固有免疫是生物体防御病原微生物感染的第一道防线,在识别并清除病原体及维持组织稳态中发挥重要作用。IL-37是新发现的IL-1细胞因子家族的成员,是免疫应答和炎症反应的天然抑制剂。IL-37通过调控病原微生物免疫识别、调节固有免疫细胞...固有免疫是生物体防御病原微生物感染的第一道防线,在识别并清除病原体及维持组织稳态中发挥重要作用。IL-37是新发现的IL-1细胞因子家族的成员,是免疫应答和炎症反应的天然抑制剂。IL-37通过调控病原微生物免疫识别、调节固有免疫细胞的功能、保护组织屏障等参与固有免疫应答环节,在多种疾病模型中表现出显著的抗炎作用,提示其可能作为炎症性疾病的潜在治疗靶点。Innate immunity serves as the first defense against pathogenic microorganisms, playing a crucial role in recognizing and eliminating pathogens as well as maintaining tissue homeostasis. IL-37, a member of the IL-1 cytokine family, is a newly discovered natural inhibitor of immune responses and inflammatory reactions. IL-37 participates in innate immune responses by regulating pathogen recognition, modulating the functions of innate immune cells, and protecting tissue barriers. It has demonstrated significant anti-inflammatory effects in various disease models, suggesting it might be a potential therapeutic target for inflammatory diseases.展开更多
目的:分析血清IL-33及IL-37对不同水平血嗜酸性粒细胞的慢性阻塞性肺疾病患者肺功能的预测价值及相关性。方法:采用ELISA法检测IL-33、IL-37、CRP及PCT在30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮...目的:分析血清IL-33及IL-37对不同水平血嗜酸性粒细胞的慢性阻塞性肺疾病患者肺功能的预测价值及相关性。方法:采用ELISA法检测IL-33、IL-37、CRP及PCT在30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮乏组患者及30例健康体检者血清中的表达情况,采用肺功能仪检测30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮乏组患者及30例健康体检者的FEV1%pred及FEV1/FVC。结果:COPD组患者血清IL-33、IL-37、CRP及PCT表达水平较健康对照组显著升高,肺功能指标FEV1%pred及FEV1/FVC较对照组显著降低(P 1%pred及FEV1/FVC进一步降低(P 1%pred、FEV1/FVC呈负相关(P Objective: To analyze the predictive value and correlation of serum IL-33 and IL-37 in patients with chronic obstructive pulmonary disease (COPD) with different levels of blood eosinophils in predicting lung function. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression of IL-33, IL-37, C-reactive protein (CRP), and procalcitonin (PCT) in the serum of 30 patients with high eosinophil counts, 30 patients with moderate eosinophil counts, 34 patients with low eosinophil counts, and 30 healthy individuals. Lung function was assessed by measuring forced expiratory volume in one second as a percentage of predicted (FEV1%pred) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) using a spirometer in the same groups. Results: The expression levels of serum IL-33, IL-37, CRP, and PCT in the COPD group were significantly higher than those in the healthy control group (P 1%pred and FEV1/FVC were significantly lower than those in the control group (P 1%pred and FEV1/FVC further decreased (P 1%pred and FEV1/FVC (P < 0.05). Conclusion: IL-33 and IL-37 may be closely related to the progression of COPD and may become new indicators for clinical diagnosis and assessment of disease severity in COPD, as well as providing new targets for clinical intervention.展开更多
文摘固有免疫是生物体防御病原微生物感染的第一道防线,在识别并清除病原体及维持组织稳态中发挥重要作用。IL-37是新发现的IL-1细胞因子家族的成员,是免疫应答和炎症反应的天然抑制剂。IL-37通过调控病原微生物免疫识别、调节固有免疫细胞的功能、保护组织屏障等参与固有免疫应答环节,在多种疾病模型中表现出显著的抗炎作用,提示其可能作为炎症性疾病的潜在治疗靶点。Innate immunity serves as the first defense against pathogenic microorganisms, playing a crucial role in recognizing and eliminating pathogens as well as maintaining tissue homeostasis. IL-37, a member of the IL-1 cytokine family, is a newly discovered natural inhibitor of immune responses and inflammatory reactions. IL-37 participates in innate immune responses by regulating pathogen recognition, modulating the functions of innate immune cells, and protecting tissue barriers. It has demonstrated significant anti-inflammatory effects in various disease models, suggesting it might be a potential therapeutic target for inflammatory diseases.
文摘目的:分析血清IL-33及IL-37对不同水平血嗜酸性粒细胞的慢性阻塞性肺疾病患者肺功能的预测价值及相关性。方法:采用ELISA法检测IL-33、IL-37、CRP及PCT在30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮乏组患者及30例健康体检者血清中的表达情况,采用肺功能仪检测30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮乏组患者及30例健康体检者的FEV1%pred及FEV1/FVC。结果:COPD组患者血清IL-33、IL-37、CRP及PCT表达水平较健康对照组显著升高,肺功能指标FEV1%pred及FEV1/FVC较对照组显著降低(P 1%pred及FEV1/FVC进一步降低(P 1%pred、FEV1/FVC呈负相关(P Objective: To analyze the predictive value and correlation of serum IL-33 and IL-37 in patients with chronic obstructive pulmonary disease (COPD) with different levels of blood eosinophils in predicting lung function. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression of IL-33, IL-37, C-reactive protein (CRP), and procalcitonin (PCT) in the serum of 30 patients with high eosinophil counts, 30 patients with moderate eosinophil counts, 34 patients with low eosinophil counts, and 30 healthy individuals. Lung function was assessed by measuring forced expiratory volume in one second as a percentage of predicted (FEV1%pred) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) using a spirometer in the same groups. Results: The expression levels of serum IL-33, IL-37, CRP, and PCT in the COPD group were significantly higher than those in the healthy control group (P 1%pred and FEV1/FVC were significantly lower than those in the control group (P 1%pred and FEV1/FVC further decreased (P 1%pred and FEV1/FVC (P < 0.05). Conclusion: IL-33 and IL-37 may be closely related to the progression of COPD and may become new indicators for clinical diagnosis and assessment of disease severity in COPD, as well as providing new targets for clinical intervention.
