Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnec...Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnectivity of porous Mg is limited due to the diverse architectures of pore struts and pore size distribution of Mg scaffold systems.In this work,biomimetic hierarchical porous Mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration casting.Mg scaffold with better interconnectivity showed lower mechanical strength.Enlarging interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface area.Nevertheless,the degradation rates of five tested Mg scaffolds were no different because of the same geometry of strut unit.Direct cell culture and evaluation of cell density at both sides of four typical Mg scaffolds indicated that cell migration through hierarchical porous Mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore size.In summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.展开更多
Open data strategies are being adopted in disaster-related data particularly because of the need to provide information on global targets and indicators for implementation of the Sendai Framework for Disaster Risk Red...Open data strategies are being adopted in disaster-related data particularly because of the need to provide information on global targets and indicators for implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030.In all phases of disaster risk management including forecasting,emergency response and post-disaster reconstruction,the need for interconnected multidisciplinary open data for collaborative reporting as well as study and analysis are apparent,in order to determine disaster impact data in timely and reportable manner.The extraordinary progress in computing and information technology in the past decade,such as broad local and wide-area network connectivity(e.g.Internet),highperformance computing,service and cloud computing,big data methods and mobile devices,provides the technical foundation for connecting open data to support disaster risk research.A new generation of disaster data infrastructure based on interconnected open data is evolving rapidly.There are two levels in the conceptual model of Linked Open Data for Global Disaster Risk Research(LODGD)Working Group of the Committee on Data for Science and Technology(CODATA),which is the Committee on Data of the International Council for Science(ICSU):data characterization and data connection.In data characterization,the knowledge about disaster taxonomy and data dependency on disaster events requires specific scientific study as it aims to understand and present the correlation between specific disaster events and scientific data through the integration of literature analysis and semantic knowledge discovery.Data connection concepts deal with technical methods to connect distributed data resources identified by data characterization of disaster type.In the science community,interconnected open data for disaster risk impact assessment are beginning to influence how disaster data are shared,and this will need to extend data coverage and provide better ways of utilizing data across domains where innovation and integration are now necessarily needed.展开更多
Porous hydroxyapatite （HA）-tricalcium phosphate （TCP） ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates （DCPD） were added at various ra...Porous hydroxyapatite （HA）-tricalcium phosphate （TCP） ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates （DCPD） were added at various ratios to obtain different HA/TCP ratios in sintered ceramic scaffolds. To further enhance the pore interconnectivity and porosity, the developed porous ceramic scaffolds were etched with acid solutions. The maximum porosity （- 85%） was observed in the Ca-P scaffold with the lowest HA （-7%） content. On the other hand, the maximum compressive strength was noted in the scaffolds with the highest HA content （ - 85%）. X-ray diffraction showed that the extent of the fl-TCP to a-TCP phase transformation increased with decreasing HA/DCPD ratio. All HCl-etched scaffolds were observed to generate micropores, which improved the interconnectivity, while biomineralization was found to be the same for both the HCl-etched and non- etched scaffolds. In particular, hydrochloric acid etching is a promising method for improving the interconnectivity and porosity of the ceramic scaffolds.展开更多
The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they ...The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they exhibit dense interconnectivity(Braitenburg and Schüz,1998;Campagnola et al.,2022).The strength and probability of connectivity depend on cell type,inter-neuronal distance,and species.Still,every cortical neuron receives input from thousands of other neurons while transmitting output to a similar number of neurons.Second,communication between neurons occurs primarily via chemical or electrical synapses.展开更多
Porous architecture in bone substitutes,notably the interconnectivity of pores,is a critical factor for bone ingrowth.However,controlling the pore interconnectivity while maintaining the microarchitecture has not yet ...Porous architecture in bone substitutes,notably the interconnectivity of pores,is a critical factor for bone ingrowth.However,controlling the pore interconnectivity while maintaining the microarchitecture has not yet been achieved using conventional methods,such as sintering.Herein,we fabricated a porous block using the crystal growth of calcium sulfate dihydrate,and controlled the pore interconnectivity by limiting the region of crystal growth.The calcium sulfate dihydrate blocks were transformed to bone apatite,carbonate apatite(CO_(3)Ap)through dissolution–precipitation reactions.Thus,CO_(3)Ap blocks with 15%and 30%interconnected pore volumes were obtained while maintaining the microarchitecture:they were designated as CO_(3)Ap-15 and CO_(3)Ap-30,respectively.At 4 weeks after implantation in a rabbit femur defect,new bone formed throughout CO_(3)Ap-30,whereas little bone was formed in the center region of CO_(3)Ap-15.At 12 weeks after implantation,a large portion of CO_(3)Ap-30 was replaced with new bone and the boundary with the host bone became blurred.In contrast,CO_(3)Ap-15 remained in the defect and the boundary with the host bone was still clear.Thus,the interconnected pores promote bone ingrowth,followed by replacement of the material with new bone.These findings provide a useful guide for designing bone substitutes for rapid bone regeneration.展开更多
Permeable electronics promise improved physiological comfort,but remain constrained by limited functional integration and poor mechanical robustness.Here,we report a three-dimensional(3D)permeable electronic system th...Permeable electronics promise improved physiological comfort,but remain constrained by limited functional integration and poor mechanical robustness.Here,we report a three-dimensional(3D)permeable electronic system that overcomes these challenges by combining electrospun SEBS nanofiber mats,high-resolution liquid metal conductors patterned via thermal imprinting(50μm),and a strain isolators(SIL)that protects vertical interconnects(VIAs)from stress concentration.This architecture achieves ultrahigh air permeability(>5.09 m L cm^(-2)min^(-1)),exceptional stretchability(750%fracture strain),and reliable conductivity maintained through more than 32,500 strain cycles.Leveraging these advances,we have integrated multilayer circuits,strain sensors,and a three-axis accelerometer to achieve a fully integrated,stretchable,permeable wireless real-time gesture recognition glove.The system enables accurate sign language interpretation(98%)and seamless robotic hand control,demonstrating its potential for assistive technologies.By uniting comfort,durability,and high-density integration,this work establishes a versatile platform for nextgeneration wearable electronics and interactive human-robot interfaces.展开更多
The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic...The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic activity across the entire brain and its numerous micro-regions remains incredibly challenging.Here,we offer a high-definition spatially resolved metabolomics technique to better understand the metabolic specialization and interconnection throughout the mouse brain using improved ambient mass spectrometry imaging.This method allows for the simultaneous mapping of thousands of metabolites at a 30 μm spatial resolution across the mouse brain,ranging from structural lipids to functional neurotransmitters.This approach effectively reveals the distribution patterns of delicate microregions and their distinctive metabolic characteristics.Using an integrated database,we annotated 259 metabolites,demonstrating that the metabolome and metabolic pathways are unique to each brain microregion.The distribution of metabolites,closely linked to functionally connected brain regions and their interactions,offers profound insights into the complexity of chemical processes and their roles in brain function.An initial dataset for future metabolomics research might be obtained from the high-definition mouse brain's spatial metabolome atlas.展开更多
A new era that will require more collaboration and shared benefits Business,trade,culture and technology have been globalized over a steady course of change and connection for the past 70 years.
This paper proposes a novel modified uni-traveling-carrier photodiode(MUTC-PD)featuring an electric field regulation layer:a p-type doped thin layer inserted behind the PD’s n-doped cliff layer.This electric field re...This paper proposes a novel modified uni-traveling-carrier photodiode(MUTC-PD)featuring an electric field regulation layer:a p-type doped thin layer inserted behind the PD’s n-doped cliff layer.This electric field regulation layer enhances the PD’s performance by not only reducing and smoothing the electric field intensity in the collector layer,allowing photo-generated electrons to transit at peak drift velocity,but also improving the electric field intensity in the depleted absorber layer and optimizing the photo-generated carriers’saturated transit performance.Additionally,the transport characteristics of the peak drift velocity of photogenerated electrons in the device’s collection layer can be used to optimize its parasitic characteristics.The electron’s peak drift velocity compensates for the lost transit time.Thus improving the 3 dB bandwidth of the PD’s photo response.Finally obtains a MUTC-PD with a 3 dB bandwidth of 68 GHz at a responsivity of 0.502 A/W,making it suitable for 100 Gbit/s optical receivers.展开更多
As global energy demand increases and environmental standards tighten,the development of efficient,eco-friendly energy conversion and storage technologies becomes crucial.Solid oxide cells(SOCs)show great promise beca...As global energy demand increases and environmental standards tighten,the development of efficient,eco-friendly energy conversion and storage technologies becomes crucial.Solid oxide cells(SOCs)show great promise because of their high energy conversion efficiency and wide range of applications.Highentropy materials(HEMs),a novel class of materials comprising several principal elements,have attracted significant interest within the materials science and energy sectors.Their distinctive structural features and adaptable functional properties offer immense potential for innovation across various applications.This review systematically covers the basic concepts,crystal structures,element selection,and major synthesis strategies of HEMs,and explores in detail the specific applications of these materials in SOCs,including its potential as air electrodes,fuel electrodes,electrolytes,and interconnects(including barrier coatings).By analyzing existing studies,this review reveals the significant advantages of HEMs in enhancing the performance,anti-poisoning,and stability of SOCs;highlights the key areas and challenges for future research;and looks into possible future directions.展开更多
Propelled by the rise of artificial intelligence,cloud services,and data center applications,next-generation,low-power,local-oscillator-less,digital signal processing(DSP)-free,and short-reach coherent optical communi...Propelled by the rise of artificial intelligence,cloud services,and data center applications,next-generation,low-power,local-oscillator-less,digital signal processing(DSP)-free,and short-reach coherent optical communication has evolved into an increasingly prominent area of research in recent years.Here,we demonstrate DSP-free coherent optical transmission by analog signal processing in frequency synchronous optical network(FSON)architecture,which supports polarization multiplexing and higher-order modulation formats.The FSON architecture that allows the numerous laser sources of optical transceivers within a data center can be quasi-synchronized by means of a tree-distributed homology architecture.In conjunction with our proposed pilot-tone assisted Costas loop for an analog coherent receiver,we achieve a record dual-polarization 224-Gb/s 16-QAM 5-km mismatch transmission with reset-free carrier phase recovery in the optical domain.Our proposed DSP-free analog coherent detection system based on the FSON makes it a promising solution for next-generation,low-power,and high-capacity coherent data center interconnects.展开更多
Industrial intelligence and secure interconnection serve as the foundational platform and critical information infrastructure for new industrialization,carrying significant strategic importance.They not only function ...Industrial intelligence and secure interconnection serve as the foundational platform and critical information infrastructure for new industrialization,carrying significant strategic importance.They not only function as the core engine driving the transformation and upgrading of the manufacturing sector and ensuring stable socioeconomic operation but are also vital to enhancing national technological competitiveness and safeguarding industrial security.展开更多
A Malawian perspective on China’s influence,innovation and shared growth In today’s interconnected world,diplomacy,trade,and culture are drawing nations once thought distant closer.A case in point is the growing rel...A Malawian perspective on China’s influence,innovation and shared growth In today’s interconnected world,diplomacy,trade,and culture are drawing nations once thought distant closer.A case in point is the growing relationship between Malawi and China-two geographically and historically distinct countries that are finding powerful common ground and shared aspirations.展开更多
With the rapid development of network technologies,a large number of deployed edge devices and information systems generate massive amounts of data which provide good support for the advancement of data-driven intelli...With the rapid development of network technologies,a large number of deployed edge devices and information systems generate massive amounts of data which provide good support for the advancement of data-driven intelligent models.However,these data often contain sensitive information of users.Federated learning(FL),as a privacy preservation machine learning setting,allows users to obtain a well-trained model without sending the privacy-sensitive local data to the central server.Despite the promising prospect of FL,several significant research challenges need to be addressed before widespread deployment,including network resource allocation,model security,model convergence,etc.In this paper,we first provide a brief survey on some of these works that have been done on FL and discuss the motivations of the Communication Networks(CNs)and FL to mutually enable each other.We analyze the support of network technologies for FL,which requires frequent communication and emphasizes security,as well as the studies on the intelligence of many network scenarios and the improvement of network performance and security by the methods based on FL.At last,some challenges and broader perspectives are explored.展开更多
Multiscale shell structure design is a rational and promising way to regulate the performance of hollow spheres in terms of both functionality and structural robustness,but it remains a big challenge to realize micro-...Multiscale shell structure design is a rational and promising way to regulate the performance of hollow spheres in terms of both functionality and structural robustness,but it remains a big challenge to realize micro-nano engineering of the thin shell while maintaining the low density.In this work,the divisional shell design strategy was adopted to obtain the glass-cobalt-cobalt sulfide composite hollow microspheres(CSH),and an unprecedented stepwise high-temperature chemical reaction-induced aggregation and sub-sequent volume expansion strategy was developed to achieve rational regulation of core-shell structured cobalt-cobalt sulfide building units(BU)assembled on hollow glass microspheres.Special attention has been paid to the sulfidation degree-induced volume control with the underlying mechanism of volume expansion during chemical conversion from metallic cobalt to cobalt sulfide.The electromagnetic prop-erty was found to depend largely on the sulfidation degree due to the volume expansion-induced inter-connecting status regulation among the BU.When evaluated as microwave absorbent,an optimized broad bandwidth of 5.12 GHz and a minimum reflection loss(RLmin)of-45.58 dB of our CSH can be achieved at a thin matching thickness of 1.67 mm and a low filling ratio of 20.04 wt%.In addition to functionality,the divisional shell design also brings the CSH high structural strength(92.36%survival rate at a high hydrostatic pressure of 20 MPa)at low density(0.73 g cm^(-3)).展开更多
Salt deposits in China predominantly originate from lake deposits,characterized by thin salt beds interspersed with numerous interlayers,collectively termed bedded salt formations.Historically,the solution mining prac...Salt deposits in China predominantly originate from lake deposits,characterized by thin salt beds interspersed with numerous interlayers,collectively termed bedded salt formations.Historically,the solution mining practices have adopted the layered solution mining approach,inspired by coal mining techniques.However,this approach fails to account for the unique challenges of salt solution mining.Practical implementation is inefficient,costs escalate post-construction,and cavern geometry is constrained by salt beds thickness.Additionally,resource loss in abandoned beds and stability risks in adjacent mining zones remain unresolved.This study investigates mining scheme selection for low-grade salt deposits in Huai'an Salt Basin,introducing a continuous solution mining method that traverses multiple interlayers.Through comprehensive analysis of plastic deformation in caverns and surrounding rock,volume shrinkage rates,and economic costs comparing continuous and layered solution mining approaches,the results demonstrate that:(1)In the layered solution mining with horizontal interconnected wells scheme,plastic deformation zones propagate unevenly,posing interlayer connectivity risks.Concurrently,roof subsidence and floor heave destabilize the structure;(2)the continuous solution mining with horizontal interconnected wells scheme reduces plastic deformation zones to 3.4%of cavern volume,with volumetric shrinkage below 17%,markedly improving stability;(3)Economically,the continuous solution mining scheme generates caverns 2.43 times larger than the layered solution mining,slashing unit volume costs to 41.1%while enhancing resource recovery and long-term viability.The continuous method demonstrates distinct economic advantages and achieves higher resource utilization efficiency in solution mining compared to layered mining.Furthermore,its superior cavern stability presents strong potential for large-scale implementation.展开更多
As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are in...As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are increasingly recognized as core requirements for next-generation intelligent computing center designs^([1, 2]). For short-range optical interconnections of intra-chip and inter-chip—typically covering tens of meters or less—microring resonant modulators (MRM) are emerging as an ideal solution.展开更多
Nano-twinned copper(nt-Cu),with a preferred orientation,is highly promising as interconnect materials in high-density advanced packaging due to its considerable mechanical strength,excellent electrical conductivity,an...Nano-twinned copper(nt-Cu),with a preferred orientation,is highly promising as interconnect materials in high-density advanced packaging due to its considerable mechanical strength,excellent electrical conductivity,and resistance to thermal migration.However,its application is impeded by sulfur-containing byproducts from the electroplating process,exacerbating the formation of Kirkendall voids within solder joints during thermal aging.Herein,through the incorporation of Zinc(Zn)into the nt-Cu layer,we develop a nt-Cu/Zn composite structure.Our findings provide the first definitive confirmation of the mechanism by which sulfur atoms migrate to the Cu_(3)Sn/nt-Cu interface through interstitial diffusion,thereby reducing the activation energy for vacancy formation.We further demonstrate that Zn effectively an-choring sulfur atoms,forming ZnS within the nt-Cu layer during heat treatment,which increases the vacancy formation energy and inhibits the development of Kirkendall voids.Remarkably,no Kirkendall voids are observed in the modified interconnects even after prolonged aging at 150℃ for 1000 h.The nt-Cu/Zn composite metallization layers significantly decrease the growth rate of interfacial intermetallic compounds by 33.6% and enhance the shear strength of solder interconnections to 228.9%.This research underscores the potential of nt-Cu in advanced electronic packaging,offering new pathways for improving the power density and reliability of electronic devices.展开更多
Metal composites produced through the liquid metal dealloying(LMD)process feature an advanced matrix-matrix composite structure,where two metallic materials form a continuous,three-dimensional interconnected network.T...Metal composites produced through the liquid metal dealloying(LMD)process feature an advanced matrix-matrix composite structure,where two metallic materials form a continuous,three-dimensional interconnected network.This study investigates the effects of Ti Cu precursor compositions on dealloying behavior and microstructural evolution in liquid Mg,using Ti_(50)Cu_(50)and Ti_(30)Cu_(70)precursors.The initial microstructure of the precursor significantly influences dealloying kinetics and phase transitions.The single-phase Ti_(50)Cu_(50)precursor exhibits a faster initial dealloying rate due to its homogeneous structure,yet complete dealloying requires 90 min.In contrast,the dualphase Ti_(30)Cu_(70)precursor achieves complete dealloying in 30 min,demonstrating the impact of a higher Cu concentration on accelerating the process kinetics.Additionally,the study explores the coarsening behavior and hardness variations during the LMD process,along with the microstructural characteristics of Mg-Ti composites fabricated from these two precursors.The findings highlight the critical role of precursor composition in tailoring the microstructure and properties of Mg-Ti composites produced through the LMD process,demonstrating its potential for advanced composite material manufacturing.展开更多
Chongqing,the only municipality directly under the central government in China’s central and western regions,is distinguished by its unique identity as both a“mountain city”and a“river city.”Recognized as the bir...Chongqing,the only municipality directly under the central government in China’s central and western regions,is distinguished by its unique identity as both a“mountain city”and a“river city.”Recognized as the birthplace of Bayu culture,an influential ancient culture native to the Chongqing area,the city boasts a recorded history of more than 3,000 years.As a crucial strategic hub in the development of China’s western regions,Chongqing occupies a pivotal position in the interconnected networks fostered by the Belt and Road Initiative and the Yangtze River Economic Belt.Leveraging the golden waterway of the Yangtze River,the China-Europe Railway Express(Chengdu-Chongqing),and the New International Land-Sea Trade Corridor,Chongqing has emerged as a crucial gateway for China’s opening-up.展开更多
基金supported by grants from Shenzhen Key Medical Subject(No.SZXK023)Shenzhen“SanMing”Project of Medicine(No.SZSM201612092)+3 种基金Shenzhen Research and Development Projects(No.JCYJ20170307111755218)Guangdong Basic and Applied Basic Research Foundation(No.2019A1515011290)National Key Research and Development Program of China(No.2016YFC1102103)China Postdoctoral Science Foundation(No.2020M672756)
文摘Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnectivity of porous Mg is limited due to the diverse architectures of pore struts and pore size distribution of Mg scaffold systems.In this work,biomimetic hierarchical porous Mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration casting.Mg scaffold with better interconnectivity showed lower mechanical strength.Enlarging interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface area.Nevertheless,the degradation rates of five tested Mg scaffolds were no different because of the same geometry of strut unit.Direct cell culture and evaluation of cell density at both sides of four typical Mg scaffolds indicated that cell migration through hierarchical porous Mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore size.In summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.
基金This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences[grant number XDA19020201].
文摘Open data strategies are being adopted in disaster-related data particularly because of the need to provide information on global targets and indicators for implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030.In all phases of disaster risk management including forecasting,emergency response and post-disaster reconstruction,the need for interconnected multidisciplinary open data for collaborative reporting as well as study and analysis are apparent,in order to determine disaster impact data in timely and reportable manner.The extraordinary progress in computing and information technology in the past decade,such as broad local and wide-area network connectivity(e.g.Internet),highperformance computing,service and cloud computing,big data methods and mobile devices,provides the technical foundation for connecting open data to support disaster risk research.A new generation of disaster data infrastructure based on interconnected open data is evolving rapidly.There are two levels in the conceptual model of Linked Open Data for Global Disaster Risk Research(LODGD)Working Group of the Committee on Data for Science and Technology(CODATA),which is the Committee on Data of the International Council for Science(ICSU):data characterization and data connection.In data characterization,the knowledge about disaster taxonomy and data dependency on disaster events requires specific scientific study as it aims to understand and present the correlation between specific disaster events and scientific data through the integration of literature analysis and semantic knowledge discovery.Data connection concepts deal with technical methods to connect distributed data resources identified by data characterization of disaster type.In the science community,interconnected open data for disaster risk impact assessment are beginning to influence how disaster data are shared,and this will need to extend data coverage and provide better ways of utilizing data across domains where innovation and integration are now necessarily needed.
基金supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A4A01014136)
文摘Porous hydroxyapatite （HA）-tricalcium phosphate （TCP） ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates （DCPD） were added at various ratios to obtain different HA/TCP ratios in sintered ceramic scaffolds. To further enhance the pore interconnectivity and porosity, the developed porous ceramic scaffolds were etched with acid solutions. The maximum porosity （- 85%） was observed in the Ca-P scaffold with the lowest HA （-7%） content. On the other hand, the maximum compressive strength was noted in the scaffolds with the highest HA content （ - 85%）. X-ray diffraction showed that the extent of the fl-TCP to a-TCP phase transformation increased with decreasing HA/DCPD ratio. All HCl-etched scaffolds were observed to generate micropores, which improved the interconnectivity, while biomineralization was found to be the same for both the HCl-etched and non- etched scaffolds. In particular, hydrochloric acid etching is a promising method for improving the interconnectivity and porosity of the ceramic scaffolds.
基金supported in part by the Rosetrees Trust(#CF-2023-I-2_113)by the Israel Ministry of Innovation,Science,and Technology(#7393)(to ES).
文摘The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they exhibit dense interconnectivity(Braitenburg and Schüz,1998;Campagnola et al.,2022).The strength and probability of connectivity depend on cell type,inter-neuronal distance,and species.Still,every cortical neuron receives input from thousands of other neurons while transmitting output to a similar number of neurons.Second,communication between neurons occurs primarily via chemical or electrical synapses.
文摘Porous architecture in bone substitutes,notably the interconnectivity of pores,is a critical factor for bone ingrowth.However,controlling the pore interconnectivity while maintaining the microarchitecture has not yet been achieved using conventional methods,such as sintering.Herein,we fabricated a porous block using the crystal growth of calcium sulfate dihydrate,and controlled the pore interconnectivity by limiting the region of crystal growth.The calcium sulfate dihydrate blocks were transformed to bone apatite,carbonate apatite(CO_(3)Ap)through dissolution–precipitation reactions.Thus,CO_(3)Ap blocks with 15%and 30%interconnected pore volumes were obtained while maintaining the microarchitecture:they were designated as CO_(3)Ap-15 and CO_(3)Ap-30,respectively.At 4 weeks after implantation in a rabbit femur defect,new bone formed throughout CO_(3)Ap-30,whereas little bone was formed in the center region of CO_(3)Ap-15.At 12 weeks after implantation,a large portion of CO_(3)Ap-30 was replaced with new bone and the boundary with the host bone became blurred.In contrast,CO_(3)Ap-15 remained in the defect and the boundary with the host bone was still clear.Thus,the interconnected pores promote bone ingrowth,followed by replacement of the material with new bone.These findings provide a useful guide for designing bone substitutes for rapid bone regeneration.
基金supported in part by the National Key R&D Program of China under Grant 2024YFB4405300 and 2022YFA1204300the Natural Science Foundation of Hunan Province under Grant 2023JJ20016+2 种基金the National Natural Science Foundation of China under Grants of 52221001 and 62090035the Key Research and Development Plan of Hunan Province under grants of 2022GK3002 and 2023GK2012the Key Program of Science and Technology Department of Hunan Province under grant of 2020XK2001。
文摘Permeable electronics promise improved physiological comfort,but remain constrained by limited functional integration and poor mechanical robustness.Here,we report a three-dimensional(3D)permeable electronic system that overcomes these challenges by combining electrospun SEBS nanofiber mats,high-resolution liquid metal conductors patterned via thermal imprinting(50μm),and a strain isolators(SIL)that protects vertical interconnects(VIAs)from stress concentration.This architecture achieves ultrahigh air permeability(>5.09 m L cm^(-2)min^(-1)),exceptional stretchability(750%fracture strain),and reliable conductivity maintained through more than 32,500 strain cycles.Leveraging these advances,we have integrated multilayer circuits,strain sensors,and a three-axis accelerometer to achieve a fully integrated,stretchable,permeable wireless real-time gesture recognition glove.The system enables accurate sign language interpretation(98%)and seamless robotic hand control,demonstrating its potential for assistive technologies.By uniting comfort,durability,and high-density integration,this work establishes a versatile platform for nextgeneration wearable electronics and interactive human-robot interfaces.
基金financial support from the National Natural Science Foundation of China (Nos.82473887 and 21927808)the Scientific and Technological Innovation Program of Shanghai (No.23DZ2202500)the CAMS Innovation Fund for Medical Sciences (No.2021-1-I2M-026)。
文摘The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic activity across the entire brain and its numerous micro-regions remains incredibly challenging.Here,we offer a high-definition spatially resolved metabolomics technique to better understand the metabolic specialization and interconnection throughout the mouse brain using improved ambient mass spectrometry imaging.This method allows for the simultaneous mapping of thousands of metabolites at a 30 μm spatial resolution across the mouse brain,ranging from structural lipids to functional neurotransmitters.This approach effectively reveals the distribution patterns of delicate microregions and their distinctive metabolic characteristics.Using an integrated database,we annotated 259 metabolites,demonstrating that the metabolome and metabolic pathways are unique to each brain microregion.The distribution of metabolites,closely linked to functionally connected brain regions and their interactions,offers profound insights into the complexity of chemical processes and their roles in brain function.An initial dataset for future metabolomics research might be obtained from the high-definition mouse brain's spatial metabolome atlas.
文摘A new era that will require more collaboration and shared benefits Business,trade,culture and technology have been globalized over a steady course of change and connection for the past 70 years.
文摘This paper proposes a novel modified uni-traveling-carrier photodiode(MUTC-PD)featuring an electric field regulation layer:a p-type doped thin layer inserted behind the PD’s n-doped cliff layer.This electric field regulation layer enhances the PD’s performance by not only reducing and smoothing the electric field intensity in the collector layer,allowing photo-generated electrons to transit at peak drift velocity,but also improving the electric field intensity in the depleted absorber layer and optimizing the photo-generated carriers’saturated transit performance.Additionally,the transport characteristics of the peak drift velocity of photogenerated electrons in the device’s collection layer can be used to optimize its parasitic characteristics.The electron’s peak drift velocity compensates for the lost transit time.Thus improving the 3 dB bandwidth of the PD’s photo response.Finally obtains a MUTC-PD with a 3 dB bandwidth of 68 GHz at a responsivity of 0.502 A/W,making it suitable for 100 Gbit/s optical receivers.
基金supported by the National Key R&D Program of China(2022YFB4004000)National Natural Science Foundation of China(U24A20542,52472210,22279057)+3 种基金Natural Science Foundation of Jiangsu Province(BK20221312)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_1465)Cultivation Program for the Excellent Doctoral Dissertation of Nanjing Tech University(2023-09)the grant of Hydrogen Energy Laboratory(No.FEUZ-2024-0009)。
文摘As global energy demand increases and environmental standards tighten,the development of efficient,eco-friendly energy conversion and storage technologies becomes crucial.Solid oxide cells(SOCs)show great promise because of their high energy conversion efficiency and wide range of applications.Highentropy materials(HEMs),a novel class of materials comprising several principal elements,have attracted significant interest within the materials science and energy sectors.Their distinctive structural features and adaptable functional properties offer immense potential for innovation across various applications.This review systematically covers the basic concepts,crystal structures,element selection,and major synthesis strategies of HEMs,and explores in detail the specific applications of these materials in SOCs,including its potential as air electrodes,fuel electrodes,electrolytes,and interconnects(including barrier coatings).By analyzing existing studies,this review reveals the significant advantages of HEMs in enhancing the performance,anti-poisoning,and stability of SOCs;highlights the key areas and challenges for future research;and looks into possible future directions.
基金supported by the National Natural Science Foundation of China(Grant Nos.62405250 and 62471404)the China Postdoctoral Science Foundation(Grant No.2024M762955)+1 种基金the Key Project of Westlake Institute for Optoelectronics(Grant No.2023GD003)the Optical Com-munication and Sensing Laboratory,School of Engineering,Westlake University.
文摘Propelled by the rise of artificial intelligence,cloud services,and data center applications,next-generation,low-power,local-oscillator-less,digital signal processing(DSP)-free,and short-reach coherent optical communication has evolved into an increasingly prominent area of research in recent years.Here,we demonstrate DSP-free coherent optical transmission by analog signal processing in frequency synchronous optical network(FSON)architecture,which supports polarization multiplexing and higher-order modulation formats.The FSON architecture that allows the numerous laser sources of optical transceivers within a data center can be quasi-synchronized by means of a tree-distributed homology architecture.In conjunction with our proposed pilot-tone assisted Costas loop for an analog coherent receiver,we achieve a record dual-polarization 224-Gb/s 16-QAM 5-km mismatch transmission with reset-free carrier phase recovery in the optical domain.Our proposed DSP-free analog coherent detection system based on the FSON makes it a promising solution for next-generation,low-power,and high-capacity coherent data center interconnects.
文摘Industrial intelligence and secure interconnection serve as the foundational platform and critical information infrastructure for new industrialization,carrying significant strategic importance.They not only function as the core engine driving the transformation and upgrading of the manufacturing sector and ensuring stable socioeconomic operation but are also vital to enhancing national technological competitiveness and safeguarding industrial security.
文摘A Malawian perspective on China’s influence,innovation and shared growth In today’s interconnected world,diplomacy,trade,and culture are drawing nations once thought distant closer.A case in point is the growing relationship between Malawi and China-two geographically and historically distinct countries that are finding powerful common ground and shared aspirations.
基金supported by National Key Research and Development Program of China(No.2023YFB2704200)Beijing Natural Science Foundation(No.4254064).
文摘With the rapid development of network technologies,a large number of deployed edge devices and information systems generate massive amounts of data which provide good support for the advancement of data-driven intelligent models.However,these data often contain sensitive information of users.Federated learning(FL),as a privacy preservation machine learning setting,allows users to obtain a well-trained model without sending the privacy-sensitive local data to the central server.Despite the promising prospect of FL,several significant research challenges need to be addressed before widespread deployment,including network resource allocation,model security,model convergence,etc.In this paper,we first provide a brief survey on some of these works that have been done on FL and discuss the motivations of the Communication Networks(CNs)and FL to mutually enable each other.We analyze the support of network technologies for FL,which requires frequent communication and emphasizes security,as well as the studies on the intelligence of many network scenarios and the improvement of network performance and security by the methods based on FL.At last,some challenges and broader perspectives are explored.
基金supported by the National Natural Science Foundation of China(project No 51872298)the fund of the State Key Laboratory of Technologies in Space Cryogenic Pro-pellants(project No SKLTSCP202202)the Strategic Priority Research Program of the Chinese Academy of Science(project No XDA22010202).
文摘Multiscale shell structure design is a rational and promising way to regulate the performance of hollow spheres in terms of both functionality and structural robustness,but it remains a big challenge to realize micro-nano engineering of the thin shell while maintaining the low density.In this work,the divisional shell design strategy was adopted to obtain the glass-cobalt-cobalt sulfide composite hollow microspheres(CSH),and an unprecedented stepwise high-temperature chemical reaction-induced aggregation and sub-sequent volume expansion strategy was developed to achieve rational regulation of core-shell structured cobalt-cobalt sulfide building units(BU)assembled on hollow glass microspheres.Special attention has been paid to the sulfidation degree-induced volume control with the underlying mechanism of volume expansion during chemical conversion from metallic cobalt to cobalt sulfide.The electromagnetic prop-erty was found to depend largely on the sulfidation degree due to the volume expansion-induced inter-connecting status regulation among the BU.When evaluated as microwave absorbent,an optimized broad bandwidth of 5.12 GHz and a minimum reflection loss(RLmin)of-45.58 dB of our CSH can be achieved at a thin matching thickness of 1.67 mm and a low filling ratio of 20.04 wt%.In addition to functionality,the divisional shell design also brings the CSH high structural strength(92.36%survival rate at a high hydrostatic pressure of 20 MPa)at low density(0.73 g cm^(-3)).
基金supported by the National Natural Science Foundation of China(Nos.42177124 and 41877277)Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences(No.SKLGME022011)+2 种基金Fundamental Research Funds for the Central Universities(No.2024KYJD1011)Frontier Technologies R&D Program of Jiangsu(No.BF2024056)the Graduate Innovation Program of China University of Mining and Technology(No.KYCX25_3085)。
文摘Salt deposits in China predominantly originate from lake deposits,characterized by thin salt beds interspersed with numerous interlayers,collectively termed bedded salt formations.Historically,the solution mining practices have adopted the layered solution mining approach,inspired by coal mining techniques.However,this approach fails to account for the unique challenges of salt solution mining.Practical implementation is inefficient,costs escalate post-construction,and cavern geometry is constrained by salt beds thickness.Additionally,resource loss in abandoned beds and stability risks in adjacent mining zones remain unresolved.This study investigates mining scheme selection for low-grade salt deposits in Huai'an Salt Basin,introducing a continuous solution mining method that traverses multiple interlayers.Through comprehensive analysis of plastic deformation in caverns and surrounding rock,volume shrinkage rates,and economic costs comparing continuous and layered solution mining approaches,the results demonstrate that:(1)In the layered solution mining with horizontal interconnected wells scheme,plastic deformation zones propagate unevenly,posing interlayer connectivity risks.Concurrently,roof subsidence and floor heave destabilize the structure;(2)the continuous solution mining with horizontal interconnected wells scheme reduces plastic deformation zones to 3.4%of cavern volume,with volumetric shrinkage below 17%,markedly improving stability;(3)Economically,the continuous solution mining scheme generates caverns 2.43 times larger than the layered solution mining,slashing unit volume costs to 41.1%while enhancing resource recovery and long-term viability.The continuous method demonstrates distinct economic advantages and achieves higher resource utilization efficiency in solution mining compared to layered mining.Furthermore,its superior cavern stability presents strong potential for large-scale implementation.
基金supported by the National Natural Science Foundation of China (Grant Nos. 61925505 and 62405070)"Pioneer" and "Leading Goose" R&D Program of Zhejiang Province (Grant No. 2024C01112)National Key Research and Development Program of China (Grant No. 2023YFB2807100)。
文摘As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are increasingly recognized as core requirements for next-generation intelligent computing center designs^([1, 2]). For short-range optical interconnections of intra-chip and inter-chip—typically covering tens of meters or less—microring resonant modulators (MRM) are emerging as an ideal solution.
基金financially supported by National Natural Science Foundation of China(No.U2241223)Pre-Research Foundation of China(No.909010203-202).
文摘Nano-twinned copper(nt-Cu),with a preferred orientation,is highly promising as interconnect materials in high-density advanced packaging due to its considerable mechanical strength,excellent electrical conductivity,and resistance to thermal migration.However,its application is impeded by sulfur-containing byproducts from the electroplating process,exacerbating the formation of Kirkendall voids within solder joints during thermal aging.Herein,through the incorporation of Zinc(Zn)into the nt-Cu layer,we develop a nt-Cu/Zn composite structure.Our findings provide the first definitive confirmation of the mechanism by which sulfur atoms migrate to the Cu_(3)Sn/nt-Cu interface through interstitial diffusion,thereby reducing the activation energy for vacancy formation.We further demonstrate that Zn effectively an-choring sulfur atoms,forming ZnS within the nt-Cu layer during heat treatment,which increases the vacancy formation energy and inhibits the development of Kirkendall voids.Remarkably,no Kirkendall voids are observed in the modified interconnects even after prolonged aging at 150℃ for 1000 h.The nt-Cu/Zn composite metallization layers significantly decrease the growth rate of interfacial intermetallic compounds by 33.6% and enhance the shear strength of solder interconnections to 228.9%.This research underscores the potential of nt-Cu in advanced electronic packaging,offering new pathways for improving the power density and reliability of electronic devices.
基金supported by the National Research Foundation of Korea(NRF)grants funded by the Korea government(MSIT)(Nos.RS-2024–00351052 and RS-2024–00450561)。
文摘Metal composites produced through the liquid metal dealloying(LMD)process feature an advanced matrix-matrix composite structure,where two metallic materials form a continuous,three-dimensional interconnected network.This study investigates the effects of Ti Cu precursor compositions on dealloying behavior and microstructural evolution in liquid Mg,using Ti_(50)Cu_(50)and Ti_(30)Cu_(70)precursors.The initial microstructure of the precursor significantly influences dealloying kinetics and phase transitions.The single-phase Ti_(50)Cu_(50)precursor exhibits a faster initial dealloying rate due to its homogeneous structure,yet complete dealloying requires 90 min.In contrast,the dualphase Ti_(30)Cu_(70)precursor achieves complete dealloying in 30 min,demonstrating the impact of a higher Cu concentration on accelerating the process kinetics.Additionally,the study explores the coarsening behavior and hardness variations during the LMD process,along with the microstructural characteristics of Mg-Ti composites fabricated from these two precursors.The findings highlight the critical role of precursor composition in tailoring the microstructure and properties of Mg-Ti composites produced through the LMD process,demonstrating its potential for advanced composite material manufacturing.
文摘Chongqing,the only municipality directly under the central government in China’s central and western regions,is distinguished by its unique identity as both a“mountain city”and a“river city.”Recognized as the birthplace of Bayu culture,an influential ancient culture native to the Chongqing area,the city boasts a recorded history of more than 3,000 years.As a crucial strategic hub in the development of China’s western regions,Chongqing occupies a pivotal position in the interconnected networks fostered by the Belt and Road Initiative and the Yangtze River Economic Belt.Leveraging the golden waterway of the Yangtze River,the China-Europe Railway Express(Chengdu-Chongqing),and the New International Land-Sea Trade Corridor,Chongqing has emerged as a crucial gateway for China’s opening-up.
