Acute toxicity of phoxim,acephate,isofenphos-methyl and isocarbophos on male SD rats of clean grade was carried out by gastric lavage method at room temperature of 18℃.These rats are 4 to 5 months old with body weigh...Acute toxicity of phoxim,acephate,isofenphos-methyl and isocarbophos on male SD rats of clean grade was carried out by gastric lavage method at room temperature of 18℃.These rats are 4 to 5 months old with body weight of 180 to 220 kg.The results indicate that the orders of the toxicity of these four pesticides on SD rats are isofenphos-methyl,isocarbophos,acephate,phoxim.We found that the median lethal concentration of phoxim in 24 h,48 h,72 h and 96 h is 3.892 g/kg,3.051 g/kg,2.618 g/kg and 2.458 g/kg respectively;the median lethal concentration of isofenphos-methyl in 24 h,48 h,72 h and 96 h is 0.015 g/kg,0.013g/kg,0.012g/kg and 0.011 g/kg respectively;the median lethal concentration of isocarbophos in 24 h,48 h,72 h and 96 h is 0.049 g/kg,0.046 g/kg,0.043 g/kg,0.041 g/kg respectively;and the median lethal concentration of acephate in 24 h,48 h,72 h and 96 h is 0.137 g/kg,0.113 g/kg,0.100 g/kg,0.085 g/kg respectively.Finally,we evaluated the characteristics of toxicity effect and safe concentration of these pesticides to SD rats.展开更多
基金Supported by Natural Science Research Project of Henan Provincial Department of Education(2010B320011)
文摘Acute toxicity of phoxim,acephate,isofenphos-methyl and isocarbophos on male SD rats of clean grade was carried out by gastric lavage method at room temperature of 18℃.These rats are 4 to 5 months old with body weight of 180 to 220 kg.The results indicate that the orders of the toxicity of these four pesticides on SD rats are isofenphos-methyl,isocarbophos,acephate,phoxim.We found that the median lethal concentration of phoxim in 24 h,48 h,72 h and 96 h is 3.892 g/kg,3.051 g/kg,2.618 g/kg and 2.458 g/kg respectively;the median lethal concentration of isofenphos-methyl in 24 h,48 h,72 h and 96 h is 0.015 g/kg,0.013g/kg,0.012g/kg and 0.011 g/kg respectively;the median lethal concentration of isocarbophos in 24 h,48 h,72 h and 96 h is 0.049 g/kg,0.046 g/kg,0.043 g/kg,0.041 g/kg respectively;and the median lethal concentration of acephate in 24 h,48 h,72 h and 96 h is 0.137 g/kg,0.113 g/kg,0.100 g/kg,0.085 g/kg respectively.Finally,we evaluated the characteristics of toxicity effect and safe concentration of these pesticides to SD rats.
