Inositol 1,4,5-trisphosphate 3-kinase(IP33-kinase/IP3K)plays an important role in signal transduction in animal cellsby phosphorylating inositol 1,4,5-trisphosphate(IP3)to inositol 1,3,4,5-tetrakisphosphate(IP4).Both ...Inositol 1,4,5-trisphosphate 3-kinase(IP33-kinase/IP3K)plays an important role in signal transduction in animal cellsby phosphorylating inositol 1,4,5-trisphosphate(IP3)to inositol 1,3,4,5-tetrakisphosphate(IP4).Both IP3 and IP4 arecritical second messengers which regulate calcium(Ca2+)homeostasis.Mammalian IP3Ks are involved in many biologicalprocesses,including brain development,memory,learning and so on.It is widely reported that Ca2+is a canonicalsecond messenger in higher plants.Therefore,plant IP3K should also play a crucial role in plant development.Recently,we reported the identification of plant IP3K gene(AtIpk2β/AtIP3K)from Arabidopsis thaliana and its characterization.Here,we summarize the molecular cloning,biochemical properties and biological functions of IP3Ks from animal,yeastand plant.This review also discusses potential functions of IP3Ks in signaling crosstalk,inositol phosphate metabolism,gene transcriptional control and so on.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.30370142)the National Special Key Project on Functional Genomics and Biochip of China(No.2002AA2Z1002)the Project sponsored by the Scientific Research Foundation for the Returned Oversea Chinese Scholars,State Education Ministry.
文摘Inositol 1,4,5-trisphosphate 3-kinase(IP33-kinase/IP3K)plays an important role in signal transduction in animal cellsby phosphorylating inositol 1,4,5-trisphosphate(IP3)to inositol 1,3,4,5-tetrakisphosphate(IP4).Both IP3 and IP4 arecritical second messengers which regulate calcium(Ca2+)homeostasis.Mammalian IP3Ks are involved in many biologicalprocesses,including brain development,memory,learning and so on.It is widely reported that Ca2+is a canonicalsecond messenger in higher plants.Therefore,plant IP3K should also play a crucial role in plant development.Recently,we reported the identification of plant IP3K gene(AtIpk2β/AtIP3K)from Arabidopsis thaliana and its characterization.Here,we summarize the molecular cloning,biochemical properties and biological functions of IP3Ks from animal,yeastand plant.This review also discusses potential functions of IP3Ks in signaling crosstalk,inositol phosphate metabolism,gene transcriptional control and so on.
