ITGS课程是IB课程体系中的人文及社会科学课程的一部分,ITGS含义是Information Technology in a Global Society,与传统意义的IT课程相比更强调社会应用。信息化社会的发展速度令人震惊,作为教师需要更新的知识更有紧迫性和必要性,课程...ITGS课程是IB课程体系中的人文及社会科学课程的一部分,ITGS含义是Information Technology in a Global Society,与传统意义的IT课程相比更强调社会应用。信息化社会的发展速度令人震惊,作为教师需要更新的知识更有紧迫性和必要性,课程围绕信息化社会展开,学生提出的问题常常带有时代感,由此引发的讨论也非常激烈。课堂生成性资源层出不穷,如何引导学生进行科学的探索将成为重要的课题。文章将通过课堂生成性资源的含义、为什么要探究以及如何应用、如何进行课堂评价进行探究。展开更多
Microturbulence excited by ion temperature gradient(ITG)-dominant and trapped electron mode(TEM)-dominant instabilities is compared in the fusion plasmas using gyrokinetic simulations based on the realistic equilibriu...Microturbulence excited by ion temperature gradient(ITG)-dominant and trapped electron mode(TEM)-dominant instabilities is compared in the fusion plasmas using gyrokinetic simulations based on the realistic equilibrium data from DⅢ-D discharges.Collisions make a difference between two plasmas and give rise to similar results to those found in previous research experiments[Chin.Phys.Lett.35(2018)105201].The mode structures and frequency spectrum of the most unstable modes characterized by the ITG-dominant and TEM-dominant instabilities are excited in the lower and higher T. plasmas in the linear simulations.In the nonlinear simulations,contour plots of the perturbed potential are shown in the saturated stage,with the radial correlation lengths being microscopic on the order of the ion thermal gyroradius ρi in both the ITG and the TEM microturbulences.The dominant mode wavelengths of the perturbed potential increase when evolving from linear to nonlinear stages in both simulations, with the fluctuation energy spreading from the linearly dominant modes to the nonlinearly dominant modes.The radial correlation lengths are about 4ρi and the electron density fluctuation intensities are about 0.85% in the nonlinear saturated stage,which are in agreement with the experimental results.展开更多
Cervical cancer(CCa)is a substantial global health concern,and its lymph node metastasis(LNM)significantly diminishes patients'survival rates.1 Hence,a thorough investigation into the molecular mechanisms driving ...Cervical cancer(CCa)is a substantial global health concern,and its lymph node metastasis(LNM)significantly diminishes patients'survival rates.1 Hence,a thorough investigation into the molecular mechanisms driving this progression is vital.Integrin alpha 2(ITGA2)plays critical roles in various tumorigenic processes via cancer-related signaling pathways.展开更多
Recent studies have highlighted the pivotal roles of circular RNAs(circRNAs)in cardiovascular diseases.Through high-throughput circRNA sequencing of both normal myocardial tissues and hypertrophic patients,we unveiled...Recent studies have highlighted the pivotal roles of circular RNAs(circRNAs)in cardiovascular diseases.Through high-throughput circRNA sequencing of both normal myocardial tissues and hypertrophic patients,we unveiled 32,034 previously undiscovered circRNAs with distinct cardiac expression patterns.Notably,circITGa9,a circRNA derived from integrin-α9,exhibited substantial up-regulation in cardiac hypertrophy patients.This elevation was validated across extensive sample pools from cardiac patients and donors.In vivo experiments revealed heightened cardiac fibrosis in mice subjected to transverse aortic constriction(TAC)after circITGa9 injection.We identified circITGa9 binding proteins through circRNA precipitation followed by liquid chromatography tandem-mass spectrometry.Furthermore,circRNA pull-down/precipitation assays demonstrated that increased circITGa9 expression facilitated binding with tropomyosin 3(TPM3).Specific binding sites between circITGa9 and TPM3 were identified through computational algorithms and further validated by site-directed mutagenesis.We further showed that circITGa9 induced actin polymerization,characteristic of tissue fibrosis.Finally,we developed approaches that improved cardiac function and decreased fibrosis by delivering small interfering RNA targeting circITGa9 or blocking oligo inhibiting the interaction of circITGa9 and TPM3 into TAC mice,which is amenable for further preclinical and translational development.We conclude that elevated circITGa9 levels drive cardiac remodeling and fibrosis.By pinpointing circITGa9 as a therapeutic target,we open doors to innovative interventions for mitigating cardiac remodeling and fibrosis.展开更多
文摘异类传感器数据关联是数据融合中的一个难点 ,综合利用角度和其他特征信息是改善异类传感器数据关联的一个重要途径。对于雷达在直角坐标系对目标进行跟踪、ESM传感器在修正的极坐标系对目标进行跟踪情况 ,本文综合利用角度、角度变化率和ITG(Inverse Time to Go)信息 ,构建了新的关联统计量 ,并进行了计算机仿真。结果表明 ,本文给出的新关联统计量较之只利用角度和ITG信息的关联统计量有更好的关联性能。
文摘ITGS课程是IB课程体系中的人文及社会科学课程的一部分,ITGS含义是Information Technology in a Global Society,与传统意义的IT课程相比更强调社会应用。信息化社会的发展速度令人震惊,作为教师需要更新的知识更有紧迫性和必要性,课程围绕信息化社会展开,学生提出的问题常常带有时代感,由此引发的讨论也非常激烈。课堂生成性资源层出不穷,如何引导学生进行科学的探索将成为重要的课题。文章将通过课堂生成性资源的含义、为什么要探究以及如何应用、如何进行课堂评价进行探究。
基金Supported by the National MCF Energy R&D Program under Grant Nos 2018YFE0304100,2017YFE0301300 and 2018YFE0311300the National Natural Science Foundation of China under Grant Nos 11675257,11675256,11875067,11835016 and 11705275+2 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences under Grant No XDB16010300the Key Research Program of Frontier Science of the Chinese Academy of Sciences under Grant No QYZDJ-SSW-SYS016the External Cooperation Program of the Chinese Academy of Sciences under Grant No 112111KYSB20160039
文摘Microturbulence excited by ion temperature gradient(ITG)-dominant and trapped electron mode(TEM)-dominant instabilities is compared in the fusion plasmas using gyrokinetic simulations based on the realistic equilibrium data from DⅢ-D discharges.Collisions make a difference between two plasmas and give rise to similar results to those found in previous research experiments[Chin.Phys.Lett.35(2018)105201].The mode structures and frequency spectrum of the most unstable modes characterized by the ITG-dominant and TEM-dominant instabilities are excited in the lower and higher T. plasmas in the linear simulations.In the nonlinear simulations,contour plots of the perturbed potential are shown in the saturated stage,with the radial correlation lengths being microscopic on the order of the ion thermal gyroradius ρi in both the ITG and the TEM microturbulences.The dominant mode wavelengths of the perturbed potential increase when evolving from linear to nonlinear stages in both simulations, with the fluctuation energy spreading from the linearly dominant modes to the nonlinearly dominant modes.The radial correlation lengths are about 4ρi and the electron density fluctuation intensities are about 0.85% in the nonlinear saturated stage,which are in agreement with the experimental results.
基金supported by grants from the Applied Basic Research Program of Shanxi,China (No.20210302123277)the Key Research and Development Program of Shanxi,China (No.201903D321152)the National Natural Science Foundation of China (No.82373107).
文摘Cervical cancer(CCa)is a substantial global health concern,and its lymph node metastasis(LNM)significantly diminishes patients'survival rates.1 Hence,a thorough investigation into the molecular mechanisms driving this progression is vital.Integrin alpha 2(ITGA2)plays critical roles in various tumorigenic processes via cancer-related signaling pathways.
基金supported by grants from Canadian Institutes of Health Research(PJT-155962 and PJT-166107)to B.B.Y.
文摘Recent studies have highlighted the pivotal roles of circular RNAs(circRNAs)in cardiovascular diseases.Through high-throughput circRNA sequencing of both normal myocardial tissues and hypertrophic patients,we unveiled 32,034 previously undiscovered circRNAs with distinct cardiac expression patterns.Notably,circITGa9,a circRNA derived from integrin-α9,exhibited substantial up-regulation in cardiac hypertrophy patients.This elevation was validated across extensive sample pools from cardiac patients and donors.In vivo experiments revealed heightened cardiac fibrosis in mice subjected to transverse aortic constriction(TAC)after circITGa9 injection.We identified circITGa9 binding proteins through circRNA precipitation followed by liquid chromatography tandem-mass spectrometry.Furthermore,circRNA pull-down/precipitation assays demonstrated that increased circITGa9 expression facilitated binding with tropomyosin 3(TPM3).Specific binding sites between circITGa9 and TPM3 were identified through computational algorithms and further validated by site-directed mutagenesis.We further showed that circITGa9 induced actin polymerization,characteristic of tissue fibrosis.Finally,we developed approaches that improved cardiac function and decreased fibrosis by delivering small interfering RNA targeting circITGa9 or blocking oligo inhibiting the interaction of circITGa9 and TPM3 into TAC mice,which is amenable for further preclinical and translational development.We conclude that elevated circITGa9 levels drive cardiac remodeling and fibrosis.By pinpointing circITGa9 as a therapeutic target,we open doors to innovative interventions for mitigating cardiac remodeling and fibrosis.
