Povidone–iodine has been leading the market of clinical disinfectants worldwide since the last century but has turned a blind eye to its cytotoxic effect on the cells of the human tissue.In this study,a commercial po...Povidone–iodine has been leading the market of clinical disinfectants worldwide since the last century but has turned a blind eye to its cytotoxic effect on the cells of the human tissue.In this study,a commercial povidone–iodine,though considered an excellent antibacterial agent,was found to have a negative influence on mammal cell growth and wound healing in preclinical trials.At the early stage of wound treatment,it even severely deteriorated the wound and enlarged the wound area.However,our newly formulated iodophors,based on rubber nanoparticles,were able to discriminate between human and bacterial cells by inhibiting the cytotoxicity damage caused by iodine to mammalian tissue and vigorously,killed the bacterial cells,thereby,presenting as superior performers of wound care,compared with povidone–iodine.Wetook advantage of a redox combination of an emulsion complex loaded with iodine to solidify a trans-polyisoprene rubber into nanocapsules.Specifically,our fabricated class of rubber nanocapsules proved to be capable of promoting remarkable cell proliferation and wound recovery,thereby,serving as a promising candidate for biocompatible and healing-favored wound disinfection agents in place of povidone–iodine.展开更多
碘伏消毒液由碘与聚醇醚类表面活性剂络合而成,为了解其杀菌效果及其他相关性能,采用悬液定量杀菌试验和理化分析方法进行了实验室观察。结果,以含有效碘250 mg/L该消毒液对金黄色葡萄球、大肠杆菌和绿脓杆菌作用1.5 m in,杀灭对数值均&...碘伏消毒液由碘与聚醇醚类表面活性剂络合而成,为了解其杀菌效果及其他相关性能,采用悬液定量杀菌试验和理化分析方法进行了实验室观察。结果,以含有效碘250 mg/L该消毒液对金黄色葡萄球、大肠杆菌和绿脓杆菌作用1.5 m in,杀灭对数值均>5.00,对白色念珠菌作用1.5 m in,杀灭对数值>4.00。现场试验结果表明,用含有效碘2500 mg/L该消毒剂对志愿者手和手臂皮肤擦拭消毒3 m in,对自然菌的杀灭对数值均>1.00。将该消毒液原液于37℃恒温保存6个月,有效碘含量下降率为0.99%。结论,洗得宝碘伏消毒液杀菌效果良好,稳定性较好。展开更多
为了解碘伏消毒液杀菌效果及相关性能,采用载体定量杀菌试验方法进行了实验室观察和现场考核。结果,以含25 mg/L有效碘的碘伏消毒液对金黄色葡萄球菌和大肠杆菌作用10 m in,杀灭率为100%;用100 mg/L有效碘的该消毒液对白色念株菌作用10 ...为了解碘伏消毒液杀菌效果及相关性能,采用载体定量杀菌试验方法进行了实验室观察和现场考核。结果,以含25 mg/L有效碘的碘伏消毒液对金黄色葡萄球菌和大肠杆菌作用10 m in,杀灭率为100%;用100 mg/L有效碘的该消毒液对白色念株菌作用10 m in,杀灭率为100%。用碘伏消毒液原液对志愿者手进行擦拭消毒作用3m in,可使手上自然菌平均减少率为97.61%。碘伏消毒液在37℃存放3个月,有效碘含量下降率为7.75%。经碘伏消毒液浸泡72 h,对不锈钢基本无腐蚀,对铝中度腐蚀,对碳钢和铜有重度腐蚀。结论,碘伏消毒液对细菌繁殖体和真菌都具有很强的杀灭效果,储存稳定,但腐蚀性明显。展开更多
为观察两种碘伏消毒剂溶液的消毒性能,采用载体定量杀菌实验方法进行了实验室研究。结果,以含有效碘50 mg/L的聚维酮碘消毒液作用3 m in,以含有效碘25 mg/L的聚醇醚碘消毒液作用3 m in,对载体上金黄色葡萄球菌和大肠杆菌平均杀灭率均达...为观察两种碘伏消毒剂溶液的消毒性能,采用载体定量杀菌实验方法进行了实验室研究。结果,以含有效碘50 mg/L的聚维酮碘消毒液作用3 m in,以含有效碘25 mg/L的聚醇醚碘消毒液作用3 m in,对载体上金黄色葡萄球菌和大肠杆菌平均杀灭率均达到99.98%以上。含有效碘100 mg/L的聚维酮碘消毒液作用5 m in,有效碘25mg/L聚醇醚碘消毒液作用3 m in,对载体上白色念珠菌平均杀灭率均达99.98%以上。以含有效碘4800 mg/L聚维酮碘消毒液作用120 m in,对载体上枯草杆菌黑色变种芽孢平均杀灭率为89.23%;有效碘5000 mg/L聚醇醚碘消毒液作用120 m in,对该细菌芽孢平均杀灭率为99.84%。结论,两种碘伏消毒液对细菌繁殖体和真菌均有较好的杀灭效果,聚维酮碘杀菌所需浓度比聚醇醚碘高1倍;两种碘伏消毒液对细菌芽孢杀灭作用很弱。展开更多
基金the National Natural Science Foundation of China(21825503 and 21674127).
文摘Povidone–iodine has been leading the market of clinical disinfectants worldwide since the last century but has turned a blind eye to its cytotoxic effect on the cells of the human tissue.In this study,a commercial povidone–iodine,though considered an excellent antibacterial agent,was found to have a negative influence on mammal cell growth and wound healing in preclinical trials.At the early stage of wound treatment,it even severely deteriorated the wound and enlarged the wound area.However,our newly formulated iodophors,based on rubber nanoparticles,were able to discriminate between human and bacterial cells by inhibiting the cytotoxicity damage caused by iodine to mammalian tissue and vigorously,killed the bacterial cells,thereby,presenting as superior performers of wound care,compared with povidone–iodine.Wetook advantage of a redox combination of an emulsion complex loaded with iodine to solidify a trans-polyisoprene rubber into nanocapsules.Specifically,our fabricated class of rubber nanocapsules proved to be capable of promoting remarkable cell proliferation and wound recovery,thereby,serving as a promising candidate for biocompatible and healing-favored wound disinfection agents in place of povidone–iodine.
文摘碘伏消毒液由碘与聚醇醚类表面活性剂络合而成,为了解其杀菌效果及其他相关性能,采用悬液定量杀菌试验和理化分析方法进行了实验室观察。结果,以含有效碘250 mg/L该消毒液对金黄色葡萄球、大肠杆菌和绿脓杆菌作用1.5 m in,杀灭对数值均>5.00,对白色念珠菌作用1.5 m in,杀灭对数值>4.00。现场试验结果表明,用含有效碘2500 mg/L该消毒剂对志愿者手和手臂皮肤擦拭消毒3 m in,对自然菌的杀灭对数值均>1.00。将该消毒液原液于37℃恒温保存6个月,有效碘含量下降率为0.99%。结论,洗得宝碘伏消毒液杀菌效果良好,稳定性较好。
文摘为了解碘伏消毒液杀菌效果及相关性能,采用载体定量杀菌试验方法进行了实验室观察和现场考核。结果,以含25 mg/L有效碘的碘伏消毒液对金黄色葡萄球菌和大肠杆菌作用10 m in,杀灭率为100%;用100 mg/L有效碘的该消毒液对白色念株菌作用10 m in,杀灭率为100%。用碘伏消毒液原液对志愿者手进行擦拭消毒作用3m in,可使手上自然菌平均减少率为97.61%。碘伏消毒液在37℃存放3个月,有效碘含量下降率为7.75%。经碘伏消毒液浸泡72 h,对不锈钢基本无腐蚀,对铝中度腐蚀,对碳钢和铜有重度腐蚀。结论,碘伏消毒液对细菌繁殖体和真菌都具有很强的杀灭效果,储存稳定,但腐蚀性明显。
文摘为观察两种碘伏消毒剂溶液的消毒性能,采用载体定量杀菌实验方法进行了实验室研究。结果,以含有效碘50 mg/L的聚维酮碘消毒液作用3 m in,以含有效碘25 mg/L的聚醇醚碘消毒液作用3 m in,对载体上金黄色葡萄球菌和大肠杆菌平均杀灭率均达到99.98%以上。含有效碘100 mg/L的聚维酮碘消毒液作用5 m in,有效碘25mg/L聚醇醚碘消毒液作用3 m in,对载体上白色念珠菌平均杀灭率均达99.98%以上。以含有效碘4800 mg/L聚维酮碘消毒液作用120 m in,对载体上枯草杆菌黑色变种芽孢平均杀灭率为89.23%;有效碘5000 mg/L聚醇醚碘消毒液作用120 m in,对该细菌芽孢平均杀灭率为99.84%。结论,两种碘伏消毒液对细菌繁殖体和真菌均有较好的杀灭效果,聚维酮碘杀菌所需浓度比聚醇醚碘高1倍;两种碘伏消毒液对细菌芽孢杀灭作用很弱。
