勃起功能障碍(ED)是男性常见的多因素疾病,其发病机制涉及血管内皮功能障碍,氧化应激,炎症反应和神经内分泌等疾病。丹参酮IIA (Tanshinone IIA)是从丹参中提取的主要活性成分,具有抗氧化、抗炎、改善微循环和保护血管内皮等药理作用。...勃起功能障碍(ED)是男性常见的多因素疾病,其发病机制涉及血管内皮功能障碍,氧化应激,炎症反应和神经内分泌等疾病。丹参酮IIA (Tanshinone IIA)是从丹参中提取的主要活性成分,具有抗氧化、抗炎、改善微循环和保护血管内皮等药理作用。近年来,研究发现丹参酮IIA可以通过调节一氧化氮(NO)通路,抑制氧化应激和炎症反应来改善ED症状,但其具体机制仍有待进一步探讨。本文就丹参酮IIA的化学特性、药理作用;丹参酮IIA与勃起功能障碍的关联;丹参酮IIA治疗ED的研究进展进行如下综述,为ED的靶向治疗提供新思路。Erectile dysfunction (ED) is a common multifactorial disease in men, and its pathogenesis involves vascular endothelial dysfunction, oxidative stress, inflammatory response, and neuroendocrine disorders. Tanshinone IIA is the main active ingredient extracted from Salvia miltiorrhizae, which has pharmacological effects such as antioxidant, anti-inflammatory, improving microcirculation and protecting vascular endothelium. In recent years, research has shown that Tanshinone IIA can improve erectile dysfunction (ED) symptoms by modulating the nitric oxide (NO) pathway and inhibiting oxidative stress and inflammatory responses. However, the specific mechanisms still need to be further explored. This article reviews the chemical properties and pharmacological effects of Tanshinone IIA, the association between Tanshinone IIA and erectile dysfunction, and the research progress of Tanshinone IIA in treating ED, providing new ideas for targeted therapy of ED.展开更多
目的:观察黄芪皂甙、丹参酮IIA注射液对大鼠骨骼肌钝挫伤后胚胎型肌球蛋白重链(embryonicmyosin heavy chain,MHC-emb)及波形蛋白(vimentin)mRNA表达的影响。方法:用打击装置将120只雄性Wistar大鼠右侧腓肠肌中段造成钝挫伤模型,随机分...目的:观察黄芪皂甙、丹参酮IIA注射液对大鼠骨骼肌钝挫伤后胚胎型肌球蛋白重链(embryonicmyosin heavy chain,MHC-emb)及波形蛋白(vimentin)mRNA表达的影响。方法:用打击装置将120只雄性Wistar大鼠右侧腓肠肌中段造成钝挫伤模型,随机分为5组,在损伤局部分别注射黄芪皂甙、丹参酮IIA、黄芪皂甙丹参酮IIA混合液、黄芪丹参混合液及生理盐水。以后每3天注射1次,直到损伤后第27天。各组分别于损伤后第1、4、7、14、28和42天取损伤处骨骼肌标本。采用荧光定量聚合酶链式反应(realtime quantitativePCR)方法分析MHC-emb及波形蛋白mRNA表达。结果:(1)在骨骼肌急性钝挫伤修复早期,各组MHC-embmRNA和波形蛋白mRNA表达量均明显升高,分别于第7～14天和第4天达到高峰,然后下降。(2)从第4天至42天,各干预组MHC-emb mRNA表达水平显著高于生理盐水组,黄芪皂甙丹参酮IIA混合组和黄芪丹参组显著高于黄芪皂甙组和丹参酮IIA组。(3)从第4天至28天,各干预组波形蛋白mRNA表达水平显著低于生理盐水组,黄芪皂甙丹参酮IIA混合组和黄芪丹参组显著低于黄芪皂甙组和丹参酮IIA组。结论:在急性骨骼肌钝挫伤修复过程中,黄芪皂甙、丹参酮IIA能促进MHC-emb mRNA表达,抑制波形蛋白mRNA表达,但其单独使用时的作用均弱于黄芪丹参,混合使用效果与黄芪丹参基本一致。展开更多
文摘勃起功能障碍(ED)是男性常见的多因素疾病,其发病机制涉及血管内皮功能障碍,氧化应激,炎症反应和神经内分泌等疾病。丹参酮IIA (Tanshinone IIA)是从丹参中提取的主要活性成分,具有抗氧化、抗炎、改善微循环和保护血管内皮等药理作用。近年来,研究发现丹参酮IIA可以通过调节一氧化氮(NO)通路,抑制氧化应激和炎症反应来改善ED症状,但其具体机制仍有待进一步探讨。本文就丹参酮IIA的化学特性、药理作用;丹参酮IIA与勃起功能障碍的关联;丹参酮IIA治疗ED的研究进展进行如下综述,为ED的靶向治疗提供新思路。Erectile dysfunction (ED) is a common multifactorial disease in men, and its pathogenesis involves vascular endothelial dysfunction, oxidative stress, inflammatory response, and neuroendocrine disorders. Tanshinone IIA is the main active ingredient extracted from Salvia miltiorrhizae, which has pharmacological effects such as antioxidant, anti-inflammatory, improving microcirculation and protecting vascular endothelium. In recent years, research has shown that Tanshinone IIA can improve erectile dysfunction (ED) symptoms by modulating the nitric oxide (NO) pathway and inhibiting oxidative stress and inflammatory responses. However, the specific mechanisms still need to be further explored. This article reviews the chemical properties and pharmacological effects of Tanshinone IIA, the association between Tanshinone IIA and erectile dysfunction, and the research progress of Tanshinone IIA in treating ED, providing new ideas for targeted therapy of ED.
