The thalamus and central dopamine signaling have been shown to play important roles in high-level cognitive processes including impulsivity. However, little is known about the role of dopamine receptors in the thalamu...The thalamus and central dopamine signaling have been shown to play important roles in high-level cognitive processes including impulsivity. However, little is known about the role of dopamine receptors in the thalamus in decisional impulsivity. In the present study,rats were tested using a delay discounting task and divided into three groups： high impulsivity（HI）, medium impulsivity（MI）, and low impulsivity（LI）. Subsequent in vivo voxel-based magnetic resonance imaging revealed that the HI rats displayed a markedly reduced density of gray matter in the lateral thalamus compared with the LI rats. In the MI rats, the dopamine D1 receptor antagonist SCH23390 or the D2 receptor antagonist eticlopride was microinjected into the lateral thalamus. SCH23390 significantly decreased their choice of a large, delayed reward and increased their omission of lever presses. In contrast,eticlopride increased the choice of a large, delayed reward but had no effect on the omissions. Together, our results indicate that the lateral thalamus is involved in decisional impulsivity, and dopamine D1 and D2 receptors in the lateral thalamus have distinct effects on decisional impulsive behaviors in rats. These results provide a new insightinto the dopamine signaling in the lateral thalamus in decisional impulsivity.展开更多
Suicide risk constitutes a complex set of interacting demographic, clinical, psychobiological and environmental variables. Impulsivity is a long-known risk factor for suicide attempts. However, research based on clear...Suicide risk constitutes a complex set of interacting demographic, clinical, psychobiological and environmental variables. Impulsivity is a long-known risk factor for suicide attempts. However, research based on clearer conceptual refinement in this area is imperative. One emerging field of study is that of decision-making. Impulsivity involves a failure of higher-order control, including decision-making. Using standardized operational definitions that take into consideration relevant aspects of impulsivity, including state- and trait-components and a deeper understanding of the process of decision-making in the suicidal mind, we may come a step closer to understanding suicidality and winning the fight in this scourge of human suffering.展开更多
AIM To compare health-related quality of life(HRQoL),anxiety, depression, and impulsivity scores in patients with and without carcinoid syndrome(CS), and correlated them with serum 5-hydroxyindoleacetic acid(5-HIAA) l...AIM To compare health-related quality of life(HRQoL),anxiety, depression, and impulsivity scores in patients with and without carcinoid syndrome(CS), and correlated them with serum 5-hydroxyindoleacetic acid(5-HIAA) levels.METHODS Patients with advanced gastroenteropancreatic neuroendocrine tumours(GEPNET), with and without CS completed HRQoL QLQ-C30 and QLQ-GI.NET21, Hospital Anxiety and Depression Scale(HADS) and Barratt Impulsivity Scale(BIS) questionnaires. Twosample Wilcoxon test was applied to assess differences in serum 5-HIAA levels, two-sample Mann-Whitney U test for HRQoL and BIS, and proportion test for HADS, between those with and without CS.RESULTS Fifty patients were included; 25 each with and without CS. Median 5-HIAA in patients with and without CS was 367 nmol/L and 86 nmol/L, respectively(P = 0.003). Scores related to endocrine symptoms were significantly higher amongst patients with CS(P = 0.04) and scores for disease-related worries approached significance in the group without CS, but no other statistically-significant differences were reported between patients with and without CS in responses on QLQ-C30 or QLQ-GI.NET21. Fifteen patients(26%) scored ≥ 8/21 on anxiety scale, and 6(12%) scored ≥ 8/21 on depression scale. There was no difference in median 5-HIAA between those scoring < or ≥ 8/21 on anxiety scale(P = 0.53). There were no statistically significant differences between groups in first or second-order factors(BIS) or total sum(P = 0.23).CONCLUSION Excepting endocrine symptoms, there were no significant differences in HRQoL, anxiety, depression or impulsivity between patients with advanced GEPNET, with or without CS. Over one quarter of patients had high anxiety scores, unrelated to peripheral serotonin metabolism.展开更多
A case-control study was conducted to investigate associations between organophosphate pesticide（OP）exposure,aggression,impulsivity,and attempted suicide.Questionnaires were used to collect information;impulsivity a...A case-control study was conducted to investigate associations between organophosphate pesticide（OP）exposure,aggression,impulsivity,and attempted suicide.Questionnaires were used to collect information;impulsivity and aggression were measured by the Barratt Impulsivity Scale（BIS）and the Aggression Inventory（AI）.展开更多
Polyunsaturated fatty acids(PUFAs),particularly the omega-3 PUFAs,are thought to be involved in neuronal processes,to play a role in neurodevelopmental disorders and to be important for the integrity of central nervou...Polyunsaturated fatty acids(PUFAs),particularly the omega-3 PUFAs,are thought to be involved in neuronal processes,to play a role in neurodevelopmental disorders and to be important for the integrity of central nervous system functioning.The present study investigated the effects of nutritional omega-3 PUFAs on attentional functions and impulsive behavior in Wistar rats.For this purpose,female Wistar rats were fed an omega-3 deficient diet over several generations,and the dams of the seventh generation were randomly assigned to two diet groups and fed an omega-3 deficient or an omega-3 sufficient diet.In addition,a group of previously untreated dams was fed an omega-3 sufficient diet.The male offspring of these three diet groups were tested using an established paradigm for the assessment of attention and impulsive behavior,i.e.a modified version of the five-choice-serial-reaction-time task(5CSRTT).The present data show that the deficiency of omega-3 PUFAs over generations led to substantial changes in attentional processes and impulsive behaviors.The impairments associated with an omega-3 deficiency were partly corrected by treatment with the omega-3 sufficient diet in the last generation of the omega-3 deficient group which showed substantial improvements in attention parameters.While there were no significant effects of dietary modifications on psychomotor activity levels,there was some evidence for changes in impulsive behavior.In conclusion,transgenerational dietary changes in the availability of omega-3 PUFAs led to changes in attentional processes and impulsive behavior in rats,supporting the hypothesis that omega-3 PUFAs play a role in cognitive and behavioral processes.The present findings offer a promising approach in the investigation of the role of omega-3 PUFAs in a variety of cognitive and behavioral domains.展开更多
Introduction: Impulsivity in intertemporal choice has been operationalized as “delay discounting,” referring to the preference for a sooner, smaller reward in neuroeconomics. It is reportedly associated with the dop...Introduction: Impulsivity in intertemporal choice has been operationalized as “delay discounting,” referring to the preference for a sooner, smaller reward in neuroeconomics. It is reportedly associated with the dopaminergic systems. Dopamine receptor D2 (DRD2) is the D2 subtype of the dopamine receptor of the G-protein coupled receptor family. The aim of this study was to explore the effect of single nucleotide polymorphisms (SNPs) in DRD2 gene on delay discounting. Methods: The participants consisted of 91 healthy Japanese people (66 males and 25 females with a mean age of 40.9 ± 6.9 years). Each participant completed the Kirby’s monetary choice questionnaire (MCQ) for delayed gain and donated a whole blood sample. Two SNPs (C957T (rs6277) and TaqI A (rs1800497)) in DRD2 were genotyped by using the DigiTag2 assay. SNP linear regression analyses with 100,000 permutations were conducted for the hyperbolic time-discount rate (k). Results: The SNP C957T showed a significant association;participants with more minor alleles (T) were more impulsive in intertemporal choice for delayed gain (multiplicity-corrected P = 0.041 with a small effect size). Conclusion: The variation in the DRD2 gene is associated with impulsive decision-making. This is the first study to demonstrate an association between DRD2 and impulsivity in intertemporal choice with a multiplicity-corrected significance.展开更多
Pathological gambling can be a serious problem, more so to a vulnerable population such as adolescents and youth. This study aims to investigate the links between gambling behaviours and impulsivity through a multidim...Pathological gambling can be a serious problem, more so to a vulnerable population such as adolescents and youth. This study aims to investigate the links between gambling behaviours and impulsivity through a multidimensional approach in a French adolescent population. A secondary aim of this study is to find out the prevalence of pathological gambling behaviour amongst adolescents who are not meant to have legal access to such games. We administered the UPPS Impulsive behaviour Scale (UPPS-P) and the Canadian Pathological Gambling Index CPGI to 1800 adolescents aged between 11 to 17 years. Our results indicate that 33% of subjects have gambled at least once during the last year and that girls gamble as much as boys (17% and 16% respectively). Scratch games are the most common games played by adolescents (81.4%). We also notice that 1.6% of our population has problematic gambling behaviour. Although we found that many dimensions of impulsivity (Urgency, Positive urgency and Sensation seeking) are correlated to gambling behaviour, only sensation seeking seems to be a good predictor of pathological gambling severity. These results can be taken into account in the development of prevention programs.展开更多
This paper is a summary of the studies done on the importance of the cognitive styles especially reflectivity/impulsivity on the process of language acquisition. It discusses the importance of this cognitive style as ...This paper is a summary of the studies done on the importance of the cognitive styles especially reflectivity/impulsivity on the process of language acquisition. It discusses the importance of this cognitive style as an important factor on the effectiveness of awareness raising activities. In the previous studies, the importance of awareness raising has been found as an effective and facilitating factor in the process of the L2 （second language） acquisition, but the effect of different individual factors on its being usefulness has not been focused on; therefore, this study is an attempt to review and explore the importance of one of the individual factors, i.e., being reflective/impulsive cognitive style on the effectiveness of awareness raising activities. It is gathered that learners with different cognitive styles （being reflective/impulsive） react differently to the awareness giving activities, and the study tries to emphasize the importance of this factor on the usefulness of awareness raising and emphasizes the fact that in the field of awareness giving this factor should be attached impotence and accounted for as an effective factor.展开更多
Excessive speed and speeding substantially compromise road safety in Germany and Switzerland.Approximately one third of all fatal accidents are caused by maladjusted speed.Recent studies attribute a special importance...Excessive speed and speeding substantially compromise road safety in Germany and Switzerland.Approximately one third of all fatal accidents are caused by maladjusted speed.Recent studies attribute a special importance to the impulsivity construct in the context of maladaptive road behavior.Thus,the effects of impulsivity on risky driving behaviors(speeding violations)were examined in a Swiss-German sample of N=361 car drivers(both on speed affine drivers and putative ordinary drivers).The participants filled in a questionnaire battery consisting of an impulsiveness scale as well as traffic-related attitudes and cognitive appraisal tendencies on the one hand and indicators for maladaptive behaviors at and beyond traffic domain on the other hand.The directions of the observed correlations between the scales were as expected,with impulsivity correlating negatively with age(young drivers scored higher)but not at all with gender or driving experience.To find out more about the functionality of impulsivity,specific personality profiles were carried out via cluster analysis.Three different control types were empirically found(impulsivity subtype,reduced compliance subtype,vulnerability subtype),while high impulsive drivers scored high in impulsivity,low on compliance,high on affective responsiveness and described themselves as affordance-prone.The impulsive type additionally shows more speeding offences stored in the driving license file,overrides speed limits for more than 15 km/h more frequently and even shows deviancy beyond traffic domain.The results are discussed in the light of the impulse control system and conclusions are drawn regarding assessment of driving aptitude and interventions.The theoretical framework including a hierarchical structured model of deviance was confirmed empirically.展开更多
Evidence is growing that aggressive behavior and impulsivity have subgroups. The subscales of the Urgency, Premeditation, Perseverance and Sensation seeking (UPPS) impulsivity scale and the Bryant and Smith shortened ...Evidence is growing that aggressive behavior and impulsivity have subgroups. The subscales of the Urgency, Premeditation, Perseverance and Sensation seeking (UPPS) impulsivity scale and the Bryant and Smith shortened and refined version of the Aggression Questionnaire were used to describe and compare impulsive and aggressive behavior in extremely violent and aggressive male inmates and non-violent healthy male controls. The Mann-Whitney test showed that there was a significant difference (p < 0. 006) in the total UPPS impulsivity scale scores between the aggressive inmates and the controls. The subscales revealed that this difference was based mainly on the urgency score (p < 0. 003). On the aggression subscales, the inmates scored significantly higher for physical aggression than the controls (p < 0.001), but no significant difference was seen between inmates and controls for verbal aggression, anger and hostility, although the exact p-value was very close to statistical significance at 0.054. Regression analysis revealed a strong relationship between urgency and the aggression subscales hostility (p = 0.0004) and anger (p = 0.003) and that urgency was also linked to symptoms of anxiety (p = 0.008). Finally, a statistically significant link was found between both hostility (p = 0.0003) and anger (p = 0.002) and symptoms of anxiety. The highly selected subgroup of extremely violent criminals in this study were more physically aggressive than non-violent controls, with urgency as the driving feature in their impulsive behavior, and hostility, anger and symptoms of anxiety as underlying traits.展开更多
Objective To explore anxiety and impulsivity in adult female patients with anorexia nervosa(AN),and the relationship with different dimensions of the core clinical symptoms.Methods From June 2014 to October 2022,96 pa...Objective To explore anxiety and impulsivity in adult female patients with anorexia nervosa(AN),and the relationship with different dimensions of the core clinical symptoms.Methods From June 2014 to October 2022,96 patients with AN,from both outpatient clinics andinpatienttwards,wereenrolled from Peking UniversitySixthHospital.Additionally,51 control participants were recruited from the community.Statetrait Anxiety Inventory(STAI)and Barratt Impulsiveness Scale(BIS-11))were used to evaluate the anxiety and impulsivityofeachggroup.TheEatingDisorder Inventory-1(EDI-1)was used to assess clinical and other psychological characteristics of ED.Correlation and regression analysis were employedtoexplore the relationship between anxiety,impulsivity,and core clinical symptoms of eating disorders.Results(1)The total EDI-1 score for the AN group((233.7±48.4)vs.(184.2±30.4),t=7.58,P<0.001)and scores in 7 subscales(Drive for Thinness:t=5.25,P<0.001;Bulimia:t=6.05,P<0.001;Ineffectiveness:t=7.91,P<0.001;Perfectionism:t=3.05,P=0.003;Interpersonal Distrust:t=5.50,P<0.001;Interoceptive Awareness:t=7.00,P<0.001;Maturity Fears:t=2.46,P=0.015)were significantly higher than the control group.(2)The AN group had significantly higher levels of state anxiety(t=8.60,P<0.001),trait anxiety(t=7.40,P<0.001),total impulsivity(t=3.55,P<0.001),attentional impulsiveness(t=2.43,P=0.017)and motor impulsiveness(t=4.29,P<0.001)compared to the control group.(3)Correlation analysis showed that state anxiety,trait anxiety,attentional impulsiveness,motor impulsiveness,and non-planning impulsiveness were positively correlated with the drive for thinness(r=0.522,0.577,0.272,0.387,0.209,allP<0.05);State anxiety,trait anxiety,attentional impulsiveness,motor impulsiveness,and non-planning impulsiveness were also positively correlated with bulimia(r=0.402,0.471,0.304,0.514,0.466,all P<0.01);Attentional impulsiveness,state anxiety,and trait anxiety were positively correlated with body dissatisfaction(r=0.333,0.448,0.409,all P<0.01).Further ridge regression analysis indicated that trait anxiety in AN patients was an influencing factor of the drive for thinness(t=3.13,P=0.002),state anxiety was an influencing factor of body dissatisfaction(t=1.99,P=0.050),and motor impulsiveness and non-planning impulsiveness were the influencing factors of bulimia(t=2.92,2.79,all P<005).Conclusion Patients with anorexia nervosa have higher anxiety and impulsivity,and the levels of anxiety and impulsivity in different dimensions are related to the core clinical symptoms of AN patients.展开更多
Background Previous studies have found that patients with epilepsy are more likely to sufer impulsivity.However,the causal relationship between impulsivity and epilepsy is unknown.In this study,we conduct a bidirectio...Background Previous studies have found that patients with epilepsy are more likely to sufer impulsivity.However,the causal relationship between impulsivity and epilepsy is unknown.In this study,we conduct a bidirectional Mendelian randomization(MR)study to explore the causal relationship between impulsivity and epilepsy with recurrent seizure.Methods Data of the genome-wide association studies(GWAS)on 14 impulsivity traits and epilepsy were obtained from the GWAS catalog and UK Biobank.Inverse-variance weighted(IVW)and weighted median(WM)methods were utilized for MR estimates.IVW,MR-Egger regression,and MR-pleiotropy residual sum and outlier(MR-PRESSO)methods were used to assess heterogeneity and pleiotropy.Results Single-nucleotide polymorphisms(SNPs)related to the lack of perseverance were associated with a decreased risk of epilepsy with recurrent seizures according to the results of IVW(odd ratio[OR]=0.93,95%confdent interval[CI]=0.90-0.97,P=0.001)and WM(OR=0.93,95%CI=0.87-0.98,P=0.007).Meanwhile,heterogeneity was not observed with a Cochran Q-derived P value of 0.819 for MR egger and a P value of 0.808 for IVW.Pleiotropy was not found according to the MR-PRESSO(P=0.273).The other 13 impulsivity traits had no causal efect on epilepsy with recurrent seizures.Meanwhile,SNPs related with epilepsy with recurrent seizures had no causal efect on the 14 impulsivity traits.Conclusions This MR study suggests that lack of perseverance may be a protective factor against epilepsy with recurrent seizures.However,epilepsy with recurrent seizures does not afect impulsivity.展开更多
Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate...Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate this impulse game problem with the modified objective function including interaction costs among the players in a discontinuous fashion,and subsequently,to derive a verification theorem for identifying the feedback Nash equilibrium strategy.展开更多
While the moisture content of soil affects significantly the blast impulse of shallow buried explosives,the role of surface-covering water(SCW)on soil in such blast impulse remains elusive.A combined experimental and ...While the moisture content of soil affects significantly the blast impulse of shallow buried explosives,the role of surface-covering water(SCW)on soil in such blast impulse remains elusive.A combined experimental and numerical study has been carried out to characterize the effect of SCW on transferred impulse and loading magnitude of shallow buried explosives.Firstly,blast tests of shallow buried explosives were conducted,with and without the SCW,to quantitatively assess the blast loading impulse.Subsequently,finite element(FE)simulations were performed and validated against experimental measurement,with good agreement achieved.The validated FE model was then employed to predict the dynamic response of a fully-clamped metallic circular target,subjected to the explosive impact of shallow buried explosives with SCW,and explore the corresponding physical mechanisms.It was demonstrated that shallow buried explosives in saturated soil generate a greater impulse transferred towards the target relative to those in dry soil.The deformation displacement of the target plate is doubled.Increasing the height of SCW results in enhanced center peak deflection of the loaded target,accompanied by subsequent fall,due to the variation of deformation pattern of the loaded target from concentrated load to uniform load.Meanwhile,the presence of SCW increases the blast impulse transferred towards the target by three times.In addition,there exists a threshold value of the burial depth that maximizes the impact impulse.This threshold exhibits a strong sensitivity to SCW height,decreasing with increasing SCW height.An empirical formula for predicting threshold has been provided.Similar conclusions can be drawn for different explosive masses.The results provide technical guidance on blast loading intensity and its spatial distribution considering shallow buried explosives in coast-land battlefields,which can ultimately contribute to better protective designs.展开更多
The problem of collision avoidance for non-cooperative targets has received significant attention from researchers in recent years.Non-cooperative targets exhibit uncertain states and unpredictable behaviors,making co...The problem of collision avoidance for non-cooperative targets has received significant attention from researchers in recent years.Non-cooperative targets exhibit uncertain states and unpredictable behaviors,making collision avoidance significantly more challenging than that for space debris.Much existing research focuses on the continuous thrust model,whereas the impulsive maneuver model is more appropriate for long-duration and long-distance avoidance missions.Additionally,it is important to minimize the impact on the original mission while avoiding noncooperative targets.On the other hand,the existing avoidance algorithms are computationally complex and time-consuming especially with the limited computing capability of the on-board computer,posing challenges for practical engineering applications.To conquer these difficulties,this paper makes the following key contributions:(A)a turn-based(sequential decision-making)limited-area impulsive collision avoidance model considering the time delay of precision orbit determination is established for the first time;(B)a novel Selection Probability Learning Adaptive Search-depth Search Tree(SPL-ASST)algorithm is proposed for non-cooperative target avoidance,which improves the decision-making efficiency by introducing an adaptive-search-depth mechanism and a neural network into the traditional Monte Carlo Tree Search(MCTS).Numerical simulations confirm the effectiveness and efficiency of the proposed method.展开更多
Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other fields.Two-dimensional material-based filed effect transistor(2D-FET)sensors are competitive ...Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other fields.Two-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate response.However,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of time.Herein we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor application.We systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 nW.The sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on it.Moreover,there was almost no performance loss for the device as left in the air for two months.展开更多
The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding sto...The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding stochastic and impulse. For the stochastic model without impulses, the existence and uniqueness of solution, and the existence of positive periodic solutions are proved, and a sufficient condition for strategy extinction is given. For the stochastic model with impulses, the existence of positive periodic solutions is proved. Numerical results show that noise and impulses directly affect the model, but the periodicity of the model does not change.展开更多
Deficits in the impulse control system are an important predictor of energy intake and body weight.Adults classified as overweight to obese may possess these deficits as a general behavioral trait or they may be foods...Deficits in the impulse control system are an important predictor of energy intake and body weight.Adults classified as overweight to obese may possess these deficits as a general behavioral trait or they may be foodspecific.The present study assessed motor impulsivity(ability to suppress a pre-potent response)when presented with food and neutral(non-food)cues,testing if deficits in motor impulsivity is specific to food cues or a general trait among participants classified as overweight to obese.The proportion of inhibitory failures to no-go targets following food cues(10.8%)was significantly greater than the proportion of inhibitory failures to no-go targets following neutral cues(1.9%,p<0.001).These differences remained when covering for sex and hunger.This indicates deficits in food-specific impulse control(as opposed to general impulse control)are present in those classified as overweight to obese.Understanding the specific aspect of impulse control that is present in this population is needed for the development of future impulse control training interventions that seek to change eating behaviors as a means for weight control.展开更多
Dear Editor,This letter studies finite-time stability (FTS) of impulsive and switched hybrid systems with delay-dependent impulses. Some conditions, based on Lyapunov method, are proposed for ensuring FTS and estimati...Dear Editor,This letter studies finite-time stability (FTS) of impulsive and switched hybrid systems with delay-dependent impulses. Some conditions, based on Lyapunov method, are proposed for ensuring FTS and estimating settling-time function (STF) of the hybrid systems.When switching dynamics are FTS and impulsive dynamics involve destabilizing delay-dependent impulses, the FTS is retained if the impulses occur infrequently.展开更多
基金supported by the National Natural Science Foundation(81471353)the National Basic Research Program of China(2015CB553500)the Science Fund for Creative Research Groups from of National Natural Science Foundation of China(81521063)
文摘The thalamus and central dopamine signaling have been shown to play important roles in high-level cognitive processes including impulsivity. However, little is known about the role of dopamine receptors in the thalamus in decisional impulsivity. In the present study,rats were tested using a delay discounting task and divided into three groups： high impulsivity（HI）, medium impulsivity（MI）, and low impulsivity（LI）. Subsequent in vivo voxel-based magnetic resonance imaging revealed that the HI rats displayed a markedly reduced density of gray matter in the lateral thalamus compared with the LI rats. In the MI rats, the dopamine D1 receptor antagonist SCH23390 or the D2 receptor antagonist eticlopride was microinjected into the lateral thalamus. SCH23390 significantly decreased their choice of a large, delayed reward and increased their omission of lever presses. In contrast,eticlopride increased the choice of a large, delayed reward but had no effect on the omissions. Together, our results indicate that the lateral thalamus is involved in decisional impulsivity, and dopamine D1 and D2 receptors in the lateral thalamus have distinct effects on decisional impulsive behaviors in rats. These results provide a new insightinto the dopamine signaling in the lateral thalamus in decisional impulsivity.
文摘Suicide risk constitutes a complex set of interacting demographic, clinical, psychobiological and environmental variables. Impulsivity is a long-known risk factor for suicide attempts. However, research based on clearer conceptual refinement in this area is imperative. One emerging field of study is that of decision-making. Impulsivity involves a failure of higher-order control, including decision-making. Using standardized operational definitions that take into consideration relevant aspects of impulsivity, including state- and trait-components and a deeper understanding of the process of decision-making in the suicidal mind, we may come a step closer to understanding suicidality and winning the fight in this scourge of human suffering.
文摘AIM To compare health-related quality of life(HRQoL),anxiety, depression, and impulsivity scores in patients with and without carcinoid syndrome(CS), and correlated them with serum 5-hydroxyindoleacetic acid(5-HIAA) levels.METHODS Patients with advanced gastroenteropancreatic neuroendocrine tumours(GEPNET), with and without CS completed HRQoL QLQ-C30 and QLQ-GI.NET21, Hospital Anxiety and Depression Scale(HADS) and Barratt Impulsivity Scale(BIS) questionnaires. Twosample Wilcoxon test was applied to assess differences in serum 5-HIAA levels, two-sample Mann-Whitney U test for HRQoL and BIS, and proportion test for HADS, between those with and without CS.RESULTS Fifty patients were included; 25 each with and without CS. Median 5-HIAA in patients with and without CS was 367 nmol/L and 86 nmol/L, respectively(P = 0.003). Scores related to endocrine symptoms were significantly higher amongst patients with CS(P = 0.04) and scores for disease-related worries approached significance in the group without CS, but no other statistically-significant differences were reported between patients with and without CS in responses on QLQ-C30 or QLQ-GI.NET21. Fifteen patients(26%) scored ≥ 8/21 on anxiety scale, and 6(12%) scored ≥ 8/21 on depression scale. There was no difference in median 5-HIAA between those scoring < or ≥ 8/21 on anxiety scale(P = 0.53). There were no statistically significant differences between groups in first or second-order factors(BIS) or total sum(P = 0.23).CONCLUSION Excepting endocrine symptoms, there were no significant differences in HRQoL, anxiety, depression or impulsivity between patients with advanced GEPNET, with or without CS. Over one quarter of patients had high anxiety scores, unrelated to peripheral serotonin metabolism.
基金partially supported by the Colorado Injury Control Research Center Grant Number 5R49CE001168 from the Centers for Disease Control and Preventionthe USA-China Agricultural Injury Research Training Project Grant Number 5DW43TW007257 from the National Institutes of Health,Fogarty International Center
文摘A case-control study was conducted to investigate associations between organophosphate pesticide（OP）exposure,aggression,impulsivity,and attempted suicide.Questionnaires were used to collect information;impulsivity and aggression were measured by the Barratt Impulsivity Scale（BIS）and the Aggression Inventory（AI）.
文摘Polyunsaturated fatty acids(PUFAs),particularly the omega-3 PUFAs,are thought to be involved in neuronal processes,to play a role in neurodevelopmental disorders and to be important for the integrity of central nervous system functioning.The present study investigated the effects of nutritional omega-3 PUFAs on attentional functions and impulsive behavior in Wistar rats.For this purpose,female Wistar rats were fed an omega-3 deficient diet over several generations,and the dams of the seventh generation were randomly assigned to two diet groups and fed an omega-3 deficient or an omega-3 sufficient diet.In addition,a group of previously untreated dams was fed an omega-3 sufficient diet.The male offspring of these three diet groups were tested using an established paradigm for the assessment of attention and impulsive behavior,i.e.a modified version of the five-choice-serial-reaction-time task(5CSRTT).The present data show that the deficiency of omega-3 PUFAs over generations led to substantial changes in attentional processes and impulsive behaviors.The impairments associated with an omega-3 deficiency were partly corrected by treatment with the omega-3 sufficient diet in the last generation of the omega-3 deficient group which showed substantial improvements in attention parameters.While there were no significant effects of dietary modifications on psychomotor activity levels,there was some evidence for changes in impulsive behavior.In conclusion,transgenerational dietary changes in the availability of omega-3 PUFAs led to changes in attentional processes and impulsive behavior in rats,supporting the hypothesis that omega-3 PUFAs play a role in cognitive and behavioral processes.The present findings offer a promising approach in the investigation of the role of omega-3 PUFAs in a variety of cognitive and behavioral domains.
文摘Introduction: Impulsivity in intertemporal choice has been operationalized as “delay discounting,” referring to the preference for a sooner, smaller reward in neuroeconomics. It is reportedly associated with the dopaminergic systems. Dopamine receptor D2 (DRD2) is the D2 subtype of the dopamine receptor of the G-protein coupled receptor family. The aim of this study was to explore the effect of single nucleotide polymorphisms (SNPs) in DRD2 gene on delay discounting. Methods: The participants consisted of 91 healthy Japanese people (66 males and 25 females with a mean age of 40.9 ± 6.9 years). Each participant completed the Kirby’s monetary choice questionnaire (MCQ) for delayed gain and donated a whole blood sample. Two SNPs (C957T (rs6277) and TaqI A (rs1800497)) in DRD2 were genotyped by using the DigiTag2 assay. SNP linear regression analyses with 100,000 permutations were conducted for the hyperbolic time-discount rate (k). Results: The SNP C957T showed a significant association;participants with more minor alleles (T) were more impulsive in intertemporal choice for delayed gain (multiplicity-corrected P = 0.041 with a small effect size). Conclusion: The variation in the DRD2 gene is associated with impulsive decision-making. This is the first study to demonstrate an association between DRD2 and impulsivity in intertemporal choice with a multiplicity-corrected significance.
文摘Pathological gambling can be a serious problem, more so to a vulnerable population such as adolescents and youth. This study aims to investigate the links between gambling behaviours and impulsivity through a multidimensional approach in a French adolescent population. A secondary aim of this study is to find out the prevalence of pathological gambling behaviour amongst adolescents who are not meant to have legal access to such games. We administered the UPPS Impulsive behaviour Scale (UPPS-P) and the Canadian Pathological Gambling Index CPGI to 1800 adolescents aged between 11 to 17 years. Our results indicate that 33% of subjects have gambled at least once during the last year and that girls gamble as much as boys (17% and 16% respectively). Scratch games are the most common games played by adolescents (81.4%). We also notice that 1.6% of our population has problematic gambling behaviour. Although we found that many dimensions of impulsivity (Urgency, Positive urgency and Sensation seeking) are correlated to gambling behaviour, only sensation seeking seems to be a good predictor of pathological gambling severity. These results can be taken into account in the development of prevention programs.
文摘This paper is a summary of the studies done on the importance of the cognitive styles especially reflectivity/impulsivity on the process of language acquisition. It discusses the importance of this cognitive style as an important factor on the effectiveness of awareness raising activities. In the previous studies, the importance of awareness raising has been found as an effective and facilitating factor in the process of the L2 （second language） acquisition, but the effect of different individual factors on its being usefulness has not been focused on; therefore, this study is an attempt to review and explore the importance of one of the individual factors, i.e., being reflective/impulsive cognitive style on the effectiveness of awareness raising activities. It is gathered that learners with different cognitive styles （being reflective/impulsive） react differently to the awareness giving activities, and the study tries to emphasize the importance of this factor on the usefulness of awareness raising and emphasizes the fact that in the field of awareness giving this factor should be attached impotence and accounted for as an effective factor.
文摘Excessive speed and speeding substantially compromise road safety in Germany and Switzerland.Approximately one third of all fatal accidents are caused by maladjusted speed.Recent studies attribute a special importance to the impulsivity construct in the context of maladaptive road behavior.Thus,the effects of impulsivity on risky driving behaviors(speeding violations)were examined in a Swiss-German sample of N=361 car drivers(both on speed affine drivers and putative ordinary drivers).The participants filled in a questionnaire battery consisting of an impulsiveness scale as well as traffic-related attitudes and cognitive appraisal tendencies on the one hand and indicators for maladaptive behaviors at and beyond traffic domain on the other hand.The directions of the observed correlations between the scales were as expected,with impulsivity correlating negatively with age(young drivers scored higher)but not at all with gender or driving experience.To find out more about the functionality of impulsivity,specific personality profiles were carried out via cluster analysis.Three different control types were empirically found(impulsivity subtype,reduced compliance subtype,vulnerability subtype),while high impulsive drivers scored high in impulsivity,low on compliance,high on affective responsiveness and described themselves as affordance-prone.The impulsive type additionally shows more speeding offences stored in the driving license file,overrides speed limits for more than 15 km/h more frequently and even shows deviancy beyond traffic domain.The results are discussed in the light of the impulse control system and conclusions are drawn regarding assessment of driving aptitude and interventions.The theoretical framework including a hierarchical structured model of deviance was confirmed empirically.
文摘Evidence is growing that aggressive behavior and impulsivity have subgroups. The subscales of the Urgency, Premeditation, Perseverance and Sensation seeking (UPPS) impulsivity scale and the Bryant and Smith shortened and refined version of the Aggression Questionnaire were used to describe and compare impulsive and aggressive behavior in extremely violent and aggressive male inmates and non-violent healthy male controls. The Mann-Whitney test showed that there was a significant difference (p < 0. 006) in the total UPPS impulsivity scale scores between the aggressive inmates and the controls. The subscales revealed that this difference was based mainly on the urgency score (p < 0. 003). On the aggression subscales, the inmates scored significantly higher for physical aggression than the controls (p < 0.001), but no significant difference was seen between inmates and controls for verbal aggression, anger and hostility, although the exact p-value was very close to statistical significance at 0.054. Regression analysis revealed a strong relationship between urgency and the aggression subscales hostility (p = 0.0004) and anger (p = 0.003) and that urgency was also linked to symptoms of anxiety (p = 0.008). Finally, a statistically significant link was found between both hostility (p = 0.0003) and anger (p = 0.002) and symptoms of anxiety. The highly selected subgroup of extremely violent criminals in this study were more physically aggressive than non-violent controls, with urgency as the driving feature in their impulsive behavior, and hostility, anger and symptoms of anxiety as underlying traits.
文摘Objective To explore anxiety and impulsivity in adult female patients with anorexia nervosa(AN),and the relationship with different dimensions of the core clinical symptoms.Methods From June 2014 to October 2022,96 patients with AN,from both outpatient clinics andinpatienttwards,wereenrolled from Peking UniversitySixthHospital.Additionally,51 control participants were recruited from the community.Statetrait Anxiety Inventory(STAI)and Barratt Impulsiveness Scale(BIS-11))were used to evaluate the anxiety and impulsivityofeachggroup.TheEatingDisorder Inventory-1(EDI-1)was used to assess clinical and other psychological characteristics of ED.Correlation and regression analysis were employedtoexplore the relationship between anxiety,impulsivity,and core clinical symptoms of eating disorders.Results(1)The total EDI-1 score for the AN group((233.7±48.4)vs.(184.2±30.4),t=7.58,P<0.001)and scores in 7 subscales(Drive for Thinness:t=5.25,P<0.001;Bulimia:t=6.05,P<0.001;Ineffectiveness:t=7.91,P<0.001;Perfectionism:t=3.05,P=0.003;Interpersonal Distrust:t=5.50,P<0.001;Interoceptive Awareness:t=7.00,P<0.001;Maturity Fears:t=2.46,P=0.015)were significantly higher than the control group.(2)The AN group had significantly higher levels of state anxiety(t=8.60,P<0.001),trait anxiety(t=7.40,P<0.001),total impulsivity(t=3.55,P<0.001),attentional impulsiveness(t=2.43,P=0.017)and motor impulsiveness(t=4.29,P<0.001)compared to the control group.(3)Correlation analysis showed that state anxiety,trait anxiety,attentional impulsiveness,motor impulsiveness,and non-planning impulsiveness were positively correlated with the drive for thinness(r=0.522,0.577,0.272,0.387,0.209,allP<0.05);State anxiety,trait anxiety,attentional impulsiveness,motor impulsiveness,and non-planning impulsiveness were also positively correlated with bulimia(r=0.402,0.471,0.304,0.514,0.466,all P<0.01);Attentional impulsiveness,state anxiety,and trait anxiety were positively correlated with body dissatisfaction(r=0.333,0.448,0.409,all P<0.01).Further ridge regression analysis indicated that trait anxiety in AN patients was an influencing factor of the drive for thinness(t=3.13,P=0.002),state anxiety was an influencing factor of body dissatisfaction(t=1.99,P=0.050),and motor impulsiveness and non-planning impulsiveness were the influencing factors of bulimia(t=2.92,2.79,all P<005).Conclusion Patients with anorexia nervosa have higher anxiety and impulsivity,and the levels of anxiety and impulsivity in different dimensions are related to the core clinical symptoms of AN patients.
文摘Background Previous studies have found that patients with epilepsy are more likely to sufer impulsivity.However,the causal relationship between impulsivity and epilepsy is unknown.In this study,we conduct a bidirectional Mendelian randomization(MR)study to explore the causal relationship between impulsivity and epilepsy with recurrent seizure.Methods Data of the genome-wide association studies(GWAS)on 14 impulsivity traits and epilepsy were obtained from the GWAS catalog and UK Biobank.Inverse-variance weighted(IVW)and weighted median(WM)methods were utilized for MR estimates.IVW,MR-Egger regression,and MR-pleiotropy residual sum and outlier(MR-PRESSO)methods were used to assess heterogeneity and pleiotropy.Results Single-nucleotide polymorphisms(SNPs)related to the lack of perseverance were associated with a decreased risk of epilepsy with recurrent seizures according to the results of IVW(odd ratio[OR]=0.93,95%confdent interval[CI]=0.90-0.97,P=0.001)and WM(OR=0.93,95%CI=0.87-0.98,P=0.007).Meanwhile,heterogeneity was not observed with a Cochran Q-derived P value of 0.819 for MR egger and a P value of 0.808 for IVW.Pleiotropy was not found according to the MR-PRESSO(P=0.273).The other 13 impulsivity traits had no causal efect on epilepsy with recurrent seizures.Meanwhile,SNPs related with epilepsy with recurrent seizures had no causal efect on the 14 impulsivity traits.Conclusions This MR study suggests that lack of perseverance may be a protective factor against epilepsy with recurrent seizures.However,epilepsy with recurrent seizures does not afect impulsivity.
基金supported in part by the National Natural Science Foundation of China(62173051)the Fundamental Research Funds for the Central Universities(2024CDJCGJ012,2023CDJXY-010)+1 种基金the Chongqing Technology Innovation and Application Development Special Key Project(CSTB2022TIADCUX0015,CSTB2022TIAD-KPX0162)the China Postdoctoral Science Foundation(2024M763865)
文摘Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate this impulse game problem with the modified objective function including interaction costs among the players in a discontinuous fashion,and subsequently,to derive a verification theorem for identifying the feedback Nash equilibrium strategy.
基金supported by the National Natural Science Foundation of China(Grant Nos.12002156,11972185,12372136)Research Fund of State Key Laboratory of Mechanics and Control for Aerospace Structures(Grant No.MCMS-I-0222K01)。
文摘While the moisture content of soil affects significantly the blast impulse of shallow buried explosives,the role of surface-covering water(SCW)on soil in such blast impulse remains elusive.A combined experimental and numerical study has been carried out to characterize the effect of SCW on transferred impulse and loading magnitude of shallow buried explosives.Firstly,blast tests of shallow buried explosives were conducted,with and without the SCW,to quantitatively assess the blast loading impulse.Subsequently,finite element(FE)simulations were performed and validated against experimental measurement,with good agreement achieved.The validated FE model was then employed to predict the dynamic response of a fully-clamped metallic circular target,subjected to the explosive impact of shallow buried explosives with SCW,and explore the corresponding physical mechanisms.It was demonstrated that shallow buried explosives in saturated soil generate a greater impulse transferred towards the target relative to those in dry soil.The deformation displacement of the target plate is doubled.Increasing the height of SCW results in enhanced center peak deflection of the loaded target,accompanied by subsequent fall,due to the variation of deformation pattern of the loaded target from concentrated load to uniform load.Meanwhile,the presence of SCW increases the blast impulse transferred towards the target by three times.In addition,there exists a threshold value of the burial depth that maximizes the impact impulse.This threshold exhibits a strong sensitivity to SCW height,decreasing with increasing SCW height.An empirical formula for predicting threshold has been provided.Similar conclusions can be drawn for different explosive masses.The results provide technical guidance on blast loading intensity and its spatial distribution considering shallow buried explosives in coast-land battlefields,which can ultimately contribute to better protective designs.
基金co-supported by the Foundation of Shanghai Astronautics Science and Technology Innovation,China(No.SAST2022-114)the National Natural Science Foundation of China(No.62303378),the National Natural Science Foundation of China(Nos.124B2031,12202281)the Foundation of China National Key Laboratory of Science and Technology on Test Physics&Numerical Mathematics,China(No.08-YY-2023-R11)。
文摘The problem of collision avoidance for non-cooperative targets has received significant attention from researchers in recent years.Non-cooperative targets exhibit uncertain states and unpredictable behaviors,making collision avoidance significantly more challenging than that for space debris.Much existing research focuses on the continuous thrust model,whereas the impulsive maneuver model is more appropriate for long-duration and long-distance avoidance missions.Additionally,it is important to minimize the impact on the original mission while avoiding noncooperative targets.On the other hand,the existing avoidance algorithms are computationally complex and time-consuming especially with the limited computing capability of the on-board computer,posing challenges for practical engineering applications.To conquer these difficulties,this paper makes the following key contributions:(A)a turn-based(sequential decision-making)limited-area impulsive collision avoidance model considering the time delay of precision orbit determination is established for the first time;(B)a novel Selection Probability Learning Adaptive Search-depth Search Tree(SPL-ASST)algorithm is proposed for non-cooperative target avoidance,which improves the decision-making efficiency by introducing an adaptive-search-depth mechanism and a neural network into the traditional Monte Carlo Tree Search(MCTS).Numerical simulations confirm the effectiveness and efficiency of the proposed method.
基金financially supported by the National Natural Science Foundation of China(Nos.52272160,U2330112,and 52002254)Sichuan Science and Technology Foundation(Nos.2020YJ0262,2021YFH0127,2022YFH0083,2022YFSY0045,and 2023YFSY0002)+1 种基金the Chunhui Plan of Ministry of Education,Fundamental Research Funds for the Central Universities,China(No.YJ201893)the Foundation of Key Laboratory of Lidar and Device,Sichuan Province,China(No.LLD2023-006)。
文摘Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other fields.Two-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate response.However,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of time.Herein we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor application.We systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 nW.The sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on it.Moreover,there was almost no performance loss for the device as left in the air for two months.
基金Supported by the National Natural Science Foundation of China(10671182)。
文摘The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding stochastic and impulse. For the stochastic model without impulses, the existence and uniqueness of solution, and the existence of positive periodic solutions are proved, and a sufficient condition for strategy extinction is given. For the stochastic model with impulses, the existence of positive periodic solutions is proved. Numerical results show that noise and impulses directly affect the model, but the periodicity of the model does not change.
文摘Deficits in the impulse control system are an important predictor of energy intake and body weight.Adults classified as overweight to obese may possess these deficits as a general behavioral trait or they may be foodspecific.The present study assessed motor impulsivity(ability to suppress a pre-potent response)when presented with food and neutral(non-food)cues,testing if deficits in motor impulsivity is specific to food cues or a general trait among participants classified as overweight to obese.The proportion of inhibitory failures to no-go targets following food cues(10.8%)was significantly greater than the proportion of inhibitory failures to no-go targets following neutral cues(1.9%,p<0.001).These differences remained when covering for sex and hunger.This indicates deficits in food-specific impulse control(as opposed to general impulse control)are present in those classified as overweight to obese.Understanding the specific aspect of impulse control that is present in this population is needed for the development of future impulse control training interventions that seek to change eating behaviors as a means for weight control.
基金supported by the National Natural Science Foundation of China(61833005)
文摘Dear Editor,This letter studies finite-time stability (FTS) of impulsive and switched hybrid systems with delay-dependent impulses. Some conditions, based on Lyapunov method, are proposed for ensuring FTS and estimating settling-time function (STF) of the hybrid systems.When switching dynamics are FTS and impulsive dynamics involve destabilizing delay-dependent impulses, the FTS is retained if the impulses occur infrequently.
