目的评价特发性黄斑裂孔行微创后部玻璃体切割联合内界膜剥除手术治疗的效果及视功能预后。方法收集2014年1~12月就诊的特发性黄斑裂孔36例（41眼）,均采用微创玻璃体切割和C3F8气体填充,在TA辅助下进行内界膜剥离,术前及术后6个月采用...目的评价特发性黄斑裂孔行微创后部玻璃体切割联合内界膜剥除手术治疗的效果及视功能预后。方法收集2014年1~12月就诊的特发性黄斑裂孔36例（41眼）,均采用微创玻璃体切割和C3F8气体填充,在TA辅助下进行内界膜剥离,术前及术后6个月采用光学相干断层扫描（OCT）,标准对数视力表等对患眼进行检查和随访。结果术后裂孔闭合率达92.7%,术后6个月矫正视力较术前有显著提高（χ2=10.25,P=0.001）,视力提高率达91.2%;视物变形、中心暗点等症状也有明显改善（χ2=35.79,P〈0.001）。并发症情况：术中4眼出现毛细血管性出血,术后1周内9眼患者出现一过性眼压升高（〉30 mm Hg）,9眼出现晶状体后囊下混浊及老年性白内障进展。结论后部微创玻璃体切割联合内界膜剥离可使特发性黄斑裂孔获得较高的闭合率,视功能亦可得到较好恢复。展开更多
Background:Hypothyroxinemia is a subclinical thyroid hormone deficiency in which the mother has inadequate levels of T_(4) during pregnancy.The fetus relies entirely on the mother's T_(4) hormone level for early n...Background:Hypothyroxinemia is a subclinical thyroid hormone deficiency in which the mother has inadequate levels of T_(4) during pregnancy.The fetus relies entirely on the mother's T_(4) hormone level for early neurodevelopment.Isolated maternal hypothyroxinemia(IMH)in the first trimester of pregnancy can lead to lower intelligence,lower motor scores,and a higher risk of mental illness in descendants.Here,we focus on the autism-like behavior of IMH offspring.Methods:The animals were administered 1 ppm of propylthiouracil(PTU)for 9 weeks.Then,the concentrations of T_(3),T_(4),and thyroid-stimulating hormone(TSH)were detected using enzyme-linked immunosorbent assay(ELISA)to verify the developed animal model of IMH.We performed four behavioral experiments,including the marble burying test,open-field test,three-chamber sociability test,and Morris water maze,to explore the autistic-like behavior of 40-day-old offspring rats.Results:The ELISA test showed that the serum T_(3) and TSH concentrations in the model group were normal compared with the negative control group,whereas the T_(4) concentration decreased.In the behavioral experiments,the number of hidden marbles in the offspring of IMH increased significantly,the frequency of entering the central compartment decreased,and the social ratio decreased significantly.Conclusion:The animal model of IMH was developed by the administration of 1 ppm of PTU for 9 weeks,and there were autistic-like behavior changes such as anxiety,weakened social ability,and repeated stereotyping in the IMH offspring by 40 days.展开更多
文摘目的评价特发性黄斑裂孔行微创后部玻璃体切割联合内界膜剥除手术治疗的效果及视功能预后。方法收集2014年1~12月就诊的特发性黄斑裂孔36例（41眼）,均采用微创玻璃体切割和C3F8气体填充,在TA辅助下进行内界膜剥离,术前及术后6个月采用光学相干断层扫描（OCT）,标准对数视力表等对患眼进行检查和随访。结果术后裂孔闭合率达92.7%,术后6个月矫正视力较术前有显著提高（χ2=10.25,P=0.001）,视力提高率达91.2%;视物变形、中心暗点等症状也有明显改善（χ2=35.79,P〈0.001）。并发症情况：术中4眼出现毛细血管性出血,术后1周内9眼患者出现一过性眼压升高（〉30 mm Hg）,9眼出现晶状体后囊下混浊及老年性白内障进展。结论后部微创玻璃体切割联合内界膜剥离可使特发性黄斑裂孔获得较高的闭合率,视功能亦可得到较好恢复。
基金supported by the CAMS Innovation Fund for Medical Science (2021-I2M-1-034)the National Natural Science Foundation of China (grant number:81700697).
文摘Background:Hypothyroxinemia is a subclinical thyroid hormone deficiency in which the mother has inadequate levels of T_(4) during pregnancy.The fetus relies entirely on the mother's T_(4) hormone level for early neurodevelopment.Isolated maternal hypothyroxinemia(IMH)in the first trimester of pregnancy can lead to lower intelligence,lower motor scores,and a higher risk of mental illness in descendants.Here,we focus on the autism-like behavior of IMH offspring.Methods:The animals were administered 1 ppm of propylthiouracil(PTU)for 9 weeks.Then,the concentrations of T_(3),T_(4),and thyroid-stimulating hormone(TSH)were detected using enzyme-linked immunosorbent assay(ELISA)to verify the developed animal model of IMH.We performed four behavioral experiments,including the marble burying test,open-field test,three-chamber sociability test,and Morris water maze,to explore the autistic-like behavior of 40-day-old offspring rats.Results:The ELISA test showed that the serum T_(3) and TSH concentrations in the model group were normal compared with the negative control group,whereas the T_(4) concentration decreased.In the behavioral experiments,the number of hidden marbles in the offspring of IMH increased significantly,the frequency of entering the central compartment decreased,and the social ratio decreased significantly.Conclusion:The animal model of IMH was developed by the administration of 1 ppm of PTU for 9 weeks,and there were autistic-like behavior changes such as anxiety,weakened social ability,and repeated stereotyping in the IMH offspring by 40 days.
