Cancer is a major public health problem in the world.There is still a long way to go before we can manage cancer as a chronic disease or cure cancer.And now,cancer immunotherapy,a strategy that harnesses the human imm...Cancer is a major public health problem in the world.There is still a long way to go before we can manage cancer as a chronic disease or cure cancer.And now,cancer immunotherapy,a strategy that harnesses the human immune system to fight against cancer is paving the path to curing it.Activating the immune system for therapeutic benefit in cancer has become a goal in immunology and oncology.展开更多
Immune Cellular Therapies(ICT)have revolutionized the treatment of blood cancer and are beginning to show positive outcomes in treating solid tumors.Despite these successes,ICT faces significant challenges,including t...Immune Cellular Therapies(ICT)have revolutionized the treatment of blood cancer and are beginning to show positive outcomes in treating solid tumors.Despite these successes,ICT faces significant challenges,including tumor accessibility,lengthy manufacturing turnaround,and limited long-term effectiveness.Recent advancements in nanomaterials,particularly nanoparticles,have offered promising solutions to these issues.This perspective introduces the current ICT manufacturing pipeline with a focus on solid tumors and showcases recent nanomaterial-mediated practices to enhance ICT.These efforts include the use of cell-targeting magnetic nanoparticles for noninvasive target identification,lipid nanoparticles for in vivo immune cell stimulation,as well as nanoparticle-mediated gene editing and cytokine delivery to enhance immune cell fitness.By better integrating nanoparticles into the design and manufacturing pipelines,we envision that the next generation of ICT could be faster,more efficient,and capable of targeting a broad spectrum of cancers and inflammatory diseases.展开更多
This perspective derives from the presentations and discussions on mechanobiology at the 2025 Cellular and Molecular Bioengineering Conference in San Diego.Mechanobiological processes play critical roles in tissue dev...This perspective derives from the presentations and discussions on mechanobiology at the 2025 Cellular and Molecular Bioengineering Conference in San Diego.Mechanobiological processes play critical roles in tissue development,regeneration,and disease progression.Recent advances in engineering,biology,and medicine have enabled the translation of mechanobiology discoveries into clinical practice,giving rise to the emerging field of mechanomedicine.The development and application of engineering technology and tools have provided new insights into how mechanical cues regulate immune cell response,stem cell differentiation,cell migration,and cell metabolism.In this perspective,we highlight exciting discoveries and innovative tools in mechanobiology research,and discuss challenges that must be overcome to truly bridge the gap between mechanobiology and mechanomedicine.展开更多
文摘Cancer is a major public health problem in the world.There is still a long way to go before we can manage cancer as a chronic disease or cure cancer.And now,cancer immunotherapy,a strategy that harnesses the human immune system to fight against cancer is paving the path to curing it.Activating the immune system for therapeutic benefit in cancer has become a goal in immunology and oncology.
基金This work was supported by the Chan Zuckerberg Initiative and the Chan Zuckerberg Biohub Chicago.
文摘Immune Cellular Therapies(ICT)have revolutionized the treatment of blood cancer and are beginning to show positive outcomes in treating solid tumors.Despite these successes,ICT faces significant challenges,including tumor accessibility,lengthy manufacturing turnaround,and limited long-term effectiveness.Recent advancements in nanomaterials,particularly nanoparticles,have offered promising solutions to these issues.This perspective introduces the current ICT manufacturing pipeline with a focus on solid tumors and showcases recent nanomaterial-mediated practices to enhance ICT.These efforts include the use of cell-targeting magnetic nanoparticles for noninvasive target identification,lipid nanoparticles for in vivo immune cell stimulation,as well as nanoparticle-mediated gene editing and cytokine delivery to enhance immune cell fitness.By better integrating nanoparticles into the design and manufacturing pipelines,we envision that the next generation of ICT could be faster,more efficient,and capable of targeting a broad spectrum of cancers and inflammatory diseases.
基金supported,in part,by grants from the National Institute of Health(HC:R35 GM147406,PM:R35 GM147101,PYH:R35 GM155045,R01 CA254060,QS:R35 GM151099,YW:EB029122,GM140929,CA262815,LL:K01 EB035649,SL:NS126918,GM143485,NS130677,JF:R01 EB034360)National Science Foundation(PYH:CAREER 2145756)+2 种基金The PEW Charitable Trust(QS:Biomedical Fellow)Howard Hughes Medical Institute(QS:Hanna Gray Fellow)the California Institute for Regenerative Medicine(SL:DISC2-14169).
文摘This perspective derives from the presentations and discussions on mechanobiology at the 2025 Cellular and Molecular Bioengineering Conference in San Diego.Mechanobiological processes play critical roles in tissue development,regeneration,and disease progression.Recent advances in engineering,biology,and medicine have enabled the translation of mechanobiology discoveries into clinical practice,giving rise to the emerging field of mechanomedicine.The development and application of engineering technology and tools have provided new insights into how mechanical cues regulate immune cell response,stem cell differentiation,cell migration,and cell metabolism.In this perspective,we highlight exciting discoveries and innovative tools in mechanobiology research,and discuss challenges that must be overcome to truly bridge the gap between mechanobiology and mechanomedicine.
