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The Ideale section at Montalbano Jonico (southern Italy): a Standard Auxiliary Boundary Stratotype (SABS) for the Middle Pleistocene Subseries of the Quaternary System
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作者 Maria Marino Patrizia Maiorano +11 位作者 Angela Girone Salvatore Gallicchio Franck Bassinot Sebastien Nomade Quentin Simon Adele Bertini Timothy Herbert Paola Petrosino Marina Addante Rafael La Perna Samanta Trotta Neri Ciaranfi 《Episodes》 2024年第1期121-146,共26页
The Ideale section(IS)at Montalbano Jonico,Italy,has been approved as a Standard Auxiliary Boundary Stratotype(SABS)for the Global boundary Stratotype Section and Point(GSSP)of the Middle Pleistocene Subseries/Subepoc... The Ideale section(IS)at Montalbano Jonico,Italy,has been approved as a Standard Auxiliary Boundary Stratotype(SABS)for the Global boundary Stratotype Section and Point(GSSP)of the Middle Pleistocene Subseries/Subepoch and Chibanian Stage/Age at the Chiba section,Japan.The proposal was submitted to the voting members of the International Commission on Stratigraphy’s Subcommission on Quaternary Stratigraphy(SQS)on May 4,2023,and following discussions was approved on July 8,2023.The 74 m thick IS continuously spans the Marine Isotope Stage(MIS)20–18 interval,and is part of the longer Montalbano Jonico succession(Basilicata,southern Italy in the Mediterranean region)encompassing MIS 37 to early MIS 16.The IS provides a detailed record based on multiple chronologically well constrained marine and terrestrial proxies,which are particularly useful for outlining the paleoclimatic evolution through the Lower–Middle Pleistocene transition.The high-resolution carbon and oxygen isotope stratigraphy outlines glacial–interglacial and stadial–interstadial phases as well as the sub-millennialscale features of Termination IX and the onset of MIS 19c.The sapropel layer equivalent to insolation cycle 74(784 ka)occurs in early MIS 19c.A prominent peak in the 10Be/9Be record at the MIS 19c–19b transition identifies the low geomagnetic dipole moment associated with the Matuyama–Brunhes boundary interval.Two tephra layers(V3 and V4)relevant to boundary interval are 40Ar/39Ar dated.The V4 layer,occurring at the MIS 19c–b transition and in the middle of the 10Be/9Be peak,has an age of 774.1±0.9 ka,corresponding to the age of the Middle Pleistocene GSSP.A high-resolution alkenone sea-surface temperature and several paleobiological records complement the rich chronological and paleoenvironmental dataset from MIS 20 to the inception of MIS 18.The GSSP boundary interval in the IS is represented from 35.50 to 39.50 m,which corresponds to the interval of the highest values of the 10Be/9Be ratio(~776.35–771.87 ka)and includes the V4 tephra layer and the MIS 19c–MIS 19b transition.This SABS extends the correlation potential of the Middle Pleistocene Subseries/Subepoch GSSP interval to the Mediterranean region. 展开更多
关键词 ideale Section global boundary stratotype section point gssp Chibanian Stage Standard Auxiliary Boundary Stratotype standard auxiliary boundary stratotype sabs commission stratigraphy s quaternary stratigraphy sqs Middle Pleistocene Subseries
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基于IDEAL问题解决的教材剖析及教学策略——以人教版“原子的核式结构模型”为例
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作者 廖元畅 晋睿杰 周少娜 《物理通报》 2026年第1期57-60,共4页
引入LRMB模型,从心理学角度探讨问题解决过程的心理机制,利用IDEAL问题解决理论剖析高中物理教材内容,揭示教材的外在编排结构和内在心理逻辑.基于此分析,提出“三化”“三维度”和“三性”教学策略,为物理问题解决教学提供可操作性的指导.
关键词 LRMB模型 IDEAL理论 教材剖析 教学策略
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积家表IDEALE代言人李嘉欣意大利 VOGUE杂志造型展示非凡魅力
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《国际服装动态》 2005年第3期92-92,共1页
李嘉欣早前特别远赴非洲摩洛哥,为积家表 Jaeger-LeCoultre女装钻石腕表系列 IDEALE 拍摄一辑宣传照片,此次工作更为她带来一次全新的体验。全新推出的积家 IDEALE 女装腕表,每个细节设计都洋溢时代女性非凡出众的特质.所表达的是经典... 李嘉欣早前特别远赴非洲摩洛哥,为积家表 Jaeger-LeCoultre女装钻石腕表系列 IDEALE 拍摄一辑宣传照片,此次工作更为她带来一次全新的体验。全新推出的积家 IDEALE 女装腕表,每个细节设计都洋溢时代女性非凡出众的特质.所表达的是经典的女性美.无疑是个中典范.而李嘉欣既拥有东方女性的温柔婉约。 展开更多
关键词 非凡魅力 李嘉欣 ideale VOGUE 时代女性 西方女性 女性美 东方女性 细节设计 Jaeg
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百年瑞士名表JAEGER-LECOULTRE积家 全新IDEALE系列真正的自我
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《国际服装动态》 2005年第3期90-91,共2页
拥有着170多年制表历史的瑞士积家表,一起始便与女性结下不解缘。这次最新推出的积家 IDEALE 系列女装腕表,是一面神秘的镜子,反映着女士们细密而难以触摸的心思,绝对是专属于个人的私密腕表。
关键词 ideale 宝石轴承 外型设计 女性美 表结 链连接 保持操作 爪形 个人气质 珍珠白
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基于FAHP-TOPSIS法的地下空间开发地质适宜性评价
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作者 李浩民 瞿婧晶 张其琪 《科学技术与工程》 北大核心 2025年第30期13187-13196,共10页
为了客观评价地下空间开发地质适宜性并为评价工作提供一种新思路和参考,提出了一种基于三角模糊数的模糊层次分析法(fuzzy analytic hierarchy process based on triangular fuzzy numbers,FAHP)和优劣解距离法(technique for order pr... 为了客观评价地下空间开发地质适宜性并为评价工作提供一种新思路和参考,提出了一种基于三角模糊数的模糊层次分析法(fuzzy analytic hierarchy process based on triangular fuzzy numbers,FAHP)和优劣解距离法(technique for order preference by similarity to ideal solution,TOPSIS)相结合的评价方法。通过地质调查研究构建基于土体工程地质性质、水文地质条件、不良地质作用、地形地貌等影响因素为主的层次分析关系模型。基于专家判别利用FAHP计算各评价因素的权重,以各评价指标层的分级临界值作为典型评价样本,利用TOPSIS法对适宜性等级进行非等分划分,基于区间值优化的TOPSIS法建立最终评价模型,通过ArcGIS的空间分析功能等确定每个评价单元适宜性等级。该方法与传统方法相比一定程度上减少了评价过程中专家评判的过多主观影响,评价过程更倾向于定量化,结果更为客观。利用该方法对无锡市区浅层地下空间开发地质适宜性进行评价,评价结果与实际工程经验相符,证明了该方法的有效性,因此该方法对地下空间开发适宜性评价工作具有一定借鉴意义。 展开更多
关键词 FAHP(fuzzy analytic hierarchy process) TOPSIS(technique for order preference by similarity to an ideal solution) 城市地下空间 地质适宜性评价
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Co-minimal Ideal Graphs of Commutative Rings
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作者 ZHANG Guanghui ZHANG Zhizheng 《数学进展》 北大核心 2025年第4期749-758,共10页
Given two ideals I and J of a commutative ring R,there are two extreme connections between I and J:I+J=R and I∩J={0}.For the former case,graphs whose vertices are defined as the proper ideals of R and that two vertic... Given two ideals I and J of a commutative ring R,there are two extreme connections between I and J:I+J=R and I∩J={0}.For the former case,graphs whose vertices are defined as the proper ideals of R and that two vertices are adjacent if and only if their sum is the whole ring R are known as co-maximal ideal graphs.In this paper,we introduce a new kind of graph structure on R,called co-minimal ideal graph,according to the second case:Its vertices are the nonzero ideals of R and two vertices are adjacent if and only if their intersection is zero.Some important graph parameters(including girth,diameter,clique number and chromatic number)and graph structures(including tree and bipartite graph)of co-minimal ideal graphs over finite commutative rings are studied.In particular,we show that the co-maximal ideal graph and the co-minimal ideal graph over R are isomorphic if and only if the number of maximal ideals of R and the number of minimal ideals of R coincide. 展开更多
关键词 minimal ideal DIAMETER clique number chromatic number
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消费者评价方法在敏感肌适用面霜中的应用
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作者 齐荣 程党党 《日用化学工业(中英文)》 北大核心 2025年第4期464-471,共8页
为了探究敏感肌适用面霜的偏好方向,筛选市售5款人气敏感肌适用面霜产品,通过9点喜好标度、Rate-all-that-apply(RATA)、Ideal profile method(IPM)等多种消费者研究方法从产品喜好度、理想产品、产品特征和情绪赋值等方面进行消费者测... 为了探究敏感肌适用面霜的偏好方向,筛选市售5款人气敏感肌适用面霜产品,通过9点喜好标度、Rate-all-that-apply(RATA)、Ideal profile method(IPM)等多种消费者研究方法从产品喜好度、理想产品、产品特征和情绪赋值等方面进行消费者测试,从多个维度对测试产品进行分析探究。结果表明,契合调查目的从而针对性地选择适用的消费者调查方法并且通过多种方法的结合应用,可以获得较为完整的敏感肌适用面霜开发思路。另外相比常规的消费者喜好度研究,当下消费者较为关注的产品概念、情绪赋值方面的评价也体现出较好的应用价值。 展开更多
关键词 敏感肌适用面霜 消费者喜好度 Ideal profile method(IPM) Rate-all-that-apply(RATA) 情绪护肤
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Triangle Bounded L⁃algebras and Triangle Ideals
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作者 Hao Chen Xiaolong Xin 《Journal of Harbin Institute of Technology(New Series)》 2025年第5期52-64,共13页
This study mainly focuses on the triangle bounded L⁃algebras and triangle ideals.Firstly,the definition of triangle bounded L⁃algebras is presented,and several examples with different conditions are outlined along wit... This study mainly focuses on the triangle bounded L⁃algebras and triangle ideals.Firstly,the definition of triangle bounded L⁃algebras is presented,and several examples with different conditions are outlined along with an exploration of their properties.Moreover,we investigate the structure of triangle bounded L⁃algebra with a special condition.Secondly,we define the concept of triangle ideals of triangle bounded L⁃algebra and explore the connection between the triangle ideals of triangle bounded L⁃algebra L and the ideals of bounded L⁃algebra E(L).In addition,we classified and studied various classes of triangle ideals,including Stonean triangle ideals,extended Stonean triangle ideals,and lattice ideals,and by introducing the notion of Stonean triangle bounded L algebras,we examine the relationship between Stonean triangle bounded L⁃algebras and Stonean triangle ideals.Finally,we investigate the interrelationships among these various types of triangle ideals. 展开更多
关键词 triangle bounded L⁃algebra Stonean triangle bounded L⁃algebra triangle ideal (extended)Stonean triangle ideal lattice ideal
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Shock-Capturing Particle Hydrodynamics with Reproducing Kernels
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作者 Stephan Rosswog 《Computer Modeling in Engineering & Sciences》 2025年第5期1713-1741,共29页
We present and explore a new shock-capturing particle hydrodynamics approach.Our starting point is a commonly used discretization of smoothed particle hydrodynamics.We enhance this discretization with Roe’s approx-im... We present and explore a new shock-capturing particle hydrodynamics approach.Our starting point is a commonly used discretization of smoothed particle hydrodynamics.We enhance this discretization with Roe’s approx-imate Riemann solver,we identify its dissipative terms,and in these terms,we use slope-limited linear reconstruction.All gradients needed for our method are calculated with linearly reproducing kernels that are constructed to enforce the two lowest-order consistency relations.We scrutinize our reproducing kernel implementation carefully on a“glass-like”particle distribution,and we find that constant and linear functions are recovered to machine precision.We probe our method in a series of challenging 3D benchmark problems ranging from shocks over instabilities to Schulz-Rinne-type vorticity-creating shocks.All of our simulations show excellent agreement with analytic/reference solutions. 展开更多
关键词 Ideal hydrodynamics reproducing kernels SHOCKS INSTABILITIES smoothed particle hydrodynamics
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Lattice activation for air deposition of micrometer-grain Pb-Sn perovskite film realizing efficient and stable ideal-bandgap solar cells
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作者 Xiaojia Zhao Weiyin Gao +7 位作者 Jianxiong Yang Zelin Wang Zhenhuang Su Lingfeng Chao He Dong Xingyu Gao Yonghua Chen Chenxin Ran 《Journal of Energy Chemistry》 2025年第9期808-818,I0021,共12页
Lead-tin(Pb-Sn)perovskites with an ideal bandgap of 1.34-1.40 eV show great promise in perovskite solar cells(PSCs).Recently,to address the environmental pollution and Sn^(2+)oxidation problems of dimethyl sulfoxide,m... Lead-tin(Pb-Sn)perovskites with an ideal bandgap of 1.34-1.40 eV show great promise in perovskite solar cells(PSCs).Recently,to address the environmental pollution and Sn^(2+)oxidation problems of dimethyl sulfoxide,methylammonium acetate(MAAc)ionic liquid has been developed as an alternative to fabricate ideal bandgap MAPb_(0.7)Sn_(0.3)I_(3)(1.36 eV)film via hot-casting in air.However,the spontaneous crystallization of Pb-Sn perovskite initiated by heat-induced supersaturation is fast and random,setting critical challenges in regulating crystal growth during the film-forming process.Herein,a lattice activation strategy is developed to control the crystallization dynamics of MAPb_(0.7)Sn_(0.3)I_(3)in MAAc to produce films with micrometer-sized grains in air.FA is shown to activate the crystal lattice that facilitates the formation of intermediates and balances the crystal growth of MAPb_(0.7)Sn_(0.3)I_(3),producing films with a grain size of 2.78±0.17μm.Furthermore,4-fluoro-phenethylammonium and phenethylammonium are adopted to passivate the defects in the film and promote the energy level alignment at the top interface,respectively.The optimized PSC device achieved an efficiency of 18.24%with a short-circuit current of 29.84 mA/cm^(2),which are both the highest values in 1.36 eV Pb-Sn PSCs to date.Notably,the unencapsulated devices show excellent storage and air stability under various conditions. 展开更多
关键词 Pb-Sn perovskite Ideal bandgap Lattice activation Air deposition Micrometer grains Stability
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First Principles Study of CoSb_(3)/Ni Interface Structure and Mechanical Properties
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作者 Cuicui Shu Pengcheng Zhai +3 位作者 Xiege Huang Sergey IMorozov Guodong Li Zhiyuan Pan 《Acta Metallurgica Sinica(English Letters)》 2025年第5期793-802,共10页
Mechanical stability is critically essential in the design of thermoelectric devices.In this study,we employed first-principles calculations based on density functional theory to investigate the failure mechanisms at ... Mechanical stability is critically essential in the design of thermoelectric devices.In this study,we employed first-principles calculations based on density functional theory to investigate the failure mechanisms at the CoSb_(3)/Ni interface.Our findings reveal that the CoSb_(3)(100)/Ni(100)and CoSb_(3)(100)/Ni(111)_1 configurations are favorable interface structures.The ideal tensile strength of the CoSb_(3)/Ni interface is markedly lower than that of bulk CoSb_(3),which can be attributed to structural rearrangements near the interface that weaken the strength of the Co–Sb bonds.Interface failure occurs in CoSb_(3),where covalent Sb–Sb bonds exhibit a tendency to soften prior to the ionic Co–Sb bonds due to their comparatively lower rigidity.Consequently,the breakage of the Co–Sb bonds leads to interface failure.Structural failure at both single-layer Sb_CoSb_(3)(100)/Ni(100)and single-layer Sb_CoSb_(3)(100)/Ni(111)_1 interfaces results from ruptures in intermediate Co–Sb bonds in CoSb_(3),whereas failures at double-layer Sb_CoSb_(3)(100)/Ni(100)and double-layer Sb_CoSb_(3)(100)/Ni(111)_1 interfaces stem from fractures in the uppermost Co–Sb bonds.This behavior is primarily driven by atomic rearrangements near the single-layer Sb_CoSb_(3)interface,which promote bond formation between Sb–Ni and Co–Ni,thereby enhancing stability within the superstructure of CoSb_(3).This study will provide a theoretical basis for the interface design of thermoelectric devices. 展开更多
关键词 THERMOELECTRIC Intercfacial structure Ideal tensile strength Failure mechanism
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A Freudian Group Psychology Perspective on the Psychological Mechanisms in South Korean Elite Sports Teams:Implications for Mental Health
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作者 Hyunkyun Ahn Yeon-Hee Choi Young-Vin Kim 《International Journal of Mental Health Promotion》 2025年第4期451-468,共18页
Objectives:In this study,we examined the psychological impact of hierarchical and authoritarian structures in elite sports teams in South Korea on the ego formation and mental health of athletes.We aimed to analyze ho... Objectives:In this study,we examined the psychological impact of hierarchical and authoritarian structures in elite sports teams in South Korea on the ego formation and mental health of athletes.We aimed to analyze how these environments shape psychological well-being in athletes,drawing on Freud’s group psychology theory,while integrating perspectives from the Self-DeterminationTheory(SDT)and Social Identity Theory(SIT).Methods:We applied a qualitative case-study approach,with data collected through in-depth interviews with eight retired elite table tennis players from South Korea.These athletes shared their experiences with psychological mechanisms in their teams and how those mechanisms impacted their mental health throughout their careers.We analyzed the collected data using thematic analysis.Results:The investigated psychological mechanisms significantly influenced the ego development and psychological well-being in athletes.In hierarchical and authoritarian environments,identification and ego idealization suppressed the autonomy of the athletes.Hierarchical order and obedience to authority figures exert significant pressure on athletes to conform,impeding the development of an independent ego.Furthermore,group pressure exacerbates ego erosion and psychological stress,while corporal punishment reinforces psychological pressure and hinders ego integrity.The integration of the SDT highlights the need for autonomy-supportive environments to mitigate such risks,while the SIT emphasizes balancing individual identity with group cohesion to address identity conflicts and psychological tension.Conclusion:Hierarchical structures and authoritarian dynamics in South Korean elite sports teams critically suppress autonomy in athletes,leading to psychological distress and identity conflicts.This study highlights the urgent need for systemic interventions to reform coaching practices and foster autonomysupportive environments.These results contribute to the global discourse on the mental health of athletes in elite sports and offer actionable strategies for improving long-term well-being.Finally,this study provides practical recommendations adaptable to diverse cultural and sporting contexts,enhancing athlete mental health worldwide. 展开更多
关键词 Ego idealization elite sports teams freud’s group psychology group pressure identification mental health
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An Inquiry Into the Effect of Peers on L2 Motivation Under the L2 Motivational Self System
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作者 Xiaoyu Zhang 《Chinese Journal of Applied Linguistics》 2025年第2期207-227,320,321,共23页
Second language(L2)motivation has been a topic which receives intensive attention.However,the peer effect on L2 motivation is insufficiently researched,although it is considered a crucial factor which may significantl... Second language(L2)motivation has been a topic which receives intensive attention.However,the peer effect on L2 motivation is insufficiently researched,although it is considered a crucial factor which may significantly mediate learners’L2 motivation.Hence,the current study adopted Dörnyei’s L2 Motivational Self System(L2MSS)as a theoretical framework and investigated in which specific aspects peers might affect the learners’L2 motivation and whether such effect was long-lasting.The research was designed as a small-scale qualitative study which was located in a language-focused experimental class project in China.Ten participants were recruited and individual interviews were conducted.The results demonstrated that,first,peers could remarkably influence the L2 motivation possessed by the students in the experimental class since they tended to create a clearer ideal L2 self and a more powerful ought-to L2 self.Second,although they had both positive and negative views towards the curriculum,a motivated peer climate could alleviate the pressure caused by the curriculum and reinforce positive attitudes.Third,such peer effect was not long-lasting.Based on the research results,pedagogical implications were proposed in terms of establishing a positive peer group and adjusting the emphasis of the curriculum. 展开更多
关键词 peer effect L2 motivation ideal L2 self ought-to L2 self curriculum
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英语学习活动观视域下的小学英语阅读教学初探
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作者 楼姝妍 《教学管理与教育研究》 2025年第19期75-77,共3页
本文基于英语学习活动观视角开展阅读教学实践,归纳、总结、形成IDEAL小学英语阅读教学模式,该模式通过五步教学依次推进阅读,从真实情境出发,激活学生已有知识,重视教学过程中的问题引领、框架搭建及语意探索,最终让学生关注、解决真... 本文基于英语学习活动观视角开展阅读教学实践,归纳、总结、形成IDEAL小学英语阅读教学模式,该模式通过五步教学依次推进阅读,从真实情境出发,激活学生已有知识,重视教学过程中的问题引领、框架搭建及语意探索,最终让学生关注、解决真实问题,发展其核心素养,进而推进小学英语阅读教学高质量发展。 展开更多
关键词 英语学习活动观 阅读教学 小学英语 IDEAL阅读模式
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A promising strategy of brain targeted delivery for the treatment of Parkinson's disease:Cyclodextrin supramolecular inclusion complex based thermosensitive gel
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作者 Yan-Qiu Wang Li-Ming Wang +2 位作者 Li-Feng Han Yi-Bing Chen Yuan-Lu Cui 《Journal of Pharmaceutical Analysis》 2025年第5期1166-1169,共4页
Parkinson's disease(PD)is a debilitating and progressive neurodegenerative disorder with complex pathology and multiple membrane barriers that hinder drug delivery,resulting in the absence of ideal therapeutic dru... Parkinson's disease(PD)is a debilitating and progressive neurodegenerative disorder with complex pathology and multiple membrane barriers that hinder drug delivery,resulting in the absence of ideal therapeutic drugs with minimal side effects[1].Recently,natural medicine has garnered significant attention due to its remarkable efficacy and limited side effects.Icariin,a naturally occurring flavonoid,exhibits excellent potential as a therapeutic agent for neurodegenerative disease[2].However,its clinical application is limited by poor water solubility,low bioavailability,and high clearance rates.Here,an aqueous formulation of icariin/hydroxypropyl-β-cyclodextrin(HP-β-CD)supramolecular inclusion complex was obtained to optimize icariin properties.Furthermore,icariin cyclodextrin supramolecular inclusion complex based thermosensitive(icariin gels)was innovated.At lower temperatures,it remained in a liquid phase with high fluidity.Upon reaching the gelation temperature,it underwent a transition to a gel phase with significantly reduced fluidity,which may be suitable for the design of an intranasal delivery system for PD treatment.The innovative approach capitalizes on the exceptional characteristics of HP-β-CD,which was utilized to synergize with nasal delivery for targeted brain delivery and with icariin for PD treatment[3,4]. 展开更多
关键词 CYCLODEXTRIN brain targeted delivery ideal therapeutic drugs supramolecular inclusion complex parkinsons disease pd neurodegenerative disorder thermosensitive gel neurodegenerative disease howeverits
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ONE-DIMENSIONAL COMPRESSIBLE RADIATION HYDRODYNAMICS MODEL WITH DENSITY-DEPENDENT VISCOSITY AND THERMAL CONDUCTIVITY
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作者 Huanyuan LI Junhao ZHANG +1 位作者 Huijiang ZHAO Jialing ZHU 《Acta Mathematica Scientia》 2025年第6期2421-2446,共26页
The radiative Euler equations is a typical model describing the motion of astrophysical flows.For its mathematical studies,it is now well-understood that the radiation effect can indeed induce some dissipative mechani... The radiative Euler equations is a typical model describing the motion of astrophysical flows.For its mathematical studies,it is now well-understood that the radiation effect can indeed induce some dissipative mechanism,which can guarantee the global regularity of smooth solutions to the radiative Euler equations for small initial data.Thus a problem of interest is to see to what extent does the viscosity and/or thermal conductivity influence the global regularity of smooth solutions to the one-dimensional radiative Euler equations for large initial data.For results in this direction,it is shown in[30]that,for a class of state equations,even if a special class of thermal conductivity is further added to the radiative Euler equations,its smooth solutions will still blow up in finite time for large initial data.The main purpose of this paper focuses on the case when both viscosity and thermal conductivity are considered.We first show that,for the state equations and the heat conductivity considered in[30],if the viscosity is further taken into account,the corresponding radiative Navier-Stokes equations does admit a unique global smooth solution for any large initial data provided that the viscosity is a smooth function of the density satisfying certain growth conditions as the density tends to zero and infinity.Moreover,we also show that similar result still holds for the case when the thermodynamics variables satisfy the state equations for ideal polytropic gases,the heat conductivity takes the form studied in[30],and the viscosity is assumed to satisfy the same conditions imposed in the first result. 展开更多
关键词 radiative Euler equations radiative Navier-Stokes equations constitutive relations for thermodynamics variables ideal polytropic gases transport coefficients global smooth large solutions global regularity
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Discovery of active compounds and key targets of Thymus quinquecostatus Celak.based on gastrointestinal metabolism and Gut flora-Compound-Target Pathway network with TOPSIS method
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作者 Xueyang Ren Jiamu Ma +11 位作者 Ying Dong Yuan Zheng Rufeng Wang Chongjun Zhao Wei Liu Mingxia Li Mengyu Sun Feng Zhang Yingyu He Xianxian Li Qingyue Deng Gaimei She 《Food Science and Human Wellness》 2025年第11期4629-4643,共15页
Thymus quinquecostatus Celak.,a traditional aromatic edible plant from Lamiaceae,is widely used as food additive,food condiment,spice,and herbal teas.Polyphenol-rich fraction of T.quinquecostatus(PRF)has been proven t... Thymus quinquecostatus Celak.,a traditional aromatic edible plant from Lamiaceae,is widely used as food additive,food condiment,spice,and herbal teas.Polyphenol-rich fraction of T.quinquecostatus(PRF)has been proven to be effective protective effect for cerebral ischemia reperfusion injury(CIRI)in our previous study.In this study,we developed a novel“Gut flora-Compound-Target-Pathway”(GCTP)network based on network pharmacology coupled with gastrointestinal metabolism for screening bio-active components,key targets and gut floras through the classical technique for order preference by similarity to ideal solution(TOPSIS).This compensates for the lack of gut floras and gastrointestinal metabolism in network pharmacology.Firstly,four incubation models covering simulated gastric juice,simulated intestinal juice,gut floras of normal and transient middle cerebral artery occlusion(tMCAO)rat in vitro were applied to PRF.The 109 proto-components and 64 metabolites were elucidated by ultra-high performance liquid chromatography Q exactive orbitrap-mass spectrometry(UPLC-QE-Orbitrap-MS).Then,the key targets of matrix metalloproteinase 9(MMP9),prostaglandin-endoperoxide synthase 2(PTGS2),tyrosine-protein kinase fyn(FYN),estrogen receptor 1(ESR1),amyloid precursor protein(APP),and epidermal growth factor receptor(EGFR),and gut floras of Enterococcus avium LY1 were selected.Moreover,the selected key proto components were rosmarinic acid,daidzein,quercetin,luteolin,apigenin,methyl rosmarinate,kaempferol,luteoloside,and caffeic acid,and the key metabolites were isokaempferide,isorhamnetin,isoquercetin,and mangiferin.Binding of compounds to the key proteins was analyzed by molecular docking,and also verified though an 2,2'-azobis(2-amidinopropane)dihydrochloride(AAPH)induced oxidative stress zebrafish model and real-time quantitative polymerase chain reaction(RT-qPCR)assays.This study provides a new idea and a better understanding of PRF for its protective effects on CIRI and its underlying mechanisms. 展开更多
关键词 Thymus quinquecostatus Celak. Gastrointestinal metabolism Gut flora Technique for order preference by similarity to ideal solution method Cerebral ischemia reperfusion injury Network pharmacology
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Using TOPSIS Model with Modified Entropy Weight for Water Quality Assessment in Guizhou Province, China
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作者 FENG Dongdong WU Liang 《Wuhan University Journal of Natural Sciences》 2025年第3期302-312,共11页
Although the Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)model has been widely applied in water quality assessment by numerous studies,several common limitations remain unresolved.Specificall... Although the Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)model has been widely applied in water quality assessment by numerous studies,several common limitations remain unresolved.Specifically:1)Subjective elements in methods such as fuzzy theory and the analytic hierarchy process(AHP)may distort evaluation outcomes;2)The utilization of raw sample data is in‐sufficient when constructing evaluation matrices;3)The traditional entropy weight method in TOPSIS merely reflects statistical character‐istics of the final matrix while neglecting richer information embedded in raw datasets.To address these issues,we proximate probability distribution function of various indicators by using cubic spline interpolation and fully exploit information in the existing massive sample data.In this paper,the entropy weight method is enhanced based on the concept mentioned above and integrated with TOPSIS model to construct a novel evaluation model.Furthermore,the experimental analysis using wastewater monitoring data from Guizhou Province,China,verifies its practicality,and its results provide valuable references for local water environmental management. 展开更多
关键词 water quality assessment entropy weight cubic spline interpolation Technique for Order Preference by Similarity to Ideal Solution(TOPSIS) big data
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New Perspective for the Philosophy of Education:Education Components,Education System Administration,Ideal Education Construction,and Engineering Education
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作者 Refet Ramiz 《Philosophy Study》 2025年第6期373-422,共50页
In this work,history of education is expressed and evaluated generally/specifically by considering the related concepts.Definition and types of education explained with specific approaches in the literature.Early chil... In this work,history of education is expressed and evaluated generally/specifically by considering the related concepts.Definition and types of education explained with specific approaches in the literature.Early childhood development briefly defined and the correlation with education systems outlined.Five education evolution phases expressed with its basic concepts.The meaning and importance of philosophy of education are then defined according to the general approaches.Some of the important philosophers of education and their philosophical/scientific interests are compared and expressed with a table.New perspective of the philosophy generally defined by considering new era philosophy,eight basic philosophies,and hybrid philosophies.R-Philosophy,R-Science,R-Information,R-Education,and R-System new disciplines are shortly expressed.New perspective for the philosophy of education defined as sub-branch of philosophy of information and explained regarding the basic information on the related theories.17 education components are defined for continuable/sustainable education,and efficiency,effective use,and improvement/development of each of the components expressed specifically.Performance of the education components for a country-X is given with a figure as an example.Relation between education,values,and basic senses is interpreted.Evaluation of the education due to 17 specific perspectives is generally mentioned.Then,evaluation of the education from philosophical,academic,and administration perspectives is specifically explained.Continuable/sustainable education administration system for a world country is defined with figures.Education system administration is defined with bloc diagrams accordingly.Ideal political/nonpolitical education construction for a progressive world country is outlined with 5x5 table,and related explanations done.Then importance of education due to 39 subjects of services is expressed with a table.Categories of education programs outlined.Digital education&digital tools and engineering education and related five industry evolution phases are defined as special education programs.New proposal is given for Education 5.0 and Engineering Education 5.0. 展开更多
关键词 philosophy of education philosophy of information philosophy of science education components information science(s) education systems education system administration ideal education construction science education engineering education
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IDEAL序列在脊柱脂肪抑制中的应用 被引量:9
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作者 黄敏华 郭勇 +2 位作者 郑奎宏 林伟 张静 《中国医学影像学杂志》 CSCD 北大核心 2012年第1期2-4,共3页
目的比较IDEALT2WI、FSET2WI序列在脊柱脂肪抑制扫描中的应用价值。资料与方法 35例脊柱MRI检查患者(颈椎10例、胸椎8例、腰椎17例)同时采用IDEALT2WI、FSET2WI两种脂肪抑制序列扫描,对图像脂肪抑制质量进行主观评价分级评估并测量信噪... 目的比较IDEALT2WI、FSET2WI序列在脊柱脂肪抑制扫描中的应用价值。资料与方法 35例脊柱MRI检查患者(颈椎10例、胸椎8例、腰椎17例)同时采用IDEALT2WI、FSET2WI两种脂肪抑制序列扫描,对图像脂肪抑制质量进行主观评价分级评估并测量信噪比。结果 FSET2WI脂肪抑制质量主观评价分级为颈椎(1.30±0.48)级、胸椎(1.80±0.71)级、腰椎(2.30±0.69)级,而IDEALT2WI序列颈、胸椎均为(3.00±0.00)级、腰椎为(2.80±0.56)级;FSET2WI脂肪抑制序列信噪比平均值分别为颈(8.73±4.66)、胸(11.33±9.27)、腰(6.81±10.15),IDEALT2WI序列信噪比平均值分别为颈(18.90±7.71)、胸(26.02±11.61)、腰(19.57±9.12),两序列信噪比差异有统计学意义(t=3.73、5.72、11.23,P<0.05)。结论脊柱MRI脂肪抑制扫描IDEALT2WI序列优于FSET2WI序列,IDEALT2WI序列能提供更均匀稳定的脂肪抑制效果,脊柱图像信噪比高,可清晰显示脊柱病变。 展开更多
关键词 IDEAL序列 脊柱 脂肪抑制 磁共振成像
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