Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases.Adverse reactions to these agents are one of the main causes of treatment discontinuation or inter...Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases.Adverse reactions to these agents are one of the main causes of treatment discontinuation or interruption.Myelosuppression is the most frequent adverse effect;however,approximately 5%-20%of patients develop gastrointestinal toxicity.The identification of biomarkers able to prevent and/or monitor these adverse reactions would be useful for clinicians for the proactive management of long-term thiopurine therapy.In this editorial,we discuss evidence supporting the use of PACSIN2,RAC1,and ITPA genes,in addition to TPMT and NUDT15,as possible biomarkers for thiopurine-related gastrointestinal toxicity.展开更多
伊利诺心理语言能力测验(Illinois Test of Psycholinguistic Abilities,ITPA)是以Osgood沟通交流模型为基础编制而成的心理语言能力测验,自1961年由Kirk和Mc Carthy发表后,目前已发展到第三版,在阅读障碍、语言障碍儿童及其他特殊人群...伊利诺心理语言能力测验(Illinois Test of Psycholinguistic Abilities,ITPA)是以Osgood沟通交流模型为基础编制而成的心理语言能力测验,自1961年由Kirk和Mc Carthy发表后,目前已发展到第三版,在阅读障碍、语言障碍儿童及其他特殊人群心理语言评估领域得到广泛应用。文章在对该测验的理论基础、开发过程和临床应用等进行梳理的基础上,对伊利诺心理语言能力测验的最新研究进展进行了综述,以期为该测验在中国的引进、应用和修订有所启示和借鉴。展开更多
文摘Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases.Adverse reactions to these agents are one of the main causes of treatment discontinuation or interruption.Myelosuppression is the most frequent adverse effect;however,approximately 5%-20%of patients develop gastrointestinal toxicity.The identification of biomarkers able to prevent and/or monitor these adverse reactions would be useful for clinicians for the proactive management of long-term thiopurine therapy.In this editorial,we discuss evidence supporting the use of PACSIN2,RAC1,and ITPA genes,in addition to TPMT and NUDT15,as possible biomarkers for thiopurine-related gastrointestinal toxicity.
文摘伊利诺心理语言能力测验(Illinois Test of Psycholinguistic Abilities,ITPA)是以Osgood沟通交流模型为基础编制而成的心理语言能力测验,自1961年由Kirk和Mc Carthy发表后,目前已发展到第三版,在阅读障碍、语言障碍儿童及其他特殊人群心理语言评估领域得到广泛应用。文章在对该测验的理论基础、开发过程和临床应用等进行梳理的基础上,对伊利诺心理语言能力测验的最新研究进展进行了综述,以期为该测验在中国的引进、应用和修订有所启示和借鉴。
