固有免疫是生物体防御病原微生物感染的第一道防线,在识别并清除病原体及维持组织稳态中发挥重要作用。IL-37是新发现的IL-1细胞因子家族的成员,是免疫应答和炎症反应的天然抑制剂。IL-37通过调控病原微生物免疫识别、调节固有免疫细胞...固有免疫是生物体防御病原微生物感染的第一道防线,在识别并清除病原体及维持组织稳态中发挥重要作用。IL-37是新发现的IL-1细胞因子家族的成员,是免疫应答和炎症反应的天然抑制剂。IL-37通过调控病原微生物免疫识别、调节固有免疫细胞的功能、保护组织屏障等参与固有免疫应答环节,在多种疾病模型中表现出显著的抗炎作用,提示其可能作为炎症性疾病的潜在治疗靶点。Innate immunity serves as the first defense against pathogenic microorganisms, playing a crucial role in recognizing and eliminating pathogens as well as maintaining tissue homeostasis. IL-37, a member of the IL-1 cytokine family, is a newly discovered natural inhibitor of immune responses and inflammatory reactions. IL-37 participates in innate immune responses by regulating pathogen recognition, modulating the functions of innate immune cells, and protecting tissue barriers. It has demonstrated significant anti-inflammatory effects in various disease models, suggesting it might be a potential therapeutic target for inflammatory diseases.展开更多
白细胞介素-1(IL-1)家族成员IL-1F7(IL-1 family 7)最近被命名为IL-37,它共有五种不同的亚型(IL-37a-e)。研究表明,IL-37b(IL-1F7b)可以与IL-18受体的α链结合,但并不影响IL-18的生理功能;IL-37b与IL-18结合蛋白(IL-18BP)结合后,可以增...白细胞介素-1(IL-1)家族成员IL-1F7(IL-1 family 7)最近被命名为IL-37,它共有五种不同的亚型(IL-37a-e)。研究表明,IL-37b(IL-1F7b)可以与IL-18受体的α链结合,但并不影响IL-18的生理功能;IL-37b与IL-18结合蛋白(IL-18BP)结合后,可以增强IL-18BP对IL-18的抑制作用。IL-37b的主要作用是抑制炎症反应,它在多种炎症相关性疾病中起重要作用。展开更多
文摘固有免疫是生物体防御病原微生物感染的第一道防线,在识别并清除病原体及维持组织稳态中发挥重要作用。IL-37是新发现的IL-1细胞因子家族的成员,是免疫应答和炎症反应的天然抑制剂。IL-37通过调控病原微生物免疫识别、调节固有免疫细胞的功能、保护组织屏障等参与固有免疫应答环节,在多种疾病模型中表现出显著的抗炎作用,提示其可能作为炎症性疾病的潜在治疗靶点。Innate immunity serves as the first defense against pathogenic microorganisms, playing a crucial role in recognizing and eliminating pathogens as well as maintaining tissue homeostasis. IL-37, a member of the IL-1 cytokine family, is a newly discovered natural inhibitor of immune responses and inflammatory reactions. IL-37 participates in innate immune responses by regulating pathogen recognition, modulating the functions of innate immune cells, and protecting tissue barriers. It has demonstrated significant anti-inflammatory effects in various disease models, suggesting it might be a potential therapeutic target for inflammatory diseases.
文摘白细胞介素-1(IL-1)家族成员IL-1F7(IL-1 family 7)最近被命名为IL-37,它共有五种不同的亚型(IL-37a-e)。研究表明,IL-37b(IL-1F7b)可以与IL-18受体的α链结合,但并不影响IL-18的生理功能;IL-37b与IL-18结合蛋白(IL-18BP)结合后,可以增强IL-18BP对IL-18的抑制作用。IL-37b的主要作用是抑制炎症反应,它在多种炎症相关性疾病中起重要作用。
