Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network con...Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network connectivity and predictors of iTBS treatment outcomes in adolescents and young adults with depression.Aim This study aimed to identify default mode network(DMN)-based connectivity patterns associated with varying iTBS treatment outcomes in depression.Methods Data from a randomised controlled trial of iTBS in depression(n=82)were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN.Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment.Furthermore,the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.Results Two distinct subgroups were identified.Subgroup 1 exhibited high heterogeneity and greater centrality in the posterior cingulate cortex and retrosplenial cortex,while subgroup 2 showed more homogeneous connectivity patterns and greater centrality in the temporoparietal junction and posterior inferior parietal lobule.No main effect for subgroup,treatment or subgroup×treatment interaction was revealed in the improvement of depressive symptoms.A significant subgroup×treatment interaction related to symbol coding improvement was detected(F=5.22,p=0.026).Within subgroup 1,the active group showed significantly greater improvement in symbol coding compared with the sham group(t=2.30,p=0.028),while baseline levels of interleukin-6 and C-reactive protein emerged as significant indicators for predicting improvements in symbolic coding(R2=0.35,RMSE(root-mean-square error)=5.72,p=0.013).Subgroup 2 showed no significant findings in terms of cognitive improvement or inflammatory cytokines predictions.展开更多
2025年10月,亚太地区旅游行业的目光聚焦于新加坡金沙会展中心,ITB Asia 2025在此盛大举行。这场旅游贸易盛会以其广泛的国际参与度、破纪录的商务会议数量以及对创新、可持续发展与战略合作的前瞻性关注,再次巩固了其在塑造亚太旅游业...2025年10月,亚太地区旅游行业的目光聚焦于新加坡金沙会展中心,ITB Asia 2025在此盛大举行。这场旅游贸易盛会以其广泛的国际参与度、破纪录的商务会议数量以及对创新、可持续发展与战略合作的前瞻性关注,再次巩固了其在塑造亚太旅游业未来中的核心地位。众多行业前沿动态和创新成果纷纷亮相,为亚太旅游业的未来发展勾勒出充满活力与希望的图景。展开更多
A transport simulation has been done by using a i.5D time dependent transportcode to reproduce a formation of the ITB on electron temperature Profile during the long pu1seLHCD in JT-60U tokamak. The transport coeffici...A transport simulation has been done by using a i.5D time dependent transportcode to reproduce a formation of the ITB on electron temperature Profile during the long pu1seLHCD in JT-60U tokamak. The transport coefficients were assumed to reduce with a reversedmagnetic shear and the LH driven current profile was evaluated by fitting dynamic change inthe measured current profile. The gradual increase in the central electron temperature could beexplained by the change in the current profile during LHCD in the present simulation model. Theestimated LH-driven current profile by the transport code analysis shows a finite current densityat the plasma center. Analysis of transport simulation suggests some mechanisms for broadeningthe LH-driven current profile at the central region of the plasma.展开更多
A new long-pulse high electron temperature(Te)regime has been achieved on experimental advanced superconducting tokamak by pure radio frequency heating.In this new scenario,there are mainly two confinement states invo...A new long-pulse high electron temperature(Te)regime has been achieved on experimental advanced superconducting tokamak by pure radio frequency heating.In this new scenario,there are mainly two confinement states involving two magneto-hydrodynamic(MHD)modes,one of which is identified as m/n=1/1 kink mode(where m and n are the poloidal and toroidal mode numbers,respectively).The frequency evolution of the kink mode is investigated through the three-dimensional,toroidal,and nonlinear Hall-MHD code CLT.We firstly find that the frequency of the m/n=1/1 kink mode significantly increases during each sawtooth crash and then confirmed it through the experimental data.The simulation results indicate that the increase of the mode frequency is mainly due to the significant increase of the electron diamagnetic frequency nearby the reconnection region.We have also observed the internal transport barrier(ITB)during the m/n=1/1 kink mode.To further investigate this m/n=1/1 kink mode in this new regime,the multi-scale interactions between the m/n=1/1 kink mode and turbulence are discussed.展开更多
Internal transport barriers(ITB) have been achieved and studied in different shear (such as positive shear, weak shear and reversed shear) discharges in most of the major tokamak devices. It is normally produced by ap...Internal transport barriers(ITB) have been achieved and studied in different shear (such as positive shear, weak shear and reversed shear) discharges in most of the major tokamak devices. It is normally produced by application of neutral beam展开更多
基金supported by the Guangzhou Municipal Key Discipline in Medicine(2021-2023)the Guangzhou High-level Clinical Key Specialty,the Guangzhou Research-oriented Hospital,the Innovative Clinical Technique of Guangzhou(2024-2026)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(grant number 2022A1515011567,2020A1515110565)the Guangzhou Science,Technology Planning Project(grant number 202201010714,202103000032)the National Natural Science Foundation of China(grant number 82471546)the Guangdong College Students Innovation and Entrepreneurship Training Project(grant number S202310570038)the Guangzhou Health Science and Technology Project(grant number 20231A010038)the Guangzhou Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine Technology Project(grant number:20232A010013)the Science and Technology Plan Project of Guangzhou(2023A03J0842).
文摘Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network connectivity and predictors of iTBS treatment outcomes in adolescents and young adults with depression.Aim This study aimed to identify default mode network(DMN)-based connectivity patterns associated with varying iTBS treatment outcomes in depression.Methods Data from a randomised controlled trial of iTBS in depression(n=82)were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN.Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment.Furthermore,the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.Results Two distinct subgroups were identified.Subgroup 1 exhibited high heterogeneity and greater centrality in the posterior cingulate cortex and retrosplenial cortex,while subgroup 2 showed more homogeneous connectivity patterns and greater centrality in the temporoparietal junction and posterior inferior parietal lobule.No main effect for subgroup,treatment or subgroup×treatment interaction was revealed in the improvement of depressive symptoms.A significant subgroup×treatment interaction related to symbol coding improvement was detected(F=5.22,p=0.026).Within subgroup 1,the active group showed significantly greater improvement in symbol coding compared with the sham group(t=2.30,p=0.028),while baseline levels of interleukin-6 and C-reactive protein emerged as significant indicators for predicting improvements in symbolic coding(R2=0.35,RMSE(root-mean-square error)=5.72,p=0.013).Subgroup 2 showed no significant findings in terms of cognitive improvement or inflammatory cytokines predictions.
文摘2025年10月,亚太地区旅游行业的目光聚焦于新加坡金沙会展中心,ITB Asia 2025在此盛大举行。这场旅游贸易盛会以其广泛的国际参与度、破纪录的商务会议数量以及对创新、可持续发展与战略合作的前瞻性关注,再次巩固了其在塑造亚太旅游业未来中的核心地位。众多行业前沿动态和创新成果纷纷亮相,为亚太旅游业的未来发展勾勒出充满活力与希望的图景。
文摘A transport simulation has been done by using a i.5D time dependent transportcode to reproduce a formation of the ITB on electron temperature Profile during the long pu1seLHCD in JT-60U tokamak. The transport coefficients were assumed to reduce with a reversedmagnetic shear and the LH driven current profile was evaluated by fitting dynamic change inthe measured current profile. The gradual increase in the central electron temperature could beexplained by the change in the current profile during LHCD in the present simulation model. Theestimated LH-driven current profile by the transport code analysis shows a finite current densityat the plasma center. Analysis of transport simulation suggests some mechanisms for broadeningthe LH-driven current profile at the central region of the plasma.
基金supported by the National Magnetic Confinement Fusion Science Program of China (No. 11505226)National Natural Science Foundation of China (Nos. 11975273 and 12005185)+2 种基金the Fundamental Research Fund for Chinese Central Universities (No. 2021FZZX003-03-02)the Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences (Nos. DSJJ-202103 and DSJJ-2021-08)the National Key R&D Program of China (No. 2019YFE03010002)
文摘A new long-pulse high electron temperature(Te)regime has been achieved on experimental advanced superconducting tokamak by pure radio frequency heating.In this new scenario,there are mainly two confinement states involving two magneto-hydrodynamic(MHD)modes,one of which is identified as m/n=1/1 kink mode(where m and n are the poloidal and toroidal mode numbers,respectively).The frequency evolution of the kink mode is investigated through the three-dimensional,toroidal,and nonlinear Hall-MHD code CLT.We firstly find that the frequency of the m/n=1/1 kink mode significantly increases during each sawtooth crash and then confirmed it through the experimental data.The simulation results indicate that the increase of the mode frequency is mainly due to the significant increase of the electron diamagnetic frequency nearby the reconnection region.We have also observed the internal transport barrier(ITB)during the m/n=1/1 kink mode.To further investigate this m/n=1/1 kink mode in this new regime,the multi-scale interactions between the m/n=1/1 kink mode and turbulence are discussed.
文摘Internal transport barriers(ITB) have been achieved and studied in different shear (such as positive shear, weak shear and reversed shear) discharges in most of the major tokamak devices. It is normally produced by application of neutral beam
