BACKGROUND: KRAS mutation plays an important role in the pathogenesis of pancreatic cancer. However, the role of wild-type KRAS in the progression of pancreatic cancer remains unknown. The present study was to investi...BACKGROUND: KRAS mutation plays an important role in the pathogenesis of pancreatic cancer. However, the role of wild-type KRAS in the progression of pancreatic cancer remains unknown. The present study was to investigate the expression of the Ras GTPase activating protein (DAB2IP) in pancreatic cancer and its clinical significance. METHODS: The expression of DAB2IP in pancreatic cancer cell lines and normal human pancreatic ductal epithelial cells was analyzed by Western blotting and realtime quantitative reverse transcription-PCR (qRT-PCR). The KRAS mutational types of pancreatic cancer tissues obtained from pancreatic cancer patients (n=20) were also analyzed. Subsequently, DAB2IP expression was detected in pancreatic cancer tissues, adjacent and normal pancreatic tissues (n=2) by immunohistochemistry, and the relationship between DAB2IP expression and the clinical characteristics of patients was evaluated. RESULTS: Western blotting and qRT-PCR results showed that DAB2IP expression in pancreatic cancer cells with wild-type KRAS was lower than that in those with mutation-type KRAS and normal human pancreatic ductal epithelial cells (P【0.05). Immunohistochemistry showed that DAB2IP expression was lower in pancreatic cancer tissues than that in adjacent and normal pancreatic tissues (Z=-4.000, P=0.000). DAB2IP expression was lower in pancreatic cancer patients with the wild-type KRAS gene than that in those with KRAS mutations (WilcoxonW=35.000, P=0.042). Furthermore,DAB2IP expression in patients with perineurial invasion was lower than that in those without invasion (WilcoxonW=71.500, P=0.028). DAB2IP expression was lower in patients with more advanced stage than that in those with early clinical stage (WilcoxonW=54.000, P=0.002). CONCLUSIONS: DAB2IP expression was reduced in patients with pancreatic cancer compared with those with no cancer. DAB2IP expression was correlated with the KRAS gene, perineurial invasion and clinical stage of the disease. Our data indicated that DAP2IP expression can be used as a potential prognostic indicator and a promising molecular target for therapeutic intervention in patients with pancreatic cancer.展开更多
IP in IP封装技术有着广泛的用途。在 Mobile IP中 ,它被指定为必须实现的、将数据包由 m obile node的 hom e net-work发向 mobile node当前位置的封装形式。而且 ,它还被用于多点传送、指定安全特性的路由选择、策略路由等。由于 IP i...IP in IP封装技术有着广泛的用途。在 Mobile IP中 ,它被指定为必须实现的、将数据包由 m obile node的 hom e net-work发向 mobile node当前位置的封装形式。而且 ,它还被用于多点传送、指定安全特性的路由选择、策略路由等。由于 IP in IP封装有如此重要作用 ,因此 L inux很早就实现了该功能模块。本文从源代码对该模块的实现进行了分析。展开更多
The red thread of the AI-IP-EI Trilogy fate of this study, may have the appearance of a pot-pourri of intellectual and intelligence natures, as a matter of fact that it emanates from the genesis and practical synergis...The red thread of the AI-IP-EI Trilogy fate of this study, may have the appearance of a pot-pourri of intellectual and intelligence natures, as a matter of fact that it emanates from the genesis and practical synergism of the trilogy components. Concretely: The paper goes from: AI (Artificial Intelligence)—to the related IP (Intellectual Property) domain—to the relevance of EI (Emotional Intelligence);thus, forming the new AI-IP-EI Trilogy and its attributes and specific impacts to the new innovation process, and business model dimensions. These impacts are outlined and illustrated in part in essays of specific sections and all along. Several concrete study cases are used in the various dedicated sections;such as cases respective to the inventor status, and the EI factor, to the sport education innovative dimension, as well as to biases as inevitably promoting and revealing, to drastically enlarge open innovation supported by constructivism and creations of musical group as a model of open reflexive education. Overall resulting adapted business models appear to have a massive potential, and a multidimensional reach with a necessary attention to the IP policy on going definition. The durable green dimension is exemplified as well. The Ethics-plus, “@LEAST<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">?</span>”, said corpus is proposed. Could a human centric, AI-adapted-IP policy, internationally embraced, take part to some level of arbitrage, normative and enduring reliability in the field of interest? This seems to be “en route”. Shall the EI (Emotional Intelligence) factor be supervised? Likely so. Is traditional open innovation renewed to a more comprehensive, more inclusive dimension reminding best business practice and now “beyond”? Definitely, and will remain an opportunity, all along the 4IR quantum game changer to come. Neither seeking an in-depth expert analysis, nor a grand public over-simplified bavardage, of the trilogy, AI-IP-EI, four authors here propose an illustrated view of scientific, educational, visionary, demonstrative value to the subject matter. They are aged about 30-40-50-60, being IP & Innovation strategist, future IP lawyer, children-teacher and professional academy sport coach, illustrator and bio-advanced materials engineering “Fellow Scientist”. With experience of large and smaller organizations, being involved innovators, inventors and private artists as well, they are sharing their “non-jargonized down-to-earth”, forward looking views through a structured analysis of the trilogy using realistic examples and data from rather diverse specialized independent sources, biotechnology, nanomaterials, sport… New invention and inventorship is been “reconceptualized” at least from an “insighter or insider” viewpoint, and sport team approach more broadly revisited from its academy level to its commercial asset impact, via educational virtues and values. Music group constructivism enters the scene as well with its exemplary reflexivity and alterity valued for open innovation. Science is the prime lead. “Emotional intelligence, EI, is still an emerging area within AI” and beyond? A new open innovation scheme is taking place. This prompted our intention to further contribute to this matter. Is EI, the tree gently challenging the wind? Generated by AI and IP streams and scientific applications therewith? Naturally. Conclusions are encouraging the follow-up of promising orientations underlined by the AI-IP-EI Trilogy, favoring human centric feature adoptions.展开更多
The study of induced polarization （IP） information extraction from magnetotelluric （MT） sounding data is of great and practical significance to the exploitation of deep mineral, oil and gas resources. The linear i...The study of induced polarization （IP） information extraction from magnetotelluric （MT） sounding data is of great and practical significance to the exploitation of deep mineral, oil and gas resources. The linear inversion method, which has been given priority in previous research on the IP information extraction method, has three main problems as follows： 1） dependency on the initial model, 2） easily falling into the local minimum, and 3） serious non-uniqueness of solutions. Taking the nonlinearity and nonconvexity of IP information extraction into consideration, a two-stage CO-PSO minimum structure inversion method using compute unified distributed architecture （CUDA） is proposed. On one hand, a novel Cauchy oscillation particle swarm optimization （CO-PSO） algorithm is applied to extract nonlinear IP information from MT sounding data, which is implemented as a parallel algorithm within CUDA computing architecture; on the other hand, the impact of the polarizability on the observation data is strengthened by introducing a second stage inversion process, and the regularization parameter is applied in the fitness function of PSO algorithm to solve the problem of multi-solution in inversion. The inversion simulation results of polarization layers in different strata of various geoelectric models show that the smooth models of resistivity and IP parameters can be obtained by the proposed algorithm, the results of which are relatively stable and accurate. The experiment results added with noise indicate that this method is robust to Gaussian white noise. Compared with the traditional PSO and GA algorithm, the proposed algorithm has more efficiency and better inversion results.展开更多
In recent years, since the Internet has given rise to mass creation and the intervention of industrial capital, China's web IP has experienced a "blowout" growth, which accelerates the development of the...In recent years, since the Internet has given rise to mass creation and the intervention of industrial capital, China's web IP has experienced a "blowout" growth, which accelerates the development of the ecological operation of its industry chain a pressing issue, especially in the ecological environment via multi-media and "full-copyright" platforms. In the thesis, the author firstly talks about the ecological operation context of web IP, and then the existing problems of the ecological operation of web IP industrial chain, such as the insufficiency in copyright protection, the economic bubbles on its expansion, the lack of originals and the cash-out mentality toward currency. Therefore, the author comes into the conclusion that, there are enormous potentials for the ecological operation of web IP industrial chain. This demands further platforms across the multiple industrial running of web IP, building its brand through the development of"full-copyright". In one word, the life of web IP would be sustained with ecological progress in multimedia consumption, and the ecological operation of web IP industrial chain would be achieved in fact.展开更多
Variable IP method mainly measures the Percent Frequency Effect (PFE), and phase IP method mainly measures phase. They both aim at finding IP anomaly. However, only using PFE anomaly or single phase anomaly can′t dis...Variable IP method mainly measures the Percent Frequency Effect (PFE), and phase IP method mainly measures phase. They both aim at finding IP anomaly. However, only using PFE anomaly or single phase anomaly can′t distinguish IP body′s property. The authors put forward a new method——dualfrequency and multiparameter IP method, which can not only find anomaly of PFE and phase, but also provide the property information of IP anomaly resource. The authors also have invented the dualfrequency and multiparameter IP instrument. A lot of experiments and field work have been done. The results show that the instrument is valuable in distinguishing IP anomalies.展开更多
This paper is devoted to excavating the mode of production of the culture of Journey to the West-taking the creators of derivative works of Journey to the West as the main body,and from their free and conscious expres...This paper is devoted to excavating the mode of production of the culture of Journey to the West-taking the creators of derivative works of Journey to the West as the main body,and from their free and conscious expression in the process of creation,to find out the path of works’development that conforms to the law of social aesthetics and creation.In the aspect of spiritual expression of the works,the freedom of the artist is reflected in the art producers’emotions,concepts,tastes,and accomplishment in the works,which is related to the artist’s life background,experience,and aesthetics:Wan Laiming(万籁鸣)’s classic national animation,Princess Iron Fan(铁扇公主),is adapted from the version of hundred times of Journey to the West.In addition to the necessary secondary creation in the text and presentation,the theme expression has also been updated and adjusted according to the social background and the author’s emotion;in the text expression of the works,the freedom of the artist is shown in the uniqueness of the work-the form and content of the works come from experience and are different from experience.The idea of building Marvel Cinematic Universe(MCU,漫威电影宇宙)is similar to the framework of“Core Task+Unit Stories”in Journey to the West;A lot of high-quality films and animations such as The Forbidden Kingdom(功夫之王),Panda do Kung Fu(功夫熊猫)and Jackie Chan Adventures(成龙历险记)used western context and culture to create cross-cultural works,but retained unique oriental corpus and images,forming the works’unique style and label.Artists’ability and experience enable them to be acutely aware of the law of artistic creation;they compare and think about different cultural works,and then apply the law to the secondary creation.The artist’s self-consciousness comes from the appreciator’s degree of acceptance of the works;it is reflected in the creator’s reasonable adjustment to the works due to the market,policy,and appreciator’s habits and tastes.The image of Sun Wukong(孙悟空)in the anime film Monkey Kin:Hero Is Back(大圣归来)-a hero of rebirth-has refreshed the audience.From the perspective of cultural studies,this is a negotiated secondary creation of Sun Wukong’s image in Journey to the West based on the interpretation psychology of the audience.In short,to analyze and summarize the ideation of various derivative works is to study the creative laws shared by artists,so as to provide more experience and reference for subsequent creation.展开更多
Against the backdrop of intangible cultural heritage(ICH)activation in China,the innovative transmission and industrial integration of ICH have become increasingly significant.As an officially recognized ICH item of Z...Against the backdrop of intangible cultural heritage(ICH)activation in China,the innovative transmission and industrial integration of ICH have become increasingly significant.As an officially recognized ICH item of Zhejiang Province,Yiwu brown sugar embodies unique artisanal techniques and carries the cultural memory of Yiwu.However,it currently faces challenges such as discontinuity in transmission,insufficient market recognition,and inadequate industrial integration.Focusing on the construction of a youth-oriented IP system for Yiwu brown sugar within the framework of ICH activation,this study employs field investigations and literature research to excavate the historical,cultural,and craft-related foundations of Yiwu brown sugar.It proposes strategies for developing a youthful IP identity through visual system innovation,digital content creation,and social-media-based dissemination,and explores integrated development pathways across culinary innovation,cultural and creative industries,and digital marketing.The aim is to provide theoretical support and practical guidance for the activation of Yiwu brown sugar as intangible cultural heritage.展开更多
基金supported by grants from the Project of International Cooperation in Guangzhou Province (2010B050700014)the Science and Technology Planning Project of Guangzhou(2011J4100006)
文摘BACKGROUND: KRAS mutation plays an important role in the pathogenesis of pancreatic cancer. However, the role of wild-type KRAS in the progression of pancreatic cancer remains unknown. The present study was to investigate the expression of the Ras GTPase activating protein (DAB2IP) in pancreatic cancer and its clinical significance. METHODS: The expression of DAB2IP in pancreatic cancer cell lines and normal human pancreatic ductal epithelial cells was analyzed by Western blotting and realtime quantitative reverse transcription-PCR (qRT-PCR). The KRAS mutational types of pancreatic cancer tissues obtained from pancreatic cancer patients (n=20) were also analyzed. Subsequently, DAB2IP expression was detected in pancreatic cancer tissues, adjacent and normal pancreatic tissues (n=2) by immunohistochemistry, and the relationship between DAB2IP expression and the clinical characteristics of patients was evaluated. RESULTS: Western blotting and qRT-PCR results showed that DAB2IP expression in pancreatic cancer cells with wild-type KRAS was lower than that in those with mutation-type KRAS and normal human pancreatic ductal epithelial cells (P【0.05). Immunohistochemistry showed that DAB2IP expression was lower in pancreatic cancer tissues than that in adjacent and normal pancreatic tissues (Z=-4.000, P=0.000). DAB2IP expression was lower in pancreatic cancer patients with the wild-type KRAS gene than that in those with KRAS mutations (WilcoxonW=35.000, P=0.042). Furthermore,DAB2IP expression in patients with perineurial invasion was lower than that in those without invasion (WilcoxonW=71.500, P=0.028). DAB2IP expression was lower in patients with more advanced stage than that in those with early clinical stage (WilcoxonW=54.000, P=0.002). CONCLUSIONS: DAB2IP expression was reduced in patients with pancreatic cancer compared with those with no cancer. DAB2IP expression was correlated with the KRAS gene, perineurial invasion and clinical stage of the disease. Our data indicated that DAP2IP expression can be used as a potential prognostic indicator and a promising molecular target for therapeutic intervention in patients with pancreatic cancer.
文摘IP in IP封装技术有着广泛的用途。在 Mobile IP中 ,它被指定为必须实现的、将数据包由 m obile node的 hom e net-work发向 mobile node当前位置的封装形式。而且 ,它还被用于多点传送、指定安全特性的路由选择、策略路由等。由于 IP in IP封装有如此重要作用 ,因此 L inux很早就实现了该功能模块。本文从源代码对该模块的实现进行了分析。
文摘The red thread of the AI-IP-EI Trilogy fate of this study, may have the appearance of a pot-pourri of intellectual and intelligence natures, as a matter of fact that it emanates from the genesis and practical synergism of the trilogy components. Concretely: The paper goes from: AI (Artificial Intelligence)—to the related IP (Intellectual Property) domain—to the relevance of EI (Emotional Intelligence);thus, forming the new AI-IP-EI Trilogy and its attributes and specific impacts to the new innovation process, and business model dimensions. These impacts are outlined and illustrated in part in essays of specific sections and all along. Several concrete study cases are used in the various dedicated sections;such as cases respective to the inventor status, and the EI factor, to the sport education innovative dimension, as well as to biases as inevitably promoting and revealing, to drastically enlarge open innovation supported by constructivism and creations of musical group as a model of open reflexive education. Overall resulting adapted business models appear to have a massive potential, and a multidimensional reach with a necessary attention to the IP policy on going definition. The durable green dimension is exemplified as well. The Ethics-plus, “@LEAST<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">?</span>”, said corpus is proposed. Could a human centric, AI-adapted-IP policy, internationally embraced, take part to some level of arbitrage, normative and enduring reliability in the field of interest? This seems to be “en route”. Shall the EI (Emotional Intelligence) factor be supervised? Likely so. Is traditional open innovation renewed to a more comprehensive, more inclusive dimension reminding best business practice and now “beyond”? Definitely, and will remain an opportunity, all along the 4IR quantum game changer to come. Neither seeking an in-depth expert analysis, nor a grand public over-simplified bavardage, of the trilogy, AI-IP-EI, four authors here propose an illustrated view of scientific, educational, visionary, demonstrative value to the subject matter. They are aged about 30-40-50-60, being IP & Innovation strategist, future IP lawyer, children-teacher and professional academy sport coach, illustrator and bio-advanced materials engineering “Fellow Scientist”. With experience of large and smaller organizations, being involved innovators, inventors and private artists as well, they are sharing their “non-jargonized down-to-earth”, forward looking views through a structured analysis of the trilogy using realistic examples and data from rather diverse specialized independent sources, biotechnology, nanomaterials, sport… New invention and inventorship is been “reconceptualized” at least from an “insighter or insider” viewpoint, and sport team approach more broadly revisited from its academy level to its commercial asset impact, via educational virtues and values. Music group constructivism enters the scene as well with its exemplary reflexivity and alterity valued for open innovation. Science is the prime lead. “Emotional intelligence, EI, is still an emerging area within AI” and beyond? A new open innovation scheme is taking place. This prompted our intention to further contribute to this matter. Is EI, the tree gently challenging the wind? Generated by AI and IP streams and scientific applications therewith? Naturally. Conclusions are encouraging the follow-up of promising orientations underlined by the AI-IP-EI Trilogy, favoring human centric feature adoptions.
基金Projects(41604117,41204054)supported by the National Natural Science Foundation of ChinaProjects(20110490149,2015M580700)supported by the Research Fund for the Doctoral Program of Higher Education,China+1 种基金Project(2015zzts064)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(16B147)supported by the Scientific Research Fund of Hunan Provincial Education Department,China
文摘The study of induced polarization （IP） information extraction from magnetotelluric （MT） sounding data is of great and practical significance to the exploitation of deep mineral, oil and gas resources. The linear inversion method, which has been given priority in previous research on the IP information extraction method, has three main problems as follows： 1） dependency on the initial model, 2） easily falling into the local minimum, and 3） serious non-uniqueness of solutions. Taking the nonlinearity and nonconvexity of IP information extraction into consideration, a two-stage CO-PSO minimum structure inversion method using compute unified distributed architecture （CUDA） is proposed. On one hand, a novel Cauchy oscillation particle swarm optimization （CO-PSO） algorithm is applied to extract nonlinear IP information from MT sounding data, which is implemented as a parallel algorithm within CUDA computing architecture; on the other hand, the impact of the polarizability on the observation data is strengthened by introducing a second stage inversion process, and the regularization parameter is applied in the fitness function of PSO algorithm to solve the problem of multi-solution in inversion. The inversion simulation results of polarization layers in different strata of various geoelectric models show that the smooth models of resistivity and IP parameters can be obtained by the proposed algorithm, the results of which are relatively stable and accurate. The experiment results added with noise indicate that this method is robust to Gaussian white noise. Compared with the traditional PSO and GA algorithm, the proposed algorithm has more efficiency and better inversion results.
基金supported by the projects of Sichuan Provincial Education Department (Grant No. 16SA0175)the project of Science & Technology Bureau of Chengdu (Grant No. 2015RK00-00308-ZF)
文摘In recent years, since the Internet has given rise to mass creation and the intervention of industrial capital, China's web IP has experienced a "blowout" growth, which accelerates the development of the ecological operation of its industry chain a pressing issue, especially in the ecological environment via multi-media and "full-copyright" platforms. In the thesis, the author firstly talks about the ecological operation context of web IP, and then the existing problems of the ecological operation of web IP industrial chain, such as the insufficiency in copyright protection, the economic bubbles on its expansion, the lack of originals and the cash-out mentality toward currency. Therefore, the author comes into the conclusion that, there are enormous potentials for the ecological operation of web IP industrial chain. This demands further platforms across the multiple industrial running of web IP, building its brand through the development of"full-copyright". In one word, the life of web IP would be sustained with ecological progress in multimedia consumption, and the ecological operation of web IP industrial chain would be achieved in fact.
文摘Variable IP method mainly measures the Percent Frequency Effect (PFE), and phase IP method mainly measures phase. They both aim at finding IP anomaly. However, only using PFE anomaly or single phase anomaly can′t distinguish IP body′s property. The authors put forward a new method——dualfrequency and multiparameter IP method, which can not only find anomaly of PFE and phase, but also provide the property information of IP anomaly resource. The authors also have invented the dualfrequency and multiparameter IP instrument. A lot of experiments and field work have been done. The results show that the instrument is valuable in distinguishing IP anomalies.
基金This paper is the periodic research result of the research project:Planning of Philosophy and Social Sciences in Guizhou Province in 2018-Individually Listed Studies of Chinese Ancient Civilization(贵州省2018年度哲学社会科学规划国学单列课题阶段性成果)“Research on the Compilation and Publication of the Anthology of Special Collections of the Works of Scholars of Song Dynasty in Song and Yuan Dynasties”(宋元时期宋人别集的编纂与刊刻研究)(Serial Number 18GZGX25).
文摘This paper is devoted to excavating the mode of production of the culture of Journey to the West-taking the creators of derivative works of Journey to the West as the main body,and from their free and conscious expression in the process of creation,to find out the path of works’development that conforms to the law of social aesthetics and creation.In the aspect of spiritual expression of the works,the freedom of the artist is reflected in the art producers’emotions,concepts,tastes,and accomplishment in the works,which is related to the artist’s life background,experience,and aesthetics:Wan Laiming(万籁鸣)’s classic national animation,Princess Iron Fan(铁扇公主),is adapted from the version of hundred times of Journey to the West.In addition to the necessary secondary creation in the text and presentation,the theme expression has also been updated and adjusted according to the social background and the author’s emotion;in the text expression of the works,the freedom of the artist is shown in the uniqueness of the work-the form and content of the works come from experience and are different from experience.The idea of building Marvel Cinematic Universe(MCU,漫威电影宇宙)is similar to the framework of“Core Task+Unit Stories”in Journey to the West;A lot of high-quality films and animations such as The Forbidden Kingdom(功夫之王),Panda do Kung Fu(功夫熊猫)and Jackie Chan Adventures(成龙历险记)used western context and culture to create cross-cultural works,but retained unique oriental corpus and images,forming the works’unique style and label.Artists’ability and experience enable them to be acutely aware of the law of artistic creation;they compare and think about different cultural works,and then apply the law to the secondary creation.The artist’s self-consciousness comes from the appreciator’s degree of acceptance of the works;it is reflected in the creator’s reasonable adjustment to the works due to the market,policy,and appreciator’s habits and tastes.The image of Sun Wukong(孙悟空)in the anime film Monkey Kin:Hero Is Back(大圣归来)-a hero of rebirth-has refreshed the audience.From the perspective of cultural studies,this is a negotiated secondary creation of Sun Wukong’s image in Journey to the West based on the interpretation psychology of the audience.In short,to analyze and summarize the ideation of various derivative works is to study the creative laws shared by artists,so as to provide more experience and reference for subsequent creation.
基金Supported by the 2025 National Undergraduate Innovation and Entrepreneurship Training Program(Project No.202511057057).
文摘Against the backdrop of intangible cultural heritage(ICH)activation in China,the innovative transmission and industrial integration of ICH have become increasingly significant.As an officially recognized ICH item of Zhejiang Province,Yiwu brown sugar embodies unique artisanal techniques and carries the cultural memory of Yiwu.However,it currently faces challenges such as discontinuity in transmission,insufficient market recognition,and inadequate industrial integration.Focusing on the construction of a youth-oriented IP system for Yiwu brown sugar within the framework of ICH activation,this study employs field investigations and literature research to excavate the historical,cultural,and craft-related foundations of Yiwu brown sugar.It proposes strategies for developing a youthful IP identity through visual system innovation,digital content creation,and social-media-based dissemination,and explores integrated development pathways across culinary innovation,cultural and creative industries,and digital marketing.The aim is to provide theoretical support and practical guidance for the activation of Yiwu brown sugar as intangible cultural heritage.
