Atrial fibrillation (AF) is the most common arrhythmia in clinic. With the increasing aging of the population in China, the incidence of atrial fibrillation is also increasing with age. The formation and progression o...Atrial fibrillation (AF) is the most common arrhythmia in clinic. With the increasing aging of the population in China, the incidence of atrial fibrillation is also increasing with age. The formation and progression of atrial fibrillation are mainly the changes of atrial anatomical structure and electrophysiological mechanism, in which atrial fibrosis plays a key role in the structural remodeling and electrical remodeling of atrial fibrillation. Although catheter ablation has been widely used in the basic treatment of atrial fibrillation, recurrence of atrial fibrillation may occur after radiofrequency ablation. The key factor of recurrence of atrial fibrillation is atrial fibrosis, so early intervention measures for early diagnosis and treatment of atrial fibrosis are helpful to reduce the recurrence rate after radiofrequency ablation. This article will comprehensively summarize the relevant studies of recurrence of atrial fibrosis after radiofrequency ablation of atrial fibrillation, in order to seek the treatment of recurrence after radiofrequency ablation of atrial fibrillation.展开更多
AIM:To study the differential expression of proteins between natural taurine treated hepatic stellate cells and controls, and investigate the underlying regulatory mechanism of natural taurine in inhibiting hepatic fi...AIM:To study the differential expression of proteins between natural taurine treated hepatic stellate cells and controls, and investigate the underlying regulatory mechanism of natural taurine in inhibiting hepatic fibrosis.METHODS: A proteomic strategy combining two-dimensional gel electrophoresis and ultraperform ance liquid chromatographyelectrospray ionizationtandem mass spectrometry (UPLCESIMS/MS) was used to study the differential expression of proteins and Western blotting was used to validate the results. Gene ontology (GO) method was utilized to analyze the functional enrichment of differentially expressed proteins. Flow cytometry was performed to compare the apoptosis rate between taurinetreated and untreated hepatic stellate cells (HSCs).RESULTS: Nineteen differentially expressed proteins (11 upregulated and 8 downregulated) were identifiedby 2D/MS, and the expression profiles of GLO1 and ANXA1 were validated by Western blotting. GO analysis found that these differentially expressed proteins were enriched within biological processes such as "cellular apoptosis", "oxidation reaction" and "metabolic process" in clusters. Flow cytometric analysis showed that taurinetreated HSCs had a significantly increased apoptosis rate when compared with the control group.CONCLUSION: Natural taurine can promote HSC apoptosis so as to inhibit hepatic fibrosis.展开更多
The probability of a radiologist interpreting a disease correctly is not only influenced by their training and experience but also on the knowledge of a particular entity.This editorial reviews certain myths and reali...The probability of a radiologist interpreting a disease correctly is not only influenced by their training and experience but also on the knowledge of a particular entity.This editorial reviews certain myths and realities associated with radiological manifestations of allergic bronchopulmonary aspergillosis(ABPA).ABPA is a hypersensitivity disorder against the antigens of Aspergillus fumigatus.Although commonly manifesting with central bronchiectasis(CB),the disorder can present without any abnormalities on high-resolution computed tomography(HRCT) of the chest,so-called serologic ABPA(ABPA-S).HRCT of the chest should not be used in screening or in the initial diagnostic work up of asthmatics,as asthma without ABPA can manifest with findings of CB.High-attenuation mucus(HAM) is the pathognomonic sign of ABPA and is very helpful in the diagnosis of ABPA complicating asthma and cystic fibrosis.Instead of classifying ABPA based on the presence and absence of CB into ABPA-CB and ABPA-S respectively,ABPA should be classif ied as ABPA-S,ABPACB and ABPA-CB-HAM.The classif ication scheme based on HAM not only identifies an immunologically severe disease but also predicts a patient with increased risk of recurrent relapses.展开更多
文摘Atrial fibrillation (AF) is the most common arrhythmia in clinic. With the increasing aging of the population in China, the incidence of atrial fibrillation is also increasing with age. The formation and progression of atrial fibrillation are mainly the changes of atrial anatomical structure and electrophysiological mechanism, in which atrial fibrosis plays a key role in the structural remodeling and electrical remodeling of atrial fibrillation. Although catheter ablation has been widely used in the basic treatment of atrial fibrillation, recurrence of atrial fibrillation may occur after radiofrequency ablation. The key factor of recurrence of atrial fibrillation is atrial fibrosis, so early intervention measures for early diagnosis and treatment of atrial fibrosis are helpful to reduce the recurrence rate after radiofrequency ablation. This article will comprehensively summarize the relevant studies of recurrence of atrial fibrosis after radiofrequency ablation of atrial fibrillation, in order to seek the treatment of recurrence after radiofrequency ablation of atrial fibrillation.
基金Supported by The National Natural Science Foundation of China, No. 30660235Guangxi Natural Science Foundation, No. 0728080
文摘AIM:To study the differential expression of proteins between natural taurine treated hepatic stellate cells and controls, and investigate the underlying regulatory mechanism of natural taurine in inhibiting hepatic fibrosis.METHODS: A proteomic strategy combining two-dimensional gel electrophoresis and ultraperform ance liquid chromatographyelectrospray ionizationtandem mass spectrometry (UPLCESIMS/MS) was used to study the differential expression of proteins and Western blotting was used to validate the results. Gene ontology (GO) method was utilized to analyze the functional enrichment of differentially expressed proteins. Flow cytometry was performed to compare the apoptosis rate between taurinetreated and untreated hepatic stellate cells (HSCs).RESULTS: Nineteen differentially expressed proteins (11 upregulated and 8 downregulated) were identifiedby 2D/MS, and the expression profiles of GLO1 and ANXA1 were validated by Western blotting. GO analysis found that these differentially expressed proteins were enriched within biological processes such as "cellular apoptosis", "oxidation reaction" and "metabolic process" in clusters. Flow cytometric analysis showed that taurinetreated HSCs had a significantly increased apoptosis rate when compared with the control group.CONCLUSION: Natural taurine can promote HSC apoptosis so as to inhibit hepatic fibrosis.
文摘The probability of a radiologist interpreting a disease correctly is not only influenced by their training and experience but also on the knowledge of a particular entity.This editorial reviews certain myths and realities associated with radiological manifestations of allergic bronchopulmonary aspergillosis(ABPA).ABPA is a hypersensitivity disorder against the antigens of Aspergillus fumigatus.Although commonly manifesting with central bronchiectasis(CB),the disorder can present without any abnormalities on high-resolution computed tomography(HRCT) of the chest,so-called serologic ABPA(ABPA-S).HRCT of the chest should not be used in screening or in the initial diagnostic work up of asthmatics,as asthma without ABPA can manifest with findings of CB.High-attenuation mucus(HAM) is the pathognomonic sign of ABPA and is very helpful in the diagnosis of ABPA complicating asthma and cystic fibrosis.Instead of classifying ABPA based on the presence and absence of CB into ABPA-CB and ABPA-S respectively,ABPA should be classif ied as ABPA-S,ABPACB and ABPA-CB-HAM.The classif ication scheme based on HAM not only identifies an immunologically severe disease but also predicts a patient with increased risk of recurrent relapses.
