习惯了使用Windows 2000系统的朋友一定对ⅡS非常熟悉吧！它是系统附带的一个功能强大的组件，全名为因特网信息服务器(internet information server)．利用它可以实现WEB、FTP、SMTP等功能，很多网站的主机都采用ⅡS做为网站的发布后...习惯了使用Windows 2000系统的朋友一定对ⅡS非常熟悉吧！它是系统附带的一个功能强大的组件，全名为因特网信息服务器(internet information server)．利用它可以实现WEB、FTP、SMTP等功能，很多网站的主机都采用ⅡS做为网站的发布后台，可以说它是Windows NT系统中的灵魂。展开更多
A new coordination polymer [Ni（L）（m-bix）（H2O）]n （1, H2L = 5-iodo-isophthalic acid, m-bix=1,3-bis（imidazol-1-ylmethyl）-benzene） has been synthesized by the hydrothermal method and characterized by IR, element...A new coordination polymer [Ni（L）（m-bix）（H2O）]n （1, H2L = 5-iodo-isophthalic acid, m-bix=1,3-bis（imidazol-1-ylmethyl）-benzene） has been synthesized by the hydrothermal method and characterized by IR, elemental analysis, powder XRD and single-crystal X-ray analysis. The crystal is of triclinic, space group Pī with a = 9.1638（3）, b = 10.2319（3）, c = 13.2463（4） ？, α = 80.1710（10）, β = 83.671（2）, γ = 70.3790（10）o,C22H19NiIN4O5, Mr = 605.02, V = 1150.85（6） ？3, Dc = 1.746 g/cm3, F（000） = 600, μ = 2.225 mm-1, S = 1.045 and Z = 2. The final R = 0.0388 and wR = 0.1257 for 5089 observed reflections with I 〉 2σ（I）. In the title complex, the M and P layers are arranged alternately to give a double-layer structure by the symmetry related hydrogen bonds, and these double-layers are further joined together to achieve a 2D supramolecular architecture through I···π interaction involving iodine atoms and imidazole rings. The thermal stability of the title complex was studied by thermal gravimetric （TG） and differential thermal analysis （DTA）.展开更多
Postoperative wound repair after transurethral resection of the prostate(TURP)in benign prostatic hyperplasia(BPH)patients is crucial for reducing complications and promoting recovery.Androgens,particularly dihydrotes...Postoperative wound repair after transurethral resection of the prostate(TURP)in benign prostatic hyperplasia(BPH)patients is crucial for reducing complications and promoting recovery.Androgens,particularly dihydrotestosterone(DHT),influence prostatic development and wound healing,with type II 5α-reductase(5αR2)playing a key role in DHT synthesis.In this study,the effects of type II 5α-reductase inhibitors(5-ARIs)on postoperative healing,inflammation control,and fibrosis reduction were evaluated.A double-blinded randomized clinical trial was performed to assess 87 BPH patients treated with type II 5-ARIs(n=47)or placebo(n=42)over six months.The type II 5-ARIs group presented a 55.0%lower complication rate(P=0.002),with reduced hematuria(0 vs 7.1%,P=0.046)and catheter reintroduction(0 vs 9.5%,P=0.025).An animal study using 12 beagles was performed,and molecular markers were analyzed via single-cell RNA sequencing,enzyme-linked immunosorbent assay(ELISA),and histology.5αR2 inhibition accelerated urothelial regeneration,decreased inflammation,and reduced myofibroblast activation by 42.0%while increasing the expression of the urothelial marker uroplakin 3A(UPK3A)by 67.0%.Organoid experiments confirmed increased urothelial differentiation and reduced glandular epithelial expansion with type II 5-ARI treatment.These findings suggest that 5αR2 inhibition promotes TURP postoperative recovery in BPH patients by reducing inflammation,inhibiting fibrosis,and promoting wound repair.These findings support the use of type II 5-ARIs as potential adjuvant therapies for optimizing BPH patient postoperative outcomes.展开更多
文摘习惯了使用Windows 2000系统的朋友一定对ⅡS非常熟悉吧！它是系统附带的一个功能强大的组件，全名为因特网信息服务器(internet information server)．利用它可以实现WEB、FTP、SMTP等功能，很多网站的主机都采用ⅡS做为网站的发布后台，可以说它是Windows NT系统中的灵魂。
基金supported by the International Technology Cooperation Project of Science and Technology Department of Henan Province(No.124300510050)
文摘A new coordination polymer [Ni（L）（m-bix）（H2O）]n （1, H2L = 5-iodo-isophthalic acid, m-bix=1,3-bis（imidazol-1-ylmethyl）-benzene） has been synthesized by the hydrothermal method and characterized by IR, elemental analysis, powder XRD and single-crystal X-ray analysis. The crystal is of triclinic, space group Pī with a = 9.1638（3）, b = 10.2319（3）, c = 13.2463（4） ？, α = 80.1710（10）, β = 83.671（2）, γ = 70.3790（10）o,C22H19NiIN4O5, Mr = 605.02, V = 1150.85（6） ？3, Dc = 1.746 g/cm3, F（000） = 600, μ = 2.225 mm-1, S = 1.045 and Z = 2. The final R = 0.0388 and wR = 0.1257 for 5089 observed reflections with I 〉 2σ（I）. In the title complex, the M and P layers are arranged alternately to give a double-layer structure by the symmetry related hydrogen bonds, and these double-layers are further joined together to achieve a 2D supramolecular architecture through I···π interaction involving iodine atoms and imidazole rings. The thermal stability of the title complex was studied by thermal gravimetric （TG） and differential thermal analysis （DTA）.
基金Supported by the NNSFC(21361011 and 21561015)the Natural Science Foundation of Jiangxi Province(20151BAB203002)the Open Project Program of Key Laboratory of Functional Small Organic Molecule,Ministry of Education,Jiangxi Normal University(KLFS-KF-201412)
基金supported by the National Natural Science Foundation of China(No.81930018 and No.82200858).
文摘Postoperative wound repair after transurethral resection of the prostate(TURP)in benign prostatic hyperplasia(BPH)patients is crucial for reducing complications and promoting recovery.Androgens,particularly dihydrotestosterone(DHT),influence prostatic development and wound healing,with type II 5α-reductase(5αR2)playing a key role in DHT synthesis.In this study,the effects of type II 5α-reductase inhibitors(5-ARIs)on postoperative healing,inflammation control,and fibrosis reduction were evaluated.A double-blinded randomized clinical trial was performed to assess 87 BPH patients treated with type II 5-ARIs(n=47)or placebo(n=42)over six months.The type II 5-ARIs group presented a 55.0%lower complication rate(P=0.002),with reduced hematuria(0 vs 7.1%,P=0.046)and catheter reintroduction(0 vs 9.5%,P=0.025).An animal study using 12 beagles was performed,and molecular markers were analyzed via single-cell RNA sequencing,enzyme-linked immunosorbent assay(ELISA),and histology.5αR2 inhibition accelerated urothelial regeneration,decreased inflammation,and reduced myofibroblast activation by 42.0%while increasing the expression of the urothelial marker uroplakin 3A(UPK3A)by 67.0%.Organoid experiments confirmed increased urothelial differentiation and reduced glandular epithelial expansion with type II 5-ARI treatment.These findings suggest that 5αR2 inhibition promotes TURP postoperative recovery in BPH patients by reducing inflammation,inhibiting fibrosis,and promoting wound repair.These findings support the use of type II 5-ARIs as potential adjuvant therapies for optimizing BPH patient postoperative outcomes.
