Intermediate filaments(IFs)in human cells are the products of six distinct gene families,all sharing homology in a core rod domain.These IFs assemble into non-polar polymers,providing cytoplasmic and nuclear mechanica...Intermediate filaments(IFs)in human cells are the products of six distinct gene families,all sharing homology in a core rod domain.These IFs assemble into non-polar polymers,providing cytoplasmic and nuclear mechanical support.Recent research has revealed the active and dynamic properties of IFs and their binding partners.This regulation extends beyond cell mechanics to include migration,mechanotransduction,and tumor growth.Therefore,this comprehensive review aims to catalog all human IF genes and IF-associated proteins(IFAPs),detailing their names,sizes,functions,associated human diseases,relevant literature,and links to resources like UniProt and the Protein Atlas database.These links provide access to additional information such as protein structure,subcellular localization,disease-causing mutations,and pathology.Using this catalog,we will provide an overview of the current understanding of the biological functions of IFs and IFAPs.This overview is crucial for identifying gaps in their characterization and understanding IF-mediated mechanotransduction.Additionally,we will consider potential future research directions.展开更多
A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states...A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states.The experimental results indicate that the dip angle of structural plane(θ)and the intermediate principal stress(σ2)have an important influence on the peak strength,cracking mode,and rockburst severity.The peak strength exhibits a first increase and then decrease as a function ofσ2 for a constantθ.However,whenσ2 is constant,the maximum peak strength is obtained atθof 90°,and the minimum peak strength is obtained atθof 30°or 45°.For the case of an inclined structural plane,the crack type at the tips of structural plane transforms from a mix of wing and anti-wing cracks to wing cracks with an increase inσ2,while the crack type around the tips of structural plane is always anti-wing cracks for the vertical structural plane,accompanied by a series of tensile cracks besides.The specimens with structural plane do not undergo slabbing failure regardless ofθ,and always exhibit composite tensile-shear failure whatever theσ2 value is.With an increase inσ2 andθ,the intensity of the rockburst is consistent with the tendency of the peak strength.By analyzing the relationship between the cohesion(c),internal friction angle(φ),andθin sandstone specimens,we incorporateθinto the true triaxial unloading strength criterion,and propose a modified linear Mogi-Coulomb criterion.Moreover,the crack propagation mechanism at the tips of structural plane,and closure degree of the structural plane under true triaxial unloading conditions are also discussed and summarized.This study provides theoretical guidance for stability assessment of surrounding rocks containing geological structures in deep complex stress environments.展开更多
The deformation of Cu–20 wt.%Fe alloy wires leads to a significant improvement in mechanical properties and a decrease in electrical conductivity.Simultaneous improvements in strength and conductivity were achieved b...The deformation of Cu–20 wt.%Fe alloy wires leads to a significant improvement in mechanical properties and a decrease in electrical conductivity.Simultaneous improvements in strength and conductivity were achieved by intermediate annealing of drawn Cu–20 wt.%Fe wires.As the annealing temperature increased,the strength of Cu–20 wt.%Fe alloy wire decreased monotonically,but the electrical conductivity first increased and then decreased,reaching its peak value after annealing at 500℃.The decrease in strength is related to dislocation recovery and static recrystallization of Cu and Fe phases,and the increase in electrical conductivity mainly results from the aging precipitation of solid solution Fe.After annealing at 500℃,there was no obvious recrystallization of Cu phase,and many of the nano-Fe particles precipitated from Cu matrix.An annealing temperature of 600℃ induced the recrystallization of Cu matrix and an increase in Fe solid solubility,resulting in a decrease in strength and electrical conductivity.Subsequently,the wires annealed at 500℃ were drawn to 2 mm.Compared with those of the continuously drawn Cu–20 wt.%Fe alloy wires,the deformation ability,strength,and electrical conductivity of Cu–20 wt.%Fe alloy wires subjected to intermediate annealing treatment are significantly greater.This is mainly related to the sufficient precipitation of Fe in Cu matrix and the strengthening of refined Fe fibers parallel to the drawing direction.展开更多
Quasi-solid-state electrolytes,which integrate the safety characteristics of inorganic materials,the flexibility of polymers,and the high ionic conductivity of liquid electrolytes,represent a transitional solution for...Quasi-solid-state electrolytes,which integrate the safety characteristics of inorganic materials,the flexibility of polymers,and the high ionic conductivity of liquid electrolytes,represent a transitional solution for high-energy-density lithium batteries.However,the mechanisms by which inorganic fillers enhance multiphase interfacial conduction remain inadequately understood.In this work,we synthesized composite quasi-solid-state electrolytes with high inorganic content to investigate interfacial phenomena and achieve enhanced electrode interface stability.Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)particles,through surface anion anchoring,improve Li^(+)transference numbers and facilitate partial dissociation of solvated Li^(+)structures,resulting in superior ion transport kinetics that achieve an ionic conductivity of 0.51 mS cm^(−1)at room temperature.The high mass fraction of inorganic components additionally promotes the formation of more stable interfacial layers,enabling lithium-symmetric cells to operate without short-circuiting for 6000 h at 0.1 mA cm^(−2).Furthermore,this system demonstrates exceptional stability in 5 V-class lithium metal full cells,maintaining 80.5%capacity retention over 200 cycles at 0.5C.These findings guide the role of inorganic interfaces in composite electrolytes and demonstrate their potential for advancing high-voltage lithium battery technology.展开更多
Addressing inadequate OH^(*)adsorption in Ru Co alloy catalysts is crucial for boosting intermediate coverage and redirecting the water-splitting pathway.Herein,the adaptive P sites were strategically incorporated to ...Addressing inadequate OH^(*)adsorption in Ru Co alloy catalysts is crucial for boosting intermediate coverage and redirecting the water-splitting pathway.Herein,the adaptive P sites were strategically incorporated to overcome the aforementioned challenge.The P sites,as potent OH^(*)adsorption centers,synergize with Co sites to promote water dissociation and enrich surrounding Ru sites with H*intermediates,thus triggering the Volmer-Tafel route for hydrogen evolution reaction(HER).Besides,during the oxygen evolution reaction(OER),the surface of P-Ru Co was reconstructed into Ru-doped Co OOH with anchored PO_(4)^(3-).These PO_(4)^(3-)not only circumvent the intrinsic OH^(*)adsorption limitations of Ru-Co OOH in the adsorbate evolution mechanism(AEM)by rerouting to a more expeditious lattice oxygen oxidation mechanism(LOM)but also improve the coverage of key oxygen-containing intermediates,significantly accelerating OER kinetics.Consequently,the P-Ru Co demonstrates exceptional bifunctional performance,with overpotentials of 29 m V for HER and 222 m V for OER at 10 m A cm^(-2).Remarkably,the mass activities of PRu Co for HER(5.48 A mg^(-1))and OER(2.13 A mg^(-1))are 6.2 and 11.2 times higher than those of its commercial counterparts(Ru/C for HER and RuO_(2)for OER),respectively.When integrated into an anionexchange-membrane electrolyzer,this catalyst achieves ampere-level current densities of 1.32 A cm^(-2)for water electrolysis and 1.23 A cm^(-2)for seawater electrolysis at 2.1 V,with a 500-h durability.展开更多
Fracture(fault)reactivation can lead to dynamic geological hazards including earthquakes,rock collapses,landslides,and rock bursts.True triaxial compression tests were conducted to analyze the fracture reactivation pr...Fracture(fault)reactivation can lead to dynamic geological hazards including earthquakes,rock collapses,landslides,and rock bursts.True triaxial compression tests were conducted to analyze the fracture reactivation process under two different orientations of σ_(2),i.e.σ_(2) parallel to the fracture plane(Scheme 2)and σ_(2) cutting through the fracture plane(Scheme 3),under varying σ_(3) from 10 MPa to 40 MPa.The peak or fracture reactivation strength,deformation,failure mode,and post-peak mechanical behavior of intact(Scheme 1)and pre-fractured(Schemes 2 and 3)specimens were also compared.Results show that for intact specimens,the stress remains nearly constant in the residual sliding stage with no stick-slip,and the newly formed fracture surface only propagates along the σ_(2) direction when σ_(3) ranges from 10 MPa to 30 MPa,while it extends along both σ_(2) and σ_(3) directions when σ_(3) increases to 40 MPa;for the pre-fractured specimens,the fractures are usually reactivated under all the σ_(3) levels in Scheme 2,but fracture reactivation only occurs when σ_(3) is greater than 25 MPa in Scheme 3,below which new faulting traversing the original macro fracture occurs.In all the test schemes,both ε_(2) and ε_(3) experience an accumulative process of elongation,after which an abrupt change occurs at the point of the final failure;the degree of this change is dependent on the orientation of the new faulting or the slip direction of the original fracture,and it is generally more than 10 times larger in the slip direction of the original fracture than in the non-slip direction.Besides,the differential stress(peak stress)required for reactivation and the post-peak stress drop increase with increasing σ_(3).Post-peak stress drop and residual strength in Scheme 3 are generally greater than those in Scheme 2 at the same σ_(3) value.Our study clearly shows that intermediate principal stress orientation not only affects the fracture reactivation strength but also influences the slip deformation and failure modes.These new findings facilitate the mitigation of dynamic geological hazards associated with fracture and fault slip.展开更多
Background:Intermediate-risk prostate cancer(IR-PC)represents a heterogeneous group requiring nuanced treatment approaches,and recent advancements in radiotherapy(RT),androgen deprivation therapy(ADT),and prostatespec...Background:Intermediate-risk prostate cancer(IR-PC)represents a heterogeneous group requiring nuanced treatment approaches,and recent advancements in radiotherapy(RT),androgen deprivation therapy(ADT),and prostatespecific membrane antigen positron emission tomography(PSMA-PET/CT)imaging have prompted growing interest in personalized,risk-adapted management strategies.This study by the Turkish Society for Radiation Oncology aims to examine radiation oncologists’practices in managing IR-PC,focusing on RT and imaging modalities to identify trends for personalized treatments.Methods:A cross-sectional survey was conducted among Turkish radiation oncologists treating at least 50 prostate cancer(PC)cases annually.The 22-item questionnaire covered IR-PC management aspects such as risk stratification,imaging preferences,androgen deprivation therapy(ADT)use and duration,RT techniques,and treatment combinations.Anonymous responses were analyzed using descriptive statistics.Results:Thirty radiation oncologists participated,57%with over 20 years of experience.The median annual number of PC cases treated was 130.For risk stratification,43% followed the National Comprehensive Cancer Network(NCCN)guidelines,while 30%used the D’Amico classification.Imaging preferences revealed 47% favored PSMA-PET/CT.External beam RT was universally preferred,with 60% adopting ultra-hypofractionation.ADT was used by 97%,with 73% recommending it for unfavorable IR-PC cases.Short-term ADT(4–6 months)was the standard,administered concurrently with RT by 57%.Cardiovascular status influenced decisions for 97% of respondents,while 37% also considered patient age,preferences,and sexual health.Conclusions:This national survey demonstrates a shift toward personalized care in intermediate-risk prostate cancer in Turkey,marked by selective PSMA-PET/CT use,tailored ADT,and evolving radiotherapy practices.The findings underscore the importance of multidisciplinary collaboration—particularly between urologists and radiation oncologists—to optimize imaging integration and treatment outcomes.展开更多
The aim of this paper is to simulate and study the early moments of the reactive ballistics of a large caliber projectile fired from a gun,combining 0D and 2D axisymmetric Computational Fluid Dynamics(CFD)approaches.F...The aim of this paper is to simulate and study the early moments of the reactive ballistics of a large caliber projectile fired from a gun,combining 0D and 2D axisymmetric Computational Fluid Dynamics(CFD)approaches.First,the methodology is introduced with the development of an interior ballistics(IB)lumped parameter code(LPC),integrating an original image processing method for calculating the specific regression of propellant grains that compose the gun propellant.The ONERA CFD code CEDRE,equipped with a Dynamic Mesh Technique(DMT),is then used in conjunction with the developed LPC to build a dedicated methodology to calculate IB.First results obtained on the AGARD gun and 40 mm gun test cases are in a good agreement with the existing literature.CEDRE is also used to calculate inter-mediate ballistics(first milliseconds of free flight of the projectile)with a multispecies and reactive approach either starting from the gun muzzle plane or directly following IB.In the latter case,an inverse problem involving a Latin hypercube sampling method is used to find a gun propellant configuration that allows the projectile to reach a given exit velocity and base pressure when IB ends.The methodology developed in this work makes it possible to study the flame front of the intermediate flash and depressurization that occurs in a base bleed(BB)channel at the gun muzzle.Average pressure variations in the BB channel during depressurization are in good agreement with literature.展开更多
This study investigates the dynamical behavior of two parallel fluid-conveying pipes by developing a non-planar dynamical model of the two pipes coupled with an intermediate spring. A systematic analysis is conducted ...This study investigates the dynamical behavior of two parallel fluid-conveying pipes by developing a non-planar dynamical model of the two pipes coupled with an intermediate spring. A systematic analysis is conducted to evaluate the effects of spring parameters on the non-planar vibration characteristics and buckling behaviors of the coupled system. The nonlinear governing equations are derived with Hamilton's principle,subsequently discretized through Galerkin's method, and finally numerically solved by the Runge-Kutta algorithm. Based on the linearized equations, an eigenvalue analysis is performed to obtain the coupled frequencies, modal shapes, and critical flow velocities for buckling instability. Quantitative assessments further elucidate the effects of the spring position and stiffness coefficient on the coupled frequencies and critical flow velocities.Nonlinear dynamic analyses reveal the evolution of buckling patterns and bifurcation behaviors between the lateral displacements of the two pipes and the flow velocity. Numerical results indicate that the intermediate spring increases the susceptibility to buckling instability in the out-of-plane direction compared with the in-plane direction. Furthermore, synchronized lateral displacements emerge in both pipes when the flow velocity of one pipe exceeds the critical threshold. This work is expected to provide a theoretical foundation for the stability assessment and vibration analysis in coupled fluid-conveying pipe systems.展开更多
Sodium-sulfur and sodium-iodine batteries are attractive due to their low cost and high capacities.However,they suffer from polysulfide/polyiodide dissolution and fast capacity decay.To solve these issues,herein,an or...Sodium-sulfur and sodium-iodine batteries are attractive due to their low cost and high capacities.However,they suffer from polysulfide/polyiodide dissolution and fast capacity decay.To solve these issues,herein,an organic species-intercalated layered MoS_(2) with oxygen-dopant(Org-MoS_(2)) was designed for the iodine encapsulation.The chemically-bonded S^(2-) from the S-Mo-S layer can not only stabilize the in situ generated I^(+) intermediate to boost the redox kinetics and deep transformations of 2I^(-)←→I_(2)←→2I^(+),but also undergo the conversion of S^(2-)←→S^(δ-) in the high voltage range of 1.5-3.4 V without structural collapse and shuttle effect.That is owning to the I^(+)-induced local charge and the electron reservoir of multi-valent Mo,which facilitate effective charge transfer via alternate dipoles of I^(δ+)-^(δ-)S^(δ+)/^(δ-)O^(δ+)-^(δ-)Mo^(δ+)-^(δ-)S^(δ+) and promote the redox of I/S/Mo.Meanwhile,the incorporated organic species are transformed into an aromatic carbonaceous material with improved electron conductivity and thinner thickness in the cycling test accompanied by the exposure of more Mo-O-Mo linkages,resulting in an increasing ultrahigh capacity and outstanding long-term durability of Org-MoS_(2)@I_(2).展开更多
This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FG...This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP)materials.The strain potential and kinetic energies of each beam along with the work done by the external force are calculated.Additionally,a higher-order beam element is introduced to derive stiffness and mass matrices,along with the force vector.The curved and straight beams are discretized,and their assembled stiffness,mass matrices,and force vectors,are obtained.Continuity conditions at the joints are used to derive the total matrices of the entire structure.Subsequently,the natural frequencies and transient response of the system are determined.The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS,demonstrating excellent agreement.Furthermore,a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.展开更多
Room and pillar mining is an underground mining method that utilizes natural pillar support to control rock mass behavior,ensuring mine stability and a safe mine environment.This study specifically documents the influ...Room and pillar mining is an underground mining method that utilizes natural pillar support to control rock mass behavior,ensuring mine stability and a safe mine environment.This study specifically documents the influence of the intermediate principal stress component on the pillar behavior.So far only classical failure criteria ignoring the influence of the intermediate principal stress component were used for underground pillar design.By using an extended Hoek-Brown failure criterion in comparison with the classical Hoek-Brown failure criterion,the influence of the intermediate principal stress component is documented by indicating those areas where the failure criterion is violated.This study demonstrates,that depending on the rock type,the intermediate principal stress component can have a significant effect.Ignoring this influence can lead to uneconomic pillar design and incorrect determination of the factor of safety.展开更多
By manipulating the distribution of surface electrons,defect engineering enables effective control over the adsorption energy between adsorbates and active sites in the CO_(2)reduction reaction(CO_(2)RR).Herein,we rep...By manipulating the distribution of surface electrons,defect engineering enables effective control over the adsorption energy between adsorbates and active sites in the CO_(2)reduction reaction(CO_(2)RR).Herein,we report a hollow indium oxide nanotube containing both oxygen vacancy and sulfur doping(V_o-Sx-In_(2)O_(3))for improved CO_(2)-to-HCOOH electroreduction and Zn-CO_(2)battery.The componential synergy significantly reduces the*OCHO formation barrier to expedite protonation process and creates a favorable electronic micro-environment for*HCOOH desorption.As a result,the CO_(2)RR performance of Vo-Sx-In_(2)O_(3)outperforms Pure-In_(2)O_(3)and V_o-In_(2)O_(3),where V_o-S53-In_(2)O_(3)exhibits a maximal HCOOH Faradaic efficiency of 92.4%at-1,2 V vs.reversible hydrogen electrode(RHE)in H-cell and above 92%over a wide window potential with high current density(119.1 mA cm^(-2)at-1.1 V vs.RHE)in flow cell.Furthermore,the rechargeable Zn-CO_(2)battery utilizing V_o-S53-In_(2)O_(3)as cathode shows a high power density of 2.29 mW cm^(-2)and a long-term stability during charge-discharge cycles.This work provides a valuable perspective to elucidate co-defective catalysts in regulating the intermediates for efficient CO_(2)RR.展开更多
The formation of oligomeric hydrogen peroxide triggered by Criegee intermediate maybe contributes significantly to the formation and growth of secondary organic aerosol(SOA).However,to date,the reactivity of C2 Criege...The formation of oligomeric hydrogen peroxide triggered by Criegee intermediate maybe contributes significantly to the formation and growth of secondary organic aerosol(SOA).However,to date,the reactivity of C2 Criegee intermediates(CH_(3)CHOO)in areas contaminated with acidic gas remains poorly understood.Herein,high-level quantum chemical calculations and Born-Oppenheimer molecular dynamics(BOMD)simulations are used to explore the reaction of CH_(3)CHOO and H_(2)SO_(4)both in the gas phase and at the airwater interface.In the gas phase,the addition reaction of CH_(3)CHOO with H_(2)SO_(4)to generate CH_(3)HC(OOH)OSO_(3)H(HPES)is near-barrierless,regardless of the presence of water molecules.BOMD simulations showthat the reaction at the air-water interface is even faster than that in the gas phase.Further calculations reveal that the HPES has a tendency to aggregate with sulfuric acids,ammonias,and water molecules to form stable clusters,meanwhile the oligomerization reaction of CH_(3)CHOO with HPES in the gas phase is both thermochemically and kinetically favored.Also,it is noted that the interfacial HPES−ion can attract H_(2)SO_(4),NH_(3),(COOH)_(2)and HNO_(3)for particle formation from the gas phase to the water surface.Thus,the results of this work not only elucidate the high atmospheric reactivity of C2 Criegee intermediates in polluted regions,but also deepen our understanding of the formation process of atmospheric SOA induced by Criegee intermediates.展开更多
Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic liver.The therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at diagnosis.Not...Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic liver.The therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at diagnosis.Notwithstanding the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical challenge.Emergent systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of HCC.This review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative intent.We also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative intent.Finally,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.展开更多
CsPbBr_(3)inorganic perovskites have been regarded as the promising materials in the field of photo-voltaics because of the high tolerance against environment.The high energy barrier of phase transition from lead brom...CsPbBr_(3)inorganic perovskites have been regarded as the promising materials in the field of photo-voltaics because of the high tolerance against environment.The high energy barrier of phase transition from lead bromide(PbBr_(2))to CsPbBr_(3)perovskite and low solubility of perovskite in organic solvent impede the further improvement of device performance in terms of CsPbBr_(3)solar cells.Herein,an intermediate phase-assisted growth of CsPbBr_(3)perovskite was proposed by introducing tetraphenylphosphonium bromide(TPPB)as additive.The TPPB is expected to react with PbBr_(2)in organic solvent to form an intermediate phase of[TPPB.DMF]-PbBr_(2),which not only effectively improves the crystallinity of PbBr2 crystals,but also greatly reduces the phase transition energy barrier,leading to uniform and compact CsPbBr_(3)perovskite films with large grain size and high crystallinity.In combination with carbon electrode,the CsPbBr_(3)solar cells yield a champion device performance of 9.57%in comparison of pristine CsPbBr_(3)solar cells showing a low efficiency of 8.17%.Furthermore,the intermediate phaseassisted growth of CsPbBr_(3)-based solar cells displays an outstanding storage over720 h.展开更多
Photocatalytic reduction of CO_(2) into fuel represents a promising approach for achieving carbon neutrality,while realizing high selectivity in this process is challenging due to uncontrollable reaction intermediate ...Photocatalytic reduction of CO_(2) into fuel represents a promising approach for achieving carbon neutrality,while realizing high selectivity in this process is challenging due to uncontrollable reaction intermediate and retarded desorption of target products.Engineering the interface microenvironment of catalysts has been proposed as a strategy to exert a significant influence on reaction outcomes,yet it remains a significant challenge.In this study,amino alkylation was successfully integrated into the melem unit of polymeric carbon nitrides(PCN),which could efficiently drive the photocatalytic CO_(2) reduction.Experimental characterization and theoretical calculations revealed that the introduction of amino alkylation lowers the energy barrier for CO_(2) reduction into^(*)COOH intermediate,transforming the adsorption of^(*)COOH intermediate from the endothermic to an exothermic process.Notably,the as-prepared materials demonstrated outstanding performance in photocatalytic CO_(2) reduction,yielding CO_(2)at a rate of 152.8μmol h^(-1) with a high selectivity of 95.4%and a quantum efficiency of 6.6%.展开更多
Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) represents a significant advancement in the imaging of prostate cancer (PCa), yet its application in low- and intermedi...Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) represents a significant advancement in the imaging of prostate cancer (PCa), yet its application in low- and intermediate-risk cases continues to be a topic of active discussion. This article delves into the nuanced role of PSMA PET/CT, critically analyzing its strengths and limitations in these specific risk categories. For patients with low-risk PCa, PSMA PET/CT demonstrates limited effectiveness in routine staging due to its minimal tracer uptake in low-grade tumors. However, its ability to differentiate between low- and high-grade tumors suggests a promising role in active surveillance, offering a potential noninvasive method for monitoring disease progression and aiding in treatment decision-making. In the intermediate-risk PCa setting, the high specificity of PSMA PET/CT in nodal staging makes it a valuable asset for precise surgical and radiation therapy planning. The article underscores the necessity for further research to fully realize the potential of PSMA PET/CT in PCa management, particularly in developing more personalized treatment approaches in these clinical scenarios.展开更多
Multi-level programmable photonic integrated circuits(PICs)and optical metasurfaces have gained widespread attention in many fields,such as neuromorphic photonics,opticalcommunications,and quantum information.In this ...Multi-level programmable photonic integrated circuits(PICs)and optical metasurfaces have gained widespread attention in many fields,such as neuromorphic photonics,opticalcommunications,and quantum information.In this paper,we propose pixelated programmable Si_(3)N_(4)PICs with record-high 20-level intermediate states at 785 nm wavelength.Such flexibility in phase or amplitude modulation is achieved by a programmable Sb_(2)S_(3)matrix,the footprint of whose elements can be as small as 1.2μm,limited only by the optical diffraction limit of anin-house developed pulsed laser writing system.We believe our work lays the foundation for laser-writing ultra-high-level(20 levels and even more)programmable photonic systems and metasurfaces based on phase change materials,which could catalyze diverse applications such as programmable neuromorphic photonics,biosensing,optical computing,photonic quantum computing,and reconfigurable metasurfaces.展开更多
Traditional particle identification methods face timeconsuming,experience-dependent,and poor repeatability challenges in heavy-ion collisions at low and intermediate energies.Researchers urgently need solutions to the...Traditional particle identification methods face timeconsuming,experience-dependent,and poor repeatability challenges in heavy-ion collisions at low and intermediate energies.Researchers urgently need solutions to the dilemma of traditional particle identification methods.This study explores the possibility of applying intelligent learning algorithms to the particle identification of heavy-ion collisions at low and intermediate energies.Multiple intelligent algorithms,including XgBoost and TabNet,were selected to test datasets from the neutron ion multi-detector for reaction-oriented dynamics(NIMROD-ISiS)and Geant4 simulation.Tree-based machine learning algorithms and deep learning algorithms e.g.TabNet show excellent performance and generalization ability.Adding additional data features besides energy deposition can improve the algorithm’s performance when the data distribution is nonuniform.Intelligent learning algorithms can be applied to solve the particle identification problem in heavy-ion collisions at low and intermediate energies.展开更多
基金the National Natural Science Foundation of China(Grant No.32070777 to F.N.).
文摘Intermediate filaments(IFs)in human cells are the products of six distinct gene families,all sharing homology in a core rod domain.These IFs assemble into non-polar polymers,providing cytoplasmic and nuclear mechanical support.Recent research has revealed the active and dynamic properties of IFs and their binding partners.This regulation extends beyond cell mechanics to include migration,mechanotransduction,and tumor growth.Therefore,this comprehensive review aims to catalog all human IF genes and IF-associated proteins(IFAPs),detailing their names,sizes,functions,associated human diseases,relevant literature,and links to resources like UniProt and the Protein Atlas database.These links provide access to additional information such as protein structure,subcellular localization,disease-causing mutations,and pathology.Using this catalog,we will provide an overview of the current understanding of the biological functions of IFs and IFAPs.This overview is crucial for identifying gaps in their characterization and understanding IF-mediated mechanotransduction.Additionally,we will consider potential future research directions.
基金supports from the National Natural Science Foundation of China (Grant Nos.52004143 and 52374095)the open fund for the Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines (Grant No.SKLMRDPC21KF06).
文摘A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states.The experimental results indicate that the dip angle of structural plane(θ)and the intermediate principal stress(σ2)have an important influence on the peak strength,cracking mode,and rockburst severity.The peak strength exhibits a first increase and then decrease as a function ofσ2 for a constantθ.However,whenσ2 is constant,the maximum peak strength is obtained atθof 90°,and the minimum peak strength is obtained atθof 30°or 45°.For the case of an inclined structural plane,the crack type at the tips of structural plane transforms from a mix of wing and anti-wing cracks to wing cracks with an increase inσ2,while the crack type around the tips of structural plane is always anti-wing cracks for the vertical structural plane,accompanied by a series of tensile cracks besides.The specimens with structural plane do not undergo slabbing failure regardless ofθ,and always exhibit composite tensile-shear failure whatever theσ2 value is.With an increase inσ2 andθ,the intensity of the rockburst is consistent with the tendency of the peak strength.By analyzing the relationship between the cohesion(c),internal friction angle(φ),andθin sandstone specimens,we incorporateθinto the true triaxial unloading strength criterion,and propose a modified linear Mogi-Coulomb criterion.Moreover,the crack propagation mechanism at the tips of structural plane,and closure degree of the structural plane under true triaxial unloading conditions are also discussed and summarized.This study provides theoretical guidance for stability assessment of surrounding rocks containing geological structures in deep complex stress environments.
基金support provided by National Natural Science Foundation of China(Nos.52405364 and 52171110)Jiangsu Funding Program for Excellent Postdoctoral Talent+3 种基金JITRI Advanced Materials R&D Co.Ltdsupport by European Union Horizon 2020 Research and Innovation Program(857470)European Regional Development Fund via the Foundation for Polish Science International Research Agenda PLUS program(MAB PLUS/2018/8)The publication was created within the framework of the project of the Minister of Science and Higher Education,Support for the Activities of Centres of Excellence established in Poland under Horizon 2020,under contract No.MEiN/2023/DIR/3795.
文摘The deformation of Cu–20 wt.%Fe alloy wires leads to a significant improvement in mechanical properties and a decrease in electrical conductivity.Simultaneous improvements in strength and conductivity were achieved by intermediate annealing of drawn Cu–20 wt.%Fe wires.As the annealing temperature increased,the strength of Cu–20 wt.%Fe alloy wire decreased monotonically,but the electrical conductivity first increased and then decreased,reaching its peak value after annealing at 500℃.The decrease in strength is related to dislocation recovery and static recrystallization of Cu and Fe phases,and the increase in electrical conductivity mainly results from the aging precipitation of solid solution Fe.After annealing at 500℃,there was no obvious recrystallization of Cu phase,and many of the nano-Fe particles precipitated from Cu matrix.An annealing temperature of 600℃ induced the recrystallization of Cu matrix and an increase in Fe solid solubility,resulting in a decrease in strength and electrical conductivity.Subsequently,the wires annealed at 500℃ were drawn to 2 mm.Compared with those of the continuously drawn Cu–20 wt.%Fe alloy wires,the deformation ability,strength,and electrical conductivity of Cu–20 wt.%Fe alloy wires subjected to intermediate annealing treatment are significantly greater.This is mainly related to the sufficient precipitation of Fe in Cu matrix and the strengthening of refined Fe fibers parallel to the drawing direction.
基金supported by the Science and Technology Commission of Shanghai Municipality(No.2024ZDSYS2),China.
文摘Quasi-solid-state electrolytes,which integrate the safety characteristics of inorganic materials,the flexibility of polymers,and the high ionic conductivity of liquid electrolytes,represent a transitional solution for high-energy-density lithium batteries.However,the mechanisms by which inorganic fillers enhance multiphase interfacial conduction remain inadequately understood.In this work,we synthesized composite quasi-solid-state electrolytes with high inorganic content to investigate interfacial phenomena and achieve enhanced electrode interface stability.Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)particles,through surface anion anchoring,improve Li^(+)transference numbers and facilitate partial dissociation of solvated Li^(+)structures,resulting in superior ion transport kinetics that achieve an ionic conductivity of 0.51 mS cm^(−1)at room temperature.The high mass fraction of inorganic components additionally promotes the formation of more stable interfacial layers,enabling lithium-symmetric cells to operate without short-circuiting for 6000 h at 0.1 mA cm^(−2).Furthermore,this system demonstrates exceptional stability in 5 V-class lithium metal full cells,maintaining 80.5%capacity retention over 200 cycles at 0.5C.These findings guide the role of inorganic interfaces in composite electrolytes and demonstrate their potential for advancing high-voltage lithium battery technology.
基金supported by the National Natural Science Foundation of China(Nos.52301279 and 51901115)the Shandong Provincial Natural Science Foundation,China(ZR2023MB122 and ZR2019PEM001)+1 种基金the Outstanding Youth Innovation Team of Universities in Shandong Province(2024KJH067)the Innovation fund project for graduate student of China University of Petroleum(East China)supported by the Fundamental Research Funds for the Central Universities(No.23CX04010A)。
文摘Addressing inadequate OH^(*)adsorption in Ru Co alloy catalysts is crucial for boosting intermediate coverage and redirecting the water-splitting pathway.Herein,the adaptive P sites were strategically incorporated to overcome the aforementioned challenge.The P sites,as potent OH^(*)adsorption centers,synergize with Co sites to promote water dissociation and enrich surrounding Ru sites with H*intermediates,thus triggering the Volmer-Tafel route for hydrogen evolution reaction(HER).Besides,during the oxygen evolution reaction(OER),the surface of P-Ru Co was reconstructed into Ru-doped Co OOH with anchored PO_(4)^(3-).These PO_(4)^(3-)not only circumvent the intrinsic OH^(*)adsorption limitations of Ru-Co OOH in the adsorbate evolution mechanism(AEM)by rerouting to a more expeditious lattice oxygen oxidation mechanism(LOM)but also improve the coverage of key oxygen-containing intermediates,significantly accelerating OER kinetics.Consequently,the P-Ru Co demonstrates exceptional bifunctional performance,with overpotentials of 29 m V for HER and 222 m V for OER at 10 m A cm^(-2).Remarkably,the mass activities of PRu Co for HER(5.48 A mg^(-1))and OER(2.13 A mg^(-1))are 6.2 and 11.2 times higher than those of its commercial counterparts(Ru/C for HER and RuO_(2)for OER),respectively.When integrated into an anionexchange-membrane electrolyzer,this catalyst achieves ampere-level current densities of 1.32 A cm^(-2)for water electrolysis and 1.23 A cm^(-2)for seawater electrolysis at 2.1 V,with a 500-h durability.
基金funding support from the National Nature Science Foundation of China(Grant No.42272334)the National Key Research and Development Program of China(Grant No.2022YFE0137200)the Taishan Scholars Program(Grant No.2019RKB01083).
文摘Fracture(fault)reactivation can lead to dynamic geological hazards including earthquakes,rock collapses,landslides,and rock bursts.True triaxial compression tests were conducted to analyze the fracture reactivation process under two different orientations of σ_(2),i.e.σ_(2) parallel to the fracture plane(Scheme 2)and σ_(2) cutting through the fracture plane(Scheme 3),under varying σ_(3) from 10 MPa to 40 MPa.The peak or fracture reactivation strength,deformation,failure mode,and post-peak mechanical behavior of intact(Scheme 1)and pre-fractured(Schemes 2 and 3)specimens were also compared.Results show that for intact specimens,the stress remains nearly constant in the residual sliding stage with no stick-slip,and the newly formed fracture surface only propagates along the σ_(2) direction when σ_(3) ranges from 10 MPa to 30 MPa,while it extends along both σ_(2) and σ_(3) directions when σ_(3) increases to 40 MPa;for the pre-fractured specimens,the fractures are usually reactivated under all the σ_(3) levels in Scheme 2,but fracture reactivation only occurs when σ_(3) is greater than 25 MPa in Scheme 3,below which new faulting traversing the original macro fracture occurs.In all the test schemes,both ε_(2) and ε_(3) experience an accumulative process of elongation,after which an abrupt change occurs at the point of the final failure;the degree of this change is dependent on the orientation of the new faulting or the slip direction of the original fracture,and it is generally more than 10 times larger in the slip direction of the original fracture than in the non-slip direction.Besides,the differential stress(peak stress)required for reactivation and the post-peak stress drop increase with increasing σ_(3).Post-peak stress drop and residual strength in Scheme 3 are generally greater than those in Scheme 2 at the same σ_(3) value.Our study clearly shows that intermediate principal stress orientation not only affects the fracture reactivation strength but also influences the slip deformation and failure modes.These new findings facilitate the mitigation of dynamic geological hazards associated with fracture and fault slip.
文摘Background:Intermediate-risk prostate cancer(IR-PC)represents a heterogeneous group requiring nuanced treatment approaches,and recent advancements in radiotherapy(RT),androgen deprivation therapy(ADT),and prostatespecific membrane antigen positron emission tomography(PSMA-PET/CT)imaging have prompted growing interest in personalized,risk-adapted management strategies.This study by the Turkish Society for Radiation Oncology aims to examine radiation oncologists’practices in managing IR-PC,focusing on RT and imaging modalities to identify trends for personalized treatments.Methods:A cross-sectional survey was conducted among Turkish radiation oncologists treating at least 50 prostate cancer(PC)cases annually.The 22-item questionnaire covered IR-PC management aspects such as risk stratification,imaging preferences,androgen deprivation therapy(ADT)use and duration,RT techniques,and treatment combinations.Anonymous responses were analyzed using descriptive statistics.Results:Thirty radiation oncologists participated,57%with over 20 years of experience.The median annual number of PC cases treated was 130.For risk stratification,43% followed the National Comprehensive Cancer Network(NCCN)guidelines,while 30%used the D’Amico classification.Imaging preferences revealed 47% favored PSMA-PET/CT.External beam RT was universally preferred,with 60% adopting ultra-hypofractionation.ADT was used by 97%,with 73% recommending it for unfavorable IR-PC cases.Short-term ADT(4–6 months)was the standard,administered concurrently with RT by 57%.Cardiovascular status influenced decisions for 97% of respondents,while 37% also considered patient age,preferences,and sexual health.Conclusions:This national survey demonstrates a shift toward personalized care in intermediate-risk prostate cancer in Turkey,marked by selective PSMA-PET/CT use,tailored ADT,and evolving radiotherapy practices.The findings underscore the importance of multidisciplinary collaboration—particularly between urologists and radiation oncologists—to optimize imaging integration and treatment outcomes.
基金the French Defense Innovation Agency (AID)the French Procurement Agency for Armament (DGA)ONERA's scientific direction for funding and supporting the present work
文摘The aim of this paper is to simulate and study the early moments of the reactive ballistics of a large caliber projectile fired from a gun,combining 0D and 2D axisymmetric Computational Fluid Dynamics(CFD)approaches.First,the methodology is introduced with the development of an interior ballistics(IB)lumped parameter code(LPC),integrating an original image processing method for calculating the specific regression of propellant grains that compose the gun propellant.The ONERA CFD code CEDRE,equipped with a Dynamic Mesh Technique(DMT),is then used in conjunction with the developed LPC to build a dedicated methodology to calculate IB.First results obtained on the AGARD gun and 40 mm gun test cases are in a good agreement with the existing literature.CEDRE is also used to calculate inter-mediate ballistics(first milliseconds of free flight of the projectile)with a multispecies and reactive approach either starting from the gun muzzle plane or directly following IB.In the latter case,an inverse problem involving a Latin hypercube sampling method is used to find a gun propellant configuration that allows the projectile to reach a given exit velocity and base pressure when IB ends.The methodology developed in this work makes it possible to study the flame front of the intermediate flash and depressurization that occurs in a base bleed(BB)channel at the gun muzzle.Average pressure variations in the BB channel during depressurization are in good agreement with literature.
基金supported by the National Natural Science Foundation of China(Nos.12325201,12272140,and 12322201)。
文摘This study investigates the dynamical behavior of two parallel fluid-conveying pipes by developing a non-planar dynamical model of the two pipes coupled with an intermediate spring. A systematic analysis is conducted to evaluate the effects of spring parameters on the non-planar vibration characteristics and buckling behaviors of the coupled system. The nonlinear governing equations are derived with Hamilton's principle,subsequently discretized through Galerkin's method, and finally numerically solved by the Runge-Kutta algorithm. Based on the linearized equations, an eigenvalue analysis is performed to obtain the coupled frequencies, modal shapes, and critical flow velocities for buckling instability. Quantitative assessments further elucidate the effects of the spring position and stiffness coefficient on the coupled frequencies and critical flow velocities.Nonlinear dynamic analyses reveal the evolution of buckling patterns and bifurcation behaviors between the lateral displacements of the two pipes and the flow velocity. Numerical results indicate that the intermediate spring increases the susceptibility to buckling instability in the out-of-plane direction compared with the in-plane direction. Furthermore, synchronized lateral displacements emerge in both pipes when the flow velocity of one pipe exceeds the critical threshold. This work is expected to provide a theoretical foundation for the stability assessment and vibration analysis in coupled fluid-conveying pipe systems.
基金supported by the National Natural Science Foundation of China (22171030 and 21771028)the Large-Scale Instrument and Equipment Open Foundation in Chongqing University (202303150030)。
文摘Sodium-sulfur and sodium-iodine batteries are attractive due to their low cost and high capacities.However,they suffer from polysulfide/polyiodide dissolution and fast capacity decay.To solve these issues,herein,an organic species-intercalated layered MoS_(2) with oxygen-dopant(Org-MoS_(2)) was designed for the iodine encapsulation.The chemically-bonded S^(2-) from the S-Mo-S layer can not only stabilize the in situ generated I^(+) intermediate to boost the redox kinetics and deep transformations of 2I^(-)←→I_(2)←→2I^(+),but also undergo the conversion of S^(2-)←→S^(δ-) in the high voltage range of 1.5-3.4 V without structural collapse and shuttle effect.That is owning to the I^(+)-induced local charge and the electron reservoir of multi-valent Mo,which facilitate effective charge transfer via alternate dipoles of I^(δ+)-^(δ-)S^(δ+)/^(δ-)O^(δ+)-^(δ-)Mo^(δ+)-^(δ-)S^(δ+) and promote the redox of I/S/Mo.Meanwhile,the incorporated organic species are transformed into an aromatic carbonaceous material with improved electron conductivity and thinner thickness in the cycling test accompanied by the exposure of more Mo-O-Mo linkages,resulting in an increasing ultrahigh capacity and outstanding long-term durability of Org-MoS_(2)@I_(2).
文摘This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP)materials.The strain potential and kinetic energies of each beam along with the work done by the external force are calculated.Additionally,a higher-order beam element is introduced to derive stiffness and mass matrices,along with the force vector.The curved and straight beams are discretized,and their assembled stiffness,mass matrices,and force vectors,are obtained.Continuity conditions at the joints are used to derive the total matrices of the entire structure.Subsequently,the natural frequencies and transient response of the system are determined.The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS,demonstrating excellent agreement.Furthermore,a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.
文摘Room and pillar mining is an underground mining method that utilizes natural pillar support to control rock mass behavior,ensuring mine stability and a safe mine environment.This study specifically documents the influence of the intermediate principal stress component on the pillar behavior.So far only classical failure criteria ignoring the influence of the intermediate principal stress component were used for underground pillar design.By using an extended Hoek-Brown failure criterion in comparison with the classical Hoek-Brown failure criterion,the influence of the intermediate principal stress component is documented by indicating those areas where the failure criterion is violated.This study demonstrates,that depending on the rock type,the intermediate principal stress component can have a significant effect.Ignoring this influence can lead to uneconomic pillar design and incorrect determination of the factor of safety.
基金supported by the Fundamental Research Funds for the Central Universities(22120230104).
文摘By manipulating the distribution of surface electrons,defect engineering enables effective control over the adsorption energy between adsorbates and active sites in the CO_(2)reduction reaction(CO_(2)RR).Herein,we report a hollow indium oxide nanotube containing both oxygen vacancy and sulfur doping(V_o-Sx-In_(2)O_(3))for improved CO_(2)-to-HCOOH electroreduction and Zn-CO_(2)battery.The componential synergy significantly reduces the*OCHO formation barrier to expedite protonation process and creates a favorable electronic micro-environment for*HCOOH desorption.As a result,the CO_(2)RR performance of Vo-Sx-In_(2)O_(3)outperforms Pure-In_(2)O_(3)and V_o-In_(2)O_(3),where V_o-S53-In_(2)O_(3)exhibits a maximal HCOOH Faradaic efficiency of 92.4%at-1,2 V vs.reversible hydrogen electrode(RHE)in H-cell and above 92%over a wide window potential with high current density(119.1 mA cm^(-2)at-1.1 V vs.RHE)in flow cell.Furthermore,the rechargeable Zn-CO_(2)battery utilizing V_o-S53-In_(2)O_(3)as cathode shows a high power density of 2.29 mW cm^(-2)and a long-term stability during charge-discharge cycles.This work provides a valuable perspective to elucidate co-defective catalysts in regulating the intermediates for efficient CO_(2)RR.
基金supported by the National Natural Science Foundation of China(Nos.22073059 and 22203052)the Natural Science Foundation of Shaanxi Province(No.2022JM-060)+1 种基金the Education Department of Shaanxi Provincial Government(No.23JC023)the Key Cultivation Project of Shaanxi University of Technology(No.SLG2101)。
文摘The formation of oligomeric hydrogen peroxide triggered by Criegee intermediate maybe contributes significantly to the formation and growth of secondary organic aerosol(SOA).However,to date,the reactivity of C2 Criegee intermediates(CH_(3)CHOO)in areas contaminated with acidic gas remains poorly understood.Herein,high-level quantum chemical calculations and Born-Oppenheimer molecular dynamics(BOMD)simulations are used to explore the reaction of CH_(3)CHOO and H_(2)SO_(4)both in the gas phase and at the airwater interface.In the gas phase,the addition reaction of CH_(3)CHOO with H_(2)SO_(4)to generate CH_(3)HC(OOH)OSO_(3)H(HPES)is near-barrierless,regardless of the presence of water molecules.BOMD simulations showthat the reaction at the air-water interface is even faster than that in the gas phase.Further calculations reveal that the HPES has a tendency to aggregate with sulfuric acids,ammonias,and water molecules to form stable clusters,meanwhile the oligomerization reaction of CH_(3)CHOO with HPES in the gas phase is both thermochemically and kinetically favored.Also,it is noted that the interfacial HPES−ion can attract H_(2)SO_(4),NH_(3),(COOH)_(2)and HNO_(3)for particle formation from the gas phase to the water surface.Thus,the results of this work not only elucidate the high atmospheric reactivity of C2 Criegee intermediates in polluted regions,but also deepen our understanding of the formation process of atmospheric SOA induced by Criegee intermediates.
文摘Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic liver.The therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at diagnosis.Notwithstanding the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical challenge.Emergent systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of HCC.This review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative intent.We also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative intent.Finally,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.
基金financially supported by the National Natural Science Foundation of China(No.U1632151)the Natural Science Foundation of Anhui Province,China(Nos.2108085ME149 and 2308085QE137)+2 种基金the State Key Laboratory of Pulsed Power Laser Technology,China(No.SKL2021ZR03)Anhui innovation and entrepreneurship support plan for Returned Overseas Students(No.2022LCX018)the Key Research and Development Plan of Anhui Province(No.212023t07020005)。
文摘CsPbBr_(3)inorganic perovskites have been regarded as the promising materials in the field of photo-voltaics because of the high tolerance against environment.The high energy barrier of phase transition from lead bromide(PbBr_(2))to CsPbBr_(3)perovskite and low solubility of perovskite in organic solvent impede the further improvement of device performance in terms of CsPbBr_(3)solar cells.Herein,an intermediate phase-assisted growth of CsPbBr_(3)perovskite was proposed by introducing tetraphenylphosphonium bromide(TPPB)as additive.The TPPB is expected to react with PbBr_(2)in organic solvent to form an intermediate phase of[TPPB.DMF]-PbBr_(2),which not only effectively improves the crystallinity of PbBr2 crystals,but also greatly reduces the phase transition energy barrier,leading to uniform and compact CsPbBr_(3)perovskite films with large grain size and high crystallinity.In combination with carbon electrode,the CsPbBr_(3)solar cells yield a champion device performance of 9.57%in comparison of pristine CsPbBr_(3)solar cells showing a low efficiency of 8.17%.Furthermore,the intermediate phaseassisted growth of CsPbBr_(3)-based solar cells displays an outstanding storage over720 h.
基金financially supported by the National Natural Science Foundation of China(22309032)the Guangdong Basic and Applied Basic Research Foundation(2022A1515011737)+1 种基金the Science and Technology Program of Guangzhou(2023A04J1395)the GDAS’Project of Science and Technology Development(2021GDASYL-20210102010)。
文摘Photocatalytic reduction of CO_(2) into fuel represents a promising approach for achieving carbon neutrality,while realizing high selectivity in this process is challenging due to uncontrollable reaction intermediate and retarded desorption of target products.Engineering the interface microenvironment of catalysts has been proposed as a strategy to exert a significant influence on reaction outcomes,yet it remains a significant challenge.In this study,amino alkylation was successfully integrated into the melem unit of polymeric carbon nitrides(PCN),which could efficiently drive the photocatalytic CO_(2) reduction.Experimental characterization and theoretical calculations revealed that the introduction of amino alkylation lowers the energy barrier for CO_(2) reduction into^(*)COOH intermediate,transforming the adsorption of^(*)COOH intermediate from the endothermic to an exothermic process.Notably,the as-prepared materials demonstrated outstanding performance in photocatalytic CO_(2) reduction,yielding CO_(2)at a rate of 152.8μmol h^(-1) with a high selectivity of 95.4%and a quantum efficiency of 6.6%.
文摘Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) represents a significant advancement in the imaging of prostate cancer (PCa), yet its application in low- and intermediate-risk cases continues to be a topic of active discussion. This article delves into the nuanced role of PSMA PET/CT, critically analyzing its strengths and limitations in these specific risk categories. For patients with low-risk PCa, PSMA PET/CT demonstrates limited effectiveness in routine staging due to its minimal tracer uptake in low-grade tumors. However, its ability to differentiate between low- and high-grade tumors suggests a promising role in active surveillance, offering a potential noninvasive method for monitoring disease progression and aiding in treatment decision-making. In the intermediate-risk PCa setting, the high specificity of PSMA PET/CT in nodal staging makes it a valuable asset for precise surgical and radiation therapy planning. The article underscores the necessity for further research to fully realize the potential of PSMA PET/CT in PCa management, particularly in developing more personalized treatment approaches in these clinical scenarios.
基金funded by the National Nature Science Foundation of China(Grant Nos.52175509 and 52130504)National Key Research and Development Program of China(2017YFF0204705)2021 Postdoctoral Innovation Research Plan of Hubei Province(0106100226)。
文摘Multi-level programmable photonic integrated circuits(PICs)and optical metasurfaces have gained widespread attention in many fields,such as neuromorphic photonics,opticalcommunications,and quantum information.In this paper,we propose pixelated programmable Si_(3)N_(4)PICs with record-high 20-level intermediate states at 785 nm wavelength.Such flexibility in phase or amplitude modulation is achieved by a programmable Sb_(2)S_(3)matrix,the footprint of whose elements can be as small as 1.2μm,limited only by the optical diffraction limit of anin-house developed pulsed laser writing system.We believe our work lays the foundation for laser-writing ultra-high-level(20 levels and even more)programmable photonic systems and metasurfaces based on phase change materials,which could catalyze diverse applications such as programmable neuromorphic photonics,biosensing,optical computing,photonic quantum computing,and reconfigurable metasurfaces.
基金This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB34030000)the National Key Research and Development Program of China(No.2022YFA1602404)+1 种基金the National Natural Science Foundation(No.U1832129)the Youth Innovation Promotion Association CAS(No.2017309).
文摘Traditional particle identification methods face timeconsuming,experience-dependent,and poor repeatability challenges in heavy-ion collisions at low and intermediate energies.Researchers urgently need solutions to the dilemma of traditional particle identification methods.This study explores the possibility of applying intelligent learning algorithms to the particle identification of heavy-ion collisions at low and intermediate energies.Multiple intelligent algorithms,including XgBoost and TabNet,were selected to test datasets from the neutron ion multi-detector for reaction-oriented dynamics(NIMROD-ISiS)and Geant4 simulation.Tree-based machine learning algorithms and deep learning algorithms e.g.TabNet show excellent performance and generalization ability.Adding additional data features besides energy deposition can improve the algorithm’s performance when the data distribution is nonuniform.Intelligent learning algorithms can be applied to solve the particle identification problem in heavy-ion collisions at low and intermediate energies.
