The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence;...The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence; the high IgE level could extend the survival time of 3-Methylcholanthrene injected mice (P<0.05) and survival time of tumor bearing mice (P<0.01), while IgG or IgGl could not. The data from this study did not show that IgE, IgG or IgGl had any significant effect on the tumor size and the tumor growth rate. The probable mechanism involved was discussed.展开更多
Background A free running asthma screening test is usually used for screening exercise-induced bronchoconstriction.The total serum allergen IgE level can reveal the patient＇s atopy characteristics.Our study is to eva...Background A free running asthma screening test is usually used for screening exercise-induced bronchoconstriction.The total serum allergen IgE level can reveal the patient＇s atopy characteristics.Our study is to evaluate the diagnostic values of the combination of the two tests in asthmatic children and compare this new diagnostic method with the Intemational Study of Asthma and Allergies in Childhood （ISSAC） questionnaires and the bronchial provocation test,which are popular diagnostic tool for pediatric asthma.Methods A total of 773 school children were recruited in this study.The children＇s asthma was diagnosed by means of a combination of the free running asthma screening test and total serum allergen IgE level.The new diagnostic method value was assessed using receiver operating characteristic （ROC） curves and compared with other diagnostic tools such as ISSAC questionnaires and the bronchial provocation test.Results The AUC of this new diagnostic method was higher than 0.9.When the cut-off value of total serum allergen IgE level was ≥47 KU/L,the sensitivity and the specificity were 71.4％ and 85.1％,respectively,which were better than those of either the ISSAC questionnaires or bronchial provocation test.Conclusion The combination of the free running asthma screening test and total serum allergen IgE level may be an effective diagnostic tool for children＇s asthma.展开更多
Centenarians have delayed or absent onset and interaction of agerelated disturbances and might be a prototype of human longevity and successful aging.1 What are the factors and models of centenarian longevity?This iss...Centenarians have delayed or absent onset and interaction of agerelated disturbances and might be a prototype of human longevity and successful aging.1 What are the factors and models of centenarian longevity?This issue has confused humans for thousands of years.Studies comparing centenarians and other oldest-old individuals could identify the factors related to centenarian longevity,and analysis of their relationships in these oldest-old individuals could improve the models of centenarian longevity.1 All these factors and models could be used to identify therapeutic targets for the prevention of age-related disturbances and the promotion of centenarian longevity.展开更多
文摘The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence; the high IgE level could extend the survival time of 3-Methylcholanthrene injected mice (P<0.05) and survival time of tumor bearing mice (P<0.01), while IgG or IgGl could not. The data from this study did not show that IgE, IgG or IgGl had any significant effect on the tumor size and the tumor growth rate. The probable mechanism involved was discussed.
文摘Background A free running asthma screening test is usually used for screening exercise-induced bronchoconstriction.The total serum allergen IgE level can reveal the patient＇s atopy characteristics.Our study is to evaluate the diagnostic values of the combination of the two tests in asthmatic children and compare this new diagnostic method with the Intemational Study of Asthma and Allergies in Childhood （ISSAC） questionnaires and the bronchial provocation test,which are popular diagnostic tool for pediatric asthma.Methods A total of 773 school children were recruited in this study.The children＇s asthma was diagnosed by means of a combination of the free running asthma screening test and total serum allergen IgE level.The new diagnostic method value was assessed using receiver operating characteristic （ROC） curves and compared with other diagnostic tools such as ISSAC questionnaires and the bronchial provocation test.Results The AUC of this new diagnostic method was higher than 0.9.When the cut-off value of total serum allergen IgE level was ≥47 KU/L,the sensitivity and the specificity were 71.4％ and 85.1％,respectively,which were better than those of either the ISSAC questionnaires or bronchial provocation test.Conclusion The combination of the free running asthma screening test and total serum allergen IgE level may be an effective diagnostic tool for children＇s asthma.
基金supported by grants from the National Key R&D Program of China(2018YFC2000400)the National Natural Science Foundation of China(81900357,81903392)+7 种基金the National S&T Resource Sharing service platform Project of China(YCZYPT[2018]07)the General Hospital of PLA Medical Big Data R&D Project(MBD2018030)the China Postdoctoral Science Foundation funded project(2019M650359)the National Geriatric Disease Clinical Medicine Research Center Project(NCRCG-PLAGH-2017-014)the Military Medical Science and Technology Youth Incubation Program(20QNPY110)the Sanya Medical and Health Science and Technology Innovation Project(2016YW21)the Sanya Institutional and Local Scientific and Technological Cooperation Project,the Military Medicine Youth Program of Chinese PLA General Hospital(QNF19069)the Clinical Scientific Research Supporting Fund of Chinese PLA General Hospital(2017FC-CXYY-3009).
文摘Centenarians have delayed or absent onset and interaction of agerelated disturbances and might be a prototype of human longevity and successful aging.1 What are the factors and models of centenarian longevity?This issue has confused humans for thousands of years.Studies comparing centenarians and other oldest-old individuals could identify the factors related to centenarian longevity,and analysis of their relationships in these oldest-old individuals could improve the models of centenarian longevity.1 All these factors and models could be used to identify therapeutic targets for the prevention of age-related disturbances and the promotion of centenarian longevity.
