期刊文献+
共找到316,666篇文章
< 1 2 250 >
每页显示 20 50 100
虚实共生视角下目的地文旅IP开发模式探索——基于洛阳IP的符号机制研究
1
作者 蔡礼彬 鲁懿慧 《四川师范大学学报(社会科学版)》 北大核心 2026年第1期148-157,205,206,共12页
新时代文旅IP化趋势,导致旅游目的地正突破单一地理空间限制,向虚实共生的多维度时空延伸。以洛阳IP为案例,从媒介与场景双维度切入,对文旅IP虚实共生的内在逻辑与演化机制的研究发现:文旅IP实现虚实共生的闭环,需先利用数字媒介建构地... 新时代文旅IP化趋势,导致旅游目的地正突破单一地理空间限制,向虚实共生的多维度时空延伸。以洛阳IP为案例,从媒介与场景双维度切入,对文旅IP虚实共生的内在逻辑与演化机制的研究发现:文旅IP实现虚实共生的闭环,需先利用数字媒介建构地方文化符号与虚拟互动场域,再通过技术与文化赋能重构目的地线下体验场景,形成虚拟与现实的交互共生;洛阳IP的实践模式,既为目的地拓宽消费市场、构建创新体验场景提供了具体开发方向,也为通过跨媒介叙事实现文旅资源的创造性转化提供了可行思路。构建市场-体验的文旅IP开发四维矩阵,可从巩固优化、传播拓展、场景深化和引领变革四个维度,为开发更具可持续性的文旅IP提供关键策略指引。 展开更多
关键词 文旅ip 旅游目的地 虚实共生 符号机制
在线阅读 下载PDF
Precipitation of metastable phases and its effect on electrical resistivity of Al-0.96Mg_2Si alloy during aging 被引量:3
2
作者 崔立新 刘振兴 +4 位作者 赵晓光 唐建国 刘科 刘星兴 钱晨 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第7期2266-2274,共9页
The precipitation behavior and its influence on the electrical resistivity of the Al-0.96Mg2Si alloy during aging were investigated with in-situ resistivity measurement and transmission electron microscopy (TEM). Th... The precipitation behavior and its influence on the electrical resistivity of the Al-0.96Mg2Si alloy during aging were investigated with in-situ resistivity measurement and transmission electron microscopy (TEM). The precipitates of the peak aged alloy include both β" and if, but the amount ratio of β" to β" varies with the aging temperature and time increasing. The precipitates during aging at 175 ℃ are dominated by needle-like β" phases (including pre-β" phase), the size of which increases with the time prolonging, but does not increase substantially after further aging. The evolution of electrical conductivity is directly related to such microstructural evolution. However, the hardness of the alloy stays at the peak value for a long term. When the alloy is aged at 195 ℃, the ratio of β" to β' becomes the main factor to influence relative resistivity (Ap) value. The higher the temperature is, the smaller the ratio is, and the faster the Ap value decreases. Moreover, the hardness peak drops with the decrease of the ratio. With the size and distribution parameters measured from TEM images, a semi-quantitative relationship between precipitates and the electrical resistivity was established. 展开更多
关键词 Al-Mg-Si alloy metastable phases electrical resistivity AGING PRECipITATE
在线阅读 下载PDF
Highly conductive and corrosion-resistant NbN coatings on Ti bipolar plate for proton exchange membrane water electrolysis 被引量:3
3
作者 Wenqian Sun Yuanjiang Lv +3 位作者 Jianping Gao Qing Feng Bo Jia Fei Ma 《Journal of Materials Science & Technology》 2025年第7期86-96,共11页
Proton exchange membrane water electrolysis(PEMWE)is one of the most promising strategies to pro-duce green hydrogen energy,and it is crucial to exploit highly conductive and good corrosion-resistant coatings on bipol... Proton exchange membrane water electrolysis(PEMWE)is one of the most promising strategies to pro-duce green hydrogen energy,and it is crucial to exploit highly conductive and good corrosion-resistant coatings on bipolar plates(BPs),one of the core components in PEMWE cells.In this work,NbN coatings are deposited on Ti BPs by magnetron sputtering to improve the corrosion resistance and conductivity,for which the critical process parameters,such as the working pressure,partial nitrogen pressure and de-position temperature are well optimized.It is found that the compact microstructure,highly conductive δ-NbN and uniform nanoparticles play a dominant role in the synergistic improvement of the corrosion resistance and electrical conductivity of NbN coatings.The optimized NbN coatings exhibit excellent cor-rosion resistance with the low corrosion current density of 1.1×10^(-8) A cm^(-2),a high potential value of-0.005 V vs.SCE and a low ICR value of 15.8 mΩcm2@1.5 MPa.Accordingly,NbN coatings can be a promising candidate for the development of the low-cost and high-anti-corrosion Ti BPs of PEMWE. 展开更多
关键词 NbN coating Corrosion resistance Bipolar plates PEMWE
原文传递
Sequential and Simultaneous Joint Inversion of Resistivity and IP Sounding Data Using Particle Swarm Optimization 被引量:2
4
作者 Yi'an Cui Zhixue Chen +2 位作者 Xiaoxiong Zhu Haifei Liu Jianxin Liu 《Journal of Earth Science》 SCIE CAS CSCD 2017年第4期709-718,共10页
In order to interpret the vertical electrical sounding data more reliably and effectively in the case of lacking proper priori information, two inverse schemes are proposed to invert combined re- sistivity and induced... In order to interpret the vertical electrical sounding data more reliably and effectively in the case of lacking proper priori information, two inverse schemes are proposed to invert combined re- sistivity and induced polarization data by using particle swarm optimization technique. Based on the computational formula of induced polarization, the inversion for chargeability/polarizability data can be transformed into inverting equivalent resistivity data. Then, the inversion for combined data can be decomposed into two procedures: inverting resistivity data and inverting equivalent resistivity data. A sequential inversion scheme is presented to run the two procedures sequentially. Contrast to the se- quential scheme, a simultaneous one is proposed to invert resistivity and induced polarization data si- multaneously. Both the sequential and simultaneous schemes are performed via centered-progressive particle swarm optimization algorithm for more exploratory purpose. Numerical experiments show that both the designed inversion algorithms can invert resistivity and induced polarization data suc- cessfully with fast convergence and high accuracy, even performed in a large search space. The inverse results are comparable to the results from generalized linear method. As an approximate importance sampler, the particle swarm optimization based algorithm can provide posterior analysis conveniently. We employ the posterior probability distributions of inverted model parameters to evaluate the per- formance and uncertainty of inversion. The posterior analysis and further field data testing show that the proposed inversion algorithms perform good sampling of the equivalence region and make sure that the global optimum can locate in the high probability areas. 展开更多
关键词 INVERSION particle swarm optimization resistivity induced polarization.
原文传递
Relationship of Resistivity with Water Content and Fissures of Unsaturated Expansive Soils 被引量:8
5
作者 CHEN Liang YIN Zong-ze ZHANG Pei 《Journal of China University of Mining and Technology》 EI 2007年第4期537-540,共4页
The development of fissures in expansive soils has a great effect on the stability of slope. Of the three phases of soils,the gas phase and solid phase are relatively insulated,so the average resistivity of soils can ... The development of fissures in expansive soils has a great effect on the stability of slope. Of the three phases of soils,the gas phase and solid phase are relatively insulated,so the average resistivity of soils can be calculated from the resistivity of the liquid phase. On this basis,the two-part model of resistivity changing with the water saturation of the expansive soil can be deduced. A 2-D resistance grid model is established based on simulating the resistance of ver-tically developed fissures. Variation in measured resistance of vertically developed fissures at different positions can be calculated from this model. Fissure development can be inversely determined from the variation in the measured resis-tance. Finally,the model is verified by an indoor resistivity test for remolded soil samples,indicating that the test result agrees well with that of the model established. 展开更多
关键词 unsaturated expansive soil resistivity fissure development degree of saturation resistivity structural model
在线阅读 下载PDF
CNN-ALSTM Soft-Sensing Model for Resistivity Gradient in CZ Monocrystalline Silicon Wafers 被引量:1
6
作者 Zhiheng Zhang Zengguo Tian 《Instrumentation》 2025年第2期71-79,共9页
This study addresses the challenge of real-time resistivity gradient measurement in the Czochralski(CZ)silicon production process.Due to the inability to directly measure this parameter,we propose a Long Short-Term Me... This study addresses the challenge of real-time resistivity gradient measurement in the Czochralski(CZ)silicon production process.Due to the inability to directly measure this parameter,we propose a Long Short-Term Memory soft-sensing model based on Convolutional Neural Network(CNN)and attention mechanism(CNN-ALSTM)that enhances traditional LSTM by integrating CNN and attention mechanism to overcome time lag variations during silicon pulling.The CNN module extracts spatial features from multi-source sensor data,while the attention-enhanced LSTM(ALSTM)dynamically adjusts historical parameter weights,enabling accurate resistivity gradient prediction.Experiments with real production data show that CNN-ALSTM outperforms SVR,FNN,RNN,XGBoost,and GRU,improving prediction accuracy by 11.76%,16.67%,21.05%,30.23%,and 9.09%,respectively.This soft-sensing approach enhances real-time monitoring and optimization of monocrystalline silicon growth. 展开更多
关键词 CZ monocrystalline silicon soft-sensing model CNN-ALSTM resistivity gradient
原文传递
Effects of polarization and p-type GaN resistivity on the spectral response of InGaN/GaN multiple quantum well solar cells 被引量:1
7
作者 杨静 赵德刚 +12 位作者 江德生 刘宗顺 陈平 李亮 吴亮亮 乐伶聪 李晓静 何晓光 王辉 朱建军 张书明 张宝顺 杨辉 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第6期629-634,共6页
Effects of polarization and p-type GaN resistivity on the spectral response of InGaN/GaN multiple quantum well (MQW) solar cells are investigated. It is found that due to the reduction of piezoelectric polarization ... Effects of polarization and p-type GaN resistivity on the spectral response of InGaN/GaN multiple quantum well (MQW) solar cells are investigated. It is found that due to the reduction of piezoelectric polarization and the enhancement of tunneling transport of photo-generated carriers in MQWs, the external quantum efficiency (EQE) of the solar cells increases in a low energy spectral range (λ 〉 370 nm) when the barrier thickness value decreases from 15 nm to 7.5 nm. But the EQE decreases abruptly when the barrier thickness value decreases down to 3.75 nm. The reasons for these experimental results are analyzed. We are aware that the reduction of depletion width in MQW region, caused by the high resistivity of the p-type GaN layer may be the main reason for the abnormally low EQE value at long wavelengths (λ 〉 370 nm). 展开更多
关键词 nitride materials external quantum efficiency POLARIZATION p-type GaN resistivity
原文传递
Experimental insights into frictional resistance and slip pattern of granite fractures and implications for thermoshearing prediction 被引量:1
8
作者 Changlun Sun Jeoung Seok Yoon +1 位作者 Ki-Bok Min Li Zhuang 《Earth Energy Science》 2025年第1期22-37,共16页
Rock fractures or faults could be reactivated by the thermal stress generated during the decay process of the high-level radioactive waste in deep geological repositories(DGRs).Understanding thermoshearing behavior an... Rock fractures or faults could be reactivated by the thermal stress generated during the decay process of the high-level radioactive waste in deep geological repositories(DGRs).Understanding thermoshearing behavior and its influencing factors are important for the long-term performance assessment of DGRs.We designed multistage mechanical(M)shear tests and thermomechanical(TM)shear tests on three 100 mm-cubic granite specimens,each containing a single inclined sawcut fracture with distinct microroughness of 8-15μm.M test results have shown that the static friction coefficient of the granite fracture decreases in proportion to the increase in the logarithm of the loading rate within the range of 1-15 kPa/s.For the given heating and boundary conditions,thermal loading rate,i.e.,thermal stress increment with heating time,is measured to be around 1 kPa/s in the fractured granite.Thermoshearing can be well predicted by the linear Mohr-Coulomb failure envelope deduced from M shear tests employing a loading rate that is comparable with the thermal loading rate.The granite fractures exhibited two distinct slip patterns during the mechanical shearing,i.e.,stick-slip observed in the smooth fracture and stable sliding in the relatively rough surface.In contrast,the mechanical loading rate(1-15 kPa/s)investigated in this study appears to not influence the slip pattern.Unlike those in M shear tests,thermoshearing in both smooth and relatively rough fractures show stable sliding with a very slow peak velocity of around 0.002μm/s. 展开更多
关键词 Granite fracture Frictional resistance Slip pattern Thermoshearing Deep geological repository
在线阅读 下载PDF
The Relationship of Carotid Plaque, Intima Media Thickness (IMT), Resistivity Index (RI) and Pulsatility Index(PI) in Asian-Indian Patients with Acute Ischemic Stroke with and without Type2 DM 被引量:3
9
作者 Sidhartha Das Kamalesh Chakrabarty +3 位作者 Madhusmita Patnaik Laxmidhar Roul Jayashree Mohanty Sarat Chandra Singh 《International Journal of Clinical Medicine》 2011年第5期561-567,共7页
Aim: To determine the relationship of carotid plaque, intima media thickness (IMT), resistivity index (RI) and pulsatility index (PI) and prevalence of different risk factors with acute ischemic stroke and stroke subt... Aim: To determine the relationship of carotid plaque, intima media thickness (IMT), resistivity index (RI) and pulsatility index (PI) and prevalence of different risk factors with acute ischemic stroke and stroke subtypes in both diabetic and non-diabetic subjects. Materials and methods: 80 cases of acute ischemic strokes and 40 healthy controls were included in the study. The plaque, IMT, RI and PI were measured by carotid duplex ultrasound. Results: 31 subjects were Type 2 diabetic, 54 hypertensive while 25 were both diabetic and hypertensive. 23 cases (28.75%) had lacunar stroke (LACI), 32 (40%) stroke involving partial anterior circulation(PACI), 10(12.5%) stroke in posterior circulation (PACI) and 15(18.75%) stroke involving total anterior circulation(TACI) respectively. The mean IMT (0.88 ± 0.19mm), RI(0.76 ± 0.05) and PI(1.71 ± 0.19) of patients and mean IMT (0.6±0.09mm), RI (0.61 ± 0.06) and PI (1.53 ± 0.11) of controls were statistically significant (p-0.000). The mean values of IMT, PI and RI were significantly higher in diabetics (IMT-0.90 ± 0.16 VS 0.64 ± 0.11, p-0.013;PI-1.76 ± 0.20 VS 1.49 ± 0.09, P-0.000 and RI-0.76 ± 0.04 VS 0.59 ± 0.06, P-0.000) and similarly the mean values for IMT, PI and RI in hypertensives as compared to controls (IMT-0.88 ± 0.16 vs 0.65 ± 0.10, P-0.006;PI1.69 ± 0.18 vs 1.49 ± 0.09, P-0.000 and RI 0.76 ± 0.04 vs 0.59 ± 0.06, P-0.000). The mean IMT, PI and RI were increased significantly in smokers compared to controls (IMT-0.93 ± 0.20 vs 0.63 ± 0.06, P-0.000;PI-1.82 ± 0.22 vs 1.49 ± 0.09, P-0.000 and RI-0.77 ± 0.04 vs 0.59 ± 0.06, P-0.000). Type 3 plaque accounted for 27 (56.2%) cases and Type 2 plaque 12 (25%) cases. The total number of plaques in patients as compared to controls were significantly more (P-0.0034) and the mean plaque area was 46 mm2 for cases and 20 mm2 for control (P-0.0001). TACI was the most common type of ischemic stroke seen in DM (60%), HTN (66.6%) and smokers (66.7%). Plaques (73.3%), IMT (0.90 ± 0.12), PI(1.72 ± 0.14) and RI (0.76 ± 0.13) were more commonly associated with TACI subtype. On multivariate analysis using ANOVA, the mean PI was highly significant (0.000) in relation to types of plaque. Summary and Conclusions: IMT, RI, PI and plaque type are useful diagnostic parameters for acute ischemic stroke and its subtypes. They can be used as noninvasive tools for predicting and preventing ischemic stroke in smokers as well as subjects with DM and hypertension. 展开更多
关键词 INTIMA MEDIAL Thickness PULSATILITY INDEX resistivity INDEX CAROTID PLAQUE Type 2 Diabetes Mellitus Ischemic Stroke and Asian Indian Subjects
暂未订购
Yip1结构域家族成员4通过IER3IP1促进肝细胞癌的恶性进展
10
作者 王小嫣 卫晶晶 +2 位作者 郭欠影 王晓楠 吴正升 《临床与实验病理学杂志》 北大核心 2026年第1期20-29,共10页
目的 探讨Yip1结构域家族成员4(Yip1 domain family member 4, YIPF4)在肝细胞癌(hepatocellular carcinoma, HCC)恶性进展中的作用及机制。方法 分别使用生物信息学分析、Western blot及免疫组化检测YIPF4在HCC和癌旁非肿瘤肝组织中的... 目的 探讨Yip1结构域家族成员4(Yip1 domain family member 4, YIPF4)在肝细胞癌(hepatocellular carcinoma, HCC)恶性进展中的作用及机制。方法 分别使用生物信息学分析、Western blot及免疫组化检测YIPF4在HCC和癌旁非肿瘤肝组织中的表达水平及其与患者临床病理特征的关系;构建稳定敲低YIPF4表达的Hep3B和PLC/PRF/5细胞系进行体外实验,通过CCK-8、克隆形成和Transwell实验研究YIPF4对HCC细胞的增殖、迁移和侵袭能力的影响;cBioPortal数据库和GEPIA2数据库筛选出与其正相关的基因,即IER3相互作用蛋白1(immediate early response 3 interacting protein 1, IER3IP1),采用生物信息学与免疫组化法,检测IER3IP1在HCC与癌旁组织中的表达差异,并分析其与患者临床病理特征及YIPF4的相关性;最后,通过Western blot检测敲低YIPF4后IER3IP1的蛋白表达变化。结果 生物信息学分析和免疫组化结果显示,YIPF4在HCC组织中的表达高于癌旁非肿瘤肝组织(P均<0.05),IER3IP1在HCC组织中的表达高于癌旁非肿瘤肝组织(P均<0.05),YIPF4和IER3IP1在HCC中表达呈正相关(P<0.01);YIPF4高表达和IER3IP1高表达均与HCC患者的年龄、性别、HBV感染状态、是否有肝硬化以及血清AFP水平不显著相关(P均> 0.05);YIPF4高表达和IER3IP1高表达均与HCC患者肿瘤大小和TNM分期显著相关(P均<0.05);CCK-8实验、克隆形成实验和Transwell实验结果显示,敲低YIPF4可抑制肝癌细胞的增殖、迁移和侵袭能力(P均<0.01);Western blot结果显示,敲低YIPF4后IER3IP1表达下调。结论 YIPF4在HCC中高表达,可能通过IER3IP1促进HCC的恶性进展,与病情进展密切相关,并且能够促进HCC的多种恶性表型和生物学行为,可能是HCC诊断和治疗的潜在生物学靶点。 展开更多
关键词 肝细胞癌 YipF4 IER3ip1 增殖 迁移 侵袭
暂未订购
Influence of N_(2) Flow Rate on Microstructure and Corrosion Resistance of TaN Coatings on Bipolar Plates of PEM Electrolyser
11
作者 Gao Jianping Lv Yuanjiang +4 位作者 Li Yongjing Sun Wenqian Ren Biying Dai Zhengfei Ma Fei 《稀有金属材料与工程》 北大核心 2025年第5期1127-1133,共7页
TaN coatings were deposited on Ti bipolar plates by magnetron sputtering to improve corrosion resistance and service life.The influence of N_(2) flow rate on the surface morphology,hydrophobicity,crystallinity,corrosi... TaN coatings were deposited on Ti bipolar plates by magnetron sputtering to improve corrosion resistance and service life.The influence of N_(2) flow rate on the surface morphology,hydrophobicity,crystallinity,corrosion resistance,and interfacial contact resistance of TaN coatings was studied.Results show that as the N_(2) flow rate increases,the roughness of TaN coatings decreases firstly and then increases,and the hydrophobicity increases firstly and then decreases.At the N_(2) flow rate of 3 mL/min,TaN coating with larger grain size presents lower roughness and high hydrophobicity.The coating possesses the lowest corrosion current density of 2.82µA·cm^(−2) and the highest corrosion potential of−0.184 V vs.SCE in the simulated proton exchange membrane water electrolyser environment.After a potentiostatic polarization test for 10 h,a few corrosion pits are observed on the TaN coatings deposited at an N_(2) flow rate of 3 mL/min.After 75 h of electrolytic water performance testing,the TaN coating on bipolar plate improves the corrosion resistance and thus enhances the electrolysis efficiency(68.87%),greatly reducing the cost of bipolar plates. 展开更多
关键词 TaN coatings corrosion resistance Ti bipolar plate water electrolysis
原文传递
Multiple linear system techniques for 3D finite element method modeling of direct current resistivity 被引量:3
12
作者 李长伟 熊彬 +1 位作者 强建科 吕玉增 《Journal of Central South University》 SCIE EI CAS 2012年第2期424-432,共9页
The strategies that minimize the overall solution time of multiple linear systems in 3D finite element method (FEM) modeling of direct current (DC) resistivity were discussed. A global stiff matrix is assembled and st... The strategies that minimize the overall solution time of multiple linear systems in 3D finite element method (FEM) modeling of direct current (DC) resistivity were discussed. A global stiff matrix is assembled and stored in two parts separately. One part is associated with the volume integral and the other is associated with the subsurface boundary integral. The equivalent multiple linear systems with closer right-hand sides than the original systems were constructed. A recycling Krylov subspace technique was employed to solve the multiple linear systems. The solution of the seed system was used as an initial guess for the subsequent systems. The results of two numerical experiments show that the improved algorithm reduces the iterations and CPU time by almost 50%, compared with the classical preconditioned conjugate gradient method. 展开更多
关键词 finite element method modeling direct current resistivity multiple linear systems preconditioned conjugate gradient recycling Krylov subspace
在线阅读 下载PDF
Realized heritability,cross-resistance patterns,and mechanisms of resistance to thiotraniliprole in Plutella xylostella(L.)
13
作者 YUAN Jing JIANG Yaqin +5 位作者 CHANG Hui LEI Qiyang OUYANG Mingxun CHEN Yingchong CHEN Jing CHEN Jie 《农药学学报》 北大核心 2025年第2期311-321,共11页
Plutella xylostella,a major pest of cruciferous vegetables worldwide,has developed resistance to diamide insecticides.Thiotraniliprole,a novel synthetic diamide insecticide,exhibits excellent activity against P.xylost... Plutella xylostella,a major pest of cruciferous vegetables worldwide,has developed resistance to diamide insecticides.Thiotraniliprole,a novel synthetic diamide insecticide,exhibits excellent activity against P.xylostella.In the present study,we aimed to confirm the resistance risk,cross-resistance,and mechanisms of resistance to thiotraniliprole in P.xylostella.After 40 consecutive generations of thiotraniliprole selection,we obtained a thiotraniliprole-resistance P.xylostella strain with a 5141.58-fold resistance ratio(RR)to thiotraniliprole.The overall realized heritability(h^(2))value of resistance was estimated as 0.9 using threshold trait analysis,indicating that the risk of developing resistance to thiotraniliprole is high in P.xylostella.The thiotraniliprole-resistant(TR)strain showed noticeable cross-resistance to chlorantraniliprole(RR=44670.05),cyantraniliprole(RR=7038.58),and tetrachlorantraniliprole(RR=1506.01),but no cross-resistance to tolfenpyrad,indoxacarb,diafenthiuron,or abamectin compared with the susceptible(S)strain.The enzyme assay data showed that the activities of glutathione-S transferase(GST),carboxylesterase(CarE),and the content of cytochrome P450 monooxygenase(P450s)were significantly higher in the TR strain than in the S strain.Sequencing of the full-length PxRyR cDNA revealed the gene site I4790K in the TR strain with a 100%frequency.This mutation in PxRyR likely underlies the high-level cross-resistance between thiotraniliprole and three other diamide insecticides.These findings provide valuable information for optimizing resistance management strategies to delay thiotraniliprole resistance development and ensure sustainable control of P.xylostella. 展开更多
关键词 Plutella xylostella thiotraniliprole realized heritability CROSS-resistANCE detoxifying enzymes ryanodine receptor resistance mechanisms
在线阅读 下载PDF
Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients:A systematic review of clinical trials
14
作者 Carlos M Ardila Pradeep K Yadalam Jaime Ramírez-Arbelaez 《World Journal of Transplantation》 2025年第1期156-164,共9页
BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ trans... BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ transplantation.AIM To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant recipients.METHODS A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and meta-analyses.This review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial resistance.The search strategy involved analyzing multiple databases,including PubMed/MEDLINE,Web of Science,Embase,Scopus,and SciELO,as well as examining gray literature sources on Google Scholar.A comprehensive electronic database search was conducted from the databases’inception until May 2024,with no language restrictions.RESULTS After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were studied.The most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also analyzed.The antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and colistin-neomycin.Of concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;P<0.05).The total reported deaths in three clinical trials were 75,and there were 24 graft rejections in two studies.CONCLUSION All clinical trials reported significant proportions of antimicrobial-resistant microorganisms following interventions.More high-quality randomized clinical trials are needed to corroborate these results. 展开更多
关键词 Antimicrobial resistance Antimicrobials ANTIVIRALS Solid organ transplant recipients INFECTIONS MICROORGANISMS CYTOMEGALOVIRUS
暂未订购
智能芯片IP软核的质量评测方法研究
15
作者 陈容 陈岚 +5 位作者 李锟 李苗 温孝谦 陆仁杰 秦兆慧 王亚丽 《电子技术应用》 2026年第1期28-32,共5页
针对IP(Intellectual Property)软核的广泛复用带来的质量管控挑战,从现有的IP核交付项质量评测出发,面向智能芯片特殊需求,构建了一套细致全面的主客观结合的IP软核综合质量评价体系。选取了主流的神经网络处理器单元软核对所提出的评... 针对IP(Intellectual Property)软核的广泛复用带来的质量管控挑战,从现有的IP核交付项质量评测出发,面向智能芯片特殊需求,构建了一套细致全面的主客观结合的IP软核综合质量评价体系。选取了主流的神经网络处理器单元软核对所提出的评价策略进行实证分析与验证,结果表明该评价体系能有效识别IP软核的优势与不足,为智能芯片IP软核的设计、优化、交付与选型提供了重要参考依据。 展开更多
关键词 智能芯片 ip软核 质量评测 集成电路
在线阅读 下载PDF
Experiments on exploring and monitoring landslip-mass using geoelectric resistivity observations
16
作者 安金珍 周平根 +3 位作者 马麦宁 陈峰 董颖 钟沛林 《Acta Seismologica Sinica(English Edition)》 CSCD 2008年第3期258-266,332,共10页
In the experiments, a high-density resistivity method is used to explore the electric structure of landslip mass, and a resistivity-changing anisotropy method is used to monitor the orientation and speed of main fract... In the experiments, a high-density resistivity method is used to explore the electric structure of landslip mass, and a resistivity-changing anisotropy method is used to monitor the orientation and speed of main fracture extending of landslip mass. The results are as follows. 1 The exploring experiments have verified a part of creep deformation borderline, the depth and thickness of groundwater horizon, and the property of superstrata in the landslip mass investigated formerly, which have proved that the landslip belts contain rich groundwater; 2 The main fracture extending orientation inferred from the resistivity-changing anisotropy accords with the strike of fracture belt of landslip mass deduced from GPS displacement. Moreover, the changing rates of resistivity-changing anisotropy coefficient matches with the changing speeds of deep displacement of landslip mass were measured by suing clinometer in the borehole. 展开更多
关键词 geoelectric resistivity resistivity anisotropy geologic hazard landslip
在线阅读 下载PDF
Enhancing resistance of honeycomb sandwich panel under local impact through face sheet-core matching relationship
17
作者 LEI Zi-ping GAO Feng +2 位作者 DI Hao LIU Jie-fu WANG Zhong-gang 《Journal of Central South University》 2025年第8期3136-3149,共14页
To enhance the resistance of honeycomb sandwich panel against local impact,this study delved into the matching relationship between face sheets and core.An integrated approach,combining experiment,simulation,and theor... To enhance the resistance of honeycomb sandwich panel against local impact,this study delved into the matching relationship between face sheets and core.An integrated approach,combining experiment,simulation,and theoretical methods,was used.Local loading experiments were conducted to validate the accuracy of the finite element model.Furthermore,a control equation was formulated to correlate structural parameters with response modes,and a matching coefficientλ(representing the ratio of core thickness to face sheet thickness)was introduced to establish a link between these parameters and impact characteristics.A demand-driven reverse design methodology for structural parameters was developed,with numerical simulations employed to assess its effectiveness.The results indicate that the proposed theory can accurately predict response modes and key indicators.An increase in theλbolsters the structural indentation resistance while concurrently heightens the likelihood of penetration.Conversely,a decrease in theλimproves the resistance to penetration,albeit potentially leading to significant deformations in the rear face sheet.Numerical simulations demonstrate that the reverse design methodology significantly enhances the structural penetration resistance.Comparative analyses indicate that appropriate matching reduces indentation depth by 27.4% and indentation radius by 41.8%of the proposed structure. 展开更多
关键词 sandwich panel local impact resistance matching relationship resistance enhancement
在线阅读 下载PDF
Transcriptomic and metabolomic analysis of fludioxonil-induced stress response and resistance in the poplar leaf blight fungus (Alternaria alternata)
18
作者 Mansoor Hayat Zhanbin Wang +3 位作者 Xiaojing Liu Zarmina Gul Qian Bai Sajid Ali 《Journal of Forestry Research》 2025年第4期233-253,共21页
The predominant causal agent of poplar leaf blight is the pathogenic fungus Alternaria alternata (Fr.) Keissl., which exhibits host specificity toward Populus species. To elucidate the molecular response mechanisms of... The predominant causal agent of poplar leaf blight is the pathogenic fungus Alternaria alternata (Fr.) Keissl., which exhibits host specificity toward Populus species. To elucidate the molecular response mechanisms of A. alternata under fludioxonil fungicide stress, the fungus was cultured at the half-maximal effective concentration (EC₅₀) of fludioxonil. Transcriptomic and metabolomic profiles were analyzed using mycelia harvested under these conditions. Comparative analysis revealed 1,001 differentially expressed genes (DEGs) in the resistant strain (RS) relative to the wild-type strain (WT), comprising 628 upregulated and 373 downregulated genes. Concurrently, 524 differentially accumulated metabolites (DAMs) were identified, with 336 upregulated and 188 downregulated metabolites. KEGG pathway enrichment demonstrated pronounced upregulation in glycerophospholipid metabolism, α-linolenic acid metabolism, nucleic acid biosynthesis, and glycosylation processes. Conversely, arachidonic acid and galactose metabolism pathways were suppressed. Significant downregulation was observed in phosphatidylinositol signaling, aflatoxin biosynthesis, and cutin/suberin/wax biosynthesis pathways. Transcriptomic profiling further indicated that upregulated DEGs were predominantly associated with amino sugar/nucleotide sugar metabolism, ABC transporters, aflatoxin biosynthesis, and purine metabolism, while downregulated DEGs were enriched in N-glycan biosynthesis, endoplasmic reticulum protein processing, steroid biosynthesis, and riboflavin metabolism. Fludioxonil exerted substantial inhibitory effects on fungal growth, pathogenicity, and metabolic activity. Mechanistically, A. alternata counteracted fungicide-induced stress through modulation of its antioxidant defense system. This integrative multi-omics study delineates the dynamic gene expression and metabolic reprogramming in A. alternata under fludioxonil exposure, providing novel insights into potential molecular targets and informing the development of next-generation fungicidal strategies for phytopathogen control. 展开更多
关键词 Alternaria alternate Fludioxonil resistance mechanism Fungicide resistance Transcriptomics and metabolomics analysis
在线阅读 下载PDF
BSA-seq and transcriptomic analyses identify Chinese cabbage NB-LRR-encoding genes conferring resistance to soft rot disease
19
作者 Yunjia Ge Kaiyun Zhao +10 位作者 Ni Wang Han Song Xudong Wang Hao Liang Xiaomeng Zhang Yin Lu Yanhua Wang Wei Ma Jianjun Zhao Lisong Ma Mengyang Liu 《Horticultural Plant Journal》 2025年第2期943-946,共4页
Pectobacterium carotovorum(Pc)is a necrotrophic bacterial pathogen that causes soft rot disease in Brassica rapa crops,including Chinese cabbage(B.rapa ssp.pekinensis),resulting in significant yield losses worldwide(R... Pectobacterium carotovorum(Pc)is a necrotrophic bacterial pathogen that causes soft rot disease in Brassica rapa crops,including Chinese cabbage(B.rapa ssp.pekinensis),resulting in significant yield losses worldwide(Roh et al.,2010).Deployment of resistant Chinese cabbage varieties and mining novel resistance genes for breeding resistant varieties against soft rot are key approaches that are currently used to prevent soft rot infections and ensure high yield and quality in Chinese cabbage.However,the highly adapted pathogen can easily overcome resistance(R)gene-mediated defense responses.Thus,discovering novel resistance genes and understanding the molecular mechanisms underlying R-mediated resistance against soft rot are sustained strategies for Chinese cabbage breeding. 展开更多
关键词 breeding CROPS resistance
在线阅读 下载PDF
Experimental study on the pile-tip resistance bearing characteristics of postgrouting at pile tip
20
作者 ZHANG Runze WANG Hongtao +2 位作者 WANG Lei GONG Weiming WAN Zhihui 《Journal of Southeast University(English Edition)》 2025年第3期295-304,共10页
Postgrouting at the pile tip enhances the performance of cast-in-place piles.To clarify the performance of tip and side resistances,this study analyzed static load test data from two test piles before and after grouti... Postgrouting at the pile tip enhances the performance of cast-in-place piles.To clarify the performance of tip and side resistances,this study analyzed static load test data from two test piles before and after grouting.Mechanisms underlying an improvement in tip resistance and the influence of postgrouting on side resistance were investigated via theoretical analysis.Finally,a design method for tip resistance control via settlement was proposed.Results indicate that the ultimate bearing capacity of piles increases after grouting compared to before,underscoring the importance of tip grouting in gravelly soils and its profound impact on load transmission in pile foundations.Postgrouting at the pile tip enhances the strength as well as initial stiffness of the bearing stratum,ultimately elevating the overall pile foundation-bearing capacity.Additionally,tip grouting helps in strengthening over-all side resistance,especially around the pile tip.The grouting procedure has an impact on the soil’s arching effect at the pile tip;the extent of the arching effect and an increase in horizontal tension close to the pile tip are positively correlated with the effectiveness of grouting reinforcement.The design method for tip resistance control via settlement based on measured data statistics was validated using engineering examples,and the method has a practical reference value. 展开更多
关键词 postgrouting at pile tip pile-tip resistance pile-side resistance negative skin friction enhancement effect precompression effect
在线阅读 下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部