【正】Dear Sir,M eridional amblyopia is sometimes put forward as a reason for not implanting Toric intraocular lenses(IOLs).It has been noted that patients with high levels of childhood astigmatism(】3 DC)can develop ...【正】Dear Sir,M eridional amblyopia is sometimes put forward as a reason for not implanting Toric intraocular lenses(IOLs).It has been noted that patients with high levels of childhood astigmatism(】3 DC)can develop persistent orientation-dependent visual deficits despite optical correction.Studies by Mitchell et al[1]demonstrated that meridional visual deprivation during the critical period of visual development results in permanently reduced response to stimuli in those orientations.This phenomenon was termed展开更多
Objective:To study the biocompatibility of F heparin surface modified IOLs (F HSM IOLs) and provide theoretical and experimental basis for clinical use and new IOL development. Methods The technique of carrier energy ...Objective:To study the biocompatibility of F heparin surface modified IOLs (F HSM IOLs) and provide theoretical and experimental basis for clinical use and new IOL development. Methods The technique of carrier energy ion beam combined with low temperature and low pressure plasma was used to modify the surface of PMMA IOLs. The physicochemical and optical properties of F HSM IOLs were examined. In vitro, the cultured cells adherence and growth on IOLs were studied. In vivo, F HSM IOLs were implanted into rabbits and Rhesus Monkeys eyes. The biocompatibility of F HSM IOLs, PMMA IOLs and HSM IOLs was compared. Results There were fewer adhered cells on the surface of F HSM IOLs with no toxicity to the cultured fibroblasts. F HSM IOLs caused less inflammatory reaction, broke BAB more slightly and decreased posterior capsular opacity. F HSM IOLs possessed better biocompatiblity. Our research also suggested that the brownish F HSM IOLs could prevent the short wave length light and ultraviolet rays from injuring the retina. Conclusion F HSM IOLs possessed better biocompatibility than conventional PMMA IOLs and can be used in clinical works after further inspection and approval.展开更多
Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified int...Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified into 3 groups which were normal,control and experimental groups.PMMA IOLs and modified PMMA IOLs were implanted into monkeyseyes.Aqueous from anterior chamber was aspirated at 15,30,60,90,180 and 360 days.The level of sIL 2R was measured by ELISA and TNF α by radioimmunoassay.Results: The level of sIL 2R in aqueous increased at 15 day,reached the highest level at 30 day and returned to normal at 90 day.At 15,30 days the level of sIL 2R in aqueous in control group was higher than that in experimental group.The content of TNF α in aqueous was the highest at 15 day and returned at 60 day.At 15 day the content of TNF α in control group was higher and decreased slower than that in experimental group.Conclusion: F heparin modified IOLs with better biocompatibility induced lower foreign body reaction and inflammatory reaction than that of polymethylmethacrylate (PMMA) IOLs.展开更多
Purpose: To compare the impact of induced astigmatism with four different types of multifocal intraocular lenses (MIOLs). Method: Prospective, comparative, interventional, mono-centered study, including 80 eyes of pat...Purpose: To compare the impact of induced astigmatism with four different types of multifocal intraocular lenses (MIOLs). Method: Prospective, comparative, interventional, mono-centered study, including 80 eyes of patients with implantation of four different MIOLs: AcrySof ReSTOR +2.5 D (20 eyes), AcrySof ReSTOR +3.0 D (20 eyes), AcrySof Panoptix (20 eyes) (Alcon Laboratories, Inc., Fort Worth, TX, USA), and Tecnis Symfony ZRX00 (Abbott Medical Optics, Santa Ana, USA) (20 eyes). Patients were followed up for 3 months after surgery. Major parameters were uncorrected (UDVA) and corrected (CDVA) distance visual acuity, subjective refraction and patient satisfaction. Results: Differences between IOLs with regard to the impact of the cylinder sign and axis on visual acuity and patient satisfaction were not significant. With mild added negative cylinder, AcrySof ReSTOR +2.5 D and Tecnis Symfony IOLs maintained the baseline visual acuity, while it was mildly reduced with AcrySof ReSTOR +3.0 D and Panoptix IOLs. With moderate induced cylinder, the Tecnis Symfony IOL maintained good visual acuity and patient associated satisfaction. Panoptix IOL was the IOL most affected by the induced astigmatism with regard to dissatisfaction and visual acuity. The highest tolerance to the astigmatic distortion and blurriness induced with a -1.50 D cylinder was obtained with the Tecnis Symfony IOL. Tecnis Symfony IOL showed less dissatisfaction and less reduction of visual acuity than the other MIOLs. Conclusion: Simulated residual cylinders after the implantation of the Tecnis Symfony IOL up to 1.0 D have a very mild and not clinically relevant impact on visual acuity or patient satisfaction. The ERV IOL showed a better tolerance to unexpected postoperative residual errors than diffractive bifocal and trifocal IOLs.展开更多
目的比较Pentacam与IOL Master测量的角膜屈光力值在角膜形态正常的白内障患者人工晶状体屈光力计算中的准确性。方法前瞻性临床研究。纳入38例(52只眼)拟行白内障超声乳化吸除联合人工晶状体植入术的角膜形态正常的白内障患者。术前分...目的比较Pentacam与IOL Master测量的角膜屈光力值在角膜形态正常的白内障患者人工晶状体屈光力计算中的准确性。方法前瞻性临床研究。纳入38例(52只眼)拟行白内障超声乳化吸除联合人工晶状体植入术的角膜形态正常的白内障患者。术前分别采用Pentacam和IOL Master检查。采集的数据包括:由Pentacam测量的Sim K、角膜中央1.0~7.0 mm直径EKR(Holladay equivalent K reading)、TNP(True net power)和由IOL Master测量的Km,将不同的K值分别联合4种IOL计算公式(SRK/T、Hoffer Q、Haigis和Holladay I)计算每种K值的IOL度数。测量患者术后3个月术眼验光结果,根据验光结果计算各种K值的屈光预测误差(ME)和平均绝对预测误差(MAE)。采用重复测量方差分析比较两种仪器所测K值联合各计算公式计算IOL屈光预测误差之间的差异。结果两种仪器所测不同K值联合四种IOL计算公式的MAE比较,IOL Master测量所得Km值MAE最小,分别为:SRK/T公式:(0.61±0.51)D、Hoffer Q公式(0.59±0.44)D、Haigis公式:(0.80±0.86)D及Holladay I公式(0.6±0.46)D,Pentacam测量所得Sim K值MAE次之,7.0 mm EKR值MAE最大。在1.0~7.0 mm EKR值的MAE比较,3.0 mm EKR值MAE最小。结论在角膜形态正常白内障患者中,应用Pentacam测量所得K值相对IOL Master测量所得Km值不能提高IOL屈光力计算的准确性。展开更多
患者男性,79岁。因左眼白内障术后6年、视力下降半年于2023年9月26日来我院就诊。患者6年前因双眼白内障于外院分别行右眼、左眼白内障超声乳化吸除联合人工晶状体(intraocular lens,IOL)植入术,右眼植入US860UV+20.0 D IOL,左眼植入US8...患者男性,79岁。因左眼白内障术后6年、视力下降半年于2023年9月26日来我院就诊。患者6年前因双眼白内障于外院分别行右眼、左眼白内障超声乳化吸除联合人工晶状体(intraocular lens,IOL)植入术,右眼植入US860UV+20.0 D IOL,左眼植入US860UV+20.0 D IOL。高血压病史18年,2005年因胃癌行胃大部切除术,2006年因肺癌行左肺小叶切除术,术后化疗。展开更多
目的:探究白内障患者人工晶状体(IOL)植入后Kappa角变化趋势及与IOL稳定性的关系。方法:选择2023-02/2024-01于我院接受IOL植入的白内障患者120例120眼为研究对象,其中左眼56眼,右眼64眼。比较手术前后眼科检查结果、Kappa角的分布,以...目的:探究白内障患者人工晶状体(IOL)植入后Kappa角变化趋势及与IOL稳定性的关系。方法:选择2023-02/2024-01于我院接受IOL植入的白内障患者120例120眼为研究对象,其中左眼56眼,右眼64眼。比较手术前后眼科检查结果、Kappa角的分布,以及术后不同时点Kappa角变化和IOL稳定性。Pearson相关及多重线性回归分析IOL旋转稳定性与各眼科检查指标的相关性。多元线性回归分析Kappa角与IOL稳定性的相关性并绘制变化趋势图。结果:术后Kappa角逐渐减小且减小程度逐渐降低(均P<0.05),IOL旋转度数也逐渐减小(P<0.05)。术后2 mo IOL旋转度数与术后1 d AL、LT、K1、K2、PD、Kappa角呈正相关(均P<0.05),与术后1 d ACD呈负相关(均P<0.05)。术后1 d AL、ACD、PD、Kappa角对IOL旋转度数产生显著影响(均P<0.05)。随着Kappa角增大,IOL旋转度数逐渐增大,即IOL稳定性逐渐降低(P<0.05)。结论:白内障患者IOL植入后Kappa角显著减小,前期减小幅度较大,而后趋于稳定,IOL稳定性随Kappa角的增大而降低。展开更多
Background:The Akreos®AO60 intraocular lens(IOL)has been employed for scleral fixation in eyes without capsular support,although surgical complications,including IOL opacification,have been reported.This study ai...Background:The Akreos®AO60 intraocular lens(IOL)has been employed for scleral fixation in eyes without capsular support,although surgical complications,including IOL opacification,have been reported.This study aims to evaluate the outcomes and complications associated with scleral fixation of the Akreos®AO60 IOL in vitrectomized eyes,with a particular focus on IOL opacification.Methods:Electronic medical records of consecutive eyes that underwent scleral-fixation of the Akreos®AO60 lens using Gore-tex®sutures from 2017 to 2022 were reviewed.The following parameters were collected:age,sex,laterality,past ocular/medical history,surgical indication,pre-operative visual acuity(VA)and intraocular pressure(IOP),surgical procedure,and post-operative VA and IOP.The types of complications,onset,management,and outcomes were also documented.Descriptive statistics,Wilcoxon signed-rank test,and Fisher’s exact test were employed for statistical analysis.Results:Eighty-nine eyes of 86 patients aged 31-100 years were included.The most common surgical indication was non-traumatic IOL displacement.Retinal tears and localized choroidal hemorrhage were found intraoperatively in 7.9%and 1.1%,respectively.The most common post-operative complications were vitreous hemorrhage(13.5%),corneal edema(12.4%),ocular hypotony(11.2%),and IOL opacification(11.2%).IOL opacification was associated with intra-/post-operative exposure to air/gas[odds ratio(OR):12.24;95%confidence interval(CI),1.46-103.0;P=0.006].Mean logarithm of the minimum angle of resolution(logMAR)best-reported VA(BRVA)improved from 1.22±0.77 pre-operatively to 0.56±0.67 on latest follow-up(P<0.001).Conclusions:The majority of the complications from scleral-fixation of the Akreos®AO60 lens in vitrectomized eyes were mild and transient;however,a proportion required surgical intervention.A significant risk for opacification was found in IOLs exposed to air/gas,although VA was often maintained.展开更多
文摘【正】Dear Sir,M eridional amblyopia is sometimes put forward as a reason for not implanting Toric intraocular lenses(IOLs).It has been noted that patients with high levels of childhood astigmatism(】3 DC)can develop persistent orientation-dependent visual deficits despite optical correction.Studies by Mitchell et al[1]demonstrated that meridional visual deprivation during the critical period of visual development results in permanently reduced response to stimuli in those orientations.This phenomenon was termed
基金This work is funded in part by the National 10 th Five- Year Plan on Capture Key of Science and Technolog (2 0 0 1BA70 6 B17)
文摘Objective:To study the biocompatibility of F heparin surface modified IOLs (F HSM IOLs) and provide theoretical and experimental basis for clinical use and new IOL development. Methods The technique of carrier energy ion beam combined with low temperature and low pressure plasma was used to modify the surface of PMMA IOLs. The physicochemical and optical properties of F HSM IOLs were examined. In vitro, the cultured cells adherence and growth on IOLs were studied. In vivo, F HSM IOLs were implanted into rabbits and Rhesus Monkeys eyes. The biocompatibility of F HSM IOLs, PMMA IOLs and HSM IOLs was compared. Results There were fewer adhered cells on the surface of F HSM IOLs with no toxicity to the cultured fibroblasts. F HSM IOLs caused less inflammatory reaction, broke BAB more slightly and decreased posterior capsular opacity. F HSM IOLs possessed better biocompatiblity. Our research also suggested that the brownish F HSM IOLs could prevent the short wave length light and ultraviolet rays from injuring the retina. Conclusion F HSM IOLs possessed better biocompatibility than conventional PMMA IOLs and can be used in clinical works after further inspection and approval.
文摘Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified into 3 groups which were normal,control and experimental groups.PMMA IOLs and modified PMMA IOLs were implanted into monkeyseyes.Aqueous from anterior chamber was aspirated at 15,30,60,90,180 and 360 days.The level of sIL 2R was measured by ELISA and TNF α by radioimmunoassay.Results: The level of sIL 2R in aqueous increased at 15 day,reached the highest level at 30 day and returned to normal at 90 day.At 15,30 days the level of sIL 2R in aqueous in control group was higher than that in experimental group.The content of TNF α in aqueous was the highest at 15 day and returned at 60 day.At 15 day the content of TNF α in control group was higher and decreased slower than that in experimental group.Conclusion: F heparin modified IOLs with better biocompatibility induced lower foreign body reaction and inflammatory reaction than that of polymethylmethacrylate (PMMA) IOLs.
文摘Purpose: To compare the impact of induced astigmatism with four different types of multifocal intraocular lenses (MIOLs). Method: Prospective, comparative, interventional, mono-centered study, including 80 eyes of patients with implantation of four different MIOLs: AcrySof ReSTOR +2.5 D (20 eyes), AcrySof ReSTOR +3.0 D (20 eyes), AcrySof Panoptix (20 eyes) (Alcon Laboratories, Inc., Fort Worth, TX, USA), and Tecnis Symfony ZRX00 (Abbott Medical Optics, Santa Ana, USA) (20 eyes). Patients were followed up for 3 months after surgery. Major parameters were uncorrected (UDVA) and corrected (CDVA) distance visual acuity, subjective refraction and patient satisfaction. Results: Differences between IOLs with regard to the impact of the cylinder sign and axis on visual acuity and patient satisfaction were not significant. With mild added negative cylinder, AcrySof ReSTOR +2.5 D and Tecnis Symfony IOLs maintained the baseline visual acuity, while it was mildly reduced with AcrySof ReSTOR +3.0 D and Panoptix IOLs. With moderate induced cylinder, the Tecnis Symfony IOL maintained good visual acuity and patient associated satisfaction. Panoptix IOL was the IOL most affected by the induced astigmatism with regard to dissatisfaction and visual acuity. The highest tolerance to the astigmatic distortion and blurriness induced with a -1.50 D cylinder was obtained with the Tecnis Symfony IOL. Tecnis Symfony IOL showed less dissatisfaction and less reduction of visual acuity than the other MIOLs. Conclusion: Simulated residual cylinders after the implantation of the Tecnis Symfony IOL up to 1.0 D have a very mild and not clinically relevant impact on visual acuity or patient satisfaction. The ERV IOL showed a better tolerance to unexpected postoperative residual errors than diffractive bifocal and trifocal IOLs.
文摘目的比较Pentacam与IOL Master测量的角膜屈光力值在角膜形态正常的白内障患者人工晶状体屈光力计算中的准确性。方法前瞻性临床研究。纳入38例(52只眼)拟行白内障超声乳化吸除联合人工晶状体植入术的角膜形态正常的白内障患者。术前分别采用Pentacam和IOL Master检查。采集的数据包括:由Pentacam测量的Sim K、角膜中央1.0~7.0 mm直径EKR(Holladay equivalent K reading)、TNP(True net power)和由IOL Master测量的Km,将不同的K值分别联合4种IOL计算公式(SRK/T、Hoffer Q、Haigis和Holladay I)计算每种K值的IOL度数。测量患者术后3个月术眼验光结果,根据验光结果计算各种K值的屈光预测误差(ME)和平均绝对预测误差(MAE)。采用重复测量方差分析比较两种仪器所测K值联合各计算公式计算IOL屈光预测误差之间的差异。结果两种仪器所测不同K值联合四种IOL计算公式的MAE比较,IOL Master测量所得Km值MAE最小,分别为:SRK/T公式:(0.61±0.51)D、Hoffer Q公式(0.59±0.44)D、Haigis公式:(0.80±0.86)D及Holladay I公式(0.6±0.46)D,Pentacam测量所得Sim K值MAE次之,7.0 mm EKR值MAE最大。在1.0~7.0 mm EKR值的MAE比较,3.0 mm EKR值MAE最小。结论在角膜形态正常白内障患者中,应用Pentacam测量所得K值相对IOL Master测量所得Km值不能提高IOL屈光力计算的准确性。
文摘患者男性,79岁。因左眼白内障术后6年、视力下降半年于2023年9月26日来我院就诊。患者6年前因双眼白内障于外院分别行右眼、左眼白内障超声乳化吸除联合人工晶状体(intraocular lens,IOL)植入术,右眼植入US860UV+20.0 D IOL,左眼植入US860UV+20.0 D IOL。高血压病史18年,2005年因胃癌行胃大部切除术,2006年因肺癌行左肺小叶切除术,术后化疗。
文摘目的:探究白内障患者人工晶状体(IOL)植入后Kappa角变化趋势及与IOL稳定性的关系。方法:选择2023-02/2024-01于我院接受IOL植入的白内障患者120例120眼为研究对象,其中左眼56眼,右眼64眼。比较手术前后眼科检查结果、Kappa角的分布,以及术后不同时点Kappa角变化和IOL稳定性。Pearson相关及多重线性回归分析IOL旋转稳定性与各眼科检查指标的相关性。多元线性回归分析Kappa角与IOL稳定性的相关性并绘制变化趋势图。结果:术后Kappa角逐渐减小且减小程度逐渐降低(均P<0.05),IOL旋转度数也逐渐减小(P<0.05)。术后2 mo IOL旋转度数与术后1 d AL、LT、K1、K2、PD、Kappa角呈正相关(均P<0.05),与术后1 d ACD呈负相关(均P<0.05)。术后1 d AL、ACD、PD、Kappa角对IOL旋转度数产生显著影响(均P<0.05)。随着Kappa角增大,IOL旋转度数逐渐增大,即IOL稳定性逐渐降低(P<0.05)。结论:白内障患者IOL植入后Kappa角显著减小,前期减小幅度较大,而后趋于稳定,IOL稳定性随Kappa角的增大而降低。
文摘Background:The Akreos®AO60 intraocular lens(IOL)has been employed for scleral fixation in eyes without capsular support,although surgical complications,including IOL opacification,have been reported.This study aims to evaluate the outcomes and complications associated with scleral fixation of the Akreos®AO60 IOL in vitrectomized eyes,with a particular focus on IOL opacification.Methods:Electronic medical records of consecutive eyes that underwent scleral-fixation of the Akreos®AO60 lens using Gore-tex®sutures from 2017 to 2022 were reviewed.The following parameters were collected:age,sex,laterality,past ocular/medical history,surgical indication,pre-operative visual acuity(VA)and intraocular pressure(IOP),surgical procedure,and post-operative VA and IOP.The types of complications,onset,management,and outcomes were also documented.Descriptive statistics,Wilcoxon signed-rank test,and Fisher’s exact test were employed for statistical analysis.Results:Eighty-nine eyes of 86 patients aged 31-100 years were included.The most common surgical indication was non-traumatic IOL displacement.Retinal tears and localized choroidal hemorrhage were found intraoperatively in 7.9%and 1.1%,respectively.The most common post-operative complications were vitreous hemorrhage(13.5%),corneal edema(12.4%),ocular hypotony(11.2%),and IOL opacification(11.2%).IOL opacification was associated with intra-/post-operative exposure to air/gas[odds ratio(OR):12.24;95%confidence interval(CI),1.46-103.0;P=0.006].Mean logarithm of the minimum angle of resolution(logMAR)best-reported VA(BRVA)improved from 1.22±0.77 pre-operatively to 0.56±0.67 on latest follow-up(P<0.001).Conclusions:The majority of the complications from scleral-fixation of the Akreos®AO60 lens in vitrectomized eyes were mild and transient;however,a proportion required surgical intervention.A significant risk for opacification was found in IOLs exposed to air/gas,although VA was often maintained.
