Severe acute respiratory coronavirus-2(SARS-CoV-2)infection course differs between the young and healthy and the elderly with co-morbidities.In the latter a potentially lethal coronavirus disease 2019(COVID-19)cytokin...Severe acute respiratory coronavirus-2(SARS-CoV-2)infection course differs between the young and healthy and the elderly with co-morbidities.In the latter a potentially lethal coronavirus disease 2019(COVID-19)cytokine storm has been described with an unrestrained renin-angiotensin(Ang)system(RAS).RAS inhibitors[Ang converting enzyme inhibitors and Ang II type 1 receptor(AT1R)blockers]while appearing appropriate in COVID-19,display enigmatic effects ranging from protection to harm.MicroRNA-155(miR-155)-induced translational repression of key cardiovascular(CV)genes(i.e.,AT1R)restrains SARS-CoV-2-engendered RAS hyperactivity to tolerable and SARS-CoV-2-protective CV phenotypes supporting a protective erythropoietin(EPO)evolutionary landscape.MiR-155’s disrupted repression of the AT1R 1166C-allele associates with adverse CV and COVID-19 outcomes,confirming its decisive role in RAS modulation.RAS inhibition disrupts this miR-155-EPO network by further lowering EPO and miR-155 in COVID-19 with co-morbidities,thereby allowing unimpeded RAS hyperactivity to progress precariously.Current pharmacological interventions in COVID-19 employing RAS inhibition should consider these complex but potentially detrimental miR-155/EPO-related effects.展开更多
In using the PGCEVD （Poisson-Gumbel Compound Extreme Value Distribution） model to calculate return values of typhoon wave height, the quantitative selection of the threshold has blocked its application. By analyzing...In using the PGCEVD （Poisson-Gumbel Compound Extreme Value Distribution） model to calculate return values of typhoon wave height, the quantitative selection of the threshold has blocked its application. By analyzing the principle of the threshold selection of PGCEVD model and in combination of the change point statistical methods, this paper proposes a new method for quantitative calculation of the threshold in PGCEVD model. Eleven samples from five engineering points in several coastal waters of Guangdong and Hainan, China, are calculated and analyzed by using PGCEVD model and the traditional Pearson type III distribution （P-III） model, respectively. By comparing the results of the two models, it is shown that the new method of selecting the optimal threshold is feasible. PGCEVD model has more stable results than that of P-III model and can be used for the return wave height in every direction.展开更多
文摘Severe acute respiratory coronavirus-2(SARS-CoV-2)infection course differs between the young and healthy and the elderly with co-morbidities.In the latter a potentially lethal coronavirus disease 2019(COVID-19)cytokine storm has been described with an unrestrained renin-angiotensin(Ang)system(RAS).RAS inhibitors[Ang converting enzyme inhibitors and Ang II type 1 receptor(AT1R)blockers]while appearing appropriate in COVID-19,display enigmatic effects ranging from protection to harm.MicroRNA-155(miR-155)-induced translational repression of key cardiovascular(CV)genes(i.e.,AT1R)restrains SARS-CoV-2-engendered RAS hyperactivity to tolerable and SARS-CoV-2-protective CV phenotypes supporting a protective erythropoietin(EPO)evolutionary landscape.MiR-155’s disrupted repression of the AT1R 1166C-allele associates with adverse CV and COVID-19 outcomes,confirming its decisive role in RAS modulation.RAS inhibition disrupts this miR-155-EPO network by further lowering EPO and miR-155 in COVID-19 with co-morbidities,thereby allowing unimpeded RAS hyperactivity to progress precariously.Current pharmacological interventions in COVID-19 employing RAS inhibition should consider these complex but potentially detrimental miR-155/EPO-related effects.
基金supported by the National Natural Science Foundation of China(Grant No.10902039)the Major Project Research of the Ministry of Railways of the People's Republic of China(Grant No.2010-201)
文摘In using the PGCEVD （Poisson-Gumbel Compound Extreme Value Distribution） model to calculate return values of typhoon wave height, the quantitative selection of the threshold has blocked its application. By analyzing the principle of the threshold selection of PGCEVD model and in combination of the change point statistical methods, this paper proposes a new method for quantitative calculation of the threshold in PGCEVD model. Eleven samples from five engineering points in several coastal waters of Guangdong and Hainan, China, are calculated and analyzed by using PGCEVD model and the traditional Pearson type III distribution （P-III） model, respectively. By comparing the results of the two models, it is shown that the new method of selecting the optimal threshold is feasible. PGCEVD model has more stable results than that of P-III model and can be used for the return wave height in every direction.
