Using isoelective focusing in immobilized pH gradients and immunoblot, C3 phenotypes (F, FS, S) and C3 HAV4-1 monoclonal (F±S±) phenotypes were performed in 90 patients with IgA glomerulonephrits,(G.N.).incl...Using isoelective focusing in immobilized pH gradients and immunoblot, C3 phenotypes (F, FS, S) and C3 HAV4-1 monoclonal (F±S±) phenotypes were performed in 90 patients with IgA glomerulonephrits,(G.N.).including 49 IgA G. N.hypertensive (H.T.) patients and 41 IgA G. N. normotensive (N.T.) patients, and in 224 normal subjects (N.S.). A significant difference of C3 phenotype distribution between both IgA G. N.(hypertensive and normotensive) and N. S. was .found (P<0.01,P<0.01respectively).In monoclonal C3 HAV4-1(±) distribution significant difference between IgA H. T.and N.S.was observed (P<0.01). Furthermore, F and S allele .frequency of IgA G. N. including HT and NT is significantly. different (P<0.05). This data suggests that hypertensive patients with IgA G. N. seems to be related io the abnormal C3 genetic factors and if this gene distributions can be used as a predictor for the prognosis still needs futher investigations.展开更多
文摘Using isoelective focusing in immobilized pH gradients and immunoblot, C3 phenotypes (F, FS, S) and C3 HAV4-1 monoclonal (F±S±) phenotypes were performed in 90 patients with IgA glomerulonephrits,(G.N.).including 49 IgA G. N.hypertensive (H.T.) patients and 41 IgA G. N. normotensive (N.T.) patients, and in 224 normal subjects (N.S.). A significant difference of C3 phenotype distribution between both IgA G. N.(hypertensive and normotensive) and N. S. was .found (P<0.01,P<0.01respectively).In monoclonal C3 HAV4-1(±) distribution significant difference between IgA H. T.and N.S.was observed (P<0.01). Furthermore, F and S allele .frequency of IgA G. N. including HT and NT is significantly. different (P<0.05). This data suggests that hypertensive patients with IgA G. N. seems to be related io the abnormal C3 genetic factors and if this gene distributions can be used as a predictor for the prognosis still needs futher investigations.
