Gastric cancer remains a major global health challenge with high morbidity and mortality rates.Recent advancements in immunology and inflammation research have highlighted the crucial roles that these biological proce...Gastric cancer remains a major global health challenge with high morbidity and mortality rates.Recent advancements in immunology and inflammation research have highlighted the crucial roles that these biological processes play in tumor progression and patient outcomes.This has sparked new interest in developing prognostic biomarkers that integrate these two key biological processes.In this letter,we discuss the recent study by Ba et al,which proposed a novel prognostic immunoinflammatory index for patients with gastric cancer.We underscore the importance of this research,its potential impact on medical practice,and the prospective avenues for further investigation in this rapidly emerging area of study.展开更多
BACKGROUND Colon cancer is one of the most common malignant tumors of the digestive system.Liver metastasis after colon cancer surgery is the primary cause of death in patients with colon cancer.AIM To construct a nov...BACKGROUND Colon cancer is one of the most common malignant tumors of the digestive system.Liver metastasis after colon cancer surgery is the primary cause of death in patients with colon cancer.AIM To construct a novel nomogram model including various factors to predict liver metastasis after colon cancer surgery.METHODS We retrospectively analyzed 242 patients with colon cancer who were admitted and underwent radical resection for colon cancer in Zhejiang Provincial People’s Hospital from December 2019 to December 2022.Patients were divided into liver metastasis and non-liver metastasis groups.Sex,age,and other general and clinicopathological data(preoperative blood routine and biochemical test indexes)were compared.The risk factors for liver metastasis were analyzed using singlefactor and multifactorial logistic regression.A predictive model was then constructed and evaluated for efficacy.RESULTS Systemic inflammatory index(SII),C-reactive protein/albumin ratio(CAR),red blood cell distribution width(RDW),alanine aminotransferase,preoperative carcinoembryonic antigen level,and lymphatic metastasis were different between groups(P<0.05).SII,CAR,and RDW were risk factors for liver metastasis after colon cancer surgery(P<0.05).The area under the curve was 0.93 for the column-line diagram prediction model constructed based on these risk factors to distinguish whether liver metastasis occurred postoperatively.The actual curve of the column-line diagram predicting the risk of postoperative liver metastasis was close to the ideal curve,with good agreement.The prediction model curves in the decision curve analysis showed higher net benefits for a larger threshold range than those in extreme cases,indicating that the model is safer.CONCLUSION Liver metastases after colorectal cancer surgery could be well predicted by a nomogram based on the SII,CAR,and RDW.展开更多
Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate...Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this condition.Psychoneuroimmunoendocrinology(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a whole.The initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and well-being.In the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are interconnected.Finally,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.展开更多
Objective: To investigate the role of oxidative stress and immunoinflammatory reaction in early stage of diffuse axonal injury (DAI). Methods: 96 adult male SD rats were divided into 2 groups (n = 48 in each): sham gr...Objective: To investigate the role of oxidative stress and immunoinflammatory reaction in early stage of diffuse axonal injury (DAI). Methods: 96 adult male SD rats were divided into 2 groups (n = 48 in each): sham group and DAI group. Rat diffuse axonal injury was induced by a rat instant lateral head rotation device, which was developed to let the rat head spin 90 degree at the moment to cause shearing injury. The modified neurological severity score (mNSS), histomorphology, PI staining, GFAP immunofluorescent staining, SOD activity, CAT activity, MDA content and western blotting (IL-6,IL-1, JNK and p-JNK) in parietal cortex were investigated at 6 h, 1 d and 3 d after DAI. Results: The neurological severity scores, GFAP positive cell, PI positive cells, MDA, IL-6, IL-1, JNK and p-JNK were significantly increased and the SOD and CAT activities were decreased after DAI. Conclusion: Oxidative stress and immunoinflammatory reaction played important roles in DAI pathophysiological process in acute phase.展开更多
blood cell derived inflammatory nmarker(including systemic immunoinflammatory index(SI),systemic inflammatory response index(SIRI),neutrophil count/lymphocyte count(NLR),platelet count/lymphocyte count(PLR),and monocy...blood cell derived inflammatory nmarker(including systemic immunoinflammatory index(SI),systemic inflammatory response index(SIRI),neutrophil count/lymphocyte count(NLR),platelet count/lymphocyte count(PLR),and monocyte count/lymphocyte count(MLR))and in combination with N-terminal pro-B-type natriuretic peptide(NT-proBNP)on the prognosis of patients with chronic heart failure.Methods This study was a retrospective cohort study.Patients with chronic heart failure hospitalized in the Department of Cardiovascular Medicine,Nanfang Hospital,Southern Medical University from January 2019 to August 2022 were enrolled.Patients were followed up and were divided into survival group and death group according to the follow-up results.Clinical characteristics of the two groups were compared.Receiver operating characteristic(ROC)curve was used to determine the optimal cut-off value of each whole blood cell derived inflammatory marker for predicting all-cause death in patients with chronic heart failure.Kaplan-Meier survival curve was drawn,and log-rank test was used to compare the difference in survival of chronic heart failure patients with different levels of whole blood cell derived inflammatory markers.Univariate and multivariate Cox proportional hazards models were used to analyze the effects of whole blood cell derived inflammatory markers and NT-proBNP on the all-cause death of patients with chronic heart failure.ROC curve was used to analyze the predictive value of whole blood cell derived inflammatory markers combined with NT-proBNP on the prognosis of patients with chronic heart failure.Results A total of 324 patients with heart failure aged(64.76±13.78)years were enrolled,with 212 males(65.43%).297 patients(91.67%)completed follow-up,27 patients(8.33%)were lost to follow-up.The follow-up time was 24.O(18.0,41.8)months.There were 258 patients in the survival group and 66 patients in the death group.The optimal cut-off values of SI,SIRI,NLR,PLR and MLR determined by R0C curve were 739.83,1.65,3.14,151.95 and 0.37,respectively.Kaplan-Meier survival curve analysis showed that patients with chronic heart failure with high levels of SII(≥739.83),SIRI(≥1.65),NLR(≥3.14),PLR(≥151.95)and MLR(≥0.37)had higher incidence of all-cause death than patients with low levels of inflammatory markers(all P<0.001).Multivariate Cox proportional hazard regression analysis showed that age(HR=1.04,95%CI 1.01-1.06,P=0.002),NT-proBNP(HR=2.93,95%CI 1.64-5.23,P<0.001),SII≥739.83(HR=3.27,95%CI 1.18-9.02,P=0.022)and PLR≥151.95(HR=2.67,95%CI 1.02-6.96,P=0.045)were independent predictors of all-cause death in patients with chronic heart failure.ROC curve analysis showed that the predictive value of SII and PLR combined with NTproBNP(AUC=0.850)for the prognosis of patients with chronic heart failure was better than that of SII(AUC=0.779)、PLR(AUC=0.782)、NT-proBNP(AUC=0.727)and CRP(AUC=0.668)alone(all P<0.001).Conclusion Whole blood cell derived inflammatory markers—SII,PLR,and NT-pro BNP are independently associated with all-cause death in patients with chronic heart failure.SII and PLR can independently predict the prognosis of patients with chronic heart failure,combination of SII and PLR with NT-pro BNP has better predictive value for the prognosis of patients with chronic heart failure.展开更多
基金Supported by the National Natural Science Foundation of China,No.62273086the Fundamental Research Funds for the Central Universities,No.2572022BD04.
文摘Gastric cancer remains a major global health challenge with high morbidity and mortality rates.Recent advancements in immunology and inflammation research have highlighted the crucial roles that these biological processes play in tumor progression and patient outcomes.This has sparked new interest in developing prognostic biomarkers that integrate these two key biological processes.In this letter,we discuss the recent study by Ba et al,which proposed a novel prognostic immunoinflammatory index for patients with gastric cancer.We underscore the importance of this research,its potential impact on medical practice,and the prospective avenues for further investigation in this rapidly emerging area of study.
基金reviewed and approved by the Institutional Review Board of Zhejiang Provincial People’s Hospital(Approval No.2023-338).
文摘BACKGROUND Colon cancer is one of the most common malignant tumors of the digestive system.Liver metastasis after colon cancer surgery is the primary cause of death in patients with colon cancer.AIM To construct a novel nomogram model including various factors to predict liver metastasis after colon cancer surgery.METHODS We retrospectively analyzed 242 patients with colon cancer who were admitted and underwent radical resection for colon cancer in Zhejiang Provincial People’s Hospital from December 2019 to December 2022.Patients were divided into liver metastasis and non-liver metastasis groups.Sex,age,and other general and clinicopathological data(preoperative blood routine and biochemical test indexes)were compared.The risk factors for liver metastasis were analyzed using singlefactor and multifactorial logistic regression.A predictive model was then constructed and evaluated for efficacy.RESULTS Systemic inflammatory index(SII),C-reactive protein/albumin ratio(CAR),red blood cell distribution width(RDW),alanine aminotransferase,preoperative carcinoembryonic antigen level,and lymphatic metastasis were different between groups(P<0.05).SII,CAR,and RDW were risk factors for liver metastasis after colon cancer surgery(P<0.05).The area under the curve was 0.93 for the column-line diagram prediction model constructed based on these risk factors to distinguish whether liver metastasis occurred postoperatively.The actual curve of the column-line diagram predicting the risk of postoperative liver metastasis was close to the ideal curve,with good agreement.The prediction model curves in the decision curve analysis showed higher net benefits for a larger threshold range than those in extreme cases,indicating that the model is safer.CONCLUSION Liver metastases after colorectal cancer surgery could be well predicted by a nomogram based on the SII,CAR,and RDW.
基金funded by grants from the Fondo de Investigacion de la Seguridad Social(Spain)(FIS PI-14/01935)the Spanish Ministerio de Ciencia y Tecnologia+4 种基金Instituto de Salud Carlos III(PI051871,CIBERehd)the Spanish Ministerio de Economia y Competitividad(SAF2017-86343-R)the Comunidad de Madrid(P2022/BMD-7321)HALEKULANY S.L.PROACAPITAL and MJR.
文摘Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this condition.Psychoneuroimmunoendocrinology(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a whole.The initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and well-being.In the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are interconnected.Finally,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.
文摘Objective: To investigate the role of oxidative stress and immunoinflammatory reaction in early stage of diffuse axonal injury (DAI). Methods: 96 adult male SD rats were divided into 2 groups (n = 48 in each): sham group and DAI group. Rat diffuse axonal injury was induced by a rat instant lateral head rotation device, which was developed to let the rat head spin 90 degree at the moment to cause shearing injury. The modified neurological severity score (mNSS), histomorphology, PI staining, GFAP immunofluorescent staining, SOD activity, CAT activity, MDA content and western blotting (IL-6,IL-1, JNK and p-JNK) in parietal cortex were investigated at 6 h, 1 d and 3 d after DAI. Results: The neurological severity scores, GFAP positive cell, PI positive cells, MDA, IL-6, IL-1, JNK and p-JNK were significantly increased and the SOD and CAT activities were decreased after DAI. Conclusion: Oxidative stress and immunoinflammatory reaction played important roles in DAI pathophysiological process in acute phase.
文摘blood cell derived inflammatory nmarker(including systemic immunoinflammatory index(SI),systemic inflammatory response index(SIRI),neutrophil count/lymphocyte count(NLR),platelet count/lymphocyte count(PLR),and monocyte count/lymphocyte count(MLR))and in combination with N-terminal pro-B-type natriuretic peptide(NT-proBNP)on the prognosis of patients with chronic heart failure.Methods This study was a retrospective cohort study.Patients with chronic heart failure hospitalized in the Department of Cardiovascular Medicine,Nanfang Hospital,Southern Medical University from January 2019 to August 2022 were enrolled.Patients were followed up and were divided into survival group and death group according to the follow-up results.Clinical characteristics of the two groups were compared.Receiver operating characteristic(ROC)curve was used to determine the optimal cut-off value of each whole blood cell derived inflammatory marker for predicting all-cause death in patients with chronic heart failure.Kaplan-Meier survival curve was drawn,and log-rank test was used to compare the difference in survival of chronic heart failure patients with different levels of whole blood cell derived inflammatory markers.Univariate and multivariate Cox proportional hazards models were used to analyze the effects of whole blood cell derived inflammatory markers and NT-proBNP on the all-cause death of patients with chronic heart failure.ROC curve was used to analyze the predictive value of whole blood cell derived inflammatory markers combined with NT-proBNP on the prognosis of patients with chronic heart failure.Results A total of 324 patients with heart failure aged(64.76±13.78)years were enrolled,with 212 males(65.43%).297 patients(91.67%)completed follow-up,27 patients(8.33%)were lost to follow-up.The follow-up time was 24.O(18.0,41.8)months.There were 258 patients in the survival group and 66 patients in the death group.The optimal cut-off values of SI,SIRI,NLR,PLR and MLR determined by R0C curve were 739.83,1.65,3.14,151.95 and 0.37,respectively.Kaplan-Meier survival curve analysis showed that patients with chronic heart failure with high levels of SII(≥739.83),SIRI(≥1.65),NLR(≥3.14),PLR(≥151.95)and MLR(≥0.37)had higher incidence of all-cause death than patients with low levels of inflammatory markers(all P<0.001).Multivariate Cox proportional hazard regression analysis showed that age(HR=1.04,95%CI 1.01-1.06,P=0.002),NT-proBNP(HR=2.93,95%CI 1.64-5.23,P<0.001),SII≥739.83(HR=3.27,95%CI 1.18-9.02,P=0.022)and PLR≥151.95(HR=2.67,95%CI 1.02-6.96,P=0.045)were independent predictors of all-cause death in patients with chronic heart failure.ROC curve analysis showed that the predictive value of SII and PLR combined with NTproBNP(AUC=0.850)for the prognosis of patients with chronic heart failure was better than that of SII(AUC=0.779)、PLR(AUC=0.782)、NT-proBNP(AUC=0.727)and CRP(AUC=0.668)alone(all P<0.001).Conclusion Whole blood cell derived inflammatory markers—SII,PLR,and NT-pro BNP are independently associated with all-cause death in patients with chronic heart failure.SII and PLR can independently predict the prognosis of patients with chronic heart failure,combination of SII and PLR with NT-pro BNP has better predictive value for the prognosis of patients with chronic heart failure.
