Given its direct borrowings from and intertextual relations to other similar texts,“A Tale of the Ragged Mountains”has often been accused of flagrant plagiarism or lack of originality.Such a simple assertion ignores...Given its direct borrowings from and intertextual relations to other similar texts,“A Tale of the Ragged Mountains”has often been accused of flagrant plagiarism or lack of originality.Such a simple assertion ignores not only Poe’s deviation from these sources but also his rationale for such initiatives.While duly recognizing Poe’s indebtedness to his predecessors and contemporaries,this paper proposes to examine Poe’s literary re-creation and parody by concentrating on his subtle treatment of these borrowed texts,and in so doing,look also at his subversive approach to colonialist discourses.It suggests that in recounting Bedloe’s encounters with“Indians”in America and Asia,the tale actually creates a world of doubles to connect the present with the past,the imperial with the exotic,and the self with the other.In this regard,Dr.Templeton’s mesmeric treatment of Bedloe is both a reenactment and purgation of haunting colonial memories.The so-called medical accident at the end of the tale,therefore,registers Poe’s reflection on and warning against the imperial mindset.展开更多
Endothelial dysfunction is the postulated link between coronary artery disease （CAD） and erectile dysfunction （ED）. Brachial artery flow-mediated vasodilatation （FMD） is a non-invasive surrogate marker for endot...Endothelial dysfunction is the postulated link between coronary artery disease （CAD） and erectile dysfunction （ED）. Brachial artery flow-mediated vasodilatation （FMD） is a non-invasive surrogate marker for endothelial function assessment. Despite Asian Indians representing a considerable global CAD burden, data on FMD and ED in these patients are lacking. Of the 225 patients undergoing coronary angiography, 72% had ED （assessed using the International Index of Erectile Function （IIEF-5） questionnaire）; ED was moderate to severe in 61% of the patients. ED patients had a higher incidence of severe and diffuse angiographic CAD, a greater number of coronary vessels involved and a lower mean brachial artery FMD （6.40%±4.60% vs. 9.10%±4.87%, P〈0.001） compared to non-ED patients. A progressive reduction in FMD was noted with increasing severity of ED. Impaired FMD （ ≤ 5.5%） was twice as common in ED patients （52% vs. 24% without ED）. Patients with impaired FMD had higher ED prevalence （85% vs. 62%） and lower mean I IEF-5 scores compared to those with normal FMD. Impaired FMD was a significant ED predictor independent of other risk factors （odds ratio, 2.33; 95% confidence interval： 0.59-9.23; P=0.03）. An inverse correlation between FMD and ED severity was observed （r=-0.22; P=0.004）. ED is common among Asian Indians with angiographically documented CAD. Patients with ED have impaired FMD independent of other risk factors, suggesting that endothelial dysfunction is the underlying pathophysiology. Urologists and cardiologists need to be aware of the association between ED, CAD and endothelial dysfunction.展开更多
AIM:To assess the predisposition for cardiovascular diseases among young Asian Indians by anthropometric data analysis.METHODS:One hundred and thirty males and 329 females aged between 15 and 26 years,attending health...AIM:To assess the predisposition for cardiovascular diseases among young Asian Indians by anthropometric data analysis.METHODS:One hundred and thirty males and 329 females aged between 15 and 26 years,attending health care check-ups at VIT University,were included in this study.Their body mass index,systolic and diastolic blood pressure,waist circumference,waist-to-hip ratio,pulse rate and pressure,along with mean arterial pressure,were measured and the data analyzed as per World Health Organization guidelines.RESULTS:Based on the analysis,54% of the male population was found to be predisposed to cardiovascular disease.Of these,approximately 40% were at highest possible risk,with greater than threshold values of body mass index,waist circumference and waist-to-hip ratio.Females were found to have lower risk.Both genders showed significant correlation(P < 0.0001) between body mass index and waist circumference.Waist-to-hip ratio correlated significantly only in males with the former index whereas it correlated significantly with waist circumference in both genders.Receiver operating curve analysis,when performed,showed optimal sensitivity and specificity for body mass index and waist circumference.CONCLUSION:The above results indicate that seeds of cardiovascular disease may have been sown at a young age in Asian Indian populations.Interventional measures are advised to prevent accelerated atherosclerosis leading to premature cardiovascular disease.展开更多
The global burden of disease due to cardiovascular diseases(CVDs) is escalating,and the changing trends of CVD risk factors are identified among Indians experiencing rapid health transition.Contributory causes include...The global burden of disease due to cardiovascular diseases(CVDs) is escalating,and the changing trends of CVD risk factors are identified among Indians experiencing rapid health transition.Contributory causes include:growing population with demographic shifts and altered age profile,socio-economic factors,lifestyle changes due to urbanization.Indians are also having genetic predisposition to cardiovascular diseases and adult are susceptible to vascular disease linking possible gene-environment interactions influencing ethnic diversity.Altered diets with more of junk foods along with diminished physical activity are additive factors contributing to the acceleration of CVD epidemics,along with all form of tobacco use.The pace of health transition,however,varies across geographical regions from urban to rural population with consequent variations in the relative burdens of the dominant CVDs.A comprehensive public health response must be looked to plan over all strategies to integrate policies and programs that effectively impact on the multiple determinants of CVDs to provide protection over the life span through primordial,primary and secondary prevention.Populations as well as individuals at risk must be protected through initiatives,enable nutritionbased preventive strategies to protect and promote cardiovascular health.展开更多
AIM To examine the differences in metabolic risk factors(RFs) by gender in the Asian Indian(AI) population in the United States. METHODS Using cross-sectional data from 1038 randomly selected Asian Indians, we investi...AIM To examine the differences in metabolic risk factors(RFs) by gender in the Asian Indian(AI) population in the United States. METHODS Using cross-sectional data from 1038 randomly selected Asian Indians, we investigated the relationship between metabolic syndrome(Met S) RFs, cardiovascular disease,and diabetes. RESULTS A greater percent of women in this group had increased waist circumference and low high density lipoprotein(HDL) levels than men, but AI males had increased blood glucose, increased blood pressure, and increased triglycerides compared to females. Those individuals who met the Met S criteria had increased cardiovascular disease. One of the biggest single RFs for cardiovascular disease and diabetes reported in the literature for AIs is low HDL. CONCLUSION Our results show that lack of knowledge about diabetes, low physical activity, increased body mass index, and age were the factors most significantly correlated with low HDL in this population. Future studies and prospective trials are needed to further elucidate causes of the Met S and diabetes in AIs.展开更多
There have been controversies over differing opinions in the source of the American Indians. In this paper, the writer criticized the so-called classical theory that the remote ancestors of the American Indians entere...There have been controversies over differing opinions in the source of the American Indians. In this paper, the writer criticized the so-called classical theory that the remote ancestors of the American Indians entered America from Asia through the Bering Straits 14,000 ~ 20,000 years ago, worn their “clothes” and carried kindling during the late Paleolithic, no matter how by “boat” across the Bering Sea or by foot through a “Bering Land Bridge” which might once link up Asia and North America during glacial period;and independently proposed a new hypothesis that American Indians might be originated from the Western Rift Valley of North America. On the basis of locus distribution of American ancient human’s remnants, the writer pointed out that American ancient humans might be first originated at Yukon Territory of Canada within the Western Rift Valley of North America (the Basin & Range Province), and then migrated south ward (Yukon Territory → Mojave Desert → Mexico → Peru → Chile). Moreover, American Indians would have long been a presence for 40,000 years, or even 100,000 ~ 200,000 years in the American continents. So far, the logical basis which American Indians came from Asia 14,000 ~ 20,000 years ago was crushed, and derived two inferences: 1) American Indians might be originated from the Western Rift Valley of North America;2) Only the Eskimo might be the mover eastward from Asia, because of their gene B.展开更多
Background and Aims: Psychometric hepatic encephalop-athy score(PHES)is used widely for diagnosis of minimal hepatic encephalopathy(MHE).This prospective study aimed to determine the utility of the inhibitory control ...Background and Aims: Psychometric hepatic encephalop-athy score(PHES)is used widely for diagnosis of minimal hepatic encephalopathy(MHE).This prospective study aimed to determine the utility of the inhibitory control test(ICT)for the diagnosis of MHE.Additionally,the efficacy of rifaximin and lactulose for reversal of MHE was evaluated.Methods:A total of 180 eligible cirrhotic patients underwent testing for MHE.When PHES was ≤ ?5 and ICT lures were ≥ 14,MHE was diagnosed.The 108 patients with MHE were randomized to three groups for treatment with either lactulose,rifaximin,or placebo.Treatment outcomes were measured at the end of 3 months.Results: The 108 patients with MHE diagnosed by PHES and/or ICT accounted for 60%.The diagnosis of MHE was made by both ICT and PHES positivity in 56 patients,by abnormal ICT and normal PHES in 37 patients,and by abnor-mal PHES and normal ICT in 15 patients.For diagnosis of MHE,ICT had sensitivity of 78.87%,specificity of 66.06%with 60.22%positive predictive value and 82.76%negative predictive value.An area under the curve value of 0.724(95%CI: 0.653–0.788)was obtained for diagnosis of MHE.Reversal of MHE was seen in 71.42%,70.27%and 11.11%of patients in the rifaximin,lactulose and placebo arms(p < 0.001).Rifaximin showed better tolerability compared to lactulose.Conclusions: For the diagnosis of MHE,ICT is a simple tool but has lower sensitivity and better specificity than PHES.Rifaximin is as efficacious as lactulose in the treat-ment of MHE and better tolerated.展开更多
Based on reanalysis data from 1979 to 2021,this study explores the spatial distribution of the Southern Indian Ocean Dipole(SIOD)and its individual and synergistic effects with the El Niño-Southern Oscillation(EN...Based on reanalysis data from 1979 to 2021,this study explores the spatial distribution of the Southern Indian Ocean Dipole(SIOD)and its individual and synergistic effects with the El Niño-Southern Oscillation(ENSO)on summer precipitation in China.The inverse phase spatial distribution of sea surface temperature anomalies(SSTAs)in the southwest and northeast of the southern Indian Ocean is defined as the SIOD.Positive SIOD events(positive SSTAs in the southwest,negative SSTAs in the northeast)are associated with La Niña events(Central Pacific(CP)type),while negative SIOD events(negative SSTAs in the southwest,positive SSTAs in the northeast)are associated with El Niño events(Eastern Pacific(EP)type).Both SIOD and ENSO have certain impacts on summer precipitation in China.Precipitation in the Yangtze River basin decreases,while precipitation in southern China increases during pure positive SIOD(P_PSIOD)events.During pure negative SIOD(P_NSIOD)events,the changes in precipitation are exactly the opposite of those during P_PSIOD events,which may be due to differences in the cross-equatorial flow in the southern Indian Ocean,particularly in low-level Australian cross-equatorial flow.When positive SIOD and CP-type La Niña events occur simultaneously(PSIOD+La_Niña),precipitation increases in the Yangtze-Huaihe River basin,while it decreases in northern China.When negative SIOD and EP-type El Niño events occur simultaneously(NSIOD+El_Niño),precipitation in the Yangtze-Huaihe River basin is significantly lower than during P_NSIOD events.This is caused by differences in water vapor originating from the Pacific Ocean during different events.展开更多
Kidney transplantation(KT)accounts for nearly three-fourths of organ transplants in India,with living donors contributing to 82%of cases.Induction immunosuppression is essential to optimize initial immunosuppression,r...Kidney transplantation(KT)accounts for nearly three-fourths of organ transplants in India,with living donors contributing to 82%of cases.Induction immunosuppression is essential to optimize initial immunosuppression,reduce acute rejections,and enable tailored use of maintenance agents.Rabbit anti-thymocyte globulin(rATG)and interleukin-2 receptor anatagonists(IL-2RA/IL-2RBs)are the most widely used induction therapies.However,data on induction practices across India are limited.To evaluate induction immunosuppression practices across KT centers in India and establish a consensus for different subsets of KT recipients.A nationwide online survey was conducted by the Indian Society of Organ Transplantation(ISOT)among its members(400 KT centers).Responses were analyzed to assess induction practices across diverse donor types,age groups,and immunological risk profiles.Heterogeneity in practices prompted consensus building using a modified Delphi process.Literature review and expert panel discussions(April 2024)were followed by structured voting,and 16 consensus statements were finalized.Of 400 centers approached,254 participated.rATG was the most commonly used induction therapy,followed by IL-2RBs;alemtuzumab was least used.Significant heterogeneity was observed in type,dose,and duration of induction therapy.Consensus recommendations were framed:rATG for high immunological risk recipients and deceased donor KTs;IL-2RB or low-dose rATG for low immunological risk;rituximab in ABOincompatible KTs;and tailoring based on age,diabetes,donor type,infection risk,and affordability.This first ISOT consensus provides 16 India-specific statements on induction therapy in KT.It emphasizes risk-stratified,evidenceinformed,and context-appropriate induction strategies,supporting standardization of care across the country.展开更多
This study investigates the influence of major climatic modes on the interannual variability of the annual minimum extent of Antarctic sea ice.It shows that the Southern Annular Mode(SAM),the Indian Ocean Dipole(IOD),...This study investigates the influence of major climatic modes on the interannual variability of the annual minimum extent of Antarctic sea ice.It shows that the Southern Annular Mode(SAM),the Indian Ocean Dipole(IOD),and the El Niño-Southern Oscillation(ENSO),along with the total sea ice condition during the preceding spring,serve as precursor signals of February sea ice extent(SIE).These climate modes interact,energizing the Pacific-South American pattern(PSA),which deepens and shifts the Amundsen Sea Low(ASL)westward in spring.This pattern generates a dipole sea ice anomaly characterized by an increase in sea ice in the northern Ross Sea but a decrease in ice in the Bellingshausen and northern Weddell Seas.However,as the season transitions into summer,the ASL exerts a pronounced delayed effect,contributing to widespread sea ice loss across West Antarctica.Strong southerly winds on the western flank of the ASL push sea ice away from the inner Ross Sea,exposing coastal waters that absorb solar radiation,thereby accelerating ice melt through positive ice-albedo feedback.Simultaneously,northwesterly winds on the eastern flank transport warm air toward the Bellingshausen and northern Weddell Seas,intensifying ice loss in these regions.Furthermore,the active PSA is accompanied by a tripole sea surface temperature pattern characterized by warming in the Weddell Sea,which promotes continued ice melt.The co-occurrence of an exceptionally positive SAM,a La Niña,and a strong negative IOD during spring 2022,combined with lower-than-normal total spring SIE,ultimately contributed to the record-low Antarctic SIE observed in February 2023.展开更多
The Indonesian Throughflow(ITF)plays important roles in global ocean circulation and climate systems.Previous studies suggested the ITF interannual variability is driven by both the El Niño-Southern Oscillation(E...The Indonesian Throughflow(ITF)plays important roles in global ocean circulation and climate systems.Previous studies suggested the ITF interannual variability is driven by both the El Niño-Southern Oscillation(ENSO)and the Indian Ocean Dipole(IOD)events.The detailed processes of ENSO and/or IOD induced anomalies impacting on the ITF,however,are still not clear.In this study,this issue is investigated through causal relation,statistical,and dynamical analyses based on satellite observation.The results show that the driven mechanisms of ENSO on the ITF include two aspects.Firstly,the ENSO related wind field anomalies driven anomalous cyclonic ocean circulation in the western Pacific,and off equatorial upwelling Rossby waves propagating westward to arrive at the western boundary of the Pacific,both tend to induce negative sea surface height anomalies(SSHA)in the western Pacific,favoring ITF reduction since the develop of the El Niño through the following year.Secondly,the ENSO events modulate equatorial Indian Ocean zonal winds through Walker Circulation,which in turn trigger eastward propagating upwelling Kelvin waves and westward propagating downwelling Rossby waves.The Rossby waves are reflected into downwelling Kelvin waves,which then propagate eastward along the equator and the Sumatra-Java coast in the Indian Ocean.As a result,the wave dynamics tend to generate negative(positive)SSHA in the eastern Indian Ocean,and thus enhance(reduce)the ITF transport with time lag of 0-6 months(9-12 months),respectively.Under the IOD condition,the wave dynamics also tend to enhance the ITF in the positive IOD year,and reduce the ITF in the following year.展开更多
From international student to professor,Tripathi Mani shares his thoughts on Chinese and Indian cultures and the beneficial exchanges between them.TRIPATHI Vivek Mani first learned about China from bedtime stories tol...From international student to professor,Tripathi Mani shares his thoughts on Chinese and Indian cultures and the beneficial exchanges between them.TRIPATHI Vivek Mani first learned about China from bedtime stories told by his father,a Sanskrit teacher in rural Bihar,a state in east India.Many of the stories were about the Chinese monk Xuanzang’s adventures during his long journey to India to find Buddhist scriptures.They kindled the young boy’s interest in China and the desire to visit it one day.展开更多
Indian Pilgrimage in China's Xizang to Resume This Summer Indian pilgrimage to Mount Gang Rinpoche and Lake Mapham Yutso in the Xizang Autonomous Region will resume this summer as agreed between the two countries,...Indian Pilgrimage in China's Xizang to Resume This Summer Indian pilgrimage to Mount Gang Rinpoche and Lake Mapham Yutso in the Xizang Autonomous Region will resume this summer as agreed between the two countries,according to China's Foreign Ministry.Mount Gang Rinpoche and Lake Mapham Yutso are the sacred mountain and lake for believers of several religions,including Tibetan Buddhism and Hinduism,and thus the pilgrimage is an important part of the cultural and people-to-people exchange between China and India.展开更多
First Published:2020 ISBN:9781421438740 Published by John Hopkins Press https://www.press.jhu.edu“The geological imagination of India,its landscapes,people,past and destiny,drive the narrative of this book”,Pratik C...First Published:2020 ISBN:9781421438740 Published by John Hopkins Press https://www.press.jhu.edu“The geological imagination of India,its landscapes,people,past and destiny,drive the narrative of this book”,Pratik Chakrabarti writes in his introduction to Inscriptions of Nature.His ambitious work examines the development of the natural and anthropological sciences on the Indian subcontinent since the early 19th century,and the shaping of knowledge about Indian nature through the exploration of its deep past:an exploration that dug not only into the depths of the earth,but also into ancient history,texts,myths,legends,folklore and the genealogies of local populations.This in-depth study not only combines the history of geology,paleontology,anthropology and ethnography,it also finely analyzes the interactions between the theoretical framework of scientific knowledge imported from Europe and local history,mythologies and indigenous beliefs.展开更多
Extraterrestrial phenomena have influenced Earth’s processes throughout geological history.Evaluating the impact of extraterrestrial material on the environment is crucial for understanding the evolution of Earth and...Extraterrestrial phenomena have influenced Earth’s processes throughout geological history.Evaluating the impact of extraterrestrial material on the environment is crucial for understanding the evolution of Earth and life.This study incorporates the investigation of micrometeorites(MMs),abundant cosmic materials on Earth,to understand their influence on the chemical composition and biogeochemistry of the ocean.Comprehensive etching and flux analyses reveal that∼95%of cosmic spherules(CSs)entering seawater are etched or wholly dissolved,supplying nutrients to phytoplankton.Barred spherules show the highest degree of etching(∼19%),followed by porphyritic(∼17%),glass(∼15%),cryptocrystalline(∼12%),scoriaceous(∼10%),G-type(∼9%),and I-type(∼6%).Annually,∼3080 tonnes(t)of olivine from MMs dissolve into seawater,contributing∼495 t of Mg^(2+),∼1110 t of Fe^(2+),and∼1928 t of silicic acid.This signifies that over the Indian Ocean’s∼40 Myr history,∼23 Gt of olivine from CSs has dissolved,providing nutrients to seawater and sequestering∼7 Gt of CO_(2).The world ocean during this time has sequestered∼35 Gt of CO_(2),with fluctuations influenced by extraterrestrial activity.For instance,the Veritas event,lasting∼1.5 Myr,sequestered∼6 Gt of CO_(2)from the atmosphere.A robust flux calculation based on∼2 t of deep-sea sediments from 3610 MMs provides a more accurate estimate of the time-averaged flux of∼229 t yr^(−1).These comprehensive analyses reveal MM’s original characteristics,post-deposition processes,geological record and their overall impact on Earth’s marine environments,thereby contributing to our knowledge of the interconnection between terrestrial and extraterrestrial processes.展开更多
Tanzania is mainly subject to a bimodal rainfall pattern,characterized by two distinct seasons:the long rains,occurring from March to May,and the short rains,which typically take place from October to December(OND).Sh...Tanzania is mainly subject to a bimodal rainfall pattern,characterized by two distinct seasons:the long rains,occurring from March to May,and the short rains,which typically take place from October to December(OND).Short rains are usually less intense but still significantly influence local agriculture.Therefore,with station-based observations and reanalysis data,the current paper examines the interannual variability of OND precipitation in Tanzania from 1993 to 2022 and explores the possible impacts from El Niño–Southern Oscillation(ENSO)and the Indian Ocean Dipole(IOD)as well as the mechanisms.It is found that the Tanzania OND precipitation is above(below)normal in 1997,2006,2011,and 2019(1993,1998,2005,and 2016).The composite difference between wet(dry)years and the climatology indicates that the anomalous lower-level convergence(divergence)and upward(downward)motion are the critical circulation characters for above(below)precipitation.Further analysis indicates ENSO and the IOD are the two main oceanic systems modulating OND precipitation in Tanzania.El Niño and a positive IOD could induce easterly anomalies and weaken the Walker circulation over the Indian Ocean,consequently leading to lower-level convergence in water vapor flux,upward anomalies,and more than normal precipitation in Tanzania.In contrast,La Niña and a negative IOD produce opposite circulation anomalies and less than normal precipitation over Tanzania.Moreover,through partial correlation and Generalized Equilibrium Feedback Analysis,the individual contributions of ENSO and the IOD to circulation are investigated.It is found that although both the IOD and ENSO impact the Walker circulation,the feedback to the IOD is stronger than ENSO.These results provide critical insights into the oceanic drivers and their mechanistic pathways underlying precipitation anomalies in Tanzania.展开更多
El Niño is frequently followed by La Niña,while La Niña tends to sustain into the next year or even longer,exhibiting a notable phase transition asymmetry(TA)of El Niño-Southern Oscillation(ENSO).T...El Niño is frequently followed by La Niña,while La Niña tends to sustain into the next year or even longer,exhibiting a notable phase transition asymmetry(TA)of El Niño-Southern Oscillation(ENSO).This study explores the potential influences of tropical Indian Ocean(TIO)decadal variability on TA based on a comparative analysis of the relationship between the TIO sea surface temperature anomalies(SSTA)and ENSO during different periods.Generally,the TIO SSTA strengthened TA before the 1980s,corresponding to a highly positive relationship between the whole TIO SSTA and ENSO.However,the weakening effect was exhibited after the 1980s when the correlation diminished.After the late 1990s,ENSO was only positively correlated with western TIO,with the westerly exhibit of the SSTA center leading to smaller impacts on TA.Moreover,TIO SSTA tends to weaken TA by promoting the transition efficiency of La Niña,while bringing little effect on that of El Niño.Physically,compared to the mid-1970s,TIO SSTA triggered westerly wind anomalies during the autumn and winter of the La Niña development phase in the central equatorial Pacific in the late 1990s,which sped up the decay of La Niña.It then regenerated westerly anomalies in the following winter,facilitating the development of El Niño.This study quantifies the impact of the TIO SSTA on TA in seasonal signals and investigates the decadal variability of such influence,aiming to further understand phase transition asymmetry and offer valuable insights for the prediction of multi-year La Niña.展开更多
In the author list,the corresponding author indicator(*)was inadvertently omitted from HOU Zengqian’s name.This has now been corrected to:“HOU Zengqian¹,*”.The online version of this article was corrected.
In recent years, traditional rice landraces have gained increasing attention among consumers, scientists, and nutritionists because of their nutritional and therapeutic value. The diverse rice gene pool of the Indian ...In recent years, traditional rice landraces have gained increasing attention among consumers, scientists, and nutritionists because of their nutritional and therapeutic value. The diverse rice gene pool of the Indian subcontinent is bestowed with indigenous rice types augmented with nutrients and phytochemicals. Landraces high in resistant starch and dietary fiber contribute to gut health and help prevent gastrointestinal disorders, whereas those with high-quality protein contents, such as glutelin and lysine, all-trans retinoic acid, as well as iron and zinc contents(even in polished rice), play a vital role in the alleviation of malnutrition and hidden hunger. Metabolomic studies have revealed the presence of novel bioactive molecules, including tocols(e.g., gamma-tocotrienol and alpha-tocopherol), phytosterols(e.g., campestrol, beta-sitosterol, and stigmasterol), phenolic acids(e.g., 2-methoxy-4-vinylphenol, 4-vinylphenol, 3,5-di-tert-butylphenol, 2,4-di-tert-butylphenol, ionol, and 2,6-di-tert-butylphenol), flavonoids [e.g., flavonolignans tricin 4′-O-(threo-β-guaiacylglyceryl) ether and tricin 4′-O-(erythro-β-guaiacylglyceryl) ether], anthocyanins(e.g., delphinidin and cyanidin), carotenoids(e.g., 7,7′,8,8′-tetrahydrolycopene and 1-hydroxylycopene), diterpenoids(e.g., sugiol), vitamin D3(a secosteroid), and bioactive vitamin D(e.g., calcitriol). These bioactive phytochemicals endow Indian rice landraces, rich in antioxidants, with antiphlogistic, antineoplastic, cardiac risk preventive, antiviral, and antitubercular activities, confirming their use in traditional Indian medicine. Furthermore, Indian landraces with a low glycemic index may benefit the Asian Indian phenotype, which is characterized by clinical anomalies such as insulin resistance, dyslipidemia(reduced high-density lipoprotein levels), and high dietary glycemic load. Therefore, the conservation of India's traditional rice varieties is vital for both sustainable agriculture and improving global health.展开更多
基金supported by the Department of Education of Hunan Province"A Study of the Metahistorical Imagination in Nathaniel Hawthorne's Fiction"(grant number:24B0071).
文摘Given its direct borrowings from and intertextual relations to other similar texts,“A Tale of the Ragged Mountains”has often been accused of flagrant plagiarism or lack of originality.Such a simple assertion ignores not only Poe’s deviation from these sources but also his rationale for such initiatives.While duly recognizing Poe’s indebtedness to his predecessors and contemporaries,this paper proposes to examine Poe’s literary re-creation and parody by concentrating on his subtle treatment of these borrowed texts,and in so doing,look also at his subversive approach to colonialist discourses.It suggests that in recounting Bedloe’s encounters with“Indians”in America and Asia,the tale actually creates a world of doubles to connect the present with the past,the imperial with the exotic,and the self with the other.In this regard,Dr.Templeton’s mesmeric treatment of Bedloe is both a reenactment and purgation of haunting colonial memories.The so-called medical accident at the end of the tale,therefore,registers Poe’s reflection on and warning against the imperial mindset.
文摘Endothelial dysfunction is the postulated link between coronary artery disease （CAD） and erectile dysfunction （ED）. Brachial artery flow-mediated vasodilatation （FMD） is a non-invasive surrogate marker for endothelial function assessment. Despite Asian Indians representing a considerable global CAD burden, data on FMD and ED in these patients are lacking. Of the 225 patients undergoing coronary angiography, 72% had ED （assessed using the International Index of Erectile Function （IIEF-5） questionnaire）; ED was moderate to severe in 61% of the patients. ED patients had a higher incidence of severe and diffuse angiographic CAD, a greater number of coronary vessels involved and a lower mean brachial artery FMD （6.40%±4.60% vs. 9.10%±4.87%, P〈0.001） compared to non-ED patients. A progressive reduction in FMD was noted with increasing severity of ED. Impaired FMD （ ≤ 5.5%） was twice as common in ED patients （52% vs. 24% without ED）. Patients with impaired FMD had higher ED prevalence （85% vs. 62%） and lower mean I IEF-5 scores compared to those with normal FMD. Impaired FMD was a significant ED predictor independent of other risk factors （odds ratio, 2.33; 95% confidence interval： 0.59-9.23; P=0.03）. An inverse correlation between FMD and ED severity was observed （r=-0.22; P=0.004）. ED is common among Asian Indians with angiographically documented CAD. Patients with ED have impaired FMD independent of other risk factors, suggesting that endothelial dysfunction is the underlying pathophysiology. Urologists and cardiologists need to be aware of the association between ED, CAD and endothelial dysfunction.
文摘AIM:To assess the predisposition for cardiovascular diseases among young Asian Indians by anthropometric data analysis.METHODS:One hundred and thirty males and 329 females aged between 15 and 26 years,attending health care check-ups at VIT University,were included in this study.Their body mass index,systolic and diastolic blood pressure,waist circumference,waist-to-hip ratio,pulse rate and pressure,along with mean arterial pressure,were measured and the data analyzed as per World Health Organization guidelines.RESULTS:Based on the analysis,54% of the male population was found to be predisposed to cardiovascular disease.Of these,approximately 40% were at highest possible risk,with greater than threshold values of body mass index,waist circumference and waist-to-hip ratio.Females were found to have lower risk.Both genders showed significant correlation(P < 0.0001) between body mass index and waist circumference.Waist-to-hip ratio correlated significantly only in males with the former index whereas it correlated significantly with waist circumference in both genders.Receiver operating curve analysis,when performed,showed optimal sensitivity and specificity for body mass index and waist circumference.CONCLUSION:The above results indicate that seeds of cardiovascular disease may have been sown at a young age in Asian Indian populations.Interventional measures are advised to prevent accelerated atherosclerosis leading to premature cardiovascular disease.
基金Supported by a grant from Confederation of Epidemiological Associations registered under Govt of Kerala(Grant number:30-956/2013 CEA)
文摘The global burden of disease due to cardiovascular diseases(CVDs) is escalating,and the changing trends of CVD risk factors are identified among Indians experiencing rapid health transition.Contributory causes include:growing population with demographic shifts and altered age profile,socio-economic factors,lifestyle changes due to urbanization.Indians are also having genetic predisposition to cardiovascular diseases and adult are susceptible to vascular disease linking possible gene-environment interactions influencing ethnic diversity.Altered diets with more of junk foods along with diminished physical activity are additive factors contributing to the acceleration of CVD epidemics,along with all form of tobacco use.The pace of health transition,however,varies across geographical regions from urban to rural population with consequent variations in the relative burdens of the dominant CVDs.A comprehensive public health response must be looked to plan over all strategies to integrate policies and programs that effectively impact on the multiple determinants of CVDs to provide protection over the life span through primordial,primary and secondary prevention.Populations as well as individuals at risk must be protected through initiatives,enable nutritionbased preventive strategies to protect and promote cardiovascular health.
文摘AIM To examine the differences in metabolic risk factors(RFs) by gender in the Asian Indian(AI) population in the United States. METHODS Using cross-sectional data from 1038 randomly selected Asian Indians, we investigated the relationship between metabolic syndrome(Met S) RFs, cardiovascular disease,and diabetes. RESULTS A greater percent of women in this group had increased waist circumference and low high density lipoprotein(HDL) levels than men, but AI males had increased blood glucose, increased blood pressure, and increased triglycerides compared to females. Those individuals who met the Met S criteria had increased cardiovascular disease. One of the biggest single RFs for cardiovascular disease and diabetes reported in the literature for AIs is low HDL. CONCLUSION Our results show that lack of knowledge about diabetes, low physical activity, increased body mass index, and age were the factors most significantly correlated with low HDL in this population. Future studies and prospective trials are needed to further elucidate causes of the Met S and diabetes in AIs.
文摘There have been controversies over differing opinions in the source of the American Indians. In this paper, the writer criticized the so-called classical theory that the remote ancestors of the American Indians entered America from Asia through the Bering Straits 14,000 ~ 20,000 years ago, worn their “clothes” and carried kindling during the late Paleolithic, no matter how by “boat” across the Bering Sea or by foot through a “Bering Land Bridge” which might once link up Asia and North America during glacial period;and independently proposed a new hypothesis that American Indians might be originated from the Western Rift Valley of North America. On the basis of locus distribution of American ancient human’s remnants, the writer pointed out that American ancient humans might be first originated at Yukon Territory of Canada within the Western Rift Valley of North America (the Basin & Range Province), and then migrated south ward (Yukon Territory → Mojave Desert → Mexico → Peru → Chile). Moreover, American Indians would have long been a presence for 40,000 years, or even 100,000 ~ 200,000 years in the American continents. So far, the logical basis which American Indians came from Asia 14,000 ~ 20,000 years ago was crushed, and derived two inferences: 1) American Indians might be originated from the Western Rift Valley of North America;2) Only the Eskimo might be the mover eastward from Asia, because of their gene B.
文摘Background and Aims: Psychometric hepatic encephalop-athy score(PHES)is used widely for diagnosis of minimal hepatic encephalopathy(MHE).This prospective study aimed to determine the utility of the inhibitory control test(ICT)for the diagnosis of MHE.Additionally,the efficacy of rifaximin and lactulose for reversal of MHE was evaluated.Methods:A total of 180 eligible cirrhotic patients underwent testing for MHE.When PHES was ≤ ?5 and ICT lures were ≥ 14,MHE was diagnosed.The 108 patients with MHE were randomized to three groups for treatment with either lactulose,rifaximin,or placebo.Treatment outcomes were measured at the end of 3 months.Results: The 108 patients with MHE diagnosed by PHES and/or ICT accounted for 60%.The diagnosis of MHE was made by both ICT and PHES positivity in 56 patients,by abnormal ICT and normal PHES in 37 patients,and by abnor-mal PHES and normal ICT in 15 patients.For diagnosis of MHE,ICT had sensitivity of 78.87%,specificity of 66.06%with 60.22%positive predictive value and 82.76%negative predictive value.An area under the curve value of 0.724(95%CI: 0.653–0.788)was obtained for diagnosis of MHE.Reversal of MHE was seen in 71.42%,70.27%and 11.11%of patients in the rifaximin,lactulose and placebo arms(p < 0.001).Rifaximin showed better tolerability compared to lactulose.Conclusions: For the diagnosis of MHE,ICT is a simple tool but has lower sensitivity and better specificity than PHES.Rifaximin is as efficacious as lactulose in the treat-ment of MHE and better tolerated.
基金supported by the National Natural Science Foundation of China[grant numbers 41975087,U2242212,and 41975085]supported by the National Natural Science Foundation of China[grant number U2242212]。
文摘Based on reanalysis data from 1979 to 2021,this study explores the spatial distribution of the Southern Indian Ocean Dipole(SIOD)and its individual and synergistic effects with the El Niño-Southern Oscillation(ENSO)on summer precipitation in China.The inverse phase spatial distribution of sea surface temperature anomalies(SSTAs)in the southwest and northeast of the southern Indian Ocean is defined as the SIOD.Positive SIOD events(positive SSTAs in the southwest,negative SSTAs in the northeast)are associated with La Niña events(Central Pacific(CP)type),while negative SIOD events(negative SSTAs in the southwest,positive SSTAs in the northeast)are associated with El Niño events(Eastern Pacific(EP)type).Both SIOD and ENSO have certain impacts on summer precipitation in China.Precipitation in the Yangtze River basin decreases,while precipitation in southern China increases during pure positive SIOD(P_PSIOD)events.During pure negative SIOD(P_NSIOD)events,the changes in precipitation are exactly the opposite of those during P_PSIOD events,which may be due to differences in the cross-equatorial flow in the southern Indian Ocean,particularly in low-level Australian cross-equatorial flow.When positive SIOD and CP-type La Niña events occur simultaneously(PSIOD+La_Niña),precipitation increases in the Yangtze-Huaihe River basin,while it decreases in northern China.When negative SIOD and EP-type El Niño events occur simultaneously(NSIOD+El_Niño),precipitation in the Yangtze-Huaihe River basin is significantly lower than during P_NSIOD events.This is caused by differences in water vapor originating from the Pacific Ocean during different events.
文摘Kidney transplantation(KT)accounts for nearly three-fourths of organ transplants in India,with living donors contributing to 82%of cases.Induction immunosuppression is essential to optimize initial immunosuppression,reduce acute rejections,and enable tailored use of maintenance agents.Rabbit anti-thymocyte globulin(rATG)and interleukin-2 receptor anatagonists(IL-2RA/IL-2RBs)are the most widely used induction therapies.However,data on induction practices across India are limited.To evaluate induction immunosuppression practices across KT centers in India and establish a consensus for different subsets of KT recipients.A nationwide online survey was conducted by the Indian Society of Organ Transplantation(ISOT)among its members(400 KT centers).Responses were analyzed to assess induction practices across diverse donor types,age groups,and immunological risk profiles.Heterogeneity in practices prompted consensus building using a modified Delphi process.Literature review and expert panel discussions(April 2024)were followed by structured voting,and 16 consensus statements were finalized.Of 400 centers approached,254 participated.rATG was the most commonly used induction therapy,followed by IL-2RBs;alemtuzumab was least used.Significant heterogeneity was observed in type,dose,and duration of induction therapy.Consensus recommendations were framed:rATG for high immunological risk recipients and deceased donor KTs;IL-2RB or low-dose rATG for low immunological risk;rituximab in ABOincompatible KTs;and tailoring based on age,diabetes,donor type,infection risk,and affordability.This first ISOT consensus provides 16 India-specific statements on induction therapy in KT.It emphasizes risk-stratified,evidenceinformed,and context-appropriate induction strategies,supporting standardization of care across the country.
基金supported by the National Natural Science Foundation of China (Grant Nos.42288101 and 42375045)
文摘This study investigates the influence of major climatic modes on the interannual variability of the annual minimum extent of Antarctic sea ice.It shows that the Southern Annular Mode(SAM),the Indian Ocean Dipole(IOD),and the El Niño-Southern Oscillation(ENSO),along with the total sea ice condition during the preceding spring,serve as precursor signals of February sea ice extent(SIE).These climate modes interact,energizing the Pacific-South American pattern(PSA),which deepens and shifts the Amundsen Sea Low(ASL)westward in spring.This pattern generates a dipole sea ice anomaly characterized by an increase in sea ice in the northern Ross Sea but a decrease in ice in the Bellingshausen and northern Weddell Seas.However,as the season transitions into summer,the ASL exerts a pronounced delayed effect,contributing to widespread sea ice loss across West Antarctica.Strong southerly winds on the western flank of the ASL push sea ice away from the inner Ross Sea,exposing coastal waters that absorb solar radiation,thereby accelerating ice melt through positive ice-albedo feedback.Simultaneously,northwesterly winds on the eastern flank transport warm air toward the Bellingshausen and northern Weddell Seas,intensifying ice loss in these regions.Furthermore,the active PSA is accompanied by a tripole sea surface temperature pattern characterized by warming in the Weddell Sea,which promotes continued ice melt.The co-occurrence of an exceptionally positive SAM,a La Niña,and a strong negative IOD during spring 2022,combined with lower-than-normal total spring SIE,ultimately contributed to the record-low Antarctic SIE observed in February 2023.
基金The Fund of Laoshan Laboratory under contract No.LSKJ202202700the Basic Scientific Fund for National Public Research Institutes of China under contract No.2024Q02+1 种基金the National Natural Science Foundation of China under contract Nos 42076023 and 42430402the Global Change and Air-Sea InteractionⅡProject under contract No.GASI-01-ATP-STwin.
文摘The Indonesian Throughflow(ITF)plays important roles in global ocean circulation and climate systems.Previous studies suggested the ITF interannual variability is driven by both the El Niño-Southern Oscillation(ENSO)and the Indian Ocean Dipole(IOD)events.The detailed processes of ENSO and/or IOD induced anomalies impacting on the ITF,however,are still not clear.In this study,this issue is investigated through causal relation,statistical,and dynamical analyses based on satellite observation.The results show that the driven mechanisms of ENSO on the ITF include two aspects.Firstly,the ENSO related wind field anomalies driven anomalous cyclonic ocean circulation in the western Pacific,and off equatorial upwelling Rossby waves propagating westward to arrive at the western boundary of the Pacific,both tend to induce negative sea surface height anomalies(SSHA)in the western Pacific,favoring ITF reduction since the develop of the El Niño through the following year.Secondly,the ENSO events modulate equatorial Indian Ocean zonal winds through Walker Circulation,which in turn trigger eastward propagating upwelling Kelvin waves and westward propagating downwelling Rossby waves.The Rossby waves are reflected into downwelling Kelvin waves,which then propagate eastward along the equator and the Sumatra-Java coast in the Indian Ocean.As a result,the wave dynamics tend to generate negative(positive)SSHA in the eastern Indian Ocean,and thus enhance(reduce)the ITF transport with time lag of 0-6 months(9-12 months),respectively.Under the IOD condition,the wave dynamics also tend to enhance the ITF in the positive IOD year,and reduce the ITF in the following year.
文摘From international student to professor,Tripathi Mani shares his thoughts on Chinese and Indian cultures and the beneficial exchanges between them.TRIPATHI Vivek Mani first learned about China from bedtime stories told by his father,a Sanskrit teacher in rural Bihar,a state in east India.Many of the stories were about the Chinese monk Xuanzang’s adventures during his long journey to India to find Buddhist scriptures.They kindled the young boy’s interest in China and the desire to visit it one day.
文摘Indian Pilgrimage in China's Xizang to Resume This Summer Indian pilgrimage to Mount Gang Rinpoche and Lake Mapham Yutso in the Xizang Autonomous Region will resume this summer as agreed between the two countries,according to China's Foreign Ministry.Mount Gang Rinpoche and Lake Mapham Yutso are the sacred mountain and lake for believers of several religions,including Tibetan Buddhism and Hinduism,and thus the pilgrimage is an important part of the cultural and people-to-people exchange between China and India.
文摘First Published:2020 ISBN:9781421438740 Published by John Hopkins Press https://www.press.jhu.edu“The geological imagination of India,its landscapes,people,past and destiny,drive the narrative of this book”,Pratik Chakrabarti writes in his introduction to Inscriptions of Nature.His ambitious work examines the development of the natural and anthropological sciences on the Indian subcontinent since the early 19th century,and the shaping of knowledge about Indian nature through the exploration of its deep past:an exploration that dug not only into the depths of the earth,but also into ancient history,texts,myths,legends,folklore and the genealogies of local populations.This in-depth study not only combines the history of geology,paleontology,anthropology and ethnography,it also finely analyzes the interactions between the theoretical framework of scientific knowledge imported from Europe and local history,mythologies and indigenous beliefs.
基金ISRO-RESPOND GAP3332 and PMN-MOES GAP2175 Project support this work.NIO-PMN and MOES-NCPOR supported the deep-sea and Antarctica micrometeorite collections,respectively.
文摘Extraterrestrial phenomena have influenced Earth’s processes throughout geological history.Evaluating the impact of extraterrestrial material on the environment is crucial for understanding the evolution of Earth and life.This study incorporates the investigation of micrometeorites(MMs),abundant cosmic materials on Earth,to understand their influence on the chemical composition and biogeochemistry of the ocean.Comprehensive etching and flux analyses reveal that∼95%of cosmic spherules(CSs)entering seawater are etched or wholly dissolved,supplying nutrients to phytoplankton.Barred spherules show the highest degree of etching(∼19%),followed by porphyritic(∼17%),glass(∼15%),cryptocrystalline(∼12%),scoriaceous(∼10%),G-type(∼9%),and I-type(∼6%).Annually,∼3080 tonnes(t)of olivine from MMs dissolve into seawater,contributing∼495 t of Mg^(2+),∼1110 t of Fe^(2+),and∼1928 t of silicic acid.This signifies that over the Indian Ocean’s∼40 Myr history,∼23 Gt of olivine from CSs has dissolved,providing nutrients to seawater and sequestering∼7 Gt of CO_(2).The world ocean during this time has sequestered∼35 Gt of CO_(2),with fluctuations influenced by extraterrestrial activity.For instance,the Veritas event,lasting∼1.5 Myr,sequestered∼6 Gt of CO_(2)from the atmosphere.A robust flux calculation based on∼2 t of deep-sea sediments from 3610 MMs provides a more accurate estimate of the time-averaged flux of∼229 t yr^(−1).These comprehensive analyses reveal MM’s original characteristics,post-deposition processes,geological record and their overall impact on Earth’s marine environments,thereby contributing to our knowledge of the interconnection between terrestrial and extraterrestrial processes.
基金supported by the National Natural Science Foundation of China[grant numbers 42105030 and 42105066]the Ministry of Commerce,People’s Republic of China.
文摘Tanzania is mainly subject to a bimodal rainfall pattern,characterized by two distinct seasons:the long rains,occurring from March to May,and the short rains,which typically take place from October to December(OND).Short rains are usually less intense but still significantly influence local agriculture.Therefore,with station-based observations and reanalysis data,the current paper examines the interannual variability of OND precipitation in Tanzania from 1993 to 2022 and explores the possible impacts from El Niño–Southern Oscillation(ENSO)and the Indian Ocean Dipole(IOD)as well as the mechanisms.It is found that the Tanzania OND precipitation is above(below)normal in 1997,2006,2011,and 2019(1993,1998,2005,and 2016).The composite difference between wet(dry)years and the climatology indicates that the anomalous lower-level convergence(divergence)and upward(downward)motion are the critical circulation characters for above(below)precipitation.Further analysis indicates ENSO and the IOD are the two main oceanic systems modulating OND precipitation in Tanzania.El Niño and a positive IOD could induce easterly anomalies and weaken the Walker circulation over the Indian Ocean,consequently leading to lower-level convergence in water vapor flux,upward anomalies,and more than normal precipitation in Tanzania.In contrast,La Niña and a negative IOD produce opposite circulation anomalies and less than normal precipitation over Tanzania.Moreover,through partial correlation and Generalized Equilibrium Feedback Analysis,the individual contributions of ENSO and the IOD to circulation are investigated.It is found that although both the IOD and ENSO impact the Walker circulation,the feedback to the IOD is stronger than ENSO.These results provide critical insights into the oceanic drivers and their mechanistic pathways underlying precipitation anomalies in Tanzania.
基金National Natural Science Foundation of China(42288101,42192564)Project of Ministry of Science and Technology of the People’s Republic of China(2020YFA0608802)Guangdong Major Project of Basic and Applied Basic Research(2020B0301030004)。
文摘El Niño is frequently followed by La Niña,while La Niña tends to sustain into the next year or even longer,exhibiting a notable phase transition asymmetry(TA)of El Niño-Southern Oscillation(ENSO).This study explores the potential influences of tropical Indian Ocean(TIO)decadal variability on TA based on a comparative analysis of the relationship between the TIO sea surface temperature anomalies(SSTA)and ENSO during different periods.Generally,the TIO SSTA strengthened TA before the 1980s,corresponding to a highly positive relationship between the whole TIO SSTA and ENSO.However,the weakening effect was exhibited after the 1980s when the correlation diminished.After the late 1990s,ENSO was only positively correlated with western TIO,with the westerly exhibit of the SSTA center leading to smaller impacts on TA.Moreover,TIO SSTA tends to weaken TA by promoting the transition efficiency of La Niña,while bringing little effect on that of El Niño.Physically,compared to the mid-1970s,TIO SSTA triggered westerly wind anomalies during the autumn and winter of the La Niña development phase in the central equatorial Pacific in the late 1990s,which sped up the decay of La Niña.It then regenerated westerly anomalies in the following winter,facilitating the development of El Niño.This study quantifies the impact of the TIO SSTA on TA in seasonal signals and investigates the decadal variability of such influence,aiming to further understand phase transition asymmetry and offer valuable insights for the prediction of multi-year La Niña.
文摘In the author list,the corresponding author indicator(*)was inadvertently omitted from HOU Zengqian’s name.This has now been corrected to:“HOU Zengqian¹,*”.The online version of this article was corrected.
文摘In recent years, traditional rice landraces have gained increasing attention among consumers, scientists, and nutritionists because of their nutritional and therapeutic value. The diverse rice gene pool of the Indian subcontinent is bestowed with indigenous rice types augmented with nutrients and phytochemicals. Landraces high in resistant starch and dietary fiber contribute to gut health and help prevent gastrointestinal disorders, whereas those with high-quality protein contents, such as glutelin and lysine, all-trans retinoic acid, as well as iron and zinc contents(even in polished rice), play a vital role in the alleviation of malnutrition and hidden hunger. Metabolomic studies have revealed the presence of novel bioactive molecules, including tocols(e.g., gamma-tocotrienol and alpha-tocopherol), phytosterols(e.g., campestrol, beta-sitosterol, and stigmasterol), phenolic acids(e.g., 2-methoxy-4-vinylphenol, 4-vinylphenol, 3,5-di-tert-butylphenol, 2,4-di-tert-butylphenol, ionol, and 2,6-di-tert-butylphenol), flavonoids [e.g., flavonolignans tricin 4′-O-(threo-β-guaiacylglyceryl) ether and tricin 4′-O-(erythro-β-guaiacylglyceryl) ether], anthocyanins(e.g., delphinidin and cyanidin), carotenoids(e.g., 7,7′,8,8′-tetrahydrolycopene and 1-hydroxylycopene), diterpenoids(e.g., sugiol), vitamin D3(a secosteroid), and bioactive vitamin D(e.g., calcitriol). These bioactive phytochemicals endow Indian rice landraces, rich in antioxidants, with antiphlogistic, antineoplastic, cardiac risk preventive, antiviral, and antitubercular activities, confirming their use in traditional Indian medicine. Furthermore, Indian landraces with a low glycemic index may benefit the Asian Indian phenotype, which is characterized by clinical anomalies such as insulin resistance, dyslipidemia(reduced high-density lipoprotein levels), and high dietary glycemic load. Therefore, the conservation of India's traditional rice varieties is vital for both sustainable agriculture and improving global health.
