Confocal laser endomicroscopy(CLE)has become an indispensable tool in the diagnosis and detection of gastrointestinal(GI)diseases due to its high-resolution and high-contrast imaging capabilities.However,the early-sta...Confocal laser endomicroscopy(CLE)has become an indispensable tool in the diagnosis and detection of gastrointestinal(GI)diseases due to its high-resolution and high-contrast imaging capabilities.However,the early-stage imaging changes of gastrointestinal disorders are often subtle,and traditional medical image analysis methods rely heavily on manual interpretation,which is time-consuming,subject to observer variability,and inefficient for accurate lesion identification across large-scale image datasets.With the introduction of artificial intelligence(AI)technologies,AI-driven CLE image analysis systems can automatically extract pathological features and have demonstrated significant clinical value in lesion recognition,classification diagnosis,and malignancy prediction of GI diseases.These systems greatly enhance diagnostic efficiency and early detection capabilities.This review summarizes the applications of AI-assisted CLE in GI diseases,analyzes the limitations of current technologies,and explores future research directions.It is expected that the deep integration of AI and confocal imaging technologies will provide strong support for precision diagnosis and personalized treatment in the field of gastrointestinal disorders.展开更多
Starting from the diffraction imaging process,we have discussed the relationship between optical imaging system and fractional Fourier transform, and proposed a specific system which can form an inverse amplified imag...Starting from the diffraction imaging process,we have discussed the relationship between optical imaging system and fractional Fourier transform, and proposed a specific system which can form an inverse amplified image of input function.展开更多
BACKGROUND Conventional plain X-ray images of rats,the most common animals used as degeneration models,exhibit unclear vertebral structure and blurry intervertebral disc spaces due to their small size,slender vertebra...BACKGROUND Conventional plain X-ray images of rats,the most common animals used as degeneration models,exhibit unclear vertebral structure and blurry intervertebral disc spaces due to their small size,slender vertebral bodies.AIM To apply molybdenum target X-ray photography in the evaluation of caudal intervertebral disc(IVD)degeneration in rat models.METHODS Two types of rat caudal IVD degeneration models(needle-punctured model and endplate-destructed model)were established,and their effectiveness was verified using nuclear magnetic resonance imaging.Molybdenum target inspection and routine plain X-ray were then performed on these models.Additionally,four observers were assigned to measure the intervertebral height of degenerated segments on molybdenum target plain X-ray images and routine plain X-ray images,respectively.The degeneration was evaluated and statistical analysis was subsequently conducted.RESULTS Nine rats in the needle-punctured model and 10 rats in the endplate-destructed model were effective.Compared with routine plain X-ray images,molybdenum target plain X-ray images showed higher clarity,stronger contrast,as well as clearer and more accurate structural development.The McNemar test confirmed that the difference was statistically significant(P=0.031).In the two models,the reliability of the intervertebral height measured by the four observers on routine plain X-ray images was poor(ICC<0.4),while the data obtained from the molybdenum target plain X-ray images were more reliable.CONCLUSIONMolybdenum target inspection can obtain clearer images and display fine calcification in the imaging evaluation of caudal IVD degeneration in rats,thus ensuring a more accurate evaluation of degeneration.展开更多
The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial in...The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial intelligence(AI)-based machine learning(ML)has developed rapidly.This technique has achieved impressive results in the field of inclusion classification in process metallurgy.The present study surveys the ML modeling of inclusion prediction in advanced steels,including the detection,classification,and feature prediction of inclusions in different steel grades.Studies on clean steel with different features based on data and image analysis via ML are summarized.Regarding the data analysis,the inclusion prediction methodology based on ML establishes a connection between the experimental parameters and inclusion characteristics and analyzes the importance of the experimental parameters.Regarding the image analysis,the focus is placed on the classification of different types of inclusions via deep learning,in comparison with data analysis.Finally,further development of inclusion analyses using ML-based methods is recommended.This work paves the way for the application of AIbased methodologies for ultraclean-steel studies from a sustainable metallurgy perspective.展开更多
Underground hydrogen storage has gained interest in recent years due to the enormous demand for clean energy.Hydrogen is more diffusive than air,with a smaller density and lower viscosity.These unique properties intro...Underground hydrogen storage has gained interest in recent years due to the enormous demand for clean energy.Hydrogen is more diffusive than air,with a smaller density and lower viscosity.These unique properties introduce distinctive hydrodynamic phenomena in hydrogen storage,one of which is fingering.Fingering could induce the fluid trapped in small clusters of pores,leading to a dramatic decrease in hydrogen saturation and a lower recovery rate.In this study,numerical simulations are performed at the microscopic scale to understand the evolution of hydrogen saturation and the impacts of injection and withdrawal cycles.Two sets of micromodels with different porosity(0.362 and 0.426)and minimum sizes of pore throats(0.362 mm and 0.181 mm)are developed in the numerical model.A parameter analysis is then conducted to understand the influence of injection velocity(in the range of 10^(-2)m/s to 10^(-5)m/s)and porous structure on the fingering pattern,followed by an image analysis to capture the evolution of the fingering pattern.Viscous fingering,capillary fingering,and crossover fingering are observed and identified under different boundary conditions.The fractal dimension,specific area,mean angle,and entropy of fingers are proposed as geometric descriptors to characterize the shape of the fingering pattern.When porosity increases from 0.362 to 0.426,the saturation of hydrogen increases by 26.2%.Narrower pore throats elevate capillary resistance,which hinders fluid invasion.These results underscore the importance of pore structures and the interaction between viscous and capillary forces for hydrogen recovery efficiency.This work illuminates the influence of the pore structures and the fluid properties on the immiscible displacement of hydrogen and can be further extended to optimize the injection strategy of hydrogen in underground hydrogen storage.展开更多
Imaging evaluation of lymph node metastasis and infiltration faces problems such as low artificial outline efficiency and insufficient consistency.Deep learning technology based on convolutional neural networks has gr...Imaging evaluation of lymph node metastasis and infiltration faces problems such as low artificial outline efficiency and insufficient consistency.Deep learning technology based on convolutional neural networks has greatly improved the technical effect of radiomics in lymph node pathological characteristics analysis and efficacy monitoring through automatic lymph node detection,precise segmentation and three-dimensional reconstruction algorithms.This review focuses on the automatic lymph node segmentation model,treatment response prediction algorithm and benign and malignant differential diagnosis system for multimodal imaging,in order to provide a basis for further research on artificial intelligence to assist lymph node disease management and clinical decision-making,and provide a reference for promoting the construction of a system for accurate diagnosis,personalized treatment and prognostic evaluation of lymph node-related diseases.展开更多
Subcutaneous vein network plays important roles to maintain microcirculation that is related to some diagnostic aspects.Despite developments of optical imaging technologies,still the difficulties about deep skin vascu...Subcutaneous vein network plays important roles to maintain microcirculation that is related to some diagnostic aspects.Despite developments of optical imaging technologies,still the difficulties about deep skin vascular imaging have been continued.On the other hand,since hemoglobin con-centration of human blood has key role in the veins imaging by optical manner,the used wavelength in vascular imaging,must be chosen considering absorption of hemoglobin.In this research,we constructed a near infrared(NIR)light source because of lower absorption of hemoglobin in this optical region.To obtain vascular image,reflectance geometry was used.Next,from recorded images,vascular network analysis,such as calculation of width of vascular of interest and complexity of selected region were implemented.By comparing with other modalities,we observed that proposed imaging system has great advantages including nonionized radiation,moderate penetration depth of 0.5-3 mm and diameter of 1 mm,cost-effective and algorit hmic simplicity for analysis.展开更多
Integrating multiple medical imaging techniques,including Magnetic Resonance Imaging(MRI),Computed Tomography,Positron Emission Tomography(PET),and ultrasound,provides a comprehensive view of the patient health status...Integrating multiple medical imaging techniques,including Magnetic Resonance Imaging(MRI),Computed Tomography,Positron Emission Tomography(PET),and ultrasound,provides a comprehensive view of the patient health status.Each of these methods contributes unique diagnostic insights,enhancing the overall assessment of patient condition.Nevertheless,the amalgamation of data from multiple modalities presents difficulties due to disparities in resolution,data collection methods,and noise levels.While traditional models like Convolutional Neural Networks(CNNs)excel in single-modality tasks,they struggle to handle multi-modal complexities,lacking the capacity to model global relationships.This research presents a novel approach for examining multi-modal medical imagery using a transformer-based system.The framework employs self-attention and cross-attention mechanisms to synchronize and integrate features across various modalities.Additionally,it shows resilience to variations in noise and image quality,making it adaptable for real-time clinical use.To address the computational hurdles linked to transformer models,particularly in real-time clinical applications in resource-constrained environments,several optimization techniques have been integrated to boost scalability and efficiency.Initially,a streamlined transformer architecture was adopted to minimize the computational load while maintaining model effectiveness.Methods such as model pruning,quantization,and knowledge distillation have been applied to reduce the parameter count and enhance the inference speed.Furthermore,efficient attention mechanisms such as linear or sparse attention were employed to alleviate the substantial memory and processing requirements of traditional self-attention operations.For further deployment optimization,researchers have implemented hardware-aware acceleration strategies,including the use of TensorRT and ONNX-based model compression,to ensure efficient execution on edge devices.These optimizations allow the approach to function effectively in real-time clinical settings,ensuring viability even in environments with limited resources.Future research directions include integrating non-imaging data to facilitate personalized treatment and enhancing computational efficiency for implementation in resource-limited environments.This study highlights the transformative potential of transformer models in multi-modal medical imaging,offering improvements in diagnostic accuracy and patient care outcomes.展开更多
Artificial intelligence(AI),particularly deep learning algorithms utilizing convolutional neural networks,plays an increasingly pivotal role in enhancing medical image examination.It demonstrates the potential for imp...Artificial intelligence(AI),particularly deep learning algorithms utilizing convolutional neural networks,plays an increasingly pivotal role in enhancing medical image examination.It demonstrates the potential for improving diagnostic accuracy within dental care.Orthopantomograms(OPGs)are essential in dentistry;however,their manual interpretation is often inconsistent and tedious.To the best of our knowledge,this is the first comprehensive application of YOLOv5m for the simultaneous detection and classification of six distinct dental pathologies using panoramic OPG images.The model was trained and refined on a custom dataset that began with 232 panoramic radiographs and was later expanded to 604 samples.These included annotated subclasses representing Caries,Infection,Impacted Teeth,Fractured Teeth,Broken Crowns,and Healthy conditions.The training was performed using GPU resources alongside tuned hyperparameters of batch size,learning rate schedule,and early stopping tailored for generalization to prevent overfitting.Evaluation on a held-out test set showed strong performance in the detection and localization of various dental pathologies and robust overall accuracy.At an IoU of 0.5,the system obtained a mean precision of 94.22%and recall of 90.42%,with mAP being 93.71%.This research confirms the use of YOLOv5m as a robust,highly efficient AI technology for the analysis of dental pathologies using OPGs,providing a clinically useful solution to enhance workflow efficiency and aid in sustaining consistency in complex multi-dimensional case evaluations.展开更多
BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM ...BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM To leverage machine learning to capture imaging features of congestive hepatopathy using incidentally acquired computed tomography(CT)scans.METHODS We retrospectively analyzed 179 chronic HF patients who underwent echocardiography and CT within one year.Right HF severity was classified into three grades.Liver CT images at the paraumbilical vein level were used to develop a ResNet-based machine learning model to predict tricuspid regurgitation(TR)severity.Model accuracy was compared with that of six gastroenterology and four radiology experts.RESULTS In the included patients,120 were male(mean age:73.1±14.4 years).The accuracy of the results predicting TR severity from a single CT image for the machine learning model was significantly higher than the average accuracy of the experts.The model was found to be exceptionally reliable for predicting severe TR.CONCLUSION Deep learning models,particularly those using ResNet architectures,can help identify morphological changes associated with TR severity,aiding in early liver dysfunction detection in patients with HF,thereby improving outcomes.展开更多
Background:Accurate classification of normal blood cells is a critical foundation for automated hematological analysis,including the detection of pathological conditions like leukemia.While convolutional neural networ...Background:Accurate classification of normal blood cells is a critical foundation for automated hematological analysis,including the detection of pathological conditions like leukemia.While convolutional neural networks(CNNs)excel in local feature extraction,their ability to capture global contextual relationships in complex cellular morphologies is limited.This study introduces a hybrid CNN-Transformer framework to enhance normal blood cell classification,laying the groundwork for future leukemia diagnostics.Methods:The proposed architecture integrates pre-trained CNNs(ResNet50,EfficientNetB3,InceptionV3,CustomCNN)with Vision Transformer(ViT)layers to combine local and global feature modeling.Four hybrid models were evaluated on the publicly available Blood Cell Images dataset from Kaggle,comprising 17,092 annotated normal blood cell images across eight classes.The models were trained using transfer learning,fine-tuning,and computational optimizations,including cross-model parameter sharing to reduce redundancy by reusing weights across CNN backbones and attention-guided layer pruning to eliminate low-contribution layers based on attention scores,improving efficiency without sacrificing accuracy.Results:The InceptionV3-ViT model achieved a weighted accuracy of 97.66%(accounting for class imbalance by weighting each class’s contribution),a macro F1-score of 0.98,and a ROC-AUC of 0.998.The framework excelled in distinguishing morphologically similar cell types demonstrating robustness and reliable calibration(ECE of 0.019).The framework addresses generalization challenges,including class imbalance and morphological similarities,ensuring robust performance across diverse cell types.Conclusion:The hybrid CNN-Transformer framework significantly improves normal blood cell classification by capturing multi-scale features and long-range dependencies.Its high accuracy,efficiency,and generalization position it as a strong baseline for automated hematological analysis,with potential for extension to leukemia subtype classification through future validation on pathological samples.展开更多
Optimizing root system architecture(RSA)is essential for plants because of its critical role in acquiring water and nutrients from the soil.However,the subterranean nature of roots complicates the measurement of RSA t...Optimizing root system architecture(RSA)is essential for plants because of its critical role in acquiring water and nutrients from the soil.However,the subterranean nature of roots complicates the measurement of RSA traits.Recently developed rhizobox methods allow for the rapid acquisition of root images.Nevertheless,effective and precise approaches for extracting RSA features from these images remain underdeveloped.Deep learning(DL)technology can enhance image segmentation and facilitate RSA trait extraction.However,comprehensive pipelines that integrate DL technologies into image-based root phenotyping techniques are still scarce,hampering their implementation.To address this challenge,we present a reproducible pipeline(faCRSA)for automated RSA traits analysis,consisting of three modules:(1)the RSA traits extraction module functions to segment soil-root images and calculate RSA traits.A lightweight convolutional neural network(CNN)named RootSeg was proposed for efficient and accurate segmentation;(2)the data storage module,which stores image and text data from other modules;and(3)the web application module,which allows researchers to analyze data online in a user-friendly manner.The correlation coefficients(R^(2))of total root length,root surface area,and root volume calculated from faCRSA and manually measured results were 0.96**,0.97**,and 0.93**,respectively,with root mean square errors(RMSE)of 8.13 cm,1.68 cm^(2),and 0.05 cm^(3),processed at a rate of 9.74 s per image,indicating satisfying accuracy.faCRSA has also demonstrated satisfactory performance in dynamically monitoring root system changes under various stress conditions,such as drought or waterlogging.The detailed code and deployable package of faCRSA are provided for researchers with the potential to replace manual and semi-automated methods.展开更多
Robust stereo disparity estimation plays a critical role in minimally invasive surgery,where dynamic soft tissues,specular reflections,and data scarcity pose major challenges to traditional end-to-end deep learning an...Robust stereo disparity estimation plays a critical role in minimally invasive surgery,where dynamic soft tissues,specular reflections,and data scarcity pose major challenges to traditional end-to-end deep learning and deformable model-based methods.In this paper,we propose a novel disparity estimation framework that leverages a pretrained StyleGAN generator to represent the disparity manifold of Minimally Invasive Surgery(MIS)scenes and reformulates the stereo matching task as a latent-space optimization problem.Specifically,given a stereo pair,we search for the optimal latent vector in the intermediate latent space of StyleGAN,such that the photometric reconstruction loss between the stereo images is minimized while regularizing the latent code to remain within the generator’s high-confidence region.Unlike existing encoder-based embedding methods,our approach directly exploits the geometry of the learned latent space and enforces both photometric consistency and manifold prior during inference,without the need for additional training or supervision.Extensive experiments on stereo-endoscopic videos demonstrate that our method achieves high-fidelity and robust disparity estimation across varying lighting,occlusion,and tissue dynamics,outperforming Thin Plate Spline(TPS)-based and linear representation baselines.This work bridges generative modeling and 3D perception by enabling efficient,training-free disparity recovery from pre-trained generative models with reduced inference latency.展开更多
Medical image analysis has become a cornerstone of modern healthcare,driven by the exponential growth of data from imaging modalities such as MRI,CT,PET,ultrasound,and X-ray.Traditional machine learning methods have m...Medical image analysis has become a cornerstone of modern healthcare,driven by the exponential growth of data from imaging modalities such as MRI,CT,PET,ultrasound,and X-ray.Traditional machine learning methods have made early contributions;however,recent advancements in deep learning(DL)have revolutionized the field,offering state-of-the-art performance in image classification,segmentation,detection,fusion,registration,and enhancement.This comprehensive review presents an in-depth analysis of deep learning methodologies applied across medical image analysis tasks,highlighting both foundational models and recent innovations.The article begins by introducing conventional techniques and their limitations,setting the stage for DL-based solutions.Core DL architectures,including Convolutional Neural Networks(CNNs),Recurrent Neural Networks(RNNs),Generative Adversarial Networks(GANs),Vision Transformers(ViTs),and hybrid models,are discussed in detail,including their advantages and domain-specific adaptations.Advanced learning paradigms such as semi-supervised learning,selfsupervised learning,and few-shot learning are explored for their potential to mitigate data annotation challenges in clinical datasets.This review further categorizes major tasks in medical image analysis,elaborating on how DL techniques have enabled precise tumor segmentation,lesion detection,modality fusion,super-resolution,and robust classification across diverse clinical settings.Emphasis is placed on applications in oncology,cardiology,neurology,and infectious diseases,including COVID-19.Challenges such as data scarcity,label imbalance,model generalizability,interpretability,and integration into clinical workflows are critically examined.Ethical considerations,explainable AI(XAI),federated learning,and regulatory compliance are discussed as essential components of real-world deployment.Benchmark datasets,evaluation metrics,and comparative performance analyses are presented to support future research.The article concludes with a forward-looking perspective on the role of foundation models,multimodal learning,edge AI,and bio-inspired computing in the future of medical imaging.Overall,this review serves as a valuable resource for researchers,clinicians,and developers aiming to harness deep learning for intelligent,efficient,and clinically viable medical image analysis.展开更多
Deep learning models have become a core technological tool in the field of medical image analysis.However,these models often suffer from a lack of transparency in their decision-making processes,leading to challenges ...Deep learning models have become a core technological tool in the field of medical image analysis.However,these models often suffer from a lack of transparency in their decision-making processes,leading to challenges related to trust and interpret ability in clinical applications.To address this issue,explainable artificial intelligence(XAI)techniques have been applied to medical image analysis.While showing promising potential,XAI also brings significant ethical risks in practice—most notably,the problem of spurious explanations.Such explanations may rise further concerns regarding patient privacy,data security,and the attribution of decisionmaking authority in medical contexts.This paper analyzes the application of XAI methods—particularly saliency aps—in medical image interpretation,identifies the underlying causes of spurious explanations,and proposes possible mitigation strategies.The aim is to contribute to the responsible and sustainable integration of explainable AI into clinical practice.展开更多
Given the importance of sentiment analysis in diverse environments,various methods are used for image sentiment analysis,including contextual sentiment analysis that utilizes character and scene relationships.However,...Given the importance of sentiment analysis in diverse environments,various methods are used for image sentiment analysis,including contextual sentiment analysis that utilizes character and scene relationships.However,most existing works employ character faces in conjunction with context,yet lack the capacity to analyze the emotions of characters in unconstrained environments,such as when their faces are obscured or blurred.Accordingly,this article presents the Adaptive Multi-Channel Sentiment Analysis Network(AMSA),a contextual image sentiment analysis framework,which consists of three channels:body,face,and context.AMSA employs Multi-task Cascaded Convolutional Networks(MTCNN)to detect faces within body frames;if detected,facial features are extracted and fused with body and context information for emotion recognition.If not,the model leverages body and context features alone.Meanwhile,to address class imbalance in the EMOTIC dataset,Focal Loss is introduced to improve classification performance,especially for minority emotion categories.Experimental results have shown that certain sentiment categories with lower representation in the dataset demonstrate leading classification accuracy,the AMSA yields a 2.53%increase compared with state-of-the-art methods.展开更多
Methods and procedures of three-dimensional （3D） characterization of the pore structure features in the packed ore particle bed are focused. X-ray computed tomography was applied to deriving the cross-sectional imag...Methods and procedures of three-dimensional （3D） characterization of the pore structure features in the packed ore particle bed are focused. X-ray computed tomography was applied to deriving the cross-sectional images of specimens with single particle size of 1-2, 2-3, 3-4, 4-5, 5-6, 6-7, 7-8, 8-9, 9-10 ram. Based on the in-house developed 3D image analysis programs using Matlab, the volume porosity, pore size distribution and degree of connectivity were calculated and analyzed in detail. The results indicate that the volume porosity, the mean diameter of pores and the effective pore size （d50） increase with the increasing of particle size. Lognormal distribution or Gauss distribution is mostly suitable to model the pore size distribution. The degree of connectivity investigated on the basis of cluster-labeling algorithm also increases with increasing the particle size approximately.展开更多
It is critical to establish a direct and precise method with a high sensitivity and selectivity in analytical chemistry. In this research, making use of a well known phenomenon of capillary flow, we have proposed an...It is critical to establish a direct and precise method with a high sensitivity and selectivity in analytical chemistry. In this research, making use of a well known phenomenon of capillary flow, we have proposed an image analysis method of nucleic acids at the price of a small amount of sample. When a droplet of the supramolecular complex solution, formed by neutral red and nucleic acids(NA) under an approximate neutral condition, was placed on the hydrophobic surface of dimethyl dichlorosilane pretreated glass slides, and it was evaporated, the supramolecular complex exhibited the periphery of the droplet due to the capillary effect, and accumulated there to form a red capillary flow directed assembly ring(CFDAR). A typical CFDAR has an outer diameter of (2 r ) about 1.18 mm and a ring width(2 δ ) of about 41 μm. Depending on the experimental conditions, a variety of CFDAR can be assembled. The experimental results are in agreement with our former theoretical discussion. It was found that when a droplet volume is 0.1 μL, the fluorescence intensity of the CFDAR formed by the NR NA is in proportion to the content of calf thymus DNA in the range of 0-0.28 ng, fish sperm DNA of 0-0.24 ng and yeast RNA of 0-0.16 ng with the limit of detection(3 σ ) of 1 7, 1.4 and 0.9 pg, respectively for the three nucleic acids.展开更多
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological me...Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological mechanisms,preventing and treating cerebral small vessel vasculopathy is challenging.Recent studies have shown that the glymphatic system plays a crucial role in interstitial solute clearance and the maintenance of brain homeostasis.Increasing evidence also suggests that dysfunction in glymphatic clearance is a key factor in the progression of cerebral small vessel disease.This review begins with a comprehensive introduction to the structure,function,and driving factors of the glymphatic system,highlighting its essential role in brain waste clearance.Afterwards,cerebral small vessel disease was reviewed from the perspective of the glymphatic system,after which the mechanisms underlying their correlation were summarized.Glymphatic dysfunction may lead to the accumulation of metabolic waste in the brain,thereby exacerbating the pathological processes associated with cerebral small vessel disease.The review also discussed the direct evidence of glymphatic dysfunction in patients and animal models exhibiting two subtypes of cerebral small vessel disease:arteriolosclerosis-related cerebral small vessel disease and amyloid-related cerebral small vessel disease.Diffusion tensor image analysis along the perivascular space is an important non-invasive tool for assessing the clearance function of the glymphatic system.However,the effectiveness of its parameters needs to be enhanced.Among various nervous system diseases,including cerebral small vessel disease,glymphatic failure may be a common final pathway toward dementia.Overall,this review summarizes prevention and treatment strategies that target glymphatic drainage and will offer valuable insight for developing novel treatments for cerebral small vessel disease.展开更多
基金Supported by Interdisciplinary Program of Shanghai Jiao Tong University,No.YG2024 LC01National Natural Science Foundation of China,No.62406190.
文摘Confocal laser endomicroscopy(CLE)has become an indispensable tool in the diagnosis and detection of gastrointestinal(GI)diseases due to its high-resolution and high-contrast imaging capabilities.However,the early-stage imaging changes of gastrointestinal disorders are often subtle,and traditional medical image analysis methods rely heavily on manual interpretation,which is time-consuming,subject to observer variability,and inefficient for accurate lesion identification across large-scale image datasets.With the introduction of artificial intelligence(AI)technologies,AI-driven CLE image analysis systems can automatically extract pathological features and have demonstrated significant clinical value in lesion recognition,classification diagnosis,and malignancy prediction of GI diseases.These systems greatly enhance diagnostic efficiency and early detection capabilities.This review summarizes the applications of AI-assisted CLE in GI diseases,analyzes the limitations of current technologies,and explores future research directions.It is expected that the deep integration of AI and confocal imaging technologies will provide strong support for precision diagnosis and personalized treatment in the field of gastrointestinal disorders.
文摘Starting from the diffraction imaging process,we have discussed the relationship between optical imaging system and fractional Fourier transform, and proposed a specific system which can form an inverse amplified image of input function.
基金Supported by the National Key Research and Development Program of China,No.2017YFA0105404。
文摘BACKGROUND Conventional plain X-ray images of rats,the most common animals used as degeneration models,exhibit unclear vertebral structure and blurry intervertebral disc spaces due to their small size,slender vertebral bodies.AIM To apply molybdenum target X-ray photography in the evaluation of caudal intervertebral disc(IVD)degeneration in rat models.METHODS Two types of rat caudal IVD degeneration models(needle-punctured model and endplate-destructed model)were established,and their effectiveness was verified using nuclear magnetic resonance imaging.Molybdenum target inspection and routine plain X-ray were then performed on these models.Additionally,four observers were assigned to measure the intervertebral height of degenerated segments on molybdenum target plain X-ray images and routine plain X-ray images,respectively.The degeneration was evaluated and statistical analysis was subsequently conducted.RESULTS Nine rats in the needle-punctured model and 10 rats in the endplate-destructed model were effective.Compared with routine plain X-ray images,molybdenum target plain X-ray images showed higher clarity,stronger contrast,as well as clearer and more accurate structural development.The McNemar test confirmed that the difference was statistically significant(P=0.031).In the two models,the reliability of the intervertebral height measured by the four observers on routine plain X-ray images was poor(ICC<0.4),while the data obtained from the molybdenum target plain X-ray images were more reliable.CONCLUSIONMolybdenum target inspection can obtain clearer images and display fine calcification in the imaging evaluation of caudal IVD degeneration in rats,thus ensuring a more accurate evaluation of degeneration.
基金support from the National Key Research and Development Program of China(No.2024YFB3713705)is acknowledgedWangzhong Mu would like to acknowledge the Strategic Mobility,Sweden(SSF,No.SM22-0039)+1 种基金the Swedish Foundation for International Cooperation in Research and Higher Education(STINT,No.IB2022-9228)the Jernkontoret(Sweden)for supporting this clean steel research.Gonghao Lian would like to acknowledge China Scholarship Council(CSC,No.202306080032).
文摘The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial intelligence(AI)-based machine learning(ML)has developed rapidly.This technique has achieved impressive results in the field of inclusion classification in process metallurgy.The present study surveys the ML modeling of inclusion prediction in advanced steels,including the detection,classification,and feature prediction of inclusions in different steel grades.Studies on clean steel with different features based on data and image analysis via ML are summarized.Regarding the data analysis,the inclusion prediction methodology based on ML establishes a connection between the experimental parameters and inclusion characteristics and analyzes the importance of the experimental parameters.Regarding the image analysis,the focus is placed on the classification of different types of inclusions via deep learning,in comparison with data analysis.Finally,further development of inclusion analyses using ML-based methods is recommended.This work paves the way for the application of AIbased methodologies for ultraclean-steel studies from a sustainable metallurgy perspective.
基金supported by the National Key Research and Development Project(Grant No.2023YFE0110900)the National Natural Science Foundation of China(Grant Nos.42320104003,42477168).
文摘Underground hydrogen storage has gained interest in recent years due to the enormous demand for clean energy.Hydrogen is more diffusive than air,with a smaller density and lower viscosity.These unique properties introduce distinctive hydrodynamic phenomena in hydrogen storage,one of which is fingering.Fingering could induce the fluid trapped in small clusters of pores,leading to a dramatic decrease in hydrogen saturation and a lower recovery rate.In this study,numerical simulations are performed at the microscopic scale to understand the evolution of hydrogen saturation and the impacts of injection and withdrawal cycles.Two sets of micromodels with different porosity(0.362 and 0.426)and minimum sizes of pore throats(0.362 mm and 0.181 mm)are developed in the numerical model.A parameter analysis is then conducted to understand the influence of injection velocity(in the range of 10^(-2)m/s to 10^(-5)m/s)and porous structure on the fingering pattern,followed by an image analysis to capture the evolution of the fingering pattern.Viscous fingering,capillary fingering,and crossover fingering are observed and identified under different boundary conditions.The fractal dimension,specific area,mean angle,and entropy of fingers are proposed as geometric descriptors to characterize the shape of the fingering pattern.When porosity increases from 0.362 to 0.426,the saturation of hydrogen increases by 26.2%.Narrower pore throats elevate capillary resistance,which hinders fluid invasion.These results underscore the importance of pore structures and the interaction between viscous and capillary forces for hydrogen recovery efficiency.This work illuminates the influence of the pore structures and the fluid properties on the immiscible displacement of hydrogen and can be further extended to optimize the injection strategy of hydrogen in underground hydrogen storage.
基金Supported by Clinical Trials from the Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,No.2021-LCYJ-MS-11Nanjing Drum Tower Hospital National Natural Science Foundation Youth Cultivation Project,No.2024-JCYJQP-15.
文摘Imaging evaluation of lymph node metastasis and infiltration faces problems such as low artificial outline efficiency and insufficient consistency.Deep learning technology based on convolutional neural networks has greatly improved the technical effect of radiomics in lymph node pathological characteristics analysis and efficacy monitoring through automatic lymph node detection,precise segmentation and three-dimensional reconstruction algorithms.This review focuses on the automatic lymph node segmentation model,treatment response prediction algorithm and benign and malignant differential diagnosis system for multimodal imaging,in order to provide a basis for further research on artificial intelligence to assist lymph node disease management and clinical decision-making,and provide a reference for promoting the construction of a system for accurate diagnosis,personalized treatment and prognostic evaluation of lymph node-related diseases.
基金Scientic and Technological Research Council of Turkey(TUBITAK),under grand,No:113E771.
文摘Subcutaneous vein network plays important roles to maintain microcirculation that is related to some diagnostic aspects.Despite developments of optical imaging technologies,still the difficulties about deep skin vascular imaging have been continued.On the other hand,since hemoglobin con-centration of human blood has key role in the veins imaging by optical manner,the used wavelength in vascular imaging,must be chosen considering absorption of hemoglobin.In this research,we constructed a near infrared(NIR)light source because of lower absorption of hemoglobin in this optical region.To obtain vascular image,reflectance geometry was used.Next,from recorded images,vascular network analysis,such as calculation of width of vascular of interest and complexity of selected region were implemented.By comparing with other modalities,we observed that proposed imaging system has great advantages including nonionized radiation,moderate penetration depth of 0.5-3 mm and diameter of 1 mm,cost-effective and algorit hmic simplicity for analysis.
基金supported by the Deanship of Research and Graduate Studies at King Khalid University under Small Research Project grant number RGP1/139/45.
文摘Integrating multiple medical imaging techniques,including Magnetic Resonance Imaging(MRI),Computed Tomography,Positron Emission Tomography(PET),and ultrasound,provides a comprehensive view of the patient health status.Each of these methods contributes unique diagnostic insights,enhancing the overall assessment of patient condition.Nevertheless,the amalgamation of data from multiple modalities presents difficulties due to disparities in resolution,data collection methods,and noise levels.While traditional models like Convolutional Neural Networks(CNNs)excel in single-modality tasks,they struggle to handle multi-modal complexities,lacking the capacity to model global relationships.This research presents a novel approach for examining multi-modal medical imagery using a transformer-based system.The framework employs self-attention and cross-attention mechanisms to synchronize and integrate features across various modalities.Additionally,it shows resilience to variations in noise and image quality,making it adaptable for real-time clinical use.To address the computational hurdles linked to transformer models,particularly in real-time clinical applications in resource-constrained environments,several optimization techniques have been integrated to boost scalability and efficiency.Initially,a streamlined transformer architecture was adopted to minimize the computational load while maintaining model effectiveness.Methods such as model pruning,quantization,and knowledge distillation have been applied to reduce the parameter count and enhance the inference speed.Furthermore,efficient attention mechanisms such as linear or sparse attention were employed to alleviate the substantial memory and processing requirements of traditional self-attention operations.For further deployment optimization,researchers have implemented hardware-aware acceleration strategies,including the use of TensorRT and ONNX-based model compression,to ensure efficient execution on edge devices.These optimizations allow the approach to function effectively in real-time clinical settings,ensuring viability even in environments with limited resources.Future research directions include integrating non-imaging data to facilitate personalized treatment and enhancing computational efficiency for implementation in resource-limited environments.This study highlights the transformative potential of transformer models in multi-modal medical imaging,offering improvements in diagnostic accuracy and patient care outcomes.
基金funding from the Princess Nourah bint Abdulrahman University Researchers Supporting Project(PNURSP2025R195)the University of Bisha through its Fast-Track Research Support Program.
文摘Artificial intelligence(AI),particularly deep learning algorithms utilizing convolutional neural networks,plays an increasingly pivotal role in enhancing medical image examination.It demonstrates the potential for improving diagnostic accuracy within dental care.Orthopantomograms(OPGs)are essential in dentistry;however,their manual interpretation is often inconsistent and tedious.To the best of our knowledge,this is the first comprehensive application of YOLOv5m for the simultaneous detection and classification of six distinct dental pathologies using panoramic OPG images.The model was trained and refined on a custom dataset that began with 232 panoramic radiographs and was later expanded to 604 samples.These included annotated subclasses representing Caries,Infection,Impacted Teeth,Fractured Teeth,Broken Crowns,and Healthy conditions.The training was performed using GPU resources alongside tuned hyperparameters of batch size,learning rate schedule,and early stopping tailored for generalization to prevent overfitting.Evaluation on a held-out test set showed strong performance in the detection and localization of various dental pathologies and robust overall accuracy.At an IoU of 0.5,the system obtained a mean precision of 94.22%and recall of 90.42%,with mAP being 93.71%.This research confirms the use of YOLOv5m as a robust,highly efficient AI technology for the analysis of dental pathologies using OPGs,providing a clinically useful solution to enhance workflow efficiency and aid in sustaining consistency in complex multi-dimensional case evaluations.
基金Supported by Grant-in-Aid for Research on Hepatitis from the Japan Agency for Medical Research and Development,No.24fk0210128h0002Grant-in-Aid for Scientific Research,No.KAKENHI-23K07372.
文摘BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM To leverage machine learning to capture imaging features of congestive hepatopathy using incidentally acquired computed tomography(CT)scans.METHODS We retrospectively analyzed 179 chronic HF patients who underwent echocardiography and CT within one year.Right HF severity was classified into three grades.Liver CT images at the paraumbilical vein level were used to develop a ResNet-based machine learning model to predict tricuspid regurgitation(TR)severity.Model accuracy was compared with that of six gastroenterology and four radiology experts.RESULTS In the included patients,120 were male(mean age:73.1±14.4 years).The accuracy of the results predicting TR severity from a single CT image for the machine learning model was significantly higher than the average accuracy of the experts.The model was found to be exceptionally reliable for predicting severe TR.CONCLUSION Deep learning models,particularly those using ResNet architectures,can help identify morphological changes associated with TR severity,aiding in early liver dysfunction detection in patients with HF,thereby improving outcomes.
基金the Deanship of Graduate Studies and Scientific Research at Najran University,Saudi Arabia,for their financial support through the Easy Track Research program,grant code(NU/EFP/MRC/13).
文摘Background:Accurate classification of normal blood cells is a critical foundation for automated hematological analysis,including the detection of pathological conditions like leukemia.While convolutional neural networks(CNNs)excel in local feature extraction,their ability to capture global contextual relationships in complex cellular morphologies is limited.This study introduces a hybrid CNN-Transformer framework to enhance normal blood cell classification,laying the groundwork for future leukemia diagnostics.Methods:The proposed architecture integrates pre-trained CNNs(ResNet50,EfficientNetB3,InceptionV3,CustomCNN)with Vision Transformer(ViT)layers to combine local and global feature modeling.Four hybrid models were evaluated on the publicly available Blood Cell Images dataset from Kaggle,comprising 17,092 annotated normal blood cell images across eight classes.The models were trained using transfer learning,fine-tuning,and computational optimizations,including cross-model parameter sharing to reduce redundancy by reusing weights across CNN backbones and attention-guided layer pruning to eliminate low-contribution layers based on attention scores,improving efficiency without sacrificing accuracy.Results:The InceptionV3-ViT model achieved a weighted accuracy of 97.66%(accounting for class imbalance by weighting each class’s contribution),a macro F1-score of 0.98,and a ROC-AUC of 0.998.The framework excelled in distinguishing morphologically similar cell types demonstrating robustness and reliable calibration(ECE of 0.019).The framework addresses generalization challenges,including class imbalance and morphological similarities,ensuring robust performance across diverse cell types.Conclusion:The hybrid CNN-Transformer framework significantly improves normal blood cell classification by capturing multi-scale features and long-range dependencies.Its high accuracy,efficiency,and generalization position it as a strong baseline for automated hematological analysis,with potential for extension to leukemia subtype classification through future validation on pathological samples.
基金supported by the projects of the National Key Research and Development Program of China(2024YFD2301305)Jiangsu Innovation Support Program for International Science and Technology Cooperation Project(BZ2023049)+2 种基金the projects of the National Natural Science Foundation of China(32272213)the China Agriculture Research System(CARS-03)Jiangsu Collaborative Innovation Center for Modern Crop Production(JCIC-MCP).
文摘Optimizing root system architecture(RSA)is essential for plants because of its critical role in acquiring water and nutrients from the soil.However,the subterranean nature of roots complicates the measurement of RSA traits.Recently developed rhizobox methods allow for the rapid acquisition of root images.Nevertheless,effective and precise approaches for extracting RSA features from these images remain underdeveloped.Deep learning(DL)technology can enhance image segmentation and facilitate RSA trait extraction.However,comprehensive pipelines that integrate DL technologies into image-based root phenotyping techniques are still scarce,hampering their implementation.To address this challenge,we present a reproducible pipeline(faCRSA)for automated RSA traits analysis,consisting of three modules:(1)the RSA traits extraction module functions to segment soil-root images and calculate RSA traits.A lightweight convolutional neural network(CNN)named RootSeg was proposed for efficient and accurate segmentation;(2)the data storage module,which stores image and text data from other modules;and(3)the web application module,which allows researchers to analyze data online in a user-friendly manner.The correlation coefficients(R^(2))of total root length,root surface area,and root volume calculated from faCRSA and manually measured results were 0.96**,0.97**,and 0.93**,respectively,with root mean square errors(RMSE)of 8.13 cm,1.68 cm^(2),and 0.05 cm^(3),processed at a rate of 9.74 s per image,indicating satisfying accuracy.faCRSA has also demonstrated satisfactory performance in dynamically monitoring root system changes under various stress conditions,such as drought or waterlogging.The detailed code and deployable package of faCRSA are provided for researchers with the potential to replace manual and semi-automated methods.
基金Support by Sichuan Science and Technology Program[2023YFSY0026,2023YFH0004]Guangzhou Huashang University[2024HSZD01].
文摘Robust stereo disparity estimation plays a critical role in minimally invasive surgery,where dynamic soft tissues,specular reflections,and data scarcity pose major challenges to traditional end-to-end deep learning and deformable model-based methods.In this paper,we propose a novel disparity estimation framework that leverages a pretrained StyleGAN generator to represent the disparity manifold of Minimally Invasive Surgery(MIS)scenes and reformulates the stereo matching task as a latent-space optimization problem.Specifically,given a stereo pair,we search for the optimal latent vector in the intermediate latent space of StyleGAN,such that the photometric reconstruction loss between the stereo images is minimized while regularizing the latent code to remain within the generator’s high-confidence region.Unlike existing encoder-based embedding methods,our approach directly exploits the geometry of the learned latent space and enforces both photometric consistency and manifold prior during inference,without the need for additional training or supervision.Extensive experiments on stereo-endoscopic videos demonstrate that our method achieves high-fidelity and robust disparity estimation across varying lighting,occlusion,and tissue dynamics,outperforming Thin Plate Spline(TPS)-based and linear representation baselines.This work bridges generative modeling and 3D perception by enabling efficient,training-free disparity recovery from pre-trained generative models with reduced inference latency.
文摘Medical image analysis has become a cornerstone of modern healthcare,driven by the exponential growth of data from imaging modalities such as MRI,CT,PET,ultrasound,and X-ray.Traditional machine learning methods have made early contributions;however,recent advancements in deep learning(DL)have revolutionized the field,offering state-of-the-art performance in image classification,segmentation,detection,fusion,registration,and enhancement.This comprehensive review presents an in-depth analysis of deep learning methodologies applied across medical image analysis tasks,highlighting both foundational models and recent innovations.The article begins by introducing conventional techniques and their limitations,setting the stage for DL-based solutions.Core DL architectures,including Convolutional Neural Networks(CNNs),Recurrent Neural Networks(RNNs),Generative Adversarial Networks(GANs),Vision Transformers(ViTs),and hybrid models,are discussed in detail,including their advantages and domain-specific adaptations.Advanced learning paradigms such as semi-supervised learning,selfsupervised learning,and few-shot learning are explored for their potential to mitigate data annotation challenges in clinical datasets.This review further categorizes major tasks in medical image analysis,elaborating on how DL techniques have enabled precise tumor segmentation,lesion detection,modality fusion,super-resolution,and robust classification across diverse clinical settings.Emphasis is placed on applications in oncology,cardiology,neurology,and infectious diseases,including COVID-19.Challenges such as data scarcity,label imbalance,model generalizability,interpretability,and integration into clinical workflows are critically examined.Ethical considerations,explainable AI(XAI),federated learning,and regulatory compliance are discussed as essential components of real-world deployment.Benchmark datasets,evaluation metrics,and comparative performance analyses are presented to support future research.The article concludes with a forward-looking perspective on the role of foundation models,multimodal learning,edge AI,and bio-inspired computing in the future of medical imaging.Overall,this review serves as a valuable resource for researchers,clinicians,and developers aiming to harness deep learning for intelligent,efficient,and clinically viable medical image analysis.
文摘Deep learning models have become a core technological tool in the field of medical image analysis.However,these models often suffer from a lack of transparency in their decision-making processes,leading to challenges related to trust and interpret ability in clinical applications.To address this issue,explainable artificial intelligence(XAI)techniques have been applied to medical image analysis.While showing promising potential,XAI also brings significant ethical risks in practice—most notably,the problem of spurious explanations.Such explanations may rise further concerns regarding patient privacy,data security,and the attribution of decisionmaking authority in medical contexts.This paper analyzes the application of XAI methods—particularly saliency aps—in medical image interpretation,identifies the underlying causes of spurious explanations,and proposes possible mitigation strategies.The aim is to contribute to the responsible and sustainable integration of explainable AI into clinical practice.
文摘Given the importance of sentiment analysis in diverse environments,various methods are used for image sentiment analysis,including contextual sentiment analysis that utilizes character and scene relationships.However,most existing works employ character faces in conjunction with context,yet lack the capacity to analyze the emotions of characters in unconstrained environments,such as when their faces are obscured or blurred.Accordingly,this article presents the Adaptive Multi-Channel Sentiment Analysis Network(AMSA),a contextual image sentiment analysis framework,which consists of three channels:body,face,and context.AMSA employs Multi-task Cascaded Convolutional Networks(MTCNN)to detect faces within body frames;if detected,facial features are extracted and fused with body and context information for emotion recognition.If not,the model leverages body and context features alone.Meanwhile,to address class imbalance in the EMOTIC dataset,Focal Loss is introduced to improve classification performance,especially for minority emotion categories.Experimental results have shown that certain sentiment categories with lower representation in the dataset demonstrate leading classification accuracy,the AMSA yields a 2.53%increase compared with state-of-the-art methods.
基金Projects(50934002,51074013,51304076,51104100)supported by the National Natural Science Foundation of ChinaProject(IRT0950)supported by the Program for Changjiang Scholars Innovative Research Team in Universities,ChinaProject(2012M510007)supported by China Postdoctoral Science Foundation
文摘Methods and procedures of three-dimensional （3D） characterization of the pore structure features in the packed ore particle bed are focused. X-ray computed tomography was applied to deriving the cross-sectional images of specimens with single particle size of 1-2, 2-3, 3-4, 4-5, 5-6, 6-7, 7-8, 8-9, 9-10 ram. Based on the in-house developed 3D image analysis programs using Matlab, the volume porosity, pore size distribution and degree of connectivity were calculated and analyzed in detail. The results indicate that the volume porosity, the mean diameter of pores and the effective pore size （d50） increase with the increasing of particle size. Lognormal distribution or Gauss distribution is mostly suitable to model the pore size distribution. The degree of connectivity investigated on the basis of cluster-labeling algorithm also increases with increasing the particle size approximately.
基金Supported by the NationalNaturalScience Foundation of China( No. 2 0 175 0 1) and U niversity Key Teachers Programdirected under the Ministry of Education ofP.R.China( No. 2 0 0 0 - 6 5 )
文摘It is critical to establish a direct and precise method with a high sensitivity and selectivity in analytical chemistry. In this research, making use of a well known phenomenon of capillary flow, we have proposed an image analysis method of nucleic acids at the price of a small amount of sample. When a droplet of the supramolecular complex solution, formed by neutral red and nucleic acids(NA) under an approximate neutral condition, was placed on the hydrophobic surface of dimethyl dichlorosilane pretreated glass slides, and it was evaporated, the supramolecular complex exhibited the periphery of the droplet due to the capillary effect, and accumulated there to form a red capillary flow directed assembly ring(CFDAR). A typical CFDAR has an outer diameter of (2 r ) about 1.18 mm and a ring width(2 δ ) of about 41 μm. Depending on the experimental conditions, a variety of CFDAR can be assembled. The experimental results are in agreement with our former theoretical discussion. It was found that when a droplet volume is 0.1 μL, the fluorescence intensity of the CFDAR formed by the NR NA is in proportion to the content of calf thymus DNA in the range of 0-0.28 ng, fish sperm DNA of 0-0.24 ng and yeast RNA of 0-0.16 ng with the limit of detection(3 σ ) of 1 7, 1.4 and 0.9 pg, respectively for the three nucleic acids.
基金supported by the National Natural Science Foundation of China,No.82274304(to YH)the Major Clinical Study Projects of Shanghai Shenkang Hospital Development Center,No.SHDC2020CR2046B(to YH)Shanghai Municipal Health Commission Talent Plan,No.2022LJ010(to YH).
文摘Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological mechanisms,preventing and treating cerebral small vessel vasculopathy is challenging.Recent studies have shown that the glymphatic system plays a crucial role in interstitial solute clearance and the maintenance of brain homeostasis.Increasing evidence also suggests that dysfunction in glymphatic clearance is a key factor in the progression of cerebral small vessel disease.This review begins with a comprehensive introduction to the structure,function,and driving factors of the glymphatic system,highlighting its essential role in brain waste clearance.Afterwards,cerebral small vessel disease was reviewed from the perspective of the glymphatic system,after which the mechanisms underlying their correlation were summarized.Glymphatic dysfunction may lead to the accumulation of metabolic waste in the brain,thereby exacerbating the pathological processes associated with cerebral small vessel disease.The review also discussed the direct evidence of glymphatic dysfunction in patients and animal models exhibiting two subtypes of cerebral small vessel disease:arteriolosclerosis-related cerebral small vessel disease and amyloid-related cerebral small vessel disease.Diffusion tensor image analysis along the perivascular space is an important non-invasive tool for assessing the clearance function of the glymphatic system.However,the effectiveness of its parameters needs to be enhanced.Among various nervous system diseases,including cerebral small vessel disease,glymphatic failure may be a common final pathway toward dementia.Overall,this review summarizes prevention and treatment strategies that target glymphatic drainage and will offer valuable insight for developing novel treatments for cerebral small vessel disease.
