Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical t...Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex(AAPIC)compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks.AAPIC achieved comparable hemoglobin improvements(from 98.3±8.7 to 126.5±9.2 g/L)to heme iron(from 97.8±9.1 to 128.3±8.6 g/L)and was significantly superior to ferrous glycinate(from 98.6±8.9 to 119.7±10.3 g/L;p<0.001).Iron absorption efficiency showed AAPIC at 23.7±4.2%,heme iron at 25.1±3.8%,and ferrous glycinate at 18.4±5.1%.Toxicological assessments revealed no hepatotoxicity,nephrotoxicity,or mutagenicity.Gastrointestinal adverse events occurred in 8.3%of AAPIC recipients versus 15.0%with ferrous glycinate and 10.0%with heme iron.The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms.AAPIC represents a promising,well-tolerated alternative with clinical efficacy comparable to established iron formulations.展开更多
Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mech...Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mechanisms underlying these processes remain incompletely understood.Iron is an essential trace element in the human body,playing a crucial role in various biological processes.The maintenance of iron homeostasis relies on the body's intricate and nuanced regulatory mechanisms.In recent years,considerable attention has been directed toward the relationship between dysregulated iron homeostasis and neurodegenerative diseases.The regulation of iron homeostasis within cells is crucial for maintaining proper nervous system function.Research has already revealed that disruptions in iron homeostasis may lead to ferroptosis and oxidative stress,which,in turn,can impact neuronal health and contribute to the development of neurodegenerative diseases.This article primarily explores the intimate relationship between iron homeostasis and neurodegenerative diseases,aiming to provide novel insights and strategies for treating these debilitating conditions.展开更多
This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the correspo...This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the corresponding ester[Fe_(2)(CO)_(6)(μ‑tedt)](2),where tedt=SCH_(2)CH(CH_(2)OOC(5‑C_(3)HNSCH_(3)))S.Further reactions of complex 2 with tri(ptolyl)phosphine(tp)or tris(4‑fluorophenyl)phosphine(fp)gave the phosphine‑substituted derivatives[Fe_(2)(CO)_(5)(tp)(μ‑tedt)](3)and[Fe_(2)(CO)_(5)(fp)(μ‑tedt)](4).The structures of the newly prepared complexes were elucidated by elemental analysis,NMR,IR,and X‑ray photoelectron spectroscopy.Moreover,single‑crystal X‑ray diffraction analysis confirmed their molecular structures,showing that they contain a di‑iron core ligated by a bridged dithiolate bearing a thiazole moiety and terminal carbonyls.The electrochemical and electrocatalytic proton reduction were probed by cyclic voltammetry,revealing that three complexes can catalyze the reduction of protons to H_(2) under the electrochemical conditions.For comparison,complex 4 possessed the best efficiency with a turnover frequency of 23.5 s^(-1)at 10 mmol·L^(-1)HOAc concentration.In addition,the fungicidal activity of these complexes was also investigated in this study.CCDC:2477511,2;2477512,3;2477513,4.展开更多
Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presen...Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presents significant challenges.In this study,a novel research method was introduced for investigating the solidification process of ductile iron pipe,namely thermal simulation of ductile iron pipe.Comparative research was conducted on the microstructure and properties of the thermal simulation sample and the ductile iron pipe.The findings indicate that the thermal simulation sample and ductile iron pipe exhibit good heat transfer similarity and microstructure similarity.The difference of cooling rate between thermal simulation sample and ductile pipe is less than 0.24℃·s^(-1),and the difference of microstructure content of free cementite,ferrite,and pearlite is less than 5%.The tensile strength of annealed ductile iron pipe is 466 MPa,with an elongation of 16.1%and a Brinell hardness of 156.5 HBW.In comparison,the tensile strength of annealed thermal simulation sample is 482.0 MPa,with an elongation of 15.5%and a Brinell hardness of 159.0 HBW.These results suggest that the thermal simulation experimental research method is both scientific and feasible,offering an objective,reliable,and cost-effective approach to laboratory research on ductile iron pipe.展开更多
With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely o...With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely obesity and neurodegeneration.展开更多
Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity an...Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T_(2)-weighted MRI contrast agent.展开更多
Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in hu...Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.展开更多
1.Introduction.Since the Industrial Revolution,the partial pressure of atmospheric carbon dioxide(pCO_(2))has increased markedly,rising from approximately 280 ppm(1 ppm=1μL/L)to about 420 ppm.This escalation has inte...1.Introduction.Since the Industrial Revolution,the partial pressure of atmospheric carbon dioxide(pCO_(2))has increased markedly,rising from approximately 280 ppm(1 ppm=1μL/L)to about 420 ppm.This escalation has intensified global warming,with 2024 the hottest year on record since 1850.The global mean temperature now stands 1.46℃ above the pre-industrial average(1850-1900),a value already approaching the 1.5℃ threshold set by the Paris Agreement(NOAA,2025).展开更多
BACKGROUND Sepsis-associated liver injury(SALI)refers to secondary liver function impairment caused by sepsis,patients with SALI often have worse clinical outcomes.The early identification and assessment of the occurr...BACKGROUND Sepsis-associated liver injury(SALI)refers to secondary liver function impairment caused by sepsis,patients with SALI often have worse clinical outcomes.The early identification and assessment of the occurrence and progression of SALI are pressing issues that urgently need to be resolved.AIM To investigate the relationship between iron metabolism and SALI.METHODS In this prospective study,139 patients were recruited,with 53 assigned to the SALI group.The relationships between SALI and various iron metabolism-related biomarkers were examined.These biomarkers included serum iron(SI),total iron-binding capacity(TIBC),serum ferritin,transferrin,and transferrin saturation.To identify independent risk factors for SALI,both univariate and multivariate logistic regression analyses were performed.Additionally,receiver operating characteristic curve analysis was utilized to assess the predictive value of these biomarkers for the occurrence of SALI.RESULTS There were no statistically significant differences in age,sex,body mass index,Sequential Organ Failure Assessment scores(excluding liver function),or APACHE II scores between the two groups of patients.Compared with the sepsis group,the SALI group presented significantly higher SI(P<0.001),TIBC(P<0.001),serum ferritin(P=0.001),transferrin(P=0.005),and transferrin saturation levels(P<0.001).Multivariate logistic regression analysis revealed that SI(odds ratio=1.24,95%confidence interval:1.11-1.40,P<0.001)and TIBC levels(odds ratio=1.13,95%confidence interval:1.05-1.21,P<0.001)were independent predictors of SALI.Receiver operating characteristic curve analysis revealed that SI and TIBC had areas under the curve of 0.816 and 0.757,respectively,indicating moderate predictive accuracy for SALI.CONCLUSION Iron metabolism disorders are closely associated with the development of SALI,and SI and TIBC may serve as potential predictive biomarkers.The combined use of SI and TIBC has superior diagnostic efficacy for SALI.These findings provide valuable insights for the early identification and management of SALI among patients with sepsis.展开更多
Ultrasmall superparamagnetic iron oxide nanoparticles(usSPIONs)are promising alternatives to gadolinium‐based contrast agents for positive contrast enhancement in magnetic resonance imaging(MRI).Unlike larger SPIONs ...Ultrasmall superparamagnetic iron oxide nanoparticles(usSPIONs)are promising alternatives to gadolinium‐based contrast agents for positive contrast enhancement in magnetic resonance imaging(MRI).Unlike larger SPIONs that primarily function as T2/T2*negative contrast agents,usSPIONs with core diameters below 5 nm can effectively shorten T1 relaxation times,producing bright signals in T1‐weighted images.This distinct behavior stems from their unique magnetic properties,including single‐domain configurations,surface spin canting,and rapid Néel relaxation dynamics,which are particularly enhanced at low magnetic field strengths.The biocompatibility of iron oxide,efficient renal clearance pathways,and versatility for surface functionalization offer potential advantages over gadolinium‐based agents,especially regarding safety concerns related to nephrogenic systemic fibrosis and gadolinium deposition.These nanoparticles show particular promise for applications in lowfield MRI,vascular imaging,targeted molecular imaging,and theranostic platforms.Although challenges remain in optimizing synthesis methods for consistent production of monodisperse usSPIONs with tailored surface chemistry,ongoing research continues to advance their potential for clinical translation.This review explores the mechanisms,synthesis approaches,applications,and future perspectives of usSPIONs as positive contrast agents in MRI.展开更多
This letter offered commentary on the recently published article by Wang et al that investigated the relationship between iron metabolism disorders and sepsis-associated liver injury(SALI).The original study identifie...This letter offered commentary on the recently published article by Wang et al that investigated the relationship between iron metabolism disorders and sepsis-associated liver injury(SALI).The original study identified serum iron and total iron-binding capacity as potential predictive markers of SALI,contributing important insights to critical care hepatology.In this correspondence several methodological considerations that may influence the interpretation and general-izability of the findings were discussed.These include the limitations of a single-center design,the lack of serial biomarker measurements,the omission of hepcidin(a central iron regulatory hormone)as a measured variable,and the exclusive reliance on biochemical criteria for diagnosing liver injury.The potential value of incorporating imaging modalities and additional iron-related markers such as ferritin and transferrin saturation were also highlighted.The aim was to reinforce the importance of a comprehensive approach to iron metabolism in sepsis and to suggest future directions for clinical research that may enhance the diagnostic and prognostic utility of iron-related biomarkers in SALI.展开更多
Colorectal cancer(CRC)considerably affects global health,and its progression is intricately tied to interactions within the tumormicroenvironment.This review focuses on the intricate crosstalk between metabolic reprog...Colorectal cancer(CRC)considerably affects global health,and its progression is intricately tied to interactions within the tumormicroenvironment.This review focuses on the intricate crosstalk between metabolic reprogramming in CRC cells and the tumor immune microenvironment(TIME),thereby emphasizing the dual functionality of metabolic pathways in tumor growth and immune regulation.Furthermore,the review delves into key metabolic changes,including alterations in glucose,lipid,iron,and ammonia metabolism,and their profound effects on the immune landscape of CRC.Enhanced glycolysis and lipid metabolism facilitate tumor survival and proliferation,while establishing an immunosuppressive TIME that hinders effective immune responses.Moreover,the roles of iron and ammonia metabolism in immune evasion and tumor progression were explored,and these metabolic pathways presented as promising targets to improve CRC therapy.By conducting a comprehensive analysis of recent studies,this review provides insights into potential therapeutic targets within these metabolic interactions,with the aim of enhancing the efficacy of existing treatments and devising novel strategies for combating CRC.展开更多
The utilization of iron coke provides a green pathway for low-carbon ironmaking.To uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the micro...The utilization of iron coke provides a green pathway for low-carbon ironmaking.To uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was investigated.Furthermore,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric method.The findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and interconnect.This provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron coke.Accelerating the heating rate in non-isothermal gasification can enhance the reactivity of iron coke.The metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon atoms.The kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore structure.Moreover,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.展开更多
Iron is an essential trace element in the human body,crucial in maintaining normal physiological functions.Recent studies have identified iron ions as a significant factor in initiating the ferroptosis process,a novel...Iron is an essential trace element in the human body,crucial in maintaining normal physiological functions.Recent studies have identified iron ions as a significant factor in initiating the ferroptosis process,a novel mode of programmed cell death characterized by iron overload and lipid peroxide accumulation.The iron metabolism pathway is one of the primary mechanisms regulating ferroptosis,as it maintains iron homeostasis within the cell.Numerous studies have demonstrated that abnormalities in iron metabolism can trigger the Fenton reaction,exacerbating oxidative stress,and leading to cell membrane rupture,cellular dysfunction,and damage to tissue structures.Therefore,regulation of iron metabolism represents a key strategy for ameliorating ferroptosis and offers new insights for treating diseases associated with iron metabolism imbalances.This review first summarizes the mechanisms that regulate iron metabolic pathways in ferroptosis and discusses the connections between the pathogenesis of various diseases and iron metabolism.Next,we introduce natural and synthetic small molecule compounds,hormones,proteins,and new nanomaterials that can affect iron metabolism.Finally,we provide an overview of the challenges faced by iron regulators in clinical translation and a summary and outlook on iron metabolism in ferroptosis,aiming to pave the way for future exploration and optimi-zation of iron metabolism regulation strategies.展开更多
Against the background of“carbon peak and carbon neutrality,”it is of great practical significance to develop non-blast furnace ironmaking technology for the sustainable development of steel industry.Carbon-bearing ...Against the background of“carbon peak and carbon neutrality,”it is of great practical significance to develop non-blast furnace ironmaking technology for the sustainable development of steel industry.Carbon-bearing iron ore pellet is an innovative burden of direct reduction ironmaking due to its excellent self-reducing property,and the thermal strength of pellet is a crucial metallurgical property that affects its wide application.The carbon-bearing iron ore pellet without binders(CIPWB)was prepared using iron concentrate and anthracite,and the effects of reducing agent addition amount,size of pellet,reduction temperature and time on the thermal compressive strength of CIPWB during the reduction process were studied.Simultaneously,the mechanism of the thermal strength evolution of CIPWB was revealed.The results showed that during the low-temperature reduction process(300-500℃),the thermal compressive strength of CIPWB linearly increases with increasing the size of pellet,while it gradually decreases with increasing the anthracite ratio.When the CIPWB with 8%anthracite is reduced at 300℃for 60 min,the thermal strength of pellet is enhanced from 13.24 to 31.88 N as the size of pellet increases from 8.04 to 12.78 mm.Meanwhile,as the temperature is 500℃,with increasing the anthracite ratio from 2%to 8%,the thermal compressive strength of pellet under reduction for 60 min remarkably decreases from 41.47 to 8.94 N.Furthermore,in the high-temperature reduction process(600-1150℃),the thermal compressive strength of CIPWB firstly increases and then reduces with increasing the temperature,while it as well as the temperature corresponding to the maximum strength decreases with increasing the anthracite ratio.With adding 18%anthracite,the thermal compressive strength of pellet reaches the maximum value at 800℃,namely 35.00 N,and obtains the minimum value at 1050℃,namely 8.60 N.The thermal compressive strength of CIPWB significantly depends on the temperature,reducing agent dosage,and pellet size.展开更多
Rolling the iron hoop is a fun and traditional Chinese children's game.Long ago,many children played this game in parks,streets,and schoolyards.It has a long history and is still loved by many people today.
This study was conducted to determine the content,distribution and transformation of iron oxides in the soils of the Middle Euphrates regions in Iraq.The study included four sites:Tuwairij area in Karbala Governorate,...This study was conducted to determine the content,distribution and transformation of iron oxides in the soils of the Middle Euphrates regions in Iraq.The study included four sites:Tuwairij area in Karbala Governorate,College of Agriculture at the University of Kufa in Najaf Governorate,College of Agriculture at the University of Qadisiyah in Diwaniyah Governorate,and the Nile District in Babylon Governorate.The results showed that the soils of Najaf and Qadisiyah were superior in terms of their content of total free iron oxides(Fet)compared to the soils of Karbala and Babylon.The relative distribution of free iron oxides was generally close among the studied sites,with a homogeneous pattern in the distribution of these oxides within the soil horizons.As for silicate iron oxides(Fes),a homogeneous pattern was observed in the soil of Babylon with its content increasing with depth,while these patterns varied in the soils of Karbala,Najaf and Qadisiyah.Regarding the ratios of crystalline iron oxides(Fed/Fet),the study showed that the Babylon and Qadisiyah soils recorded the highest values,while these values were lower in the Najaf and Karbala soils.On the other hand,amorphous iron oxides(FeO)showed similar values in the Najaf and Qadisiyah soils.In general,these results clearly showed the effect of environmental and geochemical factors of the study areas on the distribution and transformations of iron oxides in the soil of the Middle Euphrates regions.展开更多
Acute kidney injury(AKI)represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.In the last 3 decades,the disruption of iron homeostasis and the cytotoxic eff...Acute kidney injury(AKI)represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.In the last 3 decades,the disruption of iron homeostasis and the cytotoxic effects mediated by iron have been extensively acknowledged as contributors to,as well as outcomes of,renal damage.Therefore,iron metabolism has become the focus of novel therapeutic interventions for AKI,with targeted iron metabolism strategies showing great potential.In this review,we have explored the dysregulation of iron metabolism in AKI and the AKI caused by iron metabolism disorders.We have summarized the complex mechanisms of iron metabolism in the kidney and emphasized the potential role of iron metabolism-related metabolic pathways in the treatment and prevention of AKI.Finally,we have reviewed various strategies targeting iron metabolism for the treatment of AKI,hoping to provide more effective treatment options for AKI patients in the future.展开更多
文摘Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex(AAPIC)compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks.AAPIC achieved comparable hemoglobin improvements(from 98.3±8.7 to 126.5±9.2 g/L)to heme iron(from 97.8±9.1 to 128.3±8.6 g/L)and was significantly superior to ferrous glycinate(from 98.6±8.9 to 119.7±10.3 g/L;p<0.001).Iron absorption efficiency showed AAPIC at 23.7±4.2%,heme iron at 25.1±3.8%,and ferrous glycinate at 18.4±5.1%.Toxicological assessments revealed no hepatotoxicity,nephrotoxicity,or mutagenicity.Gastrointestinal adverse events occurred in 8.3%of AAPIC recipients versus 15.0%with ferrous glycinate and 10.0%with heme iron.The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms.AAPIC represents a promising,well-tolerated alternative with clinical efficacy comparable to established iron formulations.
基金supported in part by the National Natural Science Foundation of China,No.82371153(to YS)the Natural Science Foundation of Shandong Province,Nos.ZR2021MH378,ZR2022QH073(to LC)+1 种基金the Shandong Society of Geriatric Science and Technology Project,No.LKJGG2021Z020(to YS)the Yantai Science and Technology Innovation Development Project,Nos.2022YD009,2023YD050。
文摘Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mechanisms underlying these processes remain incompletely understood.Iron is an essential trace element in the human body,playing a crucial role in various biological processes.The maintenance of iron homeostasis relies on the body's intricate and nuanced regulatory mechanisms.In recent years,considerable attention has been directed toward the relationship between dysregulated iron homeostasis and neurodegenerative diseases.The regulation of iron homeostasis within cells is crucial for maintaining proper nervous system function.Research has already revealed that disruptions in iron homeostasis may lead to ferroptosis and oxidative stress,which,in turn,can impact neuronal health and contribute to the development of neurodegenerative diseases.This article primarily explores the intimate relationship between iron homeostasis and neurodegenerative diseases,aiming to provide novel insights and strategies for treating these debilitating conditions.
文摘This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the corresponding ester[Fe_(2)(CO)_(6)(μ‑tedt)](2),where tedt=SCH_(2)CH(CH_(2)OOC(5‑C_(3)HNSCH_(3)))S.Further reactions of complex 2 with tri(ptolyl)phosphine(tp)or tris(4‑fluorophenyl)phosphine(fp)gave the phosphine‑substituted derivatives[Fe_(2)(CO)_(5)(tp)(μ‑tedt)](3)and[Fe_(2)(CO)_(5)(fp)(μ‑tedt)](4).The structures of the newly prepared complexes were elucidated by elemental analysis,NMR,IR,and X‑ray photoelectron spectroscopy.Moreover,single‑crystal X‑ray diffraction analysis confirmed their molecular structures,showing that they contain a di‑iron core ligated by a bridged dithiolate bearing a thiazole moiety and terminal carbonyls.The electrochemical and electrocatalytic proton reduction were probed by cyclic voltammetry,revealing that three complexes can catalyze the reduction of protons to H_(2) under the electrochemical conditions.For comparison,complex 4 possessed the best efficiency with a turnover frequency of 23.5 s^(-1)at 10 mmol·L^(-1)HOAc concentration.In addition,the fungicidal activity of these complexes was also investigated in this study.CCDC:2477511,2;2477512,3;2477513,4.
基金financially supported by the National Natural Science Foundation of China(52130109)。
文摘Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presents significant challenges.In this study,a novel research method was introduced for investigating the solidification process of ductile iron pipe,namely thermal simulation of ductile iron pipe.Comparative research was conducted on the microstructure and properties of the thermal simulation sample and the ductile iron pipe.The findings indicate that the thermal simulation sample and ductile iron pipe exhibit good heat transfer similarity and microstructure similarity.The difference of cooling rate between thermal simulation sample and ductile pipe is less than 0.24℃·s^(-1),and the difference of microstructure content of free cementite,ferrite,and pearlite is less than 5%.The tensile strength of annealed ductile iron pipe is 466 MPa,with an elongation of 16.1%and a Brinell hardness of 156.5 HBW.In comparison,the tensile strength of annealed thermal simulation sample is 482.0 MPa,with an elongation of 15.5%and a Brinell hardness of 159.0 HBW.These results suggest that the thermal simulation experimental research method is both scientific and feasible,offering an objective,reliable,and cost-effective approach to laboratory research on ductile iron pipe.
文摘With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely obesity and neurodegeneration.
基金financially supported by the International Cooperation Program from the Ministry of Science and Technology of Hubei Province(No.2023EHA069)Shenzhen Science and Technology Program(No.JCYJ20230807143702005)National Foreign Experts Program(No.G2022027015L)。
文摘Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T_(2)-weighted MRI contrast agent.
基金supported by the National Key R&D Program of China,Nos.2017YFA0104302(to NG and XM)and 2017YFA0104304(to BW and ZZ)
文摘Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.
基金supported by the National Natural Science Foundation of China(Grant Nos.42425305,42293290,and 42172216).
文摘1.Introduction.Since the Industrial Revolution,the partial pressure of atmospheric carbon dioxide(pCO_(2))has increased markedly,rising from approximately 280 ppm(1 ppm=1μL/L)to about 420 ppm.This escalation has intensified global warming,with 2024 the hottest year on record since 1850.The global mean temperature now stands 1.46℃ above the pre-industrial average(1850-1900),a value already approaching the 1.5℃ threshold set by the Paris Agreement(NOAA,2025).
基金Supported by the National Science Foundation of Jiangsu Province,No.BK20221280the National Natural Science Foundation of China,No.82371336+2 种基金the Chinese Postdoctoral Science Foundation,No.2022M711426the Special Fund for Social Key Research and Development Plan of Yangzhou City,No.YZ2022097Yangzhou Municipal Science and Technology Bureau,No.YZ2024091 and No.YZ2022098.
文摘BACKGROUND Sepsis-associated liver injury(SALI)refers to secondary liver function impairment caused by sepsis,patients with SALI often have worse clinical outcomes.The early identification and assessment of the occurrence and progression of SALI are pressing issues that urgently need to be resolved.AIM To investigate the relationship between iron metabolism and SALI.METHODS In this prospective study,139 patients were recruited,with 53 assigned to the SALI group.The relationships between SALI and various iron metabolism-related biomarkers were examined.These biomarkers included serum iron(SI),total iron-binding capacity(TIBC),serum ferritin,transferrin,and transferrin saturation.To identify independent risk factors for SALI,both univariate and multivariate logistic regression analyses were performed.Additionally,receiver operating characteristic curve analysis was utilized to assess the predictive value of these biomarkers for the occurrence of SALI.RESULTS There were no statistically significant differences in age,sex,body mass index,Sequential Organ Failure Assessment scores(excluding liver function),or APACHE II scores between the two groups of patients.Compared with the sepsis group,the SALI group presented significantly higher SI(P<0.001),TIBC(P<0.001),serum ferritin(P=0.001),transferrin(P=0.005),and transferrin saturation levels(P<0.001).Multivariate logistic regression analysis revealed that SI(odds ratio=1.24,95%confidence interval:1.11-1.40,P<0.001)and TIBC levels(odds ratio=1.13,95%confidence interval:1.05-1.21,P<0.001)were independent predictors of SALI.Receiver operating characteristic curve analysis revealed that SI and TIBC had areas under the curve of 0.816 and 0.757,respectively,indicating moderate predictive accuracy for SALI.CONCLUSION Iron metabolism disorders are closely associated with the development of SALI,and SI and TIBC may serve as potential predictive biomarkers.The combined use of SI and TIBC has superior diagnostic efficacy for SALI.These findings provide valuable insights for the early identification and management of SALI among patients with sepsis.
文摘Ultrasmall superparamagnetic iron oxide nanoparticles(usSPIONs)are promising alternatives to gadolinium‐based contrast agents for positive contrast enhancement in magnetic resonance imaging(MRI).Unlike larger SPIONs that primarily function as T2/T2*negative contrast agents,usSPIONs with core diameters below 5 nm can effectively shorten T1 relaxation times,producing bright signals in T1‐weighted images.This distinct behavior stems from their unique magnetic properties,including single‐domain configurations,surface spin canting,and rapid Néel relaxation dynamics,which are particularly enhanced at low magnetic field strengths.The biocompatibility of iron oxide,efficient renal clearance pathways,and versatility for surface functionalization offer potential advantages over gadolinium‐based agents,especially regarding safety concerns related to nephrogenic systemic fibrosis and gadolinium deposition.These nanoparticles show particular promise for applications in lowfield MRI,vascular imaging,targeted molecular imaging,and theranostic platforms.Although challenges remain in optimizing synthesis methods for consistent production of monodisperse usSPIONs with tailored surface chemistry,ongoing research continues to advance their potential for clinical translation.This review explores the mechanisms,synthesis approaches,applications,and future perspectives of usSPIONs as positive contrast agents in MRI.
文摘This letter offered commentary on the recently published article by Wang et al that investigated the relationship between iron metabolism disorders and sepsis-associated liver injury(SALI).The original study identified serum iron and total iron-binding capacity as potential predictive markers of SALI,contributing important insights to critical care hepatology.In this correspondence several methodological considerations that may influence the interpretation and general-izability of the findings were discussed.These include the limitations of a single-center design,the lack of serial biomarker measurements,the omission of hepcidin(a central iron regulatory hormone)as a measured variable,and the exclusive reliance on biochemical criteria for diagnosing liver injury.The potential value of incorporating imaging modalities and additional iron-related markers such as ferritin and transferrin saturation were also highlighted.The aim was to reinforce the importance of a comprehensive approach to iron metabolism in sepsis and to suggest future directions for clinical research that may enhance the diagnostic and prognostic utility of iron-related biomarkers in SALI.
文摘Colorectal cancer(CRC)considerably affects global health,and its progression is intricately tied to interactions within the tumormicroenvironment.This review focuses on the intricate crosstalk between metabolic reprogramming in CRC cells and the tumor immune microenvironment(TIME),thereby emphasizing the dual functionality of metabolic pathways in tumor growth and immune regulation.Furthermore,the review delves into key metabolic changes,including alterations in glucose,lipid,iron,and ammonia metabolism,and their profound effects on the immune landscape of CRC.Enhanced glycolysis and lipid metabolism facilitate tumor survival and proliferation,while establishing an immunosuppressive TIME that hinders effective immune responses.Moreover,the roles of iron and ammonia metabolism in immune evasion and tumor progression were explored,and these metabolic pathways presented as promising targets to improve CRC therapy.By conducting a comprehensive analysis of recent studies,this review provides insights into potential therapeutic targets within these metabolic interactions,with the aim of enhancing the efficacy of existing treatments and devising novel strategies for combating CRC.
基金financially supported by the National Science Foundation of China(Nos.51974212 and 52274316)the China Baowu Low Carbon Metallurgy Innovation Foundation(No.BWLCF202116)+1 种基金the Science and Technology Major Project of Wuhan(No.2023020302020572)the Foundation of Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education(No.FMRUlab23-04)。
文摘The utilization of iron coke provides a green pathway for low-carbon ironmaking.To uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was investigated.Furthermore,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric method.The findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and interconnect.This provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron coke.Accelerating the heating rate in non-isothermal gasification can enhance the reactivity of iron coke.The metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon atoms.The kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore structure.Moreover,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.
基金the Natural Science Foundation of Shaanxi Province(Grant No.:2023-JC-QN-0125)Yan'an Science andTechnology Bureau(Grant No.:2023-SFGG-141)+1 种基金ShaanxiProvincial Health Research(Grant No.:2022E010)Innovation and Entrepreneurship Training Program for College Students(Grant No.:202310719032).
文摘Iron is an essential trace element in the human body,crucial in maintaining normal physiological functions.Recent studies have identified iron ions as a significant factor in initiating the ferroptosis process,a novel mode of programmed cell death characterized by iron overload and lipid peroxide accumulation.The iron metabolism pathway is one of the primary mechanisms regulating ferroptosis,as it maintains iron homeostasis within the cell.Numerous studies have demonstrated that abnormalities in iron metabolism can trigger the Fenton reaction,exacerbating oxidative stress,and leading to cell membrane rupture,cellular dysfunction,and damage to tissue structures.Therefore,regulation of iron metabolism represents a key strategy for ameliorating ferroptosis and offers new insights for treating diseases associated with iron metabolism imbalances.This review first summarizes the mechanisms that regulate iron metabolic pathways in ferroptosis and discusses the connections between the pathogenesis of various diseases and iron metabolism.Next,we introduce natural and synthetic small molecule compounds,hormones,proteins,and new nanomaterials that can affect iron metabolism.Finally,we provide an overview of the challenges faced by iron regulators in clinical translation and a summary and outlook on iron metabolism in ferroptosis,aiming to pave the way for future exploration and optimi-zation of iron metabolism regulation strategies.
基金support of the National Natural Science Foundation of China(52074080,52004001,and 51574002).
文摘Against the background of“carbon peak and carbon neutrality,”it is of great practical significance to develop non-blast furnace ironmaking technology for the sustainable development of steel industry.Carbon-bearing iron ore pellet is an innovative burden of direct reduction ironmaking due to its excellent self-reducing property,and the thermal strength of pellet is a crucial metallurgical property that affects its wide application.The carbon-bearing iron ore pellet without binders(CIPWB)was prepared using iron concentrate and anthracite,and the effects of reducing agent addition amount,size of pellet,reduction temperature and time on the thermal compressive strength of CIPWB during the reduction process were studied.Simultaneously,the mechanism of the thermal strength evolution of CIPWB was revealed.The results showed that during the low-temperature reduction process(300-500℃),the thermal compressive strength of CIPWB linearly increases with increasing the size of pellet,while it gradually decreases with increasing the anthracite ratio.When the CIPWB with 8%anthracite is reduced at 300℃for 60 min,the thermal strength of pellet is enhanced from 13.24 to 31.88 N as the size of pellet increases from 8.04 to 12.78 mm.Meanwhile,as the temperature is 500℃,with increasing the anthracite ratio from 2%to 8%,the thermal compressive strength of pellet under reduction for 60 min remarkably decreases from 41.47 to 8.94 N.Furthermore,in the high-temperature reduction process(600-1150℃),the thermal compressive strength of CIPWB firstly increases and then reduces with increasing the temperature,while it as well as the temperature corresponding to the maximum strength decreases with increasing the anthracite ratio.With adding 18%anthracite,the thermal compressive strength of pellet reaches the maximum value at 800℃,namely 35.00 N,and obtains the minimum value at 1050℃,namely 8.60 N.The thermal compressive strength of CIPWB significantly depends on the temperature,reducing agent dosage,and pellet size.
文摘Rolling the iron hoop is a fun and traditional Chinese children's game.Long ago,many children played this game in parks,streets,and schoolyards.It has a long history and is still loved by many people today.
文摘This study was conducted to determine the content,distribution and transformation of iron oxides in the soils of the Middle Euphrates regions in Iraq.The study included four sites:Tuwairij area in Karbala Governorate,College of Agriculture at the University of Kufa in Najaf Governorate,College of Agriculture at the University of Qadisiyah in Diwaniyah Governorate,and the Nile District in Babylon Governorate.The results showed that the soils of Najaf and Qadisiyah were superior in terms of their content of total free iron oxides(Fet)compared to the soils of Karbala and Babylon.The relative distribution of free iron oxides was generally close among the studied sites,with a homogeneous pattern in the distribution of these oxides within the soil horizons.As for silicate iron oxides(Fes),a homogeneous pattern was observed in the soil of Babylon with its content increasing with depth,while these patterns varied in the soils of Karbala,Najaf and Qadisiyah.Regarding the ratios of crystalline iron oxides(Fed/Fet),the study showed that the Babylon and Qadisiyah soils recorded the highest values,while these values were lower in the Najaf and Karbala soils.On the other hand,amorphous iron oxides(FeO)showed similar values in the Najaf and Qadisiyah soils.In general,these results clearly showed the effect of environmental and geochemical factors of the study areas on the distribution and transformations of iron oxides in the soil of the Middle Euphrates regions.
基金supported by the Major State Basic Research Development Program of China(No.2023YFB3810000)the National Natural Science Foundation of China(NSFC,No.81925019,32101113,U22A20333).
文摘Acute kidney injury(AKI)represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.In the last 3 decades,the disruption of iron homeostasis and the cytotoxic effects mediated by iron have been extensively acknowledged as contributors to,as well as outcomes of,renal damage.Therefore,iron metabolism has become the focus of novel therapeutic interventions for AKI,with targeted iron metabolism strategies showing great potential.In this review,we have explored the dysregulation of iron metabolism in AKI and the AKI caused by iron metabolism disorders.We have summarized the complex mechanisms of iron metabolism in the kidney and emphasized the potential role of iron metabolism-related metabolic pathways in the treatment and prevention of AKI.Finally,we have reviewed various strategies targeting iron metabolism for the treatment of AKI,hoping to provide more effective treatment options for AKI patients in the future.
