The article is devoted to the study of the immunomodulating activity of rectal suppositories with an extract of licorice root and essential oils of chamomile and tea tree. Taking into account that medicine is intended...The article is devoted to the study of the immunomodulating activity of rectal suppositories with an extract of licorice root and essential oils of chamomile and tea tree. Taking into account that medicine is intended and prescribed for children, all the experiments were performed on immature nonlinear one-month rats with weight of 60.0-80.0 g. As a result, it was found out that rectal insertion of suppositories with an extract of licorice root causes an increase in the phagocytic function of neutrophils and increases the quantity of antibodies in the spleen and titers of hemagglutinins and hemolysins in serum, that indicating on the activation of nonspecific and humoral immunity of immature animals. Moreover, the prospects of possible application of suppositories with an extract of licorice root are showed for prevention and treatment of various immunodependent diseases, viral in particular.展开更多
A water soluble crude extract prepared from Ornithogalum caudatum Ait. (OCA) showing a high immunomodulating activitiy was isolated and characterized by virtue of gel filtration and column chromatography. The pre...A water soluble crude extract prepared from Ornithogalum caudatum Ait. (OCA) showing a high immunomodulating activitiy was isolated and characterized by virtue of gel filtration and column chromatography. The presence of the monosaccharides has been established by the chemical analysis. The quantitative analysis of the alditol acetate derivatives of them showed the ratios of the monosaccharides analyzed by means of GC respectively. The concentrations of protein(280 nm) and carbohydrate(496 nm) were detected respectively. The information of the molecular weight from the pure polysaccharide was obtained by several standard Dextrans from the Sephadex chromatography.展开更多
Traditional fermented dairy products from Xinjiang,China,harbor rich and unique microbial communities shaped by local environmental and cultural factors.In particular,the probiotic properties and proteolytic activity ...Traditional fermented dairy products from Xinjiang,China,harbor rich and unique microbial communities shaped by local environmental and cultural factors.In particular,the probiotic properties and proteolytic activity of yeasts have a significant impact on the quality,flavor,and functional characteristics of these products,yet systematic studies on these aspects remain limited.In this study,the safety,functional properties,and probiotic potential of four yeast strains with high proteolytic capacity(Kluyveromyces marxianus M1,Kluyveromyces marxianus M4-1,Clavispora lusitaniae 0807-6,and Pichia kudriavzevii 0807-33)isolated from Chinese traditional fermented dairy products were evaluated.All strains exhibitedγ-hemolysis,indicating their safety.K.marxianus M1 demonstrated superior co-aggregation with pathogens and the highest antioxidant activity,with a DPPH scavenging rate of 76.38%.C.lusitaniae 0807-6 exhibited the highest gastric survival rate(81.65%)and cholesterol assimilation(45.5%),along with strong auto-aggregation(88.80%)and hydrophobicity(82.68%).Hydrolysates from these yeasts effectively modulated macrophage immune responses.This study demonstrates that K.marxianus M1 and C.lusitaniae 0807-6 demonstrate considerable potential for next-generation probiotic applications and may serve as promising candidates for delivering targeted health benefits.展开更多
文摘The article is devoted to the study of the immunomodulating activity of rectal suppositories with an extract of licorice root and essential oils of chamomile and tea tree. Taking into account that medicine is intended and prescribed for children, all the experiments were performed on immature nonlinear one-month rats with weight of 60.0-80.0 g. As a result, it was found out that rectal insertion of suppositories with an extract of licorice root causes an increase in the phagocytic function of neutrophils and increases the quantity of antibodies in the spleen and titers of hemagglutinins and hemolysins in serum, that indicating on the activation of nonspecific and humoral immunity of immature animals. Moreover, the prospects of possible application of suppositories with an extract of licorice root are showed for prevention and treatment of various immunodependent diseases, viral in particular.
文摘A water soluble crude extract prepared from Ornithogalum caudatum Ait. (OCA) showing a high immunomodulating activitiy was isolated and characterized by virtue of gel filtration and column chromatography. The presence of the monosaccharides has been established by the chemical analysis. The quantitative analysis of the alditol acetate derivatives of them showed the ratios of the monosaccharides analyzed by means of GC respectively. The concentrations of protein(280 nm) and carbohydrate(496 nm) were detected respectively. The information of the molecular weight from the pure polysaccharide was obtained by several standard Dextrans from the Sephadex chromatography.
基金funded by the Natural Science Foundation of China(No.32572550).
文摘Traditional fermented dairy products from Xinjiang,China,harbor rich and unique microbial communities shaped by local environmental and cultural factors.In particular,the probiotic properties and proteolytic activity of yeasts have a significant impact on the quality,flavor,and functional characteristics of these products,yet systematic studies on these aspects remain limited.In this study,the safety,functional properties,and probiotic potential of four yeast strains with high proteolytic capacity(Kluyveromyces marxianus M1,Kluyveromyces marxianus M4-1,Clavispora lusitaniae 0807-6,and Pichia kudriavzevii 0807-33)isolated from Chinese traditional fermented dairy products were evaluated.All strains exhibitedγ-hemolysis,indicating their safety.K.marxianus M1 demonstrated superior co-aggregation with pathogens and the highest antioxidant activity,with a DPPH scavenging rate of 76.38%.C.lusitaniae 0807-6 exhibited the highest gastric survival rate(81.65%)and cholesterol assimilation(45.5%),along with strong auto-aggregation(88.80%)and hydrophobicity(82.68%).Hydrolysates from these yeasts effectively modulated macrophage immune responses.This study demonstrates that K.marxianus M1 and C.lusitaniae 0807-6 demonstrate considerable potential for next-generation probiotic applications and may serve as promising candidates for delivering targeted health benefits.
