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Association of healthy lifestyle index and antihypertensive medication use with blood pressure control among employees with hypertension in China based on a workplace-based multicomponent intervention program
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作者 Zhen HU Xin WANG +6 位作者 Cong-Yi ZHENG Xue CAO Yi-Xin TIAN Run-Qing GU Jia-Yin CAI Ye TIAN Zeng-Wu WANG 《Journal of Geriatric Cardiology》 2025年第3期389-400,共12页
Background Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients.However,the association of joint changes in antihypertensive medication use and ... Background Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients.However,the association of joint changes in antihypertensive medication use and healthy lifestyle index (HLI)with BP control among hypertension patients is seldom reported,which needs to provide more evidence by prospective intervention studies.We examined the association of antihypertensive medication use and HLI with BP control among employees with hypertension in China based on a workplace-based multicomponent intervention program.Methods Between January 2013 and December 2014,a cluster randomized clinical trial of a workplace-based multicomponent intervention program was conducted in 60 workplaces across 20 urban areas in China.Workplaces were randomly divided into intervention (n=40) and control (n=20) groups.Basic information on employees at each workplace was collected by trained professionals,including sociodemographic characteristics,medical history,family history,lifestyle behaviors,medication status and physical measurements.After baseline,the intervention group received a 2-year intervention to achieve BP control,which included:(1) a workplace wellness program for all employees;(2) a guidelines-oriented hypertension management protocol.HLI including nonsmoking,nondrinking,adequate physical activity,weight within reference range and balanced diet,were coded on a 5-point scale (range:0-5,with higher score indicating a healthier lifestyle).Antihypertensive medication use was defined as taking drug within the last 2 weeks.Changes in HLI,antihypertensive medication use and BP control from baseline to 24 months were measured after the intervention.Results Overall,4655 employees were included (age:46.3±7.6 years,men:3547 (82.3%)).After 24 months of the intervention,there was a significant improvement in lifestyle[smoking (OR=0.65,95%CI:0.43-0.99;P=0.045),drinking (OR=0.52,95%CI:0.40-0.68;P<0.001),regular exercise (OR=3.10,95%CI:2.53-3.78;P<0.001),excessive intake of fatty food (OR=0.17,95%CI:0.06-0.52;P=0.002),restrictive use of salt (OR=0.26,95%CI:0.12-0.56;P=0.001)].Compare to employees with a deteriorating lifestyle after the intervention,those with an improved lifestyle had a higher BP control.In the intervention group,compared with employees not using antihypertensive medication,those who consistent used (OR=2.34;95%CI:1.16-4.72;P=0.017) or changed from not using to using antihypertensive medication (OR=2.24;95%CI:1.08-4.62;P=0.030) had higher BP control.Compared with those having lower HLI,participants with a same (OR=1.38;95%CI:0.99-1.93;P=0.056) or high (OR=1.79;95%CI:1.27~2.53;P<0.001) HLI had higher BP control.Those who used antihypertensive medication and had a high HLI had the highest BP control (OR=1.88;95%CI:1.32-2.67,P<0.001).Subgroup analysis also showed the consistent effect as the above.Conclusion These findings suggest that adherence to antihypertensive medication treatment and healthy lifestyle were associated with a significant improvement in BP control among employees with hypertension. 展开更多
关键词 Antihypertensive Medication Use Workplace Based intervention Multicomponent intervention Program Blood Pressure Control prospective intervention studieswe antihypertensive medication use healthy lifestyle index control blood pressure
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Robot-assisted percutaneous coronary intervention:a prospective,multicenter,randomized controlled,non-inferiority clinical trial
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作者 Yi YU Zheng CHEN +7 位作者 Zhi-Jian WANG Yue-Ping LI Li-Xia YANG Jing QI Jing XIE Tao HUANG Dong-Mei SHI Yu-Jie ZHOU 《Journal of Geriatric Cardiology》 2025年第8期725-735,共11页
OBJECTIVE To evaluate the safety and effectiveness of robot-assisted percutaneous coronary intervention(R-PCI)compared to traditional manual percutaneous coronary intervention(M-PCI).METHODS This prospective,multicent... OBJECTIVE To evaluate the safety and effectiveness of robot-assisted percutaneous coronary intervention(R-PCI)compared to traditional manual percutaneous coronary intervention(M-PCI).METHODS This prospective,multicenter,randomized controlled,non-inferior clinical trial enrolled patients with coronary heart disease who met the inclusion criteria and had indications for elective percutaneous coronary intervention.Participants were randomly assigned to either the R-PCI group or the M-PCI group.Primary endpoints were clinical and technical success rates.Clinical success was defined as visually estimated residual post-percutaneous coronary intervention stenosis<30% with no 30-day major adverse cardiac events.Technical success in the R-PCI group was defined as successful completion of percutaneous coronary intervention using the ETcath200 robot-assisted system,without conversion to M-PCI in the event of a guidewire or balloon/stent catheter that was unable to cross the vessel or was poorly supported by the catheter.Secondary endpoints included total procedure time,percutaneous coronary intervention procedure time,fluoroscopy time,contrast volume,operator radiation exposure,air kerma,and dose-area product.RESULTS The trial enrolled 152 patients(R-PCI:73 patients,M-PCI:79 patients).Lesions were predominantly B2/C type(73.6%).Both groups achieved 100% clinical success rate.No major adverse cardiac events occurred during the 30-day follow-up.The R-PCI group had a technical success rate of 100%.The R-PCI group had longer total procedure and fluoroscopy times,but lower operator radiation exposure.The percutaneous coronary intervention procedure time,contrast volume,air kerma,and dose-area product were similar between the two groups.CONCLUSIONS For certain complex lesions,performing percutaneous coronary intervention using the ETcath200 robot-assisted system is safe and effective and does not result in conversion to M-PCI. 展开更多
关键词 complex lesions non inferiority clinical trial technical success operator radiation exposure robot assisted percutaneous coronary intervention coronary heart disease elective percutaneous coronary interventionparticipants traditional manual percutaneous coronary intervention m pci methods
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The Effect of Interventional Nursing on Treatment Outcome,Negative Emotions and Quality of Life of Patients Undergoing Cardiovascular Interventions
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作者 Yongqiang Sun Ruhao Zhao +1 位作者 Hao Qu Juntao Li 《Journal of Clinical and Nursing Research》 2025年第7期165-172,共8页
Objective:To analyze the effect of interventional nursing on the therapeutic effect,negative emotion and quality of life of patients undergoing cardiovascular and cerebrovascular interventional therapy.Methods:Eighty-... Objective:To analyze the effect of interventional nursing on the therapeutic effect,negative emotion and quality of life of patients undergoing cardiovascular and cerebrovascular interventional therapy.Methods:Eighty-four patients who received cardio-cerebral vascular interventional therapy in a hospital during January 2024–December 2024 were selected,and were divided into the control group and the observation group by the mean score method,each with 42 cases.The control group was given standardized perioperative care,and the observation group was given interventional nursing intervention on this basis.The two groups were compared in terms of clinical efficacy,negative emotion score,incidence of related complications,quality of life score and nursing satisfaction.Results:The total effective rate of treatment of patients in the observation group(95.24%)was significantly higher than that of the control group(78.57%),and the difference was statistically significant(P<0.05);before nursing care,the difference between SDS and SAS scores of patients in the two groups was insignificant(P>0.05);after nursing care,the scores of various indexes of the two groups were significantly reduced and the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);the patients in the observation group had more negative moods than those in the control group;the complication rate of patients in the observation group(2.38%)was significantly lower than that of the control group(19.04%),and the difference was statistically significant(P<0.05);the quality of life scores of patients in the observation group were higher than that of the control group,and the difference was statistically significant(P<0.05);the satisfaction rate of patients’nursing care in the observation group was 97.62%,which was higher than that of the control group(78.57%),and the difference was statistically significant(P<0.05).The difference is statistically significant(P<0.05).Conclusion:The implementation of interventional nursing intervention for patients with cardiovascular and cerebrovascular interventional therapy can further enhance the clinical therapeutic effect,improve the negative emotions of patients’anxiety and depression,reduce the risk of related complications,improve the quality of life of patients,and obtain higher satisfaction. 展开更多
关键词 Cardiovascular disease interventional therapy interventional care EFFICACY Negative emotions Quality of life
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Quality of care combined with mindfulness-based stress reduction intervention in patients undergoing arterial interventional embolization for liver tumors
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作者 Yi Lu Ming-Yang Xu +3 位作者 Li Lu Zhi-Wei Gu Ai-Qin Yin Yin-Feng Yin 《World Journal of Gastrointestinal Surgery》 2025年第6期335-341,共7页
BACKGROUND Although transarterial chemoembolization(TACE)is an effective treatment for liver cancer,clinical practice has shown that many patients experience significant psychological distress following the procedure,... BACKGROUND Although transarterial chemoembolization(TACE)is an effective treatment for liver cancer,clinical practice has shown that many patients experience significant psychological distress following the procedure,which can hinder postoperative recovery and prognosis.Therefore,effective and evidence-based interventions are urgently needed to address this issue.AIM To evaluate the impact of nursing quality-sensitive indicators combined with mindfulness-based stress reduction(MBSR)interventions in patients undergoing TACE.METHODS A total of 84 patients who underwent TACE from June 2022 to March 2024 were enrolled in the study.They were randomly assigned to either the observation group(n=42),which received nursing quality-sensitive indicator-based care combined with MBSR intervention,or the control group(n=42),which received routine care combined with MBSR intervention.Psychological stress response levels[assessed using the Trait Meta-Mood Scale(TMMS)],coping strategies[measured with the Jalowiec Coping Scale(JCS)],quality of care[evaluated using the Perceived Nursing Service Quality(PNSQ)scale],and overall patient satisfaction were compared between the two groups.RESULTS After 4 weeks,the observation group demonstrated significantly higher TMMS scores,as well as increased optimism,support-seeking,bravery,PNSQ scores,and satisfaction(P<0.05).In contrast,scores for selfdependence,conservatism,resignation,and avoidance in the JCS were significantly lower in the observation group than in the control group(P<0.05).CONCLUSION The combination of nursing quality-sensitive indicators and MBSR intervention in TACE patients not only reduces psychological stress and encourages a more positive attitude toward illness but also enhances nursing quality and improves the overall patient experience. 展开更多
关键词 Sensitive indicators of nursing quality Mindfulness stress intervention interventional embolization of liver tumor Quality of nursing Psychological stress
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Clinical characteristics,therapeutic strategies,and outcomes in elderly patients on oral anticoagulant therapy undergoing percutaneous coronary interventions:post-hoc analysis of the PERSEO Registry
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作者 Simona Minardi Salvatore De Rosa +9 位作者 NicolòSalvi Giuseppe Andò Giuseppe Talanas ClaudioD’angelo Carolina Moretti Tiziano Maria Mazza Bernardo Cortese Giuseppe Musumeci Andrea Rubboli Alessandro Sciahbasi 《Journal of Geriatric Cardiology》 2025年第8期701-708,共8页
BACKGROUND Antithrombotic strategies after percutaneous coronary interventions(PCI)in elderly patients on oral anticoagulant therapy(OAT)are debated due to the balance between ischemic and bleeding risks.Recent guidel... BACKGROUND Antithrombotic strategies after percutaneous coronary interventions(PCI)in elderly patients on oral anticoagulant therapy(OAT)are debated due to the balance between ischemic and bleeding risks.Recent guidelines recommend early transitioning from triple antithrombotic therapy to dual antithrombotic therapy,but there are limited data on elderly patients.METHODS We performed a post-hoc age-specific analysis of the PERSEO Registry population aimed to compare clinical features,therapeutic strategies,and outcomes of individuals aged≥80 years and<80 years who were on OAT and underwent PCI with stent.The primary endpoint was net adverse clinical events at 1-year follow-up.Secondary endpoints included major adverse cardiac and cerebral events(MACCE),major bleeding[Bleeding Academic Research Consortium(BARC)type 3–5],and clinically relevant bleeding(BARC type 2-5).RESULTS Among the 1234 patients enrolled,31%of patients were aged≥80 years(84±3 years,76% males).Compared to younger patients,elderly patients had higher rates of comorbidities such as hypertension,anaemia or chronic kidney disease,and atrial fibrillation was the leading indication for OAT.Elderly patients were more often discharged on dual antithrombotic therapy(23%)compared to younger patients(13%)(P<0.0001).They experienced higher net adverse clinical events(38%vs.21%,P<0.001),MACCE(24%vs.12%,P<0.001),as well as higher bleeding rates.Specifically,rates of major bleeding(9%vs.6%,P=0.026),and clinically relevant bleeding(21%vs.12%,P<0.001)were significantly higher in elderly patients.CONCLUSIONS Elderly patients on OAT undergoing PCI are a particular frail population with higher risk of MACCE and bleeding compared to younger patients despite a less aggressive antithrombotic therapy. 展开更多
关键词 oral anticoagulant therapy oat oral anticoagulant therapy elderly patients percutaneous coronary interventions pci percutaneous coronary interventions dual antithrombotic therapybut clinical characteristics perseo registry population
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Application progress of early nutrition intervention in patients with hepatocellular carcinoma after liver transplantation 被引量:1
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作者 Shan-Shan Deng Yu-Ping Zhu +1 位作者 Zhi-Tao Chen Wan Li 《World Journal of Gastrointestinal Surgery》 2025年第3期27-37,共11页
Liver transplantation,as an effective therapy for patients with liver cancer,plays an important role in improving the quality of life of patients.However,the com-plexity and trauma of liver transplantation can easily ... Liver transplantation,as an effective therapy for patients with liver cancer,plays an important role in improving the quality of life of patients.However,the com-plexity and trauma of liver transplantation can easily lead to the occurrence of malnutrition in patients,and then increase the risk of postoperative complica-tions,which has aroused widespread clinical attention.Reasonable nutritional support can not only maintain the stability of the body’s internal environment,reduce the occurrence of complications,but also promote the recovery of liver and other organ functions.In recent years,with the in-depth understanding of nut-ritional metabolism after liver transplantation,the application of enteral nutrition and parenteral nutrition in nutritional support after liver transplantation has been increasingly extensive and achieved remarkable results.This paper discusses the effect of early postoperative nutritional intervention on patients with liver cancer and liver transplantation,and combined with its mechanism of action,can better understand the effectiveness of intervention,and provide reference for the deve-lopment of scientific and reasonable nutritional support programs in clinical pra-ctice. 展开更多
关键词 Liver cancer Liver transplantation Postoperative intervention Early nutrition Research progress Summarize
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Urgent thrombolysis followed by percutaneous coronary intervention for the simultaneous acute cardio-cerebral ischemic attack:A case report 被引量:1
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作者 Wen-Xue Zheng Ling-Yu Liu 《World Journal of Clinical Cases》 2025年第21期104-110,共7页
BACKGROUND Simultaneous acute ischemic stroke(AIS)and myocardial infarction(cardio-cerebral ischemic attack)have rarely been reported in the literature.Currently,no clear evidence-based guidelines or clinical trials e... BACKGROUND Simultaneous acute ischemic stroke(AIS)and myocardial infarction(cardio-cerebral ischemic attack)have rarely been reported in the literature.Currently,no clear evidence-based guidelines or clinical trials exist to determine the optimal therapeutic strategy for these patients.CASE SUMMARY We present the case of a 27-year-old Chinese man who simultaneously experie-nced acute concomitant cerebrocardiac infarction(CCI)and painless ST-elevation myocardial infarction.The patient was successfully treated with elective percu-taneous coronary intervention(PCI)after receiving urgent systemic thrombolysis at the standard dose for AIS.CONCLUSION Urgent thrombolysis followed by elective PCI was an appropriate strategy for the management of simultaneous CCI. 展开更多
关键词 Acute ischemic stroke Acute myocardial infarction Thrombolysis therapy ETIOLOGY Percutaneous coronary intervention Case report
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The Characteristics and Intervention Strategies of Novice Teachers’Inappropriate Behaviors in Classroom Teaching 被引量:1
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作者 Guoqing Yu 《Journal of Contemporary Educational Research》 2025年第2期46-56,共11页
This study aims to explore the characteristics of novice teachers’inappropriate behaviors in classroom teaching and their intervention strategies.With the continuous improvement of education quality,novice teachers f... This study aims to explore the characteristics of novice teachers’inappropriate behaviors in classroom teaching and their intervention strategies.With the continuous improvement of education quality,novice teachers face increasing challenges in teaching practice.Their inappropriate behaviors not only affect the classroom atmosphere but may also negatively impact students’learning outcomes.Therefore,researching the characteristics of novice teachers’inappropriate behaviors and their intervention strategies holds significant scientific and social value.This study employs a combination of quantitative and qualitative methods to analyze the behavioral patterns of novice teachers in classroom teaching and proposes corresponding intervention strategies.The results indicate that novice teachers’inappropriate behaviors mainly manifest as poor classroom management,monotonous teaching methods,and insufficient interaction with students.Based on these findings,the study proposes a series of effective intervention strategies,including enhancing teacher training,optimizing teaching design,and promoting positive interactions between teachers and students.The conclusions of the study not only provide practical guidance for educational practice but also point out directions for future research,emphasizing the crucial role of teacher professional development in improving teaching quality. 展开更多
关键词 Novice teachers Inappropriate behaviors intervention strategies Teaching quality Teacher professional development
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Effects of Rehabilitation Nursing Combined with Psychological Intervention Based on Mind Mapping Model on Emotional State and Treatment Compliance of Patients with Nephrotic Syndrome 被引量:1
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作者 Xiuju Huang Juan Zhang 《Journal of Clinical and Nursing Research》 2025年第3期64-69,共6页
Objective:To evaluate the value of rehabilitation nursing based on mind mapping model combined with psychological intervention for patients with nephrotic syndrome(NS).Methods:A total of 60 patients with NS who visite... Objective:To evaluate the value of rehabilitation nursing based on mind mapping model combined with psychological intervention for patients with nephrotic syndrome(NS).Methods:A total of 60 patients with NS who visited our hospital from January 2024 to December 2024 were selected as samples and randomly divided into groups.The observation group received rehabilitation nursing based on the mind mapping model combined with psychological intervention,while the control group received routine intervention.The differences in emotional scores,self-care ability scores,compliance,and complications were compared between the two groups.Results:The anxiety(SAS)and depression(SDS)scores of the observation group were lower than those of the control group,while the self-care ability scale(ESCA)score was higher than that of the control group(P<0.05).The compliance rate of the observation group was higher than that of the control group(P<0.05).The complication rate of NS in the observation group was lower than that in the control group(P<0.05).Conclusion:Rehabilitation nursing based on the mind mapping model combined with psychological intervention can enhance self-care ability,reduce negative emotions,and reduce complications in NS nursing,which is efficient and feasible. 展开更多
关键词 Nephrotic syndrome Psychological intervention Mind mapping model Rehabilitation nursing
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Parameter changes and influencing factors in sixty patients with interventional surgery for liver cancer diagnoses 被引量:1
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作者 Lin Zhi Zhi-Hai Chen Jun Deng 《World Journal of Gastrointestinal Surgery》 2025年第2期105-110,共6页
BACKGROUND The development of hepatocellular carcinoma(HCC)is influenced by multiple factors.Interventional therapy offers an effective treatment option for patients with unresectable intermediate-to-advanced HCC.Inte... BACKGROUND The development of hepatocellular carcinoma(HCC)is influenced by multiple factors.Interventional therapy offers an effective treatment option for patients with unresectable intermediate-to-advanced HCC.Interventional therapy can induce electrocardiographic(ECG)abnormalities that may be associated with liver dysfunction,electrolyte disorders,and cardiac injury.AIM To explore the ECG alterations and determinants following interventional therapy in patients with HCC.METHODS Sixty patients undergoing interventional treatment for liver cancer were selected as study participants.According to the results of the dynamic ECG examination 1 day after surgery,the patients were divided into an abnormal group(n=21)and a nonabnormal group(n=39).With the help of dynamic ECG examination,the ECG parameters were compared and the baseline data of patients was recorded in the two groups.RESULTS The 24 hours QT interval variability,24 hours normal atrial polarization to ventricular polarization(R-R)interval(standard deviation),24 hours consecutive 5 minutes normal R-R interval,and 24 hours continuous 5 minutes normal R-R interval(standard deviation mean)were lower than patients in the nonabnormal group(P<0.05).The logistic analysis showed that age>60 years,liver function grade B,and postoperative body temperature 38°C were risk factors for abnormal dynamic electrocardiogram in patients with liver cancer intervention(P<0.05).CONCLUSION Interventional therapy for HCC can lead to ECG abnormalities,underscoring the clinical need for enhanced cardiac monitoring to mitigate myocardial complications. 展开更多
关键词 Liver cancer interventional therapy Holter electrocardiogram PERIOPERATIVE Influencing factors
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Advances in Research of Application of Gratitude Intervention in Patients with Malignant Tumor
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作者 Xingya ZHAO Bing LIU Songhong XIE 《Medicinal Plant》 2025年第3期40-42,共3页
In recent years,gratitude intervention,as an application method of positive psychology,has gradually attracted the attention of researchers.Gratitude intervention is considered to be an effective psychological interve... In recent years,gratitude intervention,as an application method of positive psychology,has gradually attracted the attention of researchers.Gratitude intervention is considered to be an effective psychological intervention,especially in patients with malignant tumors.This study reviews the research progress of gratitude intervention in patients with malignant tumors,focusing on the mechanism,implementation methods,effect evaluation and challenges in clinical application of gratitude intervention,in the hope of providing a theoretical support and practical guideline for future research and practice. 展开更多
关键词 GRATITUDE intervention MALIGNANT TUMOR Application ADVANCES in RESEARCH
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Intervention and treatment of Alzheimer's disease
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作者 Dan-Lin Yue-Ran Ma +6 位作者 Tian-Yang Jun-Ru Yang Jia-Rui Ma Wen-Rui Wu Si-Qi He Yu-Hong Lü Chang-Wu Yue 《Life Research》 2025年第1期44-50,共7页
Background:Alzheimer's disease(AD)is a degenerative disease that occurs in the central nervous system and is characterized by progressive cognitive dysfunction and behavioral impairment.The main pathological mecha... Background:Alzheimer's disease(AD)is a degenerative disease that occurs in the central nervous system and is characterized by progressive cognitive dysfunction and behavioral impairment.The main pathological mechanisms are amyloid-βaccumulation(Aβ)and hyperphosphorylation of tau protein(P-TAU).Objective:however,there are no effective drugs for the treatment of AD,so the intervention and treatment of AD still need further research.Methods:We did a search and summary some of the new potential drugs and other interventions for the treatment of AD.Results:We found relevant anti-Aβ,anti-tau,anti-aging,the Apolipoprotein(APOE)control drugs and intervention in AD through exercise and diet.Conclusions:because most of these drugs are in clinical trials,more effort is needed to develop anti-AD drugs. 展开更多
关键词 AD AGING APOE TAU DRUGS intervention
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Impact of educational intervention on the awareness and practice of genetic screening and counseling among young adults in Calabar Municipality,Cross River State
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作者 Mathias AGBA Easter Chukwudi OSUCHUKWU +1 位作者 Rosemary EZEKIEL Affiong Mathias AGBA 《Journal of Integrative Nursing》 2025年第3期130-136,共7页
Objective:This randomized controlled trial aimed to assess the impact of a targeted educational intervention on the awareness and practice of genetic screening and counseling among young adults in Calabar Municipality... Objective:This randomized controlled trial aimed to assess the impact of a targeted educational intervention on the awareness and practice of genetic screening and counseling among young adults in Calabar Municipality,Cross River State.Materials and Methods:Participants(aged 18-45)were randomly assigned to either an intervention group receiving structured health education or a control group receiving general health information.Stratified randomization was used between the groups.A sample size of 340 participants was recruited to detect a 20%difference in outcomes with 80%power.Data were collected using prevalidated questionnaires at baseline,immediately after the intervention,and at a 3-month follow-up.The intervention consisted of three weekly 90-min educational sessions covering genetics,the benefits of screening,and practical guidance on accessing genetic services.The primary outcomes were changes in awareness and practices related to genetic screening,with secondary outcomes focusing on attitudes and intentions toward genetic counseling.Results:Findings revealed that awareness of genetic screening was higher in the intervention group,with 65.9%of participants aware of early detection,compared to 59.4%in the control group,although the difference was not statistically significant(P=0.23).In terms of practice,42.9%of the intervention group and 40.0%of the control group engaged in genetic screening programs,with no significant difference(P=0.57).Logistic regression analysis highlighted that age,educational level,and knowledge of teratogens were significant predictors of genetic screening awareness.Participants aged 36 years and above were 1.52 times more likely to be aware(odds ratio[OR]=1.52,P=0.003),and those with tertiary education had nearly double the likelihood of awareness(OR=1.96,P<0.001).Conclusion:The study underscores the importance of targeted education in improving genetic screening awareness. 展开更多
关键词 AWARENESS COUNSELING educational intervention genetic screening IMPACT PRACTICE young adults
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Effect of nursing intervention on improving awareness of high-risk patients about stroke prevention
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作者 Mona M.Abd El-Maksoud Aida S.Alqarni +2 位作者 Dawlat Ahmed Mahmoud Gharib Fatma Mohammed Ahmed Eman Elsayed Hussein 《Frontiers of Nursing》 2025年第1期133-144,共12页
Objective: Stroke is perceived as a serious illness although it is preventable, and lifestyle alterations can be made to reduce its risk. Improvement of stroke care should be achieved through awareness of public, espe... Objective: Stroke is perceived as a serious illness although it is preventable, and lifestyle alterations can be made to reduce its risk. Improvement of stroke care should be achieved through awareness of public, especially through high-risk group. Henceforth, the aim of this study was to evaluate the effect of nursing intervention on improving awareness of high-risk people about stroke prevention. Methods: A quasi-experimental design was used to carry out this study, where a purposive sample of 80 adult patients at high risk for stroke were enrolled while they were attending the out-patient clinics of Zagazig University Hospitals for follow-up treatment;they were divided into two groups: case (40 patients) and control (40 patients). An interview questionnaire was used to assess patients’ knowledge regarding warning signs, risk factors, and immediate treatment;attitude;and their practice for prevention for stroke at pretest and posttest. Results: The study revealed the poor level of knowledge, bad level of preventive behavior, and negative attitude regarding stroke prevention at pre-intervention. However, after intervention, the high-risk people had fair level of knowledge with moderate practice for stroke prevention and positive attitude, with statistically significant difference between pre-post intervention and between the case and control groups. Conclusions: The study revealed that the nursing intervention seemed to change the knowledge, practice, and attitude of subjects regarding stroke prevention. This, in turn, implies that awareness of prevention of stroke and high-risk factor control could be important to reduce the burden of stroke in Egypt. Thus, further research on a larger scale is required to improve population knowledge and behavior for stroke prevention and control. 展开更多
关键词 AWARENESS high-risk group intervention NURSING PREVENTION STROKE
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Polysialic acid-Siglec immune checkpoints of microglia and macrophages:Perspectives for therapeutic intervention
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作者 Hauke Thiesler Herbert Hildebrandt 《Neural Regeneration Research》 2026年第2期661-662,共2页
Microglia are the resident macrophages of the central nervous system.They act as the first line of defense against pathogens and play essential roles in neuroinflammation and tissue repair after brain insult or in neu... Microglia are the resident macrophages of the central nervous system.They act as the first line of defense against pathogens and play essential roles in neuroinflammation and tissue repair after brain insult or in neurodegenerative and demyelinating diseases(Borst et al.,2021).Together with infiltrating monocyte-derived macrophages,microglia also play a critical role for brain tumor development,since immunosuppressive interactions between tumor cells and tumor-associated microglia and macrophages(TAM)are linked to malignant progression.This mechanism is of particular relevance in glioblastoma(GB),the deadliest form of brain cancer with a median overall survival of less than 15 months(Khan et al.,2023).Therefore,targeting microglia and macrophage activation is a promising strategy for therapeutic interference in brain disease. 展开更多
关键词 therapeutic intervention central nervous system immune checkpoints neurodegenerative demyelinating diseases borst MACROPHAGES polysialic acid SIGLEC MICROGLIA
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Mindfulness-based interventions in oncology:A scoping review of outcomes and applications
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作者 Cheng-Yun Chen Sheng-Nan Li +1 位作者 Xin-Xin Li Bo Zhou 《World Journal of Clinical Cases》 2025年第24期10-17,共8页
Cancer significantly impacts patients'physical and mental health,leading to a wide range of effects from physical pain to psychological issues such as anxiety and depression,severely diminishing their quality of l... Cancer significantly impacts patients'physical and mental health,leading to a wide range of effects from physical pain to psychological issues such as anxiety and depression,severely diminishing their quality of life.As an emerging psychosomatic intervention,mindfulness interventions have gained increasing attention.This scoping review systematically searches and filters relevant literature,covering databases from their inception to January 2025,aiming to comprehensively outline the application,research characteristics,and main outcomes of mindfulness interventions in cancer recovery.We employed the Arksey and O'Malley framework,utilizing electronic databases and manual searches to rigorously select studies and extract key data.Results indicate that mindfulness interventions show broad potential in improving cancer patients'mental health,physical symptoms,and quality of life,despite the heterogeneity of the evidence.Future research should focus on higher-quality randomized controlled trials to explore different intervention modalities and long-term effects and to analyze their underlying mechanisms.This paper particularly highlights the advancements in Mindfulness-Based Cancer Recovery,providing valuable references for clinical practice. 展开更多
关键词 MINDFULNESS Cancer Psychosomatic intervention Scoping review Mental health Quality of life
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Endoscopic intervention in hematologic malignancy patients with severe thrombocytopenia:Methodological concerns,clinical implications,and future research directions
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作者 Arunkumar Krishnan 《World Journal of Gastrointestinal Endoscopy》 2025年第4期61-66,共6页
Gastrointestinal bleeding(GIB)presents a significant challenge for patients with hematologic malignancies,especially those with severe thrombocytopenia.Although endoscopic intervention is frequently used in managing G... Gastrointestinal bleeding(GIB)presents a significant challenge for patients with hematologic malignancies,especially those with severe thrombocytopenia.Although endoscopic intervention is frequently used in managing GIB,its safety and effectiveness in this high-risk group remain unclear.A recent study by Alhumayyd et al provided insight into this issue.However,it has notable limitations,including its retrospective nature,small sample size,and failure to adjust for important confounding factors such as disease severity,hemodynamic status,and platelet function.The study’s findings indicated that urgent endoscopy may help decrease the incidence of recurrent bleeding;however,it did not show a clear benefit in terms of mortality.Future research ought to prioritize prospective,multicenter studies that employ standardized protocols and incorporate risk stratification models to better understand the impact of endoscopic treatment for GIB in these patients.Additionally,integrating platelet function assays could improve clinical decision-making.Addressing these research gaps is essential for improving patient outcomes and developing effective guidelines for managing GIB in individuals with thrombocytopenia. 展开更多
关键词 Gastrointestinal bleeding THROMBOCYTOPENIA Hematologic malignancies Endoscopic intervention Clinical outcomes Hemostatic management
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Pilot Study of a School-Based Parenting Intervention:Prevention of Emotional and Behavioral Problems among Chinese Children
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作者 Jin Peng Jiabei He Na Li 《International Journal of Mental Health Promotion》 2025年第7期953-977,共25页
Background:Parenting exerts a profound influence on children’s mental health and behavioral development.Despite the high prevalence of children’s emotional and behavioral problems(CEBP)in China,evidence-based parent... Background:Parenting exerts a profound influence on children’s mental health and behavioral development.Despite the high prevalence of children’s emotional and behavioral problems(CEBP)in China,evidence-based parenting interventions remain scarcely investigated as preventive public health strategies.This pilot study evaluated a school-based intervention for preventing CEBP.Methods:We employed a quasi-experimental design with propensity score matching(PSM)to select 28 families(intervention:n=13;control:n=15)from two matched urban primary schools.Quantitative data from seven validated scales were analyzed using t-tests and ANCOVA.Qualitative insights were derived from 10 semi-structured interviews via thematic analysis.Results:Compared to the control group,the intervention group demonstrated significantly greater improvements in CEBP(p=0.020,Cohen’s d=0.92),parental adjustment(p=0.031,Cohen’s d=0.80),parenting confidence(p=0.003,Cohen’s d=1.04),and parentchild relationships(p=0.001,Cohen’s d=1.46).Non-significant effects were observed for parenting style,parental relationship,and parenting conflict(p>0.05).Qualitative analysis corroborated these findings and further identified contributing factors for non-significant outcomes,including challengeswithmeasurement adaptability and inconsistent co-parenting practices.Conclusions:This pilot study suggests that an authoritative parenting style may be effective and culturally adaptable in China.Positive parenting interventions appear to mitigate CEBP by reducing risk factors and enhancing protective factors.However,improving parental relationships and parenting conflict may require targeted strategies.Given the pilot nature of this PSM-matched study(n=28),the findings should be interpreted as exploratory and used primarily for intervention refinement. 展开更多
关键词 Parenting intervention CHILDREN SCHOOL-BASED China emotional and behavioral problems
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Psychological interventions for post-stroke anxiety and depression:Current approaches and future perspectives
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作者 Xiao-Yun Lei Lu-Huan Chen +1 位作者 Li-Qi Qian Xu-Dong Lu 《World Journal of Psychiatry》 2025年第6期34-40,共7页
Psychological interventions have demonstrated efficacy in improving patients’emotional state,cognition,and thinking abilities,thereby enhancing their quality of life and survival.This review examines literature from ... Psychological interventions have demonstrated efficacy in improving patients’emotional state,cognition,and thinking abilities,thereby enhancing their quality of life and survival.This review examines literature from the China National Knowledge Infrastructure,Wanfang Data,Web of Science,and PubMed databases published over the past decade,focusing on the use of psychotherapy for poststroke anxiety and depression.The prevalence of anxiety and depression is significantly higher among patients who have experienced a stroke than in the general population,possibly due to vestibular dysfunction following brain injury.Current psychological interventions for stroke patients include cognitive behavioral therapy,supportive psychotherapy,music and art therapy,and exercise therapy.These approaches have been shown to promote psychological wellbeing and physical rehabilitation. 展开更多
关键词 Psychological intervention ANXIETY DEPRESSION STROKE Cognitive behavioral therapy
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