Background:Integrase Strand Transfer Inhibitors(INSTIs)have emerged as the preferred first-line antiretroviral therapy(ART)regimen globally,primarily due to their superior efficacy and favorable safety profile.However...Background:Integrase Strand Transfer Inhibitors(INSTIs)have emerged as the preferred first-line antiretroviral therapy(ART)regimen globally,primarily due to their superior efficacy and favorable safety profile.However,in China,the high cost of INSTIs and their later market introduction have resulted in relatively limited reporting on INSTI-based regimens.Specifically,there is a lack of comprehensive data regarding side effects,immunological outcomes,and virological responses among the Chinese population living with human immunodeficiency virus(HIV).Against this backdrop,this cohort study aims to evaluate the changes in T-cells,laboratory parameters,viral decay,and CD8^(+)T-cell functional capacity after switching from non-INSTI-based regimens to INSTI-based regimens in virologically suppressed individuals living with HIV.Methods:From December 2022 to May 2023,59 adults(aged 18—60 years),all of whom had received more than three years of ART and achieved sustained virological suppression(plasma HIV RNA<200 copies/mL for≥6 months),were enrolled in this study at the Fifth Medical Center of Chinese PLA General Hospital.The participants were divided into two groups according to whether they received elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide(EVG/c/FTC/TAF)—that is,whether they switched to EVG/c/FTC/TAF(the INSTI group,n=23)or maintained a non-nucleoside reverse transcriptase inhibitor(NNRTI)-or protease inhibitor(PI)-based regimen(the n-INSTI group,n=36).Clinical and laboratory evaluations(including the CD4^(+)T-cell count,CD8^(+)T-cell count,CD4:CD8 ratio,and plasma HIV RNA)were performed at both baseline and week 24.Changes in participants’HIV DNA,cell-associated(CA)HIV RNA,and CD8^(+)T-cell functional capacity(CD107a,perforin,granzyme-B,TNF-α,and IFN-γ)were assessed at baseline and weeks 2,4,8,12,and 24.Results:At week 24,the INSTI group showed a significant increase in the CD4^(+)T-cell count from 497.30±38.20 cells/µL to 594.92±51.95 cells/µL(P<0.001)and in the CD4:CD8 ratio from 0.76(0.53,1.01)to 0.85(0.57,1.27)(P=0.006),while the CD8^(+)T-cell count remained stable.The laboratory values showed improved liver function(alanine transaminase,aspartate aminotransferase)and decreased renal function(estimated Glomerular Filtration Rate,serum creatinine,blood urea nitrogen,uric acid)in the INSTI group.The CD8^(+)T-cell functional capacity,including the expression of CD107a,perforin,and granzyme-B on CD8^(+)T-cells,was significantly enhanced in the INSTI group.The HIV DNA and CA HIV RNA levels significantly decreased in the INSTI group,suggesting a reduction in the HIV reservoir in these participants.Conclusion:The EVG/c/FTC/TAF regimen significantly improves immune recovery,enhances the CD8^(+)T-cell functional capacity,and reduces the HIV DNA and CA HIV RNA levels in virologically suppressed individuals.展开更多
On page 185,volume 4 of Infectious Diseases&Immunity,in the article“Safety Profile of COVID-19 Vaccines in HIV Patients Undergoing ART and Their Impact on Immune Recovery and HIV Reservoirs”,[1]there is an error...On page 185,volume 4 of Infectious Diseases&Immunity,in the article“Safety Profile of COVID-19 Vaccines in HIV Patients Undergoing ART and Their Impact on Immune Recovery and HIV Reservoirs”,[1]there is an error in the Funding number listed in the Funding section.The correct funding number should be 82271857,not 8227060482.展开更多
Network structures and human behaviors are considered as two important factors in virus defense currently. However, due to ignorance of network security, normal users usually take simple activities, such as reinstalli...Network structures and human behaviors are considered as two important factors in virus defense currently. However, due to ignorance of network security, normal users usually take simple activities, such as reinstalling computer system, or using the computer recovery system to clear virus. How system recovery influences virus spreading is not taken into consideration currently. In this paper, a new virus propagation model considering the system recovery is proposed first, and then in its steady-state analysis, the virus propagation steady time and steady states are deduced. Experiment results show that models considering system recovery can effectively restrain virus propagation. Furthermore, algorithm with system recovery in BA scale-free network is proposed. Simulation result turns out that target immunization strategy with system recovery works better than traditional ones in BA network.展开更多
基金supported by the National Key R&D Program of China(2023YFC2308300)National Natural Science Foundation of China(82302510).
文摘Background:Integrase Strand Transfer Inhibitors(INSTIs)have emerged as the preferred first-line antiretroviral therapy(ART)regimen globally,primarily due to their superior efficacy and favorable safety profile.However,in China,the high cost of INSTIs and their later market introduction have resulted in relatively limited reporting on INSTI-based regimens.Specifically,there is a lack of comprehensive data regarding side effects,immunological outcomes,and virological responses among the Chinese population living with human immunodeficiency virus(HIV).Against this backdrop,this cohort study aims to evaluate the changes in T-cells,laboratory parameters,viral decay,and CD8^(+)T-cell functional capacity after switching from non-INSTI-based regimens to INSTI-based regimens in virologically suppressed individuals living with HIV.Methods:From December 2022 to May 2023,59 adults(aged 18—60 years),all of whom had received more than three years of ART and achieved sustained virological suppression(plasma HIV RNA<200 copies/mL for≥6 months),were enrolled in this study at the Fifth Medical Center of Chinese PLA General Hospital.The participants were divided into two groups according to whether they received elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide(EVG/c/FTC/TAF)—that is,whether they switched to EVG/c/FTC/TAF(the INSTI group,n=23)or maintained a non-nucleoside reverse transcriptase inhibitor(NNRTI)-or protease inhibitor(PI)-based regimen(the n-INSTI group,n=36).Clinical and laboratory evaluations(including the CD4^(+)T-cell count,CD8^(+)T-cell count,CD4:CD8 ratio,and plasma HIV RNA)were performed at both baseline and week 24.Changes in participants’HIV DNA,cell-associated(CA)HIV RNA,and CD8^(+)T-cell functional capacity(CD107a,perforin,granzyme-B,TNF-α,and IFN-γ)were assessed at baseline and weeks 2,4,8,12,and 24.Results:At week 24,the INSTI group showed a significant increase in the CD4^(+)T-cell count from 497.30±38.20 cells/µL to 594.92±51.95 cells/µL(P<0.001)and in the CD4:CD8 ratio from 0.76(0.53,1.01)to 0.85(0.57,1.27)(P=0.006),while the CD8^(+)T-cell count remained stable.The laboratory values showed improved liver function(alanine transaminase,aspartate aminotransferase)and decreased renal function(estimated Glomerular Filtration Rate,serum creatinine,blood urea nitrogen,uric acid)in the INSTI group.The CD8^(+)T-cell functional capacity,including the expression of CD107a,perforin,and granzyme-B on CD8^(+)T-cells,was significantly enhanced in the INSTI group.The HIV DNA and CA HIV RNA levels significantly decreased in the INSTI group,suggesting a reduction in the HIV reservoir in these participants.Conclusion:The EVG/c/FTC/TAF regimen significantly improves immune recovery,enhances the CD8^(+)T-cell functional capacity,and reduces the HIV DNA and CA HIV RNA levels in virologically suppressed individuals.
文摘On page 185,volume 4 of Infectious Diseases&Immunity,in the article“Safety Profile of COVID-19 Vaccines in HIV Patients Undergoing ART and Their Impact on Immune Recovery and HIV Reservoirs”,[1]there is an error in the Funding number listed in the Funding section.The correct funding number should be 82271857,not 8227060482.
基金supported by China NSF(61572222, 61272405, 61272033, 61272451, 61472121)Fundamental Research Funds for the Central Universities and the open research fund of Zhejiang Provincial Key Lab of Data StorageTransmission Technology, Hangzhou Dianzi University(No. 201301)
文摘Network structures and human behaviors are considered as two important factors in virus defense currently. However, due to ignorance of network security, normal users usually take simple activities, such as reinstalling computer system, or using the computer recovery system to clear virus. How system recovery influences virus spreading is not taken into consideration currently. In this paper, a new virus propagation model considering the system recovery is proposed first, and then in its steady-state analysis, the virus propagation steady time and steady states are deduced. Experiment results show that models considering system recovery can effectively restrain virus propagation. Furthermore, algorithm with system recovery in BA scale-free network is proposed. Simulation result turns out that target immunization strategy with system recovery works better than traditional ones in BA network.
