高剂量率(High Dose Rate,HDR)近距离放射治疗在现代临床近距离放疗中得到广泛应用,临床实践依赖于^(192)Ir源的精确剂量学参数。由于不同放射源设计各异,各型号放射源需特定的剂量学参数。尽管国际上已针对^(192)Ir源进行了广泛研究,...高剂量率(High Dose Rate,HDR)近距离放射治疗在现代临床近距离放疗中得到广泛应用,临床实践依赖于^(192)Ir源的精确剂量学参数。由于不同放射源设计各异,各型号放射源需特定的剂量学参数。尽管国际上已针对^(192)Ir源进行了广泛研究,但针对原子高科股份有限公司生产的HDR ^(192)Ir源的国内研究较少。为了计算国产HDR ^(192)Ir源的剂量学参数,依据美国医学物理师协会(American Association of Physicists in Medicine,AAPM)TG43-U1推荐的剂量学参数计算方法,使用蒙特卡罗模拟软件建立^(192)Ir源的详细结构模型进行模拟计算。模拟结果显示:剂量率常数为1.105 cGy·h^(-1)·U^(-1),与文献值差异小于1.2%;单位活度空气比释动能率为9.788×10^(-8) U·Bq^(-1),差异为0.23%;径向剂量函数和各向异性函数结果与文献一致。结果表明,该模型对于国产HDR ^(192)Ir源的临床应用,具有一定的指导意义。展开更多
The hydrophobic sonosensitizer IR780 iodide(IR780)was loaded into liposomes to form Liposome@IR780 nanoparticles(NPs)for triple-negative breast cancer(TNBC)to enhance SDT via low-intensity ultrasound(LIU)irradiation.T...The hydrophobic sonosensitizer IR780 iodide(IR780)was loaded into liposomes to form Liposome@IR780 nanoparticles(NPs)for triple-negative breast cancer(TNBC)to enhance SDT via low-intensity ultrasound(LIU)irradiation.The NPs were characterized using various physicochemical methods including size distribution,zeta potential,and morphology.In vitro experiments show that the Liposome@IR780 NPs can generate more reactive oxygen species(ROS)upon LIU irradiation.The apoptosis experiment results further demonstrate that Liposome@IR780 NPs show better apoptosis rate against 4T1 cells.Our results indicate that Liposome@IR780 NPs will provide a promising approach for TNBC upon SDT treatment.展开更多
Infrared(IR) optics have garnered significant attention due to growing demands in advanced optical imaging,communication, detection, and sensing. Among various IR devices, microlenses and microlens arrays offer distin...Infrared(IR) optics have garnered significant attention due to growing demands in advanced optical imaging,communication, detection, and sensing. Among various IR devices, microlenses and microlens arrays offer distinct advantages in integration capability, imaging precision, multifunctionality, and cost-effective manufacturing. We present a novel design of high-resolution achromatic microlens in the mid-IR region. Different from traditional high-refractive-index convex microlenses embedded within a low-index background medium, the current design is a low-index air concave microlens embedded within a high-index silicon medium. The designed air microlens exhibits capabilities in high-resolution imaging(~λ/6) and achromatic performance across the 3–5 μm mid-IR spectrum. The air microlens could be assembled in large-area microlens arrays or as part of multi-lens system.When combined with the HgCdTe detector system placed on the focal plane, the air microlens can find promising applications in high-resolution optical imaging and high-sensitivity photoelectric detection.展开更多
无线供电通信网络(Wireless-powered Communication Network,WPCN)不仅可以实现远程无线充电而且能够提供无线通信服务,因此受到了学术界和工业界的广泛关注。然而,低效率的能量收集和信息传输会限制WPCN的性能,并且在WPCN中的双重远近...无线供电通信网络(Wireless-powered Communication Network,WPCN)不仅可以实现远程无线充电而且能够提供无线通信服务,因此受到了学术界和工业界的广泛关注。然而,低效率的能量收集和信息传输会限制WPCN的性能,并且在WPCN中的双重远近效应会导致物联网设备收集的能量与消耗的能量之间的不平衡。为了解决这些问题,提出基于能量回收的主动智能反射面(Intelligent Reflecting Surface,IRS)辅助WPCN波束成形算法,其中物联网设备既能从功率站端收集能量,还能从其他物联网设备的上行信息传输中回收能量。考虑能量收集、吞吐量、时间分配,以及功率站和主动IRS的最大功率等约束,基于能量回收机制,建立了系统总吞吐量最大化的资源分配模型;然后,提出一种基于内层近似和双线性变换的交替优化算法进行求解。仿真结果表明,在相应的参数配置下,能量回收机制的应用能够提升约8.13%的吞吐量,而主动IRS的应用能够提升约61.1%的吞吐量。展开更多
文摘高剂量率(High Dose Rate,HDR)近距离放射治疗在现代临床近距离放疗中得到广泛应用,临床实践依赖于^(192)Ir源的精确剂量学参数。由于不同放射源设计各异,各型号放射源需特定的剂量学参数。尽管国际上已针对^(192)Ir源进行了广泛研究,但针对原子高科股份有限公司生产的HDR ^(192)Ir源的国内研究较少。为了计算国产HDR ^(192)Ir源的剂量学参数,依据美国医学物理师协会(American Association of Physicists in Medicine,AAPM)TG43-U1推荐的剂量学参数计算方法,使用蒙特卡罗模拟软件建立^(192)Ir源的详细结构模型进行模拟计算。模拟结果显示:剂量率常数为1.105 cGy·h^(-1)·U^(-1),与文献值差异小于1.2%;单位活度空气比释动能率为9.788×10^(-8) U·Bq^(-1),差异为0.23%;径向剂量函数和各向异性函数结果与文献一致。结果表明,该模型对于国产HDR ^(192)Ir源的临床应用,具有一定的指导意义。
文摘The hydrophobic sonosensitizer IR780 iodide(IR780)was loaded into liposomes to form Liposome@IR780 nanoparticles(NPs)for triple-negative breast cancer(TNBC)to enhance SDT via low-intensity ultrasound(LIU)irradiation.The NPs were characterized using various physicochemical methods including size distribution,zeta potential,and morphology.In vitro experiments show that the Liposome@IR780 NPs can generate more reactive oxygen species(ROS)upon LIU irradiation.The apoptosis experiment results further demonstrate that Liposome@IR780 NPs show better apoptosis rate against 4T1 cells.Our results indicate that Liposome@IR780 NPs will provide a promising approach for TNBC upon SDT treatment.
基金supported by the Science and Technology Project of Guangdong Province, China (Grant No. 2020B010190001)the National Natural Science Foundation of China (Grant No. 12434016)the National Key Research and Development Program of China (Grant No. 2018YFA0306200)。
文摘Infrared(IR) optics have garnered significant attention due to growing demands in advanced optical imaging,communication, detection, and sensing. Among various IR devices, microlenses and microlens arrays offer distinct advantages in integration capability, imaging precision, multifunctionality, and cost-effective manufacturing. We present a novel design of high-resolution achromatic microlens in the mid-IR region. Different from traditional high-refractive-index convex microlenses embedded within a low-index background medium, the current design is a low-index air concave microlens embedded within a high-index silicon medium. The designed air microlens exhibits capabilities in high-resolution imaging(~λ/6) and achromatic performance across the 3–5 μm mid-IR spectrum. The air microlens could be assembled in large-area microlens arrays or as part of multi-lens system.When combined with the HgCdTe detector system placed on the focal plane, the air microlens can find promising applications in high-resolution optical imaging and high-sensitivity photoelectric detection.
文摘无线供电通信网络(Wireless-powered Communication Network,WPCN)不仅可以实现远程无线充电而且能够提供无线通信服务,因此受到了学术界和工业界的广泛关注。然而,低效率的能量收集和信息传输会限制WPCN的性能,并且在WPCN中的双重远近效应会导致物联网设备收集的能量与消耗的能量之间的不平衡。为了解决这些问题,提出基于能量回收的主动智能反射面(Intelligent Reflecting Surface,IRS)辅助WPCN波束成形算法,其中物联网设备既能从功率站端收集能量,还能从其他物联网设备的上行信息传输中回收能量。考虑能量收集、吞吐量、时间分配,以及功率站和主动IRS的最大功率等约束,基于能量回收机制,建立了系统总吞吐量最大化的资源分配模型;然后,提出一种基于内层近似和双线性变换的交替优化算法进行求解。仿真结果表明,在相应的参数配置下,能量回收机制的应用能够提升约8.13%的吞吐量,而主动IRS的应用能够提升约61.1%的吞吐量。
