【正】Dear Sir,M eridional amblyopia is sometimes put forward as a reason for not implanting Toric intraocular lenses(IOLs).It has been noted that patients with high levels of childhood astigmatism(】3 DC)can develop ...【正】Dear Sir,M eridional amblyopia is sometimes put forward as a reason for not implanting Toric intraocular lenses(IOLs).It has been noted that patients with high levels of childhood astigmatism(】3 DC)can develop persistent orientation-dependent visual deficits despite optical correction.Studies by Mitchell et al[1]demonstrated that meridional visual deprivation during the critical period of visual development results in permanently reduced response to stimuli in those orientations.This phenomenon was termed展开更多
Objective:To study the biocompatibility of F heparin surface modified IOLs (F HSM IOLs) and provide theoretical and experimental basis for clinical use and new IOL development. Methods The technique of carrier energy ...Objective:To study the biocompatibility of F heparin surface modified IOLs (F HSM IOLs) and provide theoretical and experimental basis for clinical use and new IOL development. Methods The technique of carrier energy ion beam combined with low temperature and low pressure plasma was used to modify the surface of PMMA IOLs. The physicochemical and optical properties of F HSM IOLs were examined. In vitro, the cultured cells adherence and growth on IOLs were studied. In vivo, F HSM IOLs were implanted into rabbits and Rhesus Monkeys eyes. The biocompatibility of F HSM IOLs, PMMA IOLs and HSM IOLs was compared. Results There were fewer adhered cells on the surface of F HSM IOLs with no toxicity to the cultured fibroblasts. F HSM IOLs caused less inflammatory reaction, broke BAB more slightly and decreased posterior capsular opacity. F HSM IOLs possessed better biocompatiblity. Our research also suggested that the brownish F HSM IOLs could prevent the short wave length light and ultraviolet rays from injuring the retina. Conclusion F HSM IOLs possessed better biocompatibility than conventional PMMA IOLs and can be used in clinical works after further inspection and approval.展开更多
Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified int...Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified into 3 groups which were normal,control and experimental groups.PMMA IOLs and modified PMMA IOLs were implanted into monkeyseyes.Aqueous from anterior chamber was aspirated at 15,30,60,90,180 and 360 days.The level of sIL 2R was measured by ELISA and TNF α by radioimmunoassay.Results: The level of sIL 2R in aqueous increased at 15 day,reached the highest level at 30 day and returned to normal at 90 day.At 15,30 days the level of sIL 2R in aqueous in control group was higher than that in experimental group.The content of TNF α in aqueous was the highest at 15 day and returned at 60 day.At 15 day the content of TNF α in control group was higher and decreased slower than that in experimental group.Conclusion: F heparin modified IOLs with better biocompatibility induced lower foreign body reaction and inflammatory reaction than that of polymethylmethacrylate (PMMA) IOLs.展开更多
Purpose: To compare the impact of induced astigmatism with four different types of multifocal intraocular lenses (MIOLs). Method: Prospective, comparative, interventional, mono-centered study, including 80 eyes of pat...Purpose: To compare the impact of induced astigmatism with four different types of multifocal intraocular lenses (MIOLs). Method: Prospective, comparative, interventional, mono-centered study, including 80 eyes of patients with implantation of four different MIOLs: AcrySof ReSTOR +2.5 D (20 eyes), AcrySof ReSTOR +3.0 D (20 eyes), AcrySof Panoptix (20 eyes) (Alcon Laboratories, Inc., Fort Worth, TX, USA), and Tecnis Symfony ZRX00 (Abbott Medical Optics, Santa Ana, USA) (20 eyes). Patients were followed up for 3 months after surgery. Major parameters were uncorrected (UDVA) and corrected (CDVA) distance visual acuity, subjective refraction and patient satisfaction. Results: Differences between IOLs with regard to the impact of the cylinder sign and axis on visual acuity and patient satisfaction were not significant. With mild added negative cylinder, AcrySof ReSTOR +2.5 D and Tecnis Symfony IOLs maintained the baseline visual acuity, while it was mildly reduced with AcrySof ReSTOR +3.0 D and Panoptix IOLs. With moderate induced cylinder, the Tecnis Symfony IOL maintained good visual acuity and patient associated satisfaction. Panoptix IOL was the IOL most affected by the induced astigmatism with regard to dissatisfaction and visual acuity. The highest tolerance to the astigmatic distortion and blurriness induced with a -1.50 D cylinder was obtained with the Tecnis Symfony IOL. Tecnis Symfony IOL showed less dissatisfaction and less reduction of visual acuity than the other MIOLs. Conclusion: Simulated residual cylinders after the implantation of the Tecnis Symfony IOL up to 1.0 D have a very mild and not clinically relevant impact on visual acuity or patient satisfaction. The ERV IOL showed a better tolerance to unexpected postoperative residual errors than diffractive bifocal and trifocal IOLs.展开更多
AIM:To examine how three distinct central positioning techniques for anterior capsulotomy-pupil center,limbus center,and lens apex-affect intraocular lens(IOL)placement and visual quality following femtosecond laser-a...AIM:To examine how three distinct central positioning techniques for anterior capsulotomy-pupil center,limbus center,and lens apex-affect intraocular lens(IOL)placement and visual quality following femtosecond laser-assisted cataract surgery(FLACS).METHODS:A total of 36 patients(72 eyes)with age-related cataracts who underwent FLACS and ZCB00 aspherical IOL implantation at Aier Eye Hospital Medical Center,Anhui Medical University between January and December 2023 were included in this prospective study.Patients were divided into three groups based on the central positioning mode for anterior capsulotomy:pupil center,limbus center,and lens apex center groups.IOL alignment and displacement were evaluated using the Casia2 device,and the postoperative visual quality was assessed.RESULTS:At 1 d postoperatively,the IOL tilt for the pupil,limbus,and apex groups were 3.96°±1.51°,4.63°±1.87°,and 3.90°±2.24°,respectively(F=1.07,P=0.35);IOL decentration values were 0.21±0.10 mm,0.23±0.16 mm,and 0.21±0.12 mm,respectively(F=0.14,P=0.87);total higher-order aberrations were 0.32±0.40μm,0.56±0.61μm,and 0.53±0.60μm,respectively(F=1.38,P=0.26);and coma aberrations values were 0.13±0.10μm,0.16±0.15μm,and 0.14±0.15μm,respectively(F=0.3,P=0.74).All results obtained postoperative day 1 did not differ significantly.At 3 mo postoperatively,IOL tilt values were 5.42°±2.00°,3.96°±1.44°,and 3.20°±1.19°,respectively(F=12.40,P<0.001);IOL decentration values were 0.33±0.07 mm,0.23±0.11 mm,and 0.21±0.11 mm,respectively(F=4.99,P=0.008);total higher-order aberrations were 0.67±0.29μm,0.44±0.37μm,and 0.42±0.19μm,respectively(F=5.50,P=0.006);and coma aberrations values were 0.21±0.12μm,0.19±0.12μm,and 0.12±0.11μm,respectively(F=3.87,P=0.03).All results obtained 3 mo postoperatively were statistically significant.CONCLUSION:Using the lens apex as the central positioning mode for anterior capsulotomy in FLACS improves postoperative IOL stability and reduces postoperative IOL tilt and decentration.If the lens apex cannot be determined intraoperatively,the limbus center-positioning mode is recommended.展开更多
目的:探究白内障患者人工晶状体(IOL)植入后Kappa角变化趋势及与IOL稳定性的关系。方法:选择2023-02/2024-01于我院接受IOL植入的白内障患者120例120眼为研究对象,其中左眼56眼,右眼64眼。比较手术前后眼科检查结果、Kappa角的分布,以...目的:探究白内障患者人工晶状体(IOL)植入后Kappa角变化趋势及与IOL稳定性的关系。方法:选择2023-02/2024-01于我院接受IOL植入的白内障患者120例120眼为研究对象,其中左眼56眼,右眼64眼。比较手术前后眼科检查结果、Kappa角的分布,以及术后不同时点Kappa角变化和IOL稳定性。Pearson相关及多重线性回归分析IOL旋转稳定性与各眼科检查指标的相关性。多元线性回归分析Kappa角与IOL稳定性的相关性并绘制变化趋势图。结果:术后Kappa角逐渐减小且减小程度逐渐降低(均P<0.05),IOL旋转度数也逐渐减小(P<0.05)。术后2 mo IOL旋转度数与术后1 d AL、LT、K1、K2、PD、Kappa角呈正相关(均P<0.05),与术后1 d ACD呈负相关(均P<0.05)。术后1 d AL、ACD、PD、Kappa角对IOL旋转度数产生显著影响(均P<0.05)。随着Kappa角增大,IOL旋转度数逐渐增大,即IOL稳定性逐渐降低(P<0.05)。结论:白内障患者IOL植入后Kappa角显著减小,前期减小幅度较大,而后趋于稳定,IOL稳定性随Kappa角的增大而降低。展开更多
Background and Objective:Refractive surgery has evolved significantly,with artificial intelligence(AI)offering new possibilities for enhancing patient selection,surgical planning,and postoperative outcome prediction.W...Background and Objective:Refractive surgery has evolved significantly,with artificial intelligence(AI)offering new possibilities for enhancing patient selection,surgical planning,and postoperative outcome prediction.While AI has demonstrated promising applications,its integration into clinical practice remains inconsistent due to challenges in data standardization,model interpretability,and regulatory concerns.This review examines the current applications,limitations,and future directions of AI in refractive surgery,with a focus on its role in laser vision correction(LVC)and phakic intraocular lens(IOL)implantation.Methods:A literature review was conducted using peer-reviewed studies published between January 2010 and October 2024,sourced from databases including Google Scholar,PubMed,Embase,and Web of Science.Studies were selected based on predefined inclusion criteria,covering AI applications in refractive surgery.A total of 33 key studies(16 on LVC and 17 on phakic IOLs)were analyzed,focusing on machine learning and deep learning techniques used for patient selection,surgical optimization,and complication prediction.Only English-language studies were included.Key Content and Findings:AI models utilizing structured tabular data,imaging,and multimodal inputs have demonstrated superior performance in predicting surgical outcomes and refining patient selection compared to traditional methods.Machine learning approaches such as random forests,extreme gradient boosting,and ensemble techniques,alongside deep learning architectures like convolutional neural networks and generative models,have improved risk assessment and surgical planning.In LVC,AI enhances ectasia risk assessment,keratoconus detection,and myopic regression prediction.In phakic IOL implantation,AI improves postoperative vault prediction,lens sizing,and refractive error estimation.Multimodal AI systems integrating imaging,textual data,and clinical parameters hold promise for more comprehensive patient evaluations.However,challenges such as data heterogeneity,limited external validation,and regulatory barriers hinder widespread clinical adoption.Conclusions:AI is transforming refractive surgery by enhancing precision,personalization,and patient safety.Its integration into clinical workflows has the potential to improve surgical outcomes and patient satisfaction.Future efforts should focus on advancing multimodal AI,improving model generalizability,and addressing ethical and regulatory challenges to fully harness AI’s potential in refractive surgery.展开更多
文摘【正】Dear Sir,M eridional amblyopia is sometimes put forward as a reason for not implanting Toric intraocular lenses(IOLs).It has been noted that patients with high levels of childhood astigmatism(】3 DC)can develop persistent orientation-dependent visual deficits despite optical correction.Studies by Mitchell et al[1]demonstrated that meridional visual deprivation during the critical period of visual development results in permanently reduced response to stimuli in those orientations.This phenomenon was termed
基金This work is funded in part by the National 10 th Five- Year Plan on Capture Key of Science and Technolog (2 0 0 1BA70 6 B17)
文摘Objective:To study the biocompatibility of F heparin surface modified IOLs (F HSM IOLs) and provide theoretical and experimental basis for clinical use and new IOL development. Methods The technique of carrier energy ion beam combined with low temperature and low pressure plasma was used to modify the surface of PMMA IOLs. The physicochemical and optical properties of F HSM IOLs were examined. In vitro, the cultured cells adherence and growth on IOLs were studied. In vivo, F HSM IOLs were implanted into rabbits and Rhesus Monkeys eyes. The biocompatibility of F HSM IOLs, PMMA IOLs and HSM IOLs was compared. Results There were fewer adhered cells on the surface of F HSM IOLs with no toxicity to the cultured fibroblasts. F HSM IOLs caused less inflammatory reaction, broke BAB more slightly and decreased posterior capsular opacity. F HSM IOLs possessed better biocompatiblity. Our research also suggested that the brownish F HSM IOLs could prevent the short wave length light and ultraviolet rays from injuring the retina. Conclusion F HSM IOLs possessed better biocompatibility than conventional PMMA IOLs and can be used in clinical works after further inspection and approval.
文摘Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified into 3 groups which were normal,control and experimental groups.PMMA IOLs and modified PMMA IOLs were implanted into monkeyseyes.Aqueous from anterior chamber was aspirated at 15,30,60,90,180 and 360 days.The level of sIL 2R was measured by ELISA and TNF α by radioimmunoassay.Results: The level of sIL 2R in aqueous increased at 15 day,reached the highest level at 30 day and returned to normal at 90 day.At 15,30 days the level of sIL 2R in aqueous in control group was higher than that in experimental group.The content of TNF α in aqueous was the highest at 15 day and returned at 60 day.At 15 day the content of TNF α in control group was higher and decreased slower than that in experimental group.Conclusion: F heparin modified IOLs with better biocompatibility induced lower foreign body reaction and inflammatory reaction than that of polymethylmethacrylate (PMMA) IOLs.
文摘Purpose: To compare the impact of induced astigmatism with four different types of multifocal intraocular lenses (MIOLs). Method: Prospective, comparative, interventional, mono-centered study, including 80 eyes of patients with implantation of four different MIOLs: AcrySof ReSTOR +2.5 D (20 eyes), AcrySof ReSTOR +3.0 D (20 eyes), AcrySof Panoptix (20 eyes) (Alcon Laboratories, Inc., Fort Worth, TX, USA), and Tecnis Symfony ZRX00 (Abbott Medical Optics, Santa Ana, USA) (20 eyes). Patients were followed up for 3 months after surgery. Major parameters were uncorrected (UDVA) and corrected (CDVA) distance visual acuity, subjective refraction and patient satisfaction. Results: Differences between IOLs with regard to the impact of the cylinder sign and axis on visual acuity and patient satisfaction were not significant. With mild added negative cylinder, AcrySof ReSTOR +2.5 D and Tecnis Symfony IOLs maintained the baseline visual acuity, while it was mildly reduced with AcrySof ReSTOR +3.0 D and Panoptix IOLs. With moderate induced cylinder, the Tecnis Symfony IOL maintained good visual acuity and patient associated satisfaction. Panoptix IOL was the IOL most affected by the induced astigmatism with regard to dissatisfaction and visual acuity. The highest tolerance to the astigmatic distortion and blurriness induced with a -1.50 D cylinder was obtained with the Tecnis Symfony IOL. Tecnis Symfony IOL showed less dissatisfaction and less reduction of visual acuity than the other MIOLs. Conclusion: Simulated residual cylinders after the implantation of the Tecnis Symfony IOL up to 1.0 D have a very mild and not clinically relevant impact on visual acuity or patient satisfaction. The ERV IOL showed a better tolerance to unexpected postoperative residual errors than diffractive bifocal and trifocal IOLs.
文摘AIM:To examine how three distinct central positioning techniques for anterior capsulotomy-pupil center,limbus center,and lens apex-affect intraocular lens(IOL)placement and visual quality following femtosecond laser-assisted cataract surgery(FLACS).METHODS:A total of 36 patients(72 eyes)with age-related cataracts who underwent FLACS and ZCB00 aspherical IOL implantation at Aier Eye Hospital Medical Center,Anhui Medical University between January and December 2023 were included in this prospective study.Patients were divided into three groups based on the central positioning mode for anterior capsulotomy:pupil center,limbus center,and lens apex center groups.IOL alignment and displacement were evaluated using the Casia2 device,and the postoperative visual quality was assessed.RESULTS:At 1 d postoperatively,the IOL tilt for the pupil,limbus,and apex groups were 3.96°±1.51°,4.63°±1.87°,and 3.90°±2.24°,respectively(F=1.07,P=0.35);IOL decentration values were 0.21±0.10 mm,0.23±0.16 mm,and 0.21±0.12 mm,respectively(F=0.14,P=0.87);total higher-order aberrations were 0.32±0.40μm,0.56±0.61μm,and 0.53±0.60μm,respectively(F=1.38,P=0.26);and coma aberrations values were 0.13±0.10μm,0.16±0.15μm,and 0.14±0.15μm,respectively(F=0.3,P=0.74).All results obtained postoperative day 1 did not differ significantly.At 3 mo postoperatively,IOL tilt values were 5.42°±2.00°,3.96°±1.44°,and 3.20°±1.19°,respectively(F=12.40,P<0.001);IOL decentration values were 0.33±0.07 mm,0.23±0.11 mm,and 0.21±0.11 mm,respectively(F=4.99,P=0.008);total higher-order aberrations were 0.67±0.29μm,0.44±0.37μm,and 0.42±0.19μm,respectively(F=5.50,P=0.006);and coma aberrations values were 0.21±0.12μm,0.19±0.12μm,and 0.12±0.11μm,respectively(F=3.87,P=0.03).All results obtained 3 mo postoperatively were statistically significant.CONCLUSION:Using the lens apex as the central positioning mode for anterior capsulotomy in FLACS improves postoperative IOL stability and reduces postoperative IOL tilt and decentration.If the lens apex cannot be determined intraoperatively,the limbus center-positioning mode is recommended.
文摘目的:探究白内障患者人工晶状体(IOL)植入后Kappa角变化趋势及与IOL稳定性的关系。方法:选择2023-02/2024-01于我院接受IOL植入的白内障患者120例120眼为研究对象,其中左眼56眼,右眼64眼。比较手术前后眼科检查结果、Kappa角的分布,以及术后不同时点Kappa角变化和IOL稳定性。Pearson相关及多重线性回归分析IOL旋转稳定性与各眼科检查指标的相关性。多元线性回归分析Kappa角与IOL稳定性的相关性并绘制变化趋势图。结果:术后Kappa角逐渐减小且减小程度逐渐降低(均P<0.05),IOL旋转度数也逐渐减小(P<0.05)。术后2 mo IOL旋转度数与术后1 d AL、LT、K1、K2、PD、Kappa角呈正相关(均P<0.05),与术后1 d ACD呈负相关(均P<0.05)。术后1 d AL、ACD、PD、Kappa角对IOL旋转度数产生显著影响(均P<0.05)。随着Kappa角增大,IOL旋转度数逐渐增大,即IOL稳定性逐渐降低(P<0.05)。结论:白内障患者IOL植入后Kappa角显著减小,前期减小幅度较大,而后趋于稳定,IOL稳定性随Kappa角的增大而降低。
文摘Background and Objective:Refractive surgery has evolved significantly,with artificial intelligence(AI)offering new possibilities for enhancing patient selection,surgical planning,and postoperative outcome prediction.While AI has demonstrated promising applications,its integration into clinical practice remains inconsistent due to challenges in data standardization,model interpretability,and regulatory concerns.This review examines the current applications,limitations,and future directions of AI in refractive surgery,with a focus on its role in laser vision correction(LVC)and phakic intraocular lens(IOL)implantation.Methods:A literature review was conducted using peer-reviewed studies published between January 2010 and October 2024,sourced from databases including Google Scholar,PubMed,Embase,and Web of Science.Studies were selected based on predefined inclusion criteria,covering AI applications in refractive surgery.A total of 33 key studies(16 on LVC and 17 on phakic IOLs)were analyzed,focusing on machine learning and deep learning techniques used for patient selection,surgical optimization,and complication prediction.Only English-language studies were included.Key Content and Findings:AI models utilizing structured tabular data,imaging,and multimodal inputs have demonstrated superior performance in predicting surgical outcomes and refining patient selection compared to traditional methods.Machine learning approaches such as random forests,extreme gradient boosting,and ensemble techniques,alongside deep learning architectures like convolutional neural networks and generative models,have improved risk assessment and surgical planning.In LVC,AI enhances ectasia risk assessment,keratoconus detection,and myopic regression prediction.In phakic IOL implantation,AI improves postoperative vault prediction,lens sizing,and refractive error estimation.Multimodal AI systems integrating imaging,textual data,and clinical parameters hold promise for more comprehensive patient evaluations.However,challenges such as data heterogeneity,limited external validation,and regulatory barriers hinder widespread clinical adoption.Conclusions:AI is transforming refractive surgery by enhancing precision,personalization,and patient safety.Its integration into clinical workflows has the potential to improve surgical outcomes and patient satisfaction.Future efforts should focus on advancing multimodal AI,improving model generalizability,and addressing ethical and regulatory challenges to fully harness AI’s potential in refractive surgery.
