Objective:We assessed the value of measuring the expression of CD80 and its correlations of TNF-α、and IL-4 in preeclampsia.Methods 30 patients with mild preeclampsia,27 patients with severe preeclampsia and 30 case ...Objective:We assessed the value of measuring the expression of CD80 and its correlations of TNF-α、and IL-4 in preeclampsia.Methods 30 patients with mild preeclampsia,27 patients with severe preeclampsia and 30 case of normal pregnancy were recruited.mRNA and protein expression levels of CD80,TNF-αand IL-4 were detected by qRT-PCR and ELISA.Result(1)The protein of CD80and TNF-αincreased significantly(P<0.05),while the expression level of IL-4 decreased significantly in mild and severe preeclampsia(P<0.05).(2).The mRNA of CD80and TNF-αincreased significantly in peripheral blood mononuclear cell of mild and severe preeclampsia,while the expression level of IL-4 decreased significantly.(3)There was a correlation between CD80 and TNF-αand IL-4(P<0.05).CD80 were positively correlated wi th TNF-a,but negatively with IL-4 levels.Conclusion This suggests that CD80 may cause the occurrence of preeclampsia by affecting the balance of Th1/Th2.展开更多
基金Hainan natural science foundation surface project(No.817306).
文摘Objective:We assessed the value of measuring the expression of CD80 and its correlations of TNF-α、and IL-4 in preeclampsia.Methods 30 patients with mild preeclampsia,27 patients with severe preeclampsia and 30 case of normal pregnancy were recruited.mRNA and protein expression levels of CD80,TNF-αand IL-4 were detected by qRT-PCR and ELISA.Result(1)The protein of CD80and TNF-αincreased significantly(P<0.05),while the expression level of IL-4 decreased significantly in mild and severe preeclampsia(P<0.05).(2).The mRNA of CD80and TNF-αincreased significantly in peripheral blood mononuclear cell of mild and severe preeclampsia,while the expression level of IL-4 decreased significantly.(3)There was a correlation between CD80 and TNF-αand IL-4(P<0.05).CD80 were positively correlated wi th TNF-a,but negatively with IL-4 levels.Conclusion This suggests that CD80 may cause the occurrence of preeclampsia by affecting the balance of Th1/Th2.
