Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and a...Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.展开更多
Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working...Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working memory,and emotional regulation,is notably impaired in this condition.This review consolidates current insights into the role of PFC dysfunction in schizophrenia,with a focus on its implications for therapeutic strategies.The neuroanatomical and neurobiological foundations of PFC dysfunction are explored,emphasizing structural abnormalities,functional dysconnectivity,and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making.Clinical implications are discussed,particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms.Additionally,pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options.In conclusion,a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments,and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.展开更多
Anopheles(An.)stephensi is one of the dominant malaria vectors in India,Bangladesh,Pakistan,Iran,Iraq and some other Asian countries[1].It plays a crucial role in transmitting Plasmodium falciparum and Plasmodium viva...Anopheles(An.)stephensi is one of the dominant malaria vectors in India,Bangladesh,Pakistan,Iran,Iraq and some other Asian countries[1].It plays a crucial role in transmitting Plasmodium falciparum and Plasmodium vivax in India along with its rural counterpart,An.culicifacies.This mosquito species has adapted well to urban and peri-urban environments,making it a significant public health concern in the country.The presence of An.stephensi in urban areas contrasts with other malaria vectors that predominantly inhabit rural regions,thus complicating traditional malaria control strategies.It is well-adapted to human-made environments,breeding in various containers including tanks,cisterns,and barrels used for water storage.展开更多
The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farml...The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farmland in subtropical regions.In this study,we investigated the properties of iron oxide and its environmental implications in the farmland of Meizhou city,Guangdong province.The results showed that farmland soils had higher magnetism than the red soils developed from the same metamorphic rock.The red soils displayed significantly higher concentrations of goethite and hematite than the farmland soils.The dominant factor influencing the magnetic changes in farmland and red soils was the concentration of fine-grained ferromagnetic minerals.Red soil magnetism is an indicator of soil weathering intensity,whereas farmland soil magnetism is closely related to human cultivation activities.In contrast to the red soils,the farmland soils lacked the pronounced transformation of ferromagnetic minerals into hematite and goethite.A vigorous oxidation process catalyzes the transformation of strong magnetic minerals into significant amounts of hematite and goethite,which promotes the reduced magnetism of red soils.The conversion of red soils into farmland soils initially increased the accumulation of ferromagnetic materials due to cultivation processes.However,long-term cultivation led to the gradual loss of fine-grained ferromagnetic minerals,while goethite and lepidocrocite became the dominant magnetic mineral types.展开更多
It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.The...It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.Therefore,the use of e cigarettes should not be encouraged as an alternative and pragmatic measure should be taken to profess this agenda.展开更多
Rapid technological advancements are driving embodied intelligent robots from laboratories to real-life applications to serve as a key force reshaping the future way of life.Like many other revolutionary technologies,...Rapid technological advancements are driving embodied intelligent robots from laboratories to real-life applications to serve as a key force reshaping the future way of life.Like many other revolutionary technologies,while sparking utopian visions of the future,the development of embodied intelligence has aroused concerns about safety risks, emotional ethics, and socio-cultural implications.展开更多
Introduction Small cell lung cancer(SCLC)is a highly aggressive malignancy with limited treatment options.Despite advances in immunotherapy,response rates remain low,and the efficacy of current molecular subtyping1,2 ...Introduction Small cell lung cancer(SCLC)is a highly aggressive malignancy with limited treatment options.Despite advances in immunotherapy,response rates remain low,and the efficacy of current molecular subtyping1,2 is insufficient to predict therapeutic outcomes3,4.A recently identified vulnerability in SCLC involves the dysregulation of nuclear-cytoplasmic transport,particularly through exportin 1(XPO1)5-7.展开更多
Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’p...Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’professional development and is also a crucial issue in teacher education research.From a global perspective,this study systematically reviews and examines relevant research on the professional identity of international Chinese language teachers(ICLTs).A comparative analysis is conducted between Chinese and foreign scholars’research in terms of theoretical foundations,research subjects,research content,and research methodologies.This comprehensive overview of the current research landscape in this field,along with a summary of existing achievements and identified problems,facilitates the transformation of fragmented research findings on ICLTs’professional identity into a systematic understanding and reveals research gaps.Building upon this foundation,the study proposes future research prospects for the professional identity of ICLTs from aspects such as the construction of a cross-cultural perspective-based teacher professional identity system,the transformation of teacher professional identity in the context of digital transformation,and case studies on ICLTs’professional identity.The aim is to promote high-quality development in both theory and practice of international Chinese language education.展开更多
The global aging crisis has increased the prevalence of skeletal disorders,necessitating innovative therapeutic strategies.This review employs the brain-bone axis(BBA)framework to examine the role of the sympathetic n...The global aging crisis has increased the prevalence of skeletal disorders,necessitating innovative therapeutic strategies.This review employs the brain-bone axis(BBA)framework to examine the role of the sympathetic nervous system(SNS)in bone metabolism.The research systematically elucidates the molecular mechanisms by which the SNS mediates signaling pathways through neurofibers and neurotransmitters,such as norepinephrine,dopamine,neuropeptide Y,and leptin,regulating interactions between bone-related cells to maintain skeletal homeostasis.It also identifies the pathological associations between the dysregulation of these pathways and the progression of bone-related conditions,such as osteoporosis,osteoarthritis,and intervertebral disc degeneration.By integrating current evidence,we identify novel therapeutic targets within the BBA and propose neuro-centric intervention strategies to mitigate skeletal diseases.This review deepens the understanding of neuro-skeletal interactions and lays a foundation for innovative treatments for bone-related pathologies.展开更多
This multidisciplinary study integrates structural and cave mapping,3D geological modeling,and Geographical Information System(GIS)analysis to provide constraints of the hydrogeological model for the central Lefka Ori...This multidisciplinary study integrates structural and cave mapping,3D geological modeling,and Geographical Information System(GIS)analysis to provide constraints of the hydrogeological model for the central Lefka Ori Massif.Through 44 km of linear mapping,we discovered the new mid-Miocene Pachnes Thrust(PT)which plays a key role in the central Lefka Ori Massif structural framework.展开更多
The relationship between heaven and humanity is one of the fundamental philosophical foundations of ecological ethics in ancient Chinese Confucian thought.As a master of Confucian philosophy of mind,Wang Yangming inte...The relationship between heaven and humanity is one of the fundamental philosophical foundations of ecological ethics in ancient Chinese Confucian thought.As a master of Confucian philosophy of mind,Wang Yangming integrated the traditional Confucian discourse on the relationship between heaven and humanity into the principles of the philosophy of mind.Building on the traditional doctrine of benevolence centered on moral concern,he further developed an ecological view of‘benevolence as the unity of heaven and earth’.In his work Inquiry on the Great Learning,Wang Yangming systematically elaborated on this notion,emphasizing the philosophical expression of the relationship between humans and nature within an ethical framework and outlining the new implications of traditional Confucian ecological thought.This paper aims to analyze Wang Yangming’s ecological view of‘benevolence as the unity of heaven and earth’by examining the ecological ideas in his Inquiry on the Great Learning.On this basis,it seeks to refine the valuable achievements of traditional Chinese ecological civilization thought and strengthen the theoretical foundation of contemporary ecological ideas with Chinese characteristics.展开更多
Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functio...Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functions,(light)interval-valued pre-t-norms were initially proposed by Wang and Hu,but their properties were not further discussed by the authors.The main purpose of this paper is to study in depth the properties and generation of(light)intervalvalued pre-t-norms.Firstly,several properties of(light)interval-valued pre-t-norms and their relationship with(light)pre-t-norms are presented.Then,two different generation methods for(light)interval-valued pre-t-norms are introduced.Finally,it demonstrates a specific application of(light)interval-valued pre-t-norms in constructing interval-valued directional monotonic fuzzy implications,namely,using the(light)interval-valued pre-t-norm IT,interval-valued fuzzy negations IN,and(light)interval-valued pre-t-conorm IS to construct interval-valued QL-directional monotonic operations.展开更多
Although the late Quaternary slip rate of the Northern Margin Fault of the Huaizhuo Basin(NFHB)was studied approximately 30 years ago using thermoluminescence and geomorphic methods,the underlying uncertainty cannot b...Although the late Quaternary slip rate of the Northern Margin Fault of the Huaizhuo Basin(NFHB)was studied approximately 30 years ago using thermoluminescence and geomorphic methods,the underlying uncertainty cannot be neglected,considering the limitations resulting from age and displacement measurements.Accordingly,we attempted to re-estimate the late Quaternary slip rate of the NFHB using high-precision remote sensing image interpretation,large-scale geological and geomorphic mapping,paleoseismic analysis,and Quaternary geochronology testing.The results,based on stratigraphic dislocation and age constraint in the trenches,show that the present deformation of the NFHB has been dominated by the extension,with a vertical slip rate~0.04-0.11 mm/a.We estimate a vertical slip rate of~0.06 mm/a,with an R^(2) value of~0.91,which is much lower than the~0.5 mm/a result estimated previously.There are three possible reasons for this discrepancy.The first is the limitation resulting from dating and displacement measurements in earlier studies;the second is the slip decomposition caused by multiple branches of the NFHB,which leads to the low slip rate observed at a single fault;and third possible explanation is that the fault may be locked at present with a low slip rate,which means that the earthquake hazard of the NFHB cannot be ignored,and more in-depth research,such as geodetic and intensive observations of earthquake precursors,is urgently needed.This discovery poses a new challenge for the active study of the NFHB and the northeast corner of the Ordos Plateau in the North China Block.展开更多
Many eukaryotic genes are members of multi-gene families due to gene duplications, which generate new copies that allow functional divergence. However, the relationship between
Over past decades,takotsubo cardiomyopathy(TTC)has drawn a substantial interest as a unique form of acute and reversible cardiomyopathy that usually emerges in response to adrenergic hyperactivation associated with a ...Over past decades,takotsubo cardiomyopathy(TTC)has drawn a substantial interest as a unique form of acute and reversible cardiomyopathy that usually emerges in response to adrenergic hyperactivation associated with a variety of emotional and physical triggers.[1,2]Even though,this phenomenon is generally characterized by an apical balloning pattern(classical variant),it might occasionally present with atypical morphological variants including mid-ventricular,inverted and focal forms of myocardial involvement.展开更多
Based on SPOT-5 images, 1：1 million topographic maps, the maps of the returning farmland to forest project and the Chongqing forest project, social and economic statistics, etc., this paper identifies the features an...Based on SPOT-5 images, 1：1 million topographic maps, the maps of the returning farmland to forest project and the Chongqing forest project, social and economic statistics, etc., this paper identifies the features and factors influencing farmland marginalization. The results showed： （1） During 2002-2012, the rate of farmland marginalization was 16.18%, which was mainly found in the high areas of northern Qiyao mountains and the medium-altitude areas of southern Qiyao mountains. And this farmland marginalization will increase, associated with non-agriculturalization of rural labourers and aging of the remaining labourers. （2） Elevation, distance radius from villages and road connections had a great in- fluence on farmland marginalization. Farmland marginalization rates showed an increasing trend with the increase of elevation, and 60.88% of the total farmland marginalization area is found at an altitude greater than 1000 m above sea level. The marginalization trend also increases with slope and distance from the distribution network. （3） Farmland area per labourer and the average age of farm labourers were major factors driving farmland marginalization. Farmland transfer and small agricultural machinery sets affect farmland marginalization with respect to management and productivity efficiency. （4） Farmland with ＂comparative-disadvantage-dominated marginalization＂ accounted for 55.32% of the total farmland marginalization area, followed by ＂location-dominated marginalization＂ （33.80%）. （5） According to the specifics of each real situation, different policies are suggested to mitigate the margin- alization. A ＂continuous marginalization＂ policy will encourage the return of farmland to forest in ＂terrain-dominated marginalization＂. An ＂anti-marginalization＂ policy is suggested to create new rural accommodation and improve the rural road system to counteract ＂terrain-dominated marginalization＂. And another ＂anti-marginalization＂ policy is planned to improve management and micro-mechanization for ＂comparative-disadvantage-dominated marginalization＂. A new idea was developed to integrate high resolution remote sensing and statistical data with survey information to identify land marginalization and its driving forces in mountainous areas.展开更多
Objective The formation and evolution of Songnen massif has always been a hot topic,and the presence of Precambrian basement on the Songnen massif is still controversial:(1)Lacking of Pre-Paleozoic dating results,the ...Objective The formation and evolution of Songnen massif has always been a hot topic,and the presence of Precambrian basement on the Songnen massif is still controversial:(1)Lacking of Pre-Paleozoic dating results,the Precambrian basement on Songnen massif does not extend largely according to the isotopic dating results of core from basement,(2)the existence of gneiss from deep drill holes展开更多
The Songnen–Zhangguangcai Range Massif(SZRM)is located in the eastern Central Asian Orogenic Belt and crops out over an extensive part of NE China.The massif was originally thought to contain numerous Precambrian ter...The Songnen–Zhangguangcai Range Massif(SZRM)is located in the eastern Central Asian Orogenic Belt and crops out over an extensive part of NE China.The massif was originally thought to contain numerous Precambrian terranes(e.g.,Xingdong,Dongfengshan,Yimianpo and Zhangguangcailing groups).However,more recent zircon U–Pb dating indicates that the majority of these so-called Precambrian sedimentary and igneous rocks actually formed during either the Paleozoic or Mesozoic and contain only minor Precambrian components(Wang et al.,2014).The presence of Neoproterozoic and Paleoproterozoic detrital zircons with magmatic origins from and Paleozoic units of the SZRM indicating that this area occurs Proterozoic magmatism(Wang et al.,2014),whereas no Proterozoic magmastism has been found.Recently,Pei et al.(2007)reported the ca.1800Ma magmastism,as evidenced by the data of exploration drillholes in the southern Songliao basin.However,an alternative view is that the basement within the SZRM is predominantly Phanerozoic,as evidenced by the presence of Paleozoic fossils and comparatively rare geochronological data(Guo and Liu,1985;Wu et al.,2011),meaning that the ca.1800 Ma rocks in this area may be a tectonically emplaced slice of the North China Craton(Zhang et al.,2005).All of this means that the age and nature of the SZRM basement,and whether this area records Neoproterozoic magmatism,remain unclear.This study presents new geochronological,whole-rock geochemical,and zircon Hf isotopic data for early Proterozoic granitoids within the eastern margin of the SZRM of NE China.These data provide insights into the Neoproterozoic tectonic setting of the SZRM and the links between this magmatism and the evolution of the Rodinia supercontinent.The zircon U–Pb dating indicates that the Neoproterozoic magmatism within the SZRM can be subdivided into two stages:(1)a^917–911 Ma suite of syenogranites and monzogranites,and(2)an^841 Ma suite of granodiorites.The 917–911 Ma granitoids contain high concentrations of Si O2(67.89–71.18 wt.%),K2O(4.24–6.91 wt.%),and Al2O3(14.89–16.14 wt.%),and low concentrations of TFe2O3(1.63–3.70 wt.%)and Mg O(0.53–0.88 wt.%).They are enriched in the light rare earth elements(LREE)and the light ion lithophile elements(LILE),are depleted in the heavy REE(HREE)and the heavy field strength elements(HFSE;e.g.,Nb,Ta,and Ti),and have slightly positive Eu anomalies,indicating they are geochemically similar to high-K adakitic rocks.They have zirconεHf(t)values and TDM2 ages from–4.4 to+1.5and from 1915 Ma to 1592 Ma,respectively,suggesting they were derived from a primary magma generated by the partial melting of ancient thickened lower crustal material.In comparison,the 841 Ma granodiorites contain relatively low concentrations of Al2O3(14.50–14.58 wt.%)and K2O(3.27–3.29 wt.%),relatively high concentrations of TFe2O3(3.78–3.81 wt.%)and the HREE,have negative Eu anomalies,and have zirconεHf(t)values and TDM2ages from–4.7 to+1.0 and from 1875 to 1559 Ma,respectively.These granodiorites formed from a primary magma generated by the partial melting of ancient crustal material.The^917–911 Ma magmatism within the SZRM is inferred to have formed in an orogenic setting,whereas the^841 Ma magmatism formed in an anorogenic setting related to either a post-orogenic tectonic event or the onset of Neoproterozoic continental rifting.It is proposed that the microcontinental massifs within the SZRM formed during or following the final stage of assembly of Rodinia before rifting away from the Tarim Craton in response to Rodinia breakup.展开更多
Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects ...Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research.展开更多
The Himalayan leucogranites provide insights into the partial melting behavior of relatively deeper crustal rocks and tectono-magmatic history of the Himalayan Orogen. The Paiku leucogranites of northern Himalaya can ...The Himalayan leucogranites provide insights into the partial melting behavior of relatively deeper crustal rocks and tectono-magmatic history of the Himalayan Orogen. The Paiku leucogranites of northern Himalaya can be subdivided into two-mica leucogranite(TML), garnet-bearing leucogranite(GL), cordierite-bearing leucogranite(CL), and tourmaline-bearing leucogranite(TL). All of them are high-K, peraluminous, calc-alkalic to alkali-calcic rocks. They are enriched in light rare earth elements(LREE) and large ion lithophile elements(LILE), and show pronounced negative anomalies of Sr, Ba, K and Ti, but positive anomalies of Nb and Rb. LA-ICP-MS U-Pb zircon dating of one TML, one GL, and two CL samples yielded variable 206Pb/238U ages ranging from 23.6 to 16.1 Ma, indicating the Paiku leucogranites underwent a low degree of partial melting process. Combining with previous studies, we suggest the Paiku leucogranites were derived from partial melting of metasedimentary rocks of the Higher Himalayan Sequence(HHS). The GL and TL mainly resulted from the muscovite-dehydration melting, whereas the TML and CL were mainly derived from the biotite-dehydration melting. Finally, it is concluded that the Paiku leucogranites were probably formed during the subduction of the Indian crust.展开更多
基金supported by the Natural Science Foundation of Sichuan Province,China(2024NSFSC1272)the Innovation Team Development Funds for Sichuan Mutton Goat&Sheep,China(SCCXTD-2024-14)Scientific and Technological Innovation Team for Qinghai-Tibetan Plateau Research in Southwest Minzu University,China(2024CXTD08)。
文摘Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.
文摘Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations,delusions,cognitive deficits,and emotional dysregulation.The prefrontal cortex(PFC),essential for executive functions,working memory,and emotional regulation,is notably impaired in this condition.This review consolidates current insights into the role of PFC dysfunction in schizophrenia,with a focus on its implications for therapeutic strategies.The neuroanatomical and neurobiological foundations of PFC dysfunction are explored,emphasizing structural abnormalities,functional dysconnectivity,and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making.Clinical implications are discussed,particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms.Additionally,pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options.In conclusion,a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments,and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.
文摘Anopheles(An.)stephensi is one of the dominant malaria vectors in India,Bangladesh,Pakistan,Iran,Iraq and some other Asian countries[1].It plays a crucial role in transmitting Plasmodium falciparum and Plasmodium vivax in India along with its rural counterpart,An.culicifacies.This mosquito species has adapted well to urban and peri-urban environments,making it a significant public health concern in the country.The presence of An.stephensi in urban areas contrasts with other malaria vectors that predominantly inhabit rural regions,thus complicating traditional malaria control strategies.It is well-adapted to human-made environments,breeding in various containers including tanks,cisterns,and barrels used for water storage.
基金Technology Program of Jiaying University,No.2024KJZ01Open Funding of Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas,No.2023JYKF08National Natural Science Foundation of China,No.42277442。
文摘The conversion of subtropical red soils into farmland involves complex transformations of iron oxides.Investigating iron mineralogy can enhance understanding of magnetic minerals in relation to soil formation on farmland in subtropical regions.In this study,we investigated the properties of iron oxide and its environmental implications in the farmland of Meizhou city,Guangdong province.The results showed that farmland soils had higher magnetism than the red soils developed from the same metamorphic rock.The red soils displayed significantly higher concentrations of goethite and hematite than the farmland soils.The dominant factor influencing the magnetic changes in farmland and red soils was the concentration of fine-grained ferromagnetic minerals.Red soil magnetism is an indicator of soil weathering intensity,whereas farmland soil magnetism is closely related to human cultivation activities.In contrast to the red soils,the farmland soils lacked the pronounced transformation of ferromagnetic minerals into hematite and goethite.A vigorous oxidation process catalyzes the transformation of strong magnetic minerals into significant amounts of hematite and goethite,which promotes the reduced magnetism of red soils.The conversion of red soils into farmland soils initially increased the accumulation of ferromagnetic materials due to cultivation processes.However,long-term cultivation led to the gradual loss of fine-grained ferromagnetic minerals,while goethite and lepidocrocite became the dominant magnetic mineral types.
文摘It is a common misconception that e-cigarettes are safer than tobacco smoking,given their adverse cardiopulmonary effects,habituation,and the fact that it is only a fashion based manifestation to sell and use them.Therefore,the use of e cigarettes should not be encouraged as an alternative and pragmatic measure should be taken to profess this agenda.
文摘Rapid technological advancements are driving embodied intelligent robots from laboratories to real-life applications to serve as a key force reshaping the future way of life.Like many other revolutionary technologies,while sparking utopian visions of the future,the development of embodied intelligence has aroused concerns about safety risks, emotional ethics, and socio-cultural implications.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82172635,82272686,and 82203628)Natural Science Foundation of Tianjin(Grant No.23JCZDJC00200)Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-010A).
文摘Introduction Small cell lung cancer(SCLC)is a highly aggressive malignancy with limited treatment options.Despite advances in immunotherapy,response rates remain low,and the efficacy of current molecular subtyping1,2 is insufficient to predict therapeutic outcomes3,4.A recently identified vulnerability in SCLC involves the dysregulation of nuclear-cytoplasmic transport,particularly through exportin 1(XPO1)5-7.
文摘Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’professional development and is also a crucial issue in teacher education research.From a global perspective,this study systematically reviews and examines relevant research on the professional identity of international Chinese language teachers(ICLTs).A comparative analysis is conducted between Chinese and foreign scholars’research in terms of theoretical foundations,research subjects,research content,and research methodologies.This comprehensive overview of the current research landscape in this field,along with a summary of existing achievements and identified problems,facilitates the transformation of fragmented research findings on ICLTs’professional identity into a systematic understanding and reveals research gaps.Building upon this foundation,the study proposes future research prospects for the professional identity of ICLTs from aspects such as the construction of a cross-cultural perspective-based teacher professional identity system,the transformation of teacher professional identity in the context of digital transformation,and case studies on ICLTs’professional identity.The aim is to promote high-quality development in both theory and practice of international Chinese language education.
基金funded by Shaoxing University’s enterprise important horizontal topic(No.2024USXH287)the Graduate research project of Shaoxing University(Nos.Y20240280)。
文摘The global aging crisis has increased the prevalence of skeletal disorders,necessitating innovative therapeutic strategies.This review employs the brain-bone axis(BBA)framework to examine the role of the sympathetic nervous system(SNS)in bone metabolism.The research systematically elucidates the molecular mechanisms by which the SNS mediates signaling pathways through neurofibers and neurotransmitters,such as norepinephrine,dopamine,neuropeptide Y,and leptin,regulating interactions between bone-related cells to maintain skeletal homeostasis.It also identifies the pathological associations between the dysregulation of these pathways and the progression of bone-related conditions,such as osteoporosis,osteoarthritis,and intervertebral disc degeneration.By integrating current evidence,we identify novel therapeutic targets within the BBA and propose neuro-centric intervention strategies to mitigate skeletal diseases.This review deepens the understanding of neuro-skeletal interactions and lays a foundation for innovative treatments for bone-related pathologies.
基金funded by IUGS and UNESCO through the IGCP-715 initiativethe collection of rock samples and topographical data.Special recognition goes to the Sternes Cave Expeditions(2018–2023)the Gourgouthakas Expedition(2022)and the Lion Expeditions(2013–2015)for their substantial contributions.
文摘This multidisciplinary study integrates structural and cave mapping,3D geological modeling,and Geographical Information System(GIS)analysis to provide constraints of the hydrogeological model for the central Lefka Ori Massif.Through 44 km of linear mapping,we discovered the new mid-Miocene Pachnes Thrust(PT)which plays a key role in the central Lefka Ori Massif structural framework.
文摘The relationship between heaven and humanity is one of the fundamental philosophical foundations of ecological ethics in ancient Chinese Confucian thought.As a master of Confucian philosophy of mind,Wang Yangming integrated the traditional Confucian discourse on the relationship between heaven and humanity into the principles of the philosophy of mind.Building on the traditional doctrine of benevolence centered on moral concern,he further developed an ecological view of‘benevolence as the unity of heaven and earth’.In his work Inquiry on the Great Learning,Wang Yangming systematically elaborated on this notion,emphasizing the philosophical expression of the relationship between humans and nature within an ethical framework and outlining the new implications of traditional Confucian ecological thought.This paper aims to analyze Wang Yangming’s ecological view of‘benevolence as the unity of heaven and earth’by examining the ecological ideas in his Inquiry on the Great Learning.On this basis,it seeks to refine the valuable achievements of traditional Chinese ecological civilization thought and strengthen the theoretical foundation of contemporary ecological ideas with Chinese characteristics.
基金the National Natural Science Foundation of China(Grant No.12171294)。
文摘Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functions,(light)interval-valued pre-t-norms were initially proposed by Wang and Hu,but their properties were not further discussed by the authors.The main purpose of this paper is to study in depth the properties and generation of(light)intervalvalued pre-t-norms.Firstly,several properties of(light)interval-valued pre-t-norms and their relationship with(light)pre-t-norms are presented.Then,two different generation methods for(light)interval-valued pre-t-norms are introduced.Finally,it demonstrates a specific application of(light)interval-valued pre-t-norms in constructing interval-valued directional monotonic fuzzy implications,namely,using the(light)interval-valued pre-t-norm IT,interval-valued fuzzy negations IN,and(light)interval-valued pre-t-conorm IS to construct interval-valued QL-directional monotonic operations.
基金The research and development project of Beijing Disaster Prevention Technology Co.,Ltd.(FZKJYF202201)funded this work.
文摘Although the late Quaternary slip rate of the Northern Margin Fault of the Huaizhuo Basin(NFHB)was studied approximately 30 years ago using thermoluminescence and geomorphic methods,the underlying uncertainty cannot be neglected,considering the limitations resulting from age and displacement measurements.Accordingly,we attempted to re-estimate the late Quaternary slip rate of the NFHB using high-precision remote sensing image interpretation,large-scale geological and geomorphic mapping,paleoseismic analysis,and Quaternary geochronology testing.The results,based on stratigraphic dislocation and age constraint in the trenches,show that the present deformation of the NFHB has been dominated by the extension,with a vertical slip rate~0.04-0.11 mm/a.We estimate a vertical slip rate of~0.06 mm/a,with an R^(2) value of~0.91,which is much lower than the~0.5 mm/a result estimated previously.There are three possible reasons for this discrepancy.The first is the limitation resulting from dating and displacement measurements in earlier studies;the second is the slip decomposition caused by multiple branches of the NFHB,which leads to the low slip rate observed at a single fault;and third possible explanation is that the fault may be locked at present with a low slip rate,which means that the earthquake hazard of the NFHB cannot be ignored,and more in-depth research,such as geodetic and intensive observations of earthquake precursors,is urgently needed.This discovery poses a new challenge for the active study of the NFHB and the northeast corner of the Ordos Plateau in the North China Block.
文摘Many eukaryotic genes are members of multi-gene families due to gene duplications, which generate new copies that allow functional divergence. However, the relationship between
文摘Over past decades,takotsubo cardiomyopathy(TTC)has drawn a substantial interest as a unique form of acute and reversible cardiomyopathy that usually emerges in response to adrenergic hyperactivation associated with a variety of emotional and physical triggers.[1,2]Even though,this phenomenon is generally characterized by an apical balloning pattern(classical variant),it might occasionally present with atypical morphological variants including mid-ventricular,inverted and focal forms of myocardial involvement.
基金The NSFC-IIASA Major International Joint Research Project, No.41161140352 Natural Science Foundation of Chongqing, No.2010JJ0069 Science and Technology Great Special Project on Controlling and Fathering Water Pollution during the National 12th Five-year Plan, No.2012ZX07104-003
文摘Based on SPOT-5 images, 1：1 million topographic maps, the maps of the returning farmland to forest project and the Chongqing forest project, social and economic statistics, etc., this paper identifies the features and factors influencing farmland marginalization. The results showed： （1） During 2002-2012, the rate of farmland marginalization was 16.18%, which was mainly found in the high areas of northern Qiyao mountains and the medium-altitude areas of southern Qiyao mountains. And this farmland marginalization will increase, associated with non-agriculturalization of rural labourers and aging of the remaining labourers. （2） Elevation, distance radius from villages and road connections had a great in- fluence on farmland marginalization. Farmland marginalization rates showed an increasing trend with the increase of elevation, and 60.88% of the total farmland marginalization area is found at an altitude greater than 1000 m above sea level. The marginalization trend also increases with slope and distance from the distribution network. （3） Farmland area per labourer and the average age of farm labourers were major factors driving farmland marginalization. Farmland transfer and small agricultural machinery sets affect farmland marginalization with respect to management and productivity efficiency. （4） Farmland with ＂comparative-disadvantage-dominated marginalization＂ accounted for 55.32% of the total farmland marginalization area, followed by ＂location-dominated marginalization＂ （33.80%）. （5） According to the specifics of each real situation, different policies are suggested to mitigate the margin- alization. A ＂continuous marginalization＂ policy will encourage the return of farmland to forest in ＂terrain-dominated marginalization＂. An ＂anti-marginalization＂ policy is suggested to create new rural accommodation and improve the rural road system to counteract ＂terrain-dominated marginalization＂. And another ＂anti-marginalization＂ policy is planned to improve management and micro-mechanization for ＂comparative-disadvantage-dominated marginalization＂. A new idea was developed to integrate high resolution remote sensing and statistical data with survey information to identify land marginalization and its driving forces in mountainous areas.
基金financially supported by China Geological Survey (Grants12120113053900 and DD20160047)
文摘Objective The formation and evolution of Songnen massif has always been a hot topic,and the presence of Precambrian basement on the Songnen massif is still controversial:(1)Lacking of Pre-Paleozoic dating results,the Precambrian basement on Songnen massif does not extend largely according to the isotopic dating results of core from basement,(2)the existence of gneiss from deep drill holes
基金financially supported by the National Natural Science Foundation of China (Grants 41330206)National Key Basic Research Program of China (2013CB429803)
文摘The Songnen–Zhangguangcai Range Massif(SZRM)is located in the eastern Central Asian Orogenic Belt and crops out over an extensive part of NE China.The massif was originally thought to contain numerous Precambrian terranes(e.g.,Xingdong,Dongfengshan,Yimianpo and Zhangguangcailing groups).However,more recent zircon U–Pb dating indicates that the majority of these so-called Precambrian sedimentary and igneous rocks actually formed during either the Paleozoic or Mesozoic and contain only minor Precambrian components(Wang et al.,2014).The presence of Neoproterozoic and Paleoproterozoic detrital zircons with magmatic origins from and Paleozoic units of the SZRM indicating that this area occurs Proterozoic magmatism(Wang et al.,2014),whereas no Proterozoic magmastism has been found.Recently,Pei et al.(2007)reported the ca.1800Ma magmastism,as evidenced by the data of exploration drillholes in the southern Songliao basin.However,an alternative view is that the basement within the SZRM is predominantly Phanerozoic,as evidenced by the presence of Paleozoic fossils and comparatively rare geochronological data(Guo and Liu,1985;Wu et al.,2011),meaning that the ca.1800 Ma rocks in this area may be a tectonically emplaced slice of the North China Craton(Zhang et al.,2005).All of this means that the age and nature of the SZRM basement,and whether this area records Neoproterozoic magmatism,remain unclear.This study presents new geochronological,whole-rock geochemical,and zircon Hf isotopic data for early Proterozoic granitoids within the eastern margin of the SZRM of NE China.These data provide insights into the Neoproterozoic tectonic setting of the SZRM and the links between this magmatism and the evolution of the Rodinia supercontinent.The zircon U–Pb dating indicates that the Neoproterozoic magmatism within the SZRM can be subdivided into two stages:(1)a^917–911 Ma suite of syenogranites and monzogranites,and(2)an^841 Ma suite of granodiorites.The 917–911 Ma granitoids contain high concentrations of Si O2(67.89–71.18 wt.%),K2O(4.24–6.91 wt.%),and Al2O3(14.89–16.14 wt.%),and low concentrations of TFe2O3(1.63–3.70 wt.%)and Mg O(0.53–0.88 wt.%).They are enriched in the light rare earth elements(LREE)and the light ion lithophile elements(LILE),are depleted in the heavy REE(HREE)and the heavy field strength elements(HFSE;e.g.,Nb,Ta,and Ti),and have slightly positive Eu anomalies,indicating they are geochemically similar to high-K adakitic rocks.They have zirconεHf(t)values and TDM2 ages from–4.4 to+1.5and from 1915 Ma to 1592 Ma,respectively,suggesting they were derived from a primary magma generated by the partial melting of ancient thickened lower crustal material.In comparison,the 841 Ma granodiorites contain relatively low concentrations of Al2O3(14.50–14.58 wt.%)and K2O(3.27–3.29 wt.%),relatively high concentrations of TFe2O3(3.78–3.81 wt.%)and the HREE,have negative Eu anomalies,and have zirconεHf(t)values and TDM2ages from–4.7 to+1.0 and from 1875 to 1559 Ma,respectively.These granodiorites formed from a primary magma generated by the partial melting of ancient crustal material.The^917–911 Ma magmatism within the SZRM is inferred to have formed in an orogenic setting,whereas the^841 Ma magmatism formed in an anorogenic setting related to either a post-orogenic tectonic event or the onset of Neoproterozoic continental rifting.It is proposed that the microcontinental massifs within the SZRM formed during or following the final stage of assembly of Rodinia before rifting away from the Tarim Craton in response to Rodinia breakup.
文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research.
基金supported by the National Natural Science Foundation of China (Nos. 41872070, 41802071, 41773026 and 41303028)the China Geological Survey (No. DD20190053)
文摘The Himalayan leucogranites provide insights into the partial melting behavior of relatively deeper crustal rocks and tectono-magmatic history of the Himalayan Orogen. The Paiku leucogranites of northern Himalaya can be subdivided into two-mica leucogranite(TML), garnet-bearing leucogranite(GL), cordierite-bearing leucogranite(CL), and tourmaline-bearing leucogranite(TL). All of them are high-K, peraluminous, calc-alkalic to alkali-calcic rocks. They are enriched in light rare earth elements(LREE) and large ion lithophile elements(LILE), and show pronounced negative anomalies of Sr, Ba, K and Ti, but positive anomalies of Nb and Rb. LA-ICP-MS U-Pb zircon dating of one TML, one GL, and two CL samples yielded variable 206Pb/238U ages ranging from 23.6 to 16.1 Ma, indicating the Paiku leucogranites underwent a low degree of partial melting process. Combining with previous studies, we suggest the Paiku leucogranites were derived from partial melting of metasedimentary rocks of the Higher Himalayan Sequence(HHS). The GL and TL mainly resulted from the muscovite-dehydration melting, whereas the TML and CL were mainly derived from the biotite-dehydration melting. Finally, it is concluded that the Paiku leucogranites were probably formed during the subduction of the Indian crust.
