point increase abruptly,then reduce and tend to the static value gradually at last.The wave attenuates along the radial,therefore the farther the wave is from the source,the smaller the stress and the displacement are,and the stress and the displacement are just functions of the radial distance from the axis.展开更多
Bridge piers are impacted by autos sometimes. The pier usually has not been destroyed after once impact by auto. But there are few research on damage which will affect pier's capability, and most relative studies ...Bridge piers are impacted by autos sometimes. The pier usually has not been destroyed after once impact by auto. But there are few research on damage which will affect pier's capability, and most relative studies have focused the problems on piers impacted by vessels. The methods involve mainly sutra experience theory, numerical analysis, and experimental method. Owing to the complicacy of the bridge pier impacted by a vessel, there are few research derived with the sutra mechanics model and the piers impacted by autos. The dynamic response is studied here under the assumption of the rigid-plastic small-deformation for the pier impacted by auto. According to the Parkes beam model, the rigid-plastic theoretical solution is deduced. The final deformation is calculated by a practical example for the pier impacted by auto.展开更多
文摘BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.
基金supported by the National Natural Science Foundation of China(Nos.82573045,82460602,82560459)the Hainan Provincial Graduate Student Innovative Research Project(No.Qhys2024-440).
文摘Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immune tolerance of cancer cells.The classical theory holds that prostate apoptosis response-4(PAR-4)is a tumor suppressor protein.However,our recent research has found that PAR-4 has a biological function of promoting cancer in hepatocellular carcinoma(HCC),and our analysis shows that PAR-4 can be modified of lactic acid.These research evidences suggest that PAR-4 lactylation modification may drive immune tolerance in HCC.Therefore,inhibiting PAR-4 lactylation modification is very likely to increase the sensitivity of HCC to immunotherapy.
基金Project(52274130)supported by the National Natural Science Foundation of ChinaProject(ZR2024ZD22)supported by the Major Basic Research Project of the Shandong Provincial Natural Science Foundation,China+1 种基金Project(2023375)supported by the Guizhou University Research and Innovation Team,ChinaProject(LH[2024]-026)supported by the Guizhou Science and Technology Plan Project,China。
文摘To investigate the mechanical response during failure and the impact tendency characteristics of gangue-coal combined structure,uniaxial compression tests were conducted on nine groups of combined structures,each with varying gangue thicknesses and positions.The response patterns of compressive strength,elastic modulus,pre-peak accumulated energy,elastic energy index,and impact energy index were systematically analyzed.Furthermore,a new index for evaluating the impact tendency of gangue-containing coal was proposed,and its effectiveness was verified.The findings are as follows:(1)As the gangue thickness increases,both the compressive strength and the pre-peak energy of the combined structure decrease,whereas the elastic modulus increases accordingly.When the gangue is located in the lower middle position,the combined structure exhibits the lowest compressive strength and elastic modulus but the highest pre peak energy.(2)As the gangue shifts toward the middle position of the combined structure,the failure mode gradually transitions from comple te“crushing”failure to an incomplete“point-type”failure.As gangue thickness further increases,the failure region evolves from overall failure to localized failure,with the degree of failure shifting from complete to incomplete.The K_(crc)value corresponding to“crushing”complete failure is higher and has a stronger impact tendency compared to“point-type”incomplete failure.(3)The proposed comprehensive impact instability evaluation index K_(crc)for the gangue-coal combined structure has shown a significant positive correlation with compressive strength(R_(c))and impact energy index(K_(E)),further verifyi ng its rationality in comprehensively assessing the impact tendency of gangue-containing coal bodies.Applying this index to the evaluation of gangue-containing coal seams provides a more accurate reflection of their impact tendency compared with the residual energy index,which has a wide range of potential applications and practical significance.
文摘Polymethacrylimide(PMI)foam has the highest specific stiffness and strength among polymer foams,with excellent radar-absorbing capabilities,which provide it with broad prospects in underwater ap-plications.To evaluate the impact resistance of PMI foam sandwich structures,the dynamic response and energy absorption characteristics of PMI foam sandwich structures with different core layers under various water impact loads were investigated using combined experimental and numerical methods.A fluid-structure interaction device with a diffusion angle was used for water impact testing of the PMI foam sandwich structures.The 3D-DIC technique was employed to process the deformation images of the sandwich-structure back panel captured by the high-speed cameras.Numerical simulations were performed to analyze the dynamic deformation process of the PMI foam core.The results indicated that the maximum deformation of the back panel exhibited a nonlinear relationship with the impulse.Below the critical impulse,the maximum deformation of the back panel plateaued,which was determined by the core density.Beyond the critical impulse,the rate of deformation increased with the impulse was governed by the core thickness.Compared with different sandwich panels,PMI foam sandwich struc-tures demonstrate significant advantages in terms of impact resistance under high-impulse conditions.
基金supported by the National Natural Science Foundation of China(32272332,31972052,32021005,31820103010)the Fundamental Research Funds for the Central Universities(JUSRP622020,JUSRP22006,JUSRP51501)the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province,Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_2391).
文摘Infants exhibit diminished susceptibility to external infections,a phenomenon closely linked to the pervasive presence of the bifidobacterial community within their intestinal tract.Nonetheless,a significant knowledge gap remains concerning the distinct species of bifidobacteria initiating anti-infection immune responses during the early developmental stages.In this study,the impact of early intervention with Bifidobacterium bifidum,Bifidobacterium breve,and Bifidobacterium longum on neonatal rats infected with Salmonella enterica serovar Typhimurium SL1344 were compared.The study encompasses various immunity levels,including gut immunity,central immunity(thymus),peripheral immunity(spleen),and brain immunity.Following Salmonella infection,significant alterations in neonatal rats were observed in growth and developmental levels,immune markers,cytokine levels,balance of T lymphocyte subpopulations,intestinal barrier function,and blood-brain barrier integrity.Compared with B.breve and B.longum,B.bifidum demonstrated more pronounced efficacy in regulating these physiological processes.By conducting multi-level analyses of gut microbiota,bifidobacterial community,colonic content metabolomics,and serum metabolomics,the significance of B.bifidum’s role is underscored,and the immune-enhancing function of messenger metabolites is unveiled.Among these metabolites,γ-L-glutamyl-L-glutamic acid and orotic acid were found to be shared by all 3 species,while hippuric acid and 1a,1b-dihomo prostaglandin F2αwere unique to B.bifidum,and DL-arginine was specific to B.longum.Overall,this study has provided novel insights into the intervention and immunomodulation by Bifidobacterium in early-life infections,emphasizing the significant role of B.bifidum.
基金sponsored by Natural Science Research Project of Anhui Educational Committee(GrantNo.2022AH050810),NationalNatural Science Foundation of China(GrantNos.42402276,41972286,42072309,42102329)State Key Laboratory of Precision Blasting and Hubei Key Laboratory of Blasting Engineering,Jianghan University(No.PBSKL2023A1)the Open Fund of National Center for International Research on Deep Earth Drilling and Resource Development(No.DEDRD-2023-02).
文摘During the construction of bank slopes involving pile driving,ensuring slope stability is crucial.This requires the design of appropriate support systems and a thorough evaluation of the failure mechanisms of pile structures under dynamic loading conditions.Based on the Huarong Coal Wharf project,various support schemes are analyzed using numerical simulation methods to calculate and compare slope stability coefficients.The optimal scheme is then identified.Under the selected support scheme,a numerical model of double-row suspended steel sheet piles is developed to investigate the dynamic response of the pile structures under pile driving loads.A time-history analysis is performed to assess the slope’s dynamic stability.The results show that the maximum displacements of the upper and lower steel sheet pile rows are 2.51 and 3.14 cm,respectively.The maximum principal stresses remain below 20 MPa in both rows,while the maximum von Mises stresses are 20.85 MPa for the upper row and 25.40 MPa for the lower row.The dominant frequencies of the steel sheet pile structures fall between 30 and 35 Hz,with a frequency bandwidth ranging from 0 to 500 Hz.The stability coefficient of the pile structures varies over time during the pile driving process,ultimately reaching a value of 1.26—exceeding the required safety threshold.This research provides practical guidance for designing support systems in wharf piling projects and offers a reliable basis for evaluating the safety performance of steel sheet piles in bank slopes.
文摘Structures modelled with flexible-base assumptions,incorporating soil effects,generally exhibit longer natural periods and higher damping compared to fixed-base models that exclude soil-structure interaction(SSI).However,the beneficial or detrimental nature of SSI remains contentious in current earthquake damage analyses and research findings.This study introduces a numerical modelling technique,validated by experimental shaking table tests,to examine the effects of SSI on high-rise buildings.The study considers various substructure parameters,including foundation types,soil types,and bedrock depths.Both advantageous and adverse impacts of SSI are identified and analysed.Numerical simulations reveal that increased subsoil stiffness significantly amplifies the base shear of structures compared to bedrock depth effects.Additionally,increased foundation rocking results in higher inter-storey drifts and reduced base shear.Overall,SSI tends to amplify inter-storey drifts,indicating detrimental effects.Specifically,the study found that the inclusion of SSI increased maximum inter-storey drifts by up to 38%,particularly in softer soils,while reducing base shear by up to 44%in structures with classical compensated foundations on D_(e)and E_(e)soil types.In contrast,piled foundation systems experienced an increase in base shear of up to 27%under the same conditions.Conversely,SSI has beneficial impacts on base shear for structures with classical compensated foundations on soil types of D_(e)and E_(e),as it reduces the base shear.For structures with piled foundations and those with classical compensated foundations on C_(e)soil,SSI effects are detrimental.C_(e),D_(e),and E_(e)soils correspond to geotechnical classifications per AS1170,representing stiff,medium,and soft soils respectively.The study also presents minimum base shear ratios considering SSI reduction effects for various foundation types.
文摘Based on ANSYS/LS-DYNA, the dynamics analysis software, and using nonlinear dynamic finite element method, the process of a submarine pipeline impacted by dropped objects is simulated, Some conclusions are drawn： First, the damage depth of suspended pipe is smaller than that of the bare pipe in case of the same fall energy, and with the increase of fall energy, the difference grows; Second, with the falling object＇s speed and mass rising, the deformation of pipeline intensifies at the impact site and the maximum vibration amplitude of submarine pipeline increases; Third, when the fall energy is equal, the smaller the contact area of falling objects and pipeline is, the greater the damage depth of pipeline becomes; Fourth, changes of seabed soil parameters （shear elastic modulus, internal friction angle, density） have less influence on the suspended pipeline＇s dent depths and maximum vibration amplitude,
文摘To study the response characteristics of the carbon fiber fabric reinforced composites under impact loading, one dimensional strain impact test, multi gauge technique and Lagrange analysis method are used. The decaying rule of the stress σ , strain ε , strain rate ε · and density ρ with time and space is obtained. By the theory of dynamics, the impact response characteristics of the material is analyzed and discussed.
文摘Objective： To investigate prognostic impact of histopathologic response induced by neoadjuvant chemotherapy in patients with stage ⅢA non-small cell lung cancer （NSCLC）. Methods： Forty patients with stage ⅢA NSCLC underwent two cycles of neoadjuvant chemotherapy with mitomycin, vindosine, and cisplatin followed by surgery. Histopathologic response in resection of the tumor was examined after surgery. Tumor regression was classified as grade Ⅳ, grade Ⅲ, grade Ⅱ, and grade Ⅰ according to the extent of tumor necrosis and the extent of the vital tumor tissues. The tumor regression grading was correlated with the survival time of the patients. Results： After two cycles of chemotherapy, 19 （47.5%） of 40 patients had objective response （2 complete and 17 partial response）. In 40 resected tumor specimens, 2 （5%） were classified as regression grade Ⅳ, 16 （40%） as regression grade Ⅲ, 18 （45%） as regression gradeⅡ, and 4 （10%） as regression grade Ⅰ. The rate of complete surgical resection was significantly higher in patients with tumor regression grade Ⅲ-Ⅳ （〈10% vital tumor tissue）（P〈0.05）. The median survival time in patients classified as having tumor regression grade Ⅲ-Ⅳ was significantly longer than that in patients who had regression grade Ⅰ-Ⅱ （P〈0.05）. The 3-year survival rate in patients with regression grade Ⅲ-Ⅳ was markedly higher than that in patients who had regression grade Ⅰ-Ⅱ （P〈0.05）. Conclusion： The extent of tumor regression induced by neoadjuvant chemotherapy is a critical issue for successful therapeutic approach in patients with stage ⅢA NSCLC. In resected specimens of tumors after chemotherapy, the presence of marked tumor regression （regression grade Ⅲ-Ⅳ） is predictive for superior survival time.
文摘Aim To study the influence of restraint system performance upon the occupant's response during impact, and provide a scientific base for occupant restraint system design. Methods \ In the light of basic theory of multibody system dynamics and impact dynamics on the basis of classical theory of impact, R W method is adopted to construct the vehicle occupant system model consisting of fourteen rigid bodies, thirty seven DOFs and slip joints for the simulation. A software named SVC3D(3 dimensional simulation of vehicle crash) is developed in the FORTRAN language. Results\ The results of simulation have a good coincidence with those of tests and the restraint system with low elongation webbing and equipped with pretensioner provides better restraint effect for the occupant. Conclusion\ The model of vehicle occupant multibody system and SVC3D are suitable for use. Occupant should be belted with low elongation webbing to a certain degree and occupant restraint system should be equipped with pretensioner.
文摘Al-Sc and Al-Ti semi-infinite targets were impacted by high-speed projectiles at velocities of 0.8, 1.0, 1.2 and 1.5 km/s, respectively. It is found that the Al-Sc targets demonstrate more excellent ability to resist high-speed impact. It is concluded that different microstructures of Al-Sc and Al-Ti alloys, including different grain sizes and secondary particles precipitated in the matrix, result in their greatly different capabilities of resisting impact. Furthermore, the effect of the size range ofnanoscale A13Sc precipitate in A1-Sc alloy on the resistance of high-speed impact was investigated. In addition, computer simulations and validation of these simulations were developed which fairly accurately represented residual crater shapes/geometries. Validated computer simulations allowed representative extrapolations of impact craters well beyond the laboratory where melt and solidification occurred at the crater wall, especially for hypervelocity impact （〉5 km/s）.
基金supported by the National Natural Science Foundation of China (Grant 11472034)
文摘Taylor impact is a widely used strategy in which a flat-nosed projectile is fired onto a rigid anvil directly to determine the dynamic strength of rod specimens. Nowadays, the rigid anvil is often replaced by an output target bar to ensure the accuracy of measurement via recording strain signals in the output bar. For testing the dynamic strength of low-density materials, a low-impedance target bar, which exhibits viscoelastic characteristics is often employed. In this paper, an extended Taylor model is proposed to improve the idealization of treating the target bar as perfectly rigid material in the classic Taylor model, and the viscoelastic effect of the target bar is incorporated. The viscoelastic target bar is depicted by two elastic springs and one dashpot. Based on the plastic shock wave theory in the flat-nosed projectile associated with the viscoelastic wave analysis in the target bar, the viscoelastic effect of the target bar on the impact response of the flat-nosed projectile is investigated. The finite element simulation is also carried out to verify the theoretical model,and good agreement is found. The present theoretical model is also called the Taylor-cylinder Hopkinson impact, which provides a more accurate way to identify the dynamic material parameters. The dynamic responses of the present model are further compared with previous elastic and rigid target bar models. It is found that the viscoelastic effect of the target bar should be taken into consideration in the Taylor-cylinder Hopkinson impact test for low-impedance materials.
基金the National Natural Science Foundation of China(No.11472005)the National Key Research and Development Project(No.2016YFC0701507-2)the Natural Science Foundation of Anhui Province(No.1908085ME173)。
文摘Taking the excellent energy absorption performances of cellular structures into consideration,three beam-column steel joints are proposed to analyze the effect of cellular metallic fillers on impact mechanical responses of beam-column joints.Based on the existing experimental results,the finite element models of the associated joints are established by using finite element method software.The deformation mode,the bearing capacity and energy absorption performance of various joints subjected to impact loadings with the loading velocities from 10 to 100 m/s are analyzed,respectively.The dynamic responses of cellular metal-filled beamcolumn joints are quantitatively analyzed by means of displacements of central region,nominal impacting stress and energy absorption efficiency.The results can be concluded that the filling of cellular filler weakens the stress concentration on joints,alleviates the occurrence of tearing in connection region among column and beam,and reduces the displacement caused by impact loading.Energy absorption efficiency of filled joints subjected to impact loading increases as the impacting velocity increases,and the cellular metallic filler improves their impact resistance of beam-column joints.The energy absorption efficiency of fully filled joints is superior to that of others.This study can provide a reference for steel structural design and post-disaster repair under extreme working conditions.
文摘The impacts of climate change on agriculture are still shadowed with uncertainty. However, climate change is expected to adversely affect Iran＇s agricultural practices through changes in precipitation, temperature and carbon dioxide fertilization. Therefore, adaptation of this sector to the increasing weather events is imperative. This study is aimed to document the likely impacts of climate change on Iran＇s agriculture and the current adaptation efforts made by government and farmers. The review of literature shows that changes in rainfall and water endowments will have significant impacts on crop yield, crops＇ water requirements and income and welfare of farm families. The extent of the changes in yield depends on the crop type, assumptions related to the CO2 fertilization effect, climate scenarios and adaptation abilities. On adaptation, the government＇s efforts have been distinguished in the improving agricultural productivity and irrigation development based on current technology, developing new technologies and policy reforms. Farmers＇ adaptive responses have also been identified. Some conclusions and recommendations are offered to increase the adaptive capacity of farmers and reduce negative impacts of climate change.
基金supported by the National Natural Science Foundation of China(Nos.52071139,51905166,52075167)well as from the Natural Science Foundation of Hunan Province(2020JJ5198)the Open Platform Fund of Hunan Institute of Technology(KFA20014).
文摘Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommodation mechanism of the pre-rolled AZ31 magnesium alloy under high-speed impact loading were investigated.The twin and shear band are prevailing at low temperature,and the coexistence of twins and recrystallized grains is the dominant microstructure at medium temperature,while at high temperature,dynamic recrystallization(DRX)is almost complete.The increment of temperature reduces the critical condition difference between twinning and DRX,and the recrystallized temperature decreases with increasing strain rate.The mechanical response is related to the competition among the shear band strengthen,the twin strengthen and the fine grain strengthen and determined by the prevailing grain structure.The fine grain strengthen could compensate soften caused by the temperature increase and the reduction of twin and shear band.During high-speed deformation,different twin variants,introduced by pre-rolling,induce different deformation mechanism to accommodate plastic deformation and are in favor for non-basal slip.At low temperature,the high-speed deformation is achieved by twinning,dislocation slip and the following deformation shear band at different deformation stages.At high temperature,the high-speed deformation is realized by twinning and dislocation slip of early deformation stage,transition shear band of medium deformation stage and DRX of final deformation stage.
文摘The dynamic response behaviors of upright breakwaters under broken wave impact are analysed based on the mass-damper-spring dynamic system model. The effects of the mass, damping, stiffness, natural period, and impulse duration (or oscillation period) on the translation, rotation, sliding force, overturning moment, and corresponding dynamic amplifying factors are studied. It is concluded that the ampli-ying factors only depend on the ratio of the system natural period to impulse duration (or oscillation period) under a certain damping ratio. Moreover, the equivalent static approach to breakwater design is also discussed.
基金This study was financially supported by the National Natural Science Foundation of China(51579062,51379147),which is gratefully appreciated.
文摘The mechanical behaviors and energy dissipation characteristics of heat-treated granite were investigated under repeated impact loading.The granite samples were firstly heat-treated at the temperature of 20℃,200℃,400℃,and 600℃,respectively.The thermal damage characteristics of these samples were then observed and measured before impact tests.Dynamic impact compression tests finally were carried out using a modified split-Hopkinson pressure bar under three impact velocities of 12 m/s,15 m/s,and 18 m/s.These test results show that the mineral composition and the main oxides of the granite do not change with these treatment temperatures.The number of microcracks and microvoids decreases in the sample after 200℃ treatment.The mechanical properties of a sample after 600℃ treatment were rapidly deteriorated under the same impact velocity.The average of peak stress is much smaller than those after 20℃,200℃ and 400℃ treatments.The heat-treated samples have an energy threshold each.When the dissipated energy of a sample under a single impact is less than this threshold,the repeated impacts hardly lead to further damage accumulation even if its total breakage energy dissipation(BED)density is large.Under the same number of repeated impacts,the cumulative BED density of a sample after 600℃ treatment is the largest and its damage evolves most quickly.The total BED density of the sample after 200℃ treatment is the highest,which implies that this sample has better resistance to repeated impact,thus having less crack initiation and growth.
文摘The transient response of an unlimited cylindrical cavity buried in the infinite elastic soil subjected to an anti-plane impact load along the cavern axis direction was studied.Using Laplace transform combining with contour integral of the Laplace inverse transform specifically,the general analytical expressions of the soil displacement and stress are obtained in the time domain,respectively.And the numerical solutions of the problem computed by analytical expressions are presented.In the time domain,the dynamic responses of the infinite elastic soil are analyzed,and the calculation results are compared with those from numerical inversion proposed by Durbin and the static results.One observes good agreement between analytical and numerical inversion results,lending the further support to the method presented.Finally,some valuable shear wave propagation laws are gained: the displacement of the soil remains zero before the wave arrival,and after the shear wave arrival,the stress and the displacement at this point increase abruptly,then reduce and tend to the static value gradually at last.The wave attenuates along the radial,therefore the farther the wave is from the source,the smaller the stress and the displacement are,and the stress and the displacement are just functions of the radial distance from the axis.
文摘Bridge piers are impacted by autos sometimes. The pier usually has not been destroyed after once impact by auto. But there are few research on damage which will affect pier's capability, and most relative studies have focused the problems on piers impacted by vessels. The methods involve mainly sutra experience theory, numerical analysis, and experimental method. Owing to the complicacy of the bridge pier impacted by a vessel, there are few research derived with the sutra mechanics model and the piers impacted by autos. The dynamic response is studied here under the assumption of the rigid-plastic small-deformation for the pier impacted by auto. According to the Parkes beam model, the rigid-plastic theoretical solution is deduced. The final deformation is calculated by a practical example for the pier impacted by auto.
