Objective:To explore the imaging characteristics changes of pulmonary infections in patients with hypo-immunity and analyze the correlation between NLR,PCT levels and their severity.Methods:This study included 80 pati...Objective:To explore the imaging characteristics changes of pulmonary infections in patients with hypo-immunity and analyze the correlation between NLR,PCT levels and their severity.Methods:This study included 80 patients with hypo-immunity and pulmonary infections who were diagnosed and treated at our hospital from October 2022 to October 2024.Imaging examinations were performed on the patients.Subsequently,the patients were divided into a severe group and a mild group based on the severity of their disease.Univariate analysis was conducted,and variables with statistical significance from the univariate analysis were included in a multivariate logistic regression analysis to clarify the correlation between plasma NLR,PCT levels,and their severity.Results:Imaging examinations revealed that ground-glass opacities in the lungs were centered around the hilum,with patchy or map-like distributions accompanied by reticular shadows.The affected areas and normal lung areas were interspersed,with a tendency to merge.Some patients also developed pneumothorax.Ground-glass opacities were the most characteristic manifestation,which could also present as reticular shadows,interstitial thickening,miliary shadows,multiple small nodules,intrathoracic lymphadenopathy,and a small amount of pleural effusion.In the correlation analysis,NLR and PCT were statistically significant in the univariate analysis(p<0.05).When included in the multivariate logistic regression analysis,NLR(OR=2.846,95%CI:2.402-3.358)and PCT(OR=1.958,95%CI:1.554-2.601)were found to be positively correlated with the severity of pulmonary infections in patients with hypo-immunity.Conclusion:The imaging manifestations of patients with impaired immune function are complex and diverse,primarily including patchy,linear,massive,cavitary,and diffuse lesions,among other forms.These manifestations not only assist physicians in identifying the presence of pulmonary infections but also provide crucial information for diagnosing the type,severity,and complications of the infections.The levels of NLR(Neutrophil-to-Lymphocyte Ratio)and PCT(Procalcitonin)exhibit a positive correlation with the severity of pulmonary infections in patients with impaired immune function,warranting significant attention.展开更多
Dear Editors,Radiation can result in DNA damage,excessive oxidative stress,inflammatory responses,and impaired immune function,1 further leading to damage to different systems.For example,radiation exposure during Com...Dear Editors,Radiation can result in DNA damage,excessive oxidative stress,inflammatory responses,and impaired immune function,1 further leading to damage to different systems.For example,radiation exposure during Computed Tomography increases the risk of leukemia in children.2 In addition,radiation therapy is one of the common treatment methods for cancer patients.However,radiation during the treatment process may cause upper and lower gastrointestinal mucositis,which can seriously affect the effectiveness of tumor treatment.3 At present,antiradiation drugs on the market include amifostine,sargramostim,and potassium iodide.However,these chemically synthesized drugs have certain side effects,such as hypotension,nausea,and vomiting.4 Therefore,in recent years,natural compounds with lower toxicity have attracted much attention as potential therapeutic agents against radiation damage.5 Licochalcone B,the main active substance of licorice(Glycyrrhiza uralensis Fisch.),has a variety of biological activities and pharmacological effects,including antioxidant,anti-inflammatory,anti-tumor,and immunomodulatory properties.6 Therefore,Licochalcone B may be a potential therapeutic agent against radiation damage.展开更多
基金Pathogen Distribution,Imaging Features,and Clinical Manifestations of Pulmonary Infections in Patients with Impaired Immune Function(Project No.:2023-1-NS-017)。
文摘Objective:To explore the imaging characteristics changes of pulmonary infections in patients with hypo-immunity and analyze the correlation between NLR,PCT levels and their severity.Methods:This study included 80 patients with hypo-immunity and pulmonary infections who were diagnosed and treated at our hospital from October 2022 to October 2024.Imaging examinations were performed on the patients.Subsequently,the patients were divided into a severe group and a mild group based on the severity of their disease.Univariate analysis was conducted,and variables with statistical significance from the univariate analysis were included in a multivariate logistic regression analysis to clarify the correlation between plasma NLR,PCT levels,and their severity.Results:Imaging examinations revealed that ground-glass opacities in the lungs were centered around the hilum,with patchy or map-like distributions accompanied by reticular shadows.The affected areas and normal lung areas were interspersed,with a tendency to merge.Some patients also developed pneumothorax.Ground-glass opacities were the most characteristic manifestation,which could also present as reticular shadows,interstitial thickening,miliary shadows,multiple small nodules,intrathoracic lymphadenopathy,and a small amount of pleural effusion.In the correlation analysis,NLR and PCT were statistically significant in the univariate analysis(p<0.05).When included in the multivariate logistic regression analysis,NLR(OR=2.846,95%CI:2.402-3.358)and PCT(OR=1.958,95%CI:1.554-2.601)were found to be positively correlated with the severity of pulmonary infections in patients with hypo-immunity.Conclusion:The imaging manifestations of patients with impaired immune function are complex and diverse,primarily including patchy,linear,massive,cavitary,and diffuse lesions,among other forms.These manifestations not only assist physicians in identifying the presence of pulmonary infections but also provide crucial information for diagnosing the type,severity,and complications of the infections.The levels of NLR(Neutrophil-to-Lymphocyte Ratio)and PCT(Procalcitonin)exhibit a positive correlation with the severity of pulmonary infections in patients with impaired immune function,warranting significant attention.
基金funded by the Yangtze University Science and Technology Aid to Tibet Medical Talent Training Program Project(2023YZ13 to XCP)the National Innovation and Entrepreneurship Training Program for College Students(202310489021 to XCP)+1 种基金the Graduate Innovation Fund of the Health Science Center,Yangtze University(202303 to XCP)the Wujieping Medical Foundation-Digestive Tract Cancer Research Fund(320.6750.2024-10-3 to XCP).
文摘Dear Editors,Radiation can result in DNA damage,excessive oxidative stress,inflammatory responses,and impaired immune function,1 further leading to damage to different systems.For example,radiation exposure during Computed Tomography increases the risk of leukemia in children.2 In addition,radiation therapy is one of the common treatment methods for cancer patients.However,radiation during the treatment process may cause upper and lower gastrointestinal mucositis,which can seriously affect the effectiveness of tumor treatment.3 At present,antiradiation drugs on the market include amifostine,sargramostim,and potassium iodide.However,these chemically synthesized drugs have certain side effects,such as hypotension,nausea,and vomiting.4 Therefore,in recent years,natural compounds with lower toxicity have attracted much attention as potential therapeutic agents against radiation damage.5 Licochalcone B,the main active substance of licorice(Glycyrrhiza uralensis Fisch.),has a variety of biological activities and pharmacological effects,including antioxidant,anti-inflammatory,anti-tumor,and immunomodulatory properties.6 Therefore,Licochalcone B may be a potential therapeutic agent against radiation damage.
