Bone is highly innervated,and its regeneration is significantly nerve-dependent.Extensive evidence suggests that the nervous system plays an active role in bone metabolism and development by modulating osteoblast and ...Bone is highly innervated,and its regeneration is significantly nerve-dependent.Extensive evidence suggests that the nervous system plays an active role in bone metabolism and development by modulating osteoblast and osteoclast activity.However,the majority of research to date has focused on the direct effects of peripheral nerves and their neurotransmitters on bone regeneration.Emerging studies have begun to reveal a more intricate role of nerves in regulating the immune microenvironment,which is crucial for bone regeneration.This review summarizes how nerves influence bone regeneration through modulation of the immune microenvironment.We first discuss the changes in peripheral nerves during the regenerative process.We then describe conduction and paracrine pathways through which nerves affect the osteogenic immune microenvironment,emphasizing nerves,neural factors,and their impacts.Our goal is to deepen the understanding of the nerve-immune axis in bone regeneration.A better grasp of how nerves influence the osteogenic immune microenvironment may lead to new strategies that integrate the nervous,immune,and skeletal systems to promote bone regeneration.展开更多
Recently,Richter et al.[1]revealed the potential functions of the interaction between the serine/threonine kinase Tank-binding kinase 1（TBK1）and the autophagy receptor optineurin（OPTN）.The TBK1-OPTN axis targets d...Recently,Richter et al.[1]revealed the potential functions of the interaction between the serine/threonine kinase Tank-binding kinase 1（TBK1）and the autophagy receptor optineurin（OPTN）.The TBK1-OPTN axis targets damaged mitochondria for degradation via PINK1/parkin-mediated mitophagy[2,3].Indeed,TBK1 can phosphorylate OPTN at Ser177,Ser473,or Ser513 to enhance the binding capacity of OPTN with poly-ubiquitin（poly-UB）chains.Conversely,展开更多
Chimeric antigen receptor T cell therapy has revolutionized cancer treatment,but its efficacy remains constrained by the immunosuppressive tumor microenvironment.Emerging evidence identifies the neuro-immune-cancer ax...Chimeric antigen receptor T cell therapy has revolutionized cancer treatment,but its efficacy remains constrained by the immunosuppressive tumor microenvironment.Emerging evidence identifies the neuro-immune-cancer axis as a critical modulator of tumor microenvironment dynamics,offering novel opportunities to reshape immune responses.Neural signaling influences chimeric antigen receptor T cell function,yet therapeutic strategies targeting this axis remain largely unexplored.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.82372382,82002333,32371412,32071349)the Central Guidance on Local Science and Technology Development Fund of Zhejiang Province(No.2024ZY01033)+1 种基金the Zhejiang Provincial Natural Science Foundation of China(No.LY24C100001)the Key Research and Development Program of Zhejiang(No.2022C01076)。
文摘Bone is highly innervated,and its regeneration is significantly nerve-dependent.Extensive evidence suggests that the nervous system plays an active role in bone metabolism and development by modulating osteoblast and osteoclast activity.However,the majority of research to date has focused on the direct effects of peripheral nerves and their neurotransmitters on bone regeneration.Emerging studies have begun to reveal a more intricate role of nerves in regulating the immune microenvironment,which is crucial for bone regeneration.This review summarizes how nerves influence bone regeneration through modulation of the immune microenvironment.We first discuss the changes in peripheral nerves during the regenerative process.We then describe conduction and paracrine pathways through which nerves affect the osteogenic immune microenvironment,emphasizing nerves,neural factors,and their impacts.Our goal is to deepen the understanding of the nerve-immune axis in bone regeneration.A better grasp of how nerves influence the osteogenic immune microenvironment may lead to new strategies that integrate the nervous,immune,and skeletal systems to promote bone regeneration.
基金supported by the National Natural Science Foundation of China(81470434,81503074,and81670265)the Science and Technology Project of Hunan Province,China(2015RS4040)+1 种基金the Administration of Traditional Chinese Medicine of Hunan Province,China(201578)the Health and Family-planning Commission of Hunan Province,China(B2015-48)
文摘Recently,Richter et al.[1]revealed the potential functions of the interaction between the serine/threonine kinase Tank-binding kinase 1（TBK1）and the autophagy receptor optineurin（OPTN）.The TBK1-OPTN axis targets damaged mitochondria for degradation via PINK1/parkin-mediated mitophagy[2,3].Indeed,TBK1 can phosphorylate OPTN at Ser177,Ser473,or Ser513 to enhance the binding capacity of OPTN with poly-ubiquitin（poly-UB）chains.Conversely,
基金supported by the National Natural Science Foundation of China(82530008)。
文摘Chimeric antigen receptor T cell therapy has revolutionized cancer treatment,but its efficacy remains constrained by the immunosuppressive tumor microenvironment.Emerging evidence identifies the neuro-immune-cancer axis as a critical modulator of tumor microenvironment dynamics,offering novel opportunities to reshape immune responses.Neural signaling influences chimeric antigen receptor T cell function,yet therapeutic strategies targeting this axis remain largely unexplored.
