目的:总结一例64岁II型糖尿病合并血栓性血小板减少性紫癜患者在院治疗调控血糖期间针对在血浆置换治疗过程中出现感染、内分泌代谢紊乱、出血、气体交换障碍等主要护理问题的护理要点,以期为相似案例提供借鉴。方法:就患者治疗全周期...目的:总结一例64岁II型糖尿病合并血栓性血小板减少性紫癜患者在院治疗调控血糖期间针对在血浆置换治疗过程中出现感染、内分泌代谢紊乱、出血、气体交换障碍等主要护理问题的护理要点,以期为相似案例提供借鉴。方法:就患者治疗全周期进行管理,以抢救生命、治疗疾病为重点,期间以控制管理基础疾病为基础,包括预防感染、血糖管理、症状护理、血浆置换护理、管道管理、心理护理等方面。结果:连续治疗10 d后患者生命体征暂时能够平稳,病情得到控制。结论:对患者生命治疗周期进行整体管控护理,针对基础慢性疾病合并疑难急症进行科学合理地护理,能迅速保障患者生命安全、提升治疗效率。Objective: To summarize the key points of nursing for a 64-year-old patient with type II diabetes mellitus complicated with thrombotic thrombocytopenic purpura during inpatient treatment for major nursing problems such as infection, endocrine and metabolic disorders, bleeding and gas exchange disorders during plasma exchange treatment, in order to provide reference for similar cases. Methods: The whole cycle of treatment was managed, focusing on life-saving and disease treatment, and the control and management of underlying diseases were the basis, including infection prevention, blood glucose management, symptom nursing, plasmapheresis nursing, pipeline management, and psychological nursing. Results: After 10 days of continuous treatment, the patient’s vital signs were temporarily stable and the condition was controlled. Conclusion: The overall control and nursing of the patient’s life cycle and the scientific and reasonable nursing for the underlying chronic diseases combined with intractable and urgent diseases can quickly ensure the life safety of patients and improve the treatment efficiency.展开更多
With the approval of more and more genetically modified(GM)crops in our country,GM safety management has become more important.Transgenic detection is a major approach for transgenic safety management.Nevertheless,a c...With the approval of more and more genetically modified(GM)crops in our country,GM safety management has become more important.Transgenic detection is a major approach for transgenic safety management.Nevertheless,a convenient and visual technique with low equipment requirements and high sensitivity for the field detection of GM plants is still lacking.On the basis of the existing recombinase polymerase amplification(RPA)technique,we developed a multiplex RPA(multi-RPA)method that can simultaneously detect three transgenic elements,including the cauliflower mosaic virus 35S gene(CaMV35S)promoter,neomycin phosphotransferaseⅡgene(NptⅡ)and hygromycin B phosphotransferase gene(Hyg),thus improving the detection rate.Moreover,we coupled this multi-RPA technique with the CRISPR/Cas12a reporter system,which enabled the detection results to be clearly observed by naked eyes under ultraviolet(UV)light(254 nm;which could be achieved by a portable UV flashlight),therefore establishing a multi-RPA visual detection technique.Compared with the traditional test strip detection method,this multi-RPA-CRISPR/Cas12a technique has the higher specificity,higher sensitivity,wider application range and lower cost.Compared with other polymerase chain reaction(PCR)techniques,it also has the advantages of low equipment requirements and visualization,making it a potentially feasible method for the field detection of GM plants.展开更多
Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular factors.Although the spinal cord ...Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular factors.Although the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).展开更多
To reduce the temperature diseases of asphalt pavement,improve the service quality of road and extend service life,the research of inorganic powders that reduce the temperature of asphalt pavements was systematically ...To reduce the temperature diseases of asphalt pavement,improve the service quality of road and extend service life,the research of inorganic powders that reduce the temperature of asphalt pavements was systematically sorted out.The common types,physicochemical properties and application methods of inorganic powders were defined.The road performances of modified asphalt and its mixture were evaluated.The modification mechanism of inorganic powders in asphalt was analyzed.On this basis,the cooling effect and cooling mechanism of inorganic powders was revealed.The results indicate that inorganic powders are classified into hollow,porous,and energy conversion types.The high-temperature performance of inorganic powders modified asphalt and its mixture is significantly improved,while there is no significant change in low-temperature performance and water stability.The average increase in rutting resistance factor(G*/sin(δ))and dynamic stability is 40%–72%and 30%–50%,respectively.The modification mechanism of inorganic powders in asphalt is physical blending.The thermal conductivity of hollow and porous inorganic powders modified asphalt mixture decreases by 30.05%and 43.14%,respectively.The temperature of hollow,porous and energy conversion inorganic powders modified asphalt mixture at 5 cm decreases by 2.3 ℃–3.5 ℃,0.8 ℃–3.7 ℃and 4.1 ℃–4.7℃,respectively.Hollow and porous inorganic powders block heat conduction,while energy conversion inorganic powders achieve cooling through their functional properties.展开更多
Semenov-Tian-Shansky has given the solution of the modified classical Yang-Baxter equation, which was called the modified r-matrix. Relevant studies have been extensive in recent times. In this paper, we introduce the...Semenov-Tian-Shansky has given the solution of the modified classical Yang-Baxter equation, which was called the modified r-matrix. Relevant studies have been extensive in recent times. In this paper, we introduce the concept and representations of modified RotaBaxter Hom-Lie algebras. We develop a cohomology of modified Rota-Baxter Hom-Lie algebras with coefficients in a suitable representation. As applications, we study formal deformations and abelian extensions of modified Rota-Baxter Hom-Lie algebras in terms of second cohomology groups.展开更多
As a crucial human activity,dam construction can profoundly impact the surface hydrology patterns.The Three Gorges Reservoir(TGR),as one of the largest hydraulic engineering projects in the world,has gained continuous...As a crucial human activity,dam construction can profoundly impact the surface hydrology patterns.The Three Gorges Reservoir(TGR),as one of the largest hydraulic engineering projects in the world,has gained continuous attention for its eco-hydrological effects.However,further investigation is necessary to understand the runoff and social impacts of the TGR on the Upper Yangtze River.This study first employed a modified SWAT model to simulate runoff,compared scenarios with and without the TGR,and finally evaluated water supply and demand in the Upper Yangtze River.The results showed a significant increasing trend in the surface water area of the Upper Yangtze River from 2000-2020.The modified SWAT model performs well in simulating the runoff,with Nash-Sutcliffe Efficiency and Percent Bias improved by 0.04-0.30 and 2-31.90,respectively.Scenario simulation results revealed that the TGR reduced seasonal differences in runoff.During the flood season,the runoff volume at the Yichang Station in the scenario with the TGR is lower than in the scenario without the TGR,peaking at 4500 m3/s.Conversely,in the dry season,the runoff volume of the scenario with TGR is higher,with a maximum increase of 1500 m3/s.The region exhibiting the greatest runoff variations is the Yangtze River's main stem in the Three Gorges Reservoir region.Besides,the TGR notably alleviated the water supply-demand imbalance in Chongqing during the winter and spring seasons,with a maximum increase of 0.16 in the supplydemand index.This study can contribute significantly to understanding the natural and social impacts of the TGR from the perspective of hydrological and scenario simulation.展开更多
Graphene oxide nanomaterials are increasingly used in various fields due to their superior properties.In order to study the influence of graphene oxide additives on the performance of modified asphalt,in this study,gr...Graphene oxide nanomaterials are increasingly used in various fields due to their superior properties.In order to study the influence of graphene oxide additives on the performance of modified asphalt,in this study,graphene oxide modified asphalt was prepared and characteristics was studied including the high deformation resistance performance and the self-healing property of modified asphalt.Functional groups and morphology of graphene oxide modified asphalt were described by Fourier transform infrared spectroscopy.The high deformation resistance performance and self-healing effect of asphalt samples were obtained through dynamic slear rheometer(DSR)test.Results shows that graphene oxide dispersions improve the performance of asphalt relatively well compared to graphene oxide powder.There is no chemical reaction between graphene oxide and asphalt,but physical connection.The addition of graphene oxide improved the high deformation resistance of modified asphalt and expedited the self-healing ability of asphalt under fatigue load.展开更多
目的:探讨外周血平均血小板体积/淋巴细胞计数(MPVLR)联合APACHE II评分对脓毒症患者预后的预测价值。方法:采用回顾性队列研究方法,选择该院2020年8月至2023年8月收治的符合脓毒症3.0诊断标准的患者。根据脓毒症患者的28 d预后情况分...目的:探讨外周血平均血小板体积/淋巴细胞计数(MPVLR)联合APACHE II评分对脓毒症患者预后的预测价值。方法:采用回顾性队列研究方法,选择该院2020年8月至2023年8月收治的符合脓毒症3.0诊断标准的患者。根据脓毒症患者的28 d预后情况分为生存组及死亡组。收集患者的临床资料及确诊脓毒症后24 h内血小板体积(MPV)、淋巴细胞(LYM)计数的最差值,并计算平均血小板体积/淋巴细胞计数(MPVLR)、APACHE II评分及SOFA评分。随后使用多因素Logistic回归分析,确定脓毒症患者预后的影响因素,再构建受试者工作特征曲线,评估各项指标对脓毒症患者预后的预测价值。结果:共纳入患者127例,生存组患者76例,死亡组患者51例。死亡组患者更易合并慢性阻塞性肺疾病,且平均血小板体积(MPV)、平均血小板体积/淋巴细胞计数(MPVLR)、APACHE II评分、SOFA评分、及年龄均高于生存组,且差异具有统计学意义(P Objective: To investigate the prognostic value of the mean platelet volume (MPV)-to-lymphocyte ratio (MPVLR) combined with the APACHE II score in predicting the outcomes of patients with sepsis. Methods: This retrospective study screened patients with sepsis who were hospitalized in our hospital, from August 2020 to August 2023 were included and categorized into the survival group and the non-survival group based on 28-day outcomes of sepsis patients. Clinical date and the worst of mean platelet volume (MPV), lymphocyte (LYM) count values within 24 hours of sepsis diagnosis were collected, MPVLR and APACHE II scores were calculated. Multifactorial logistic regression analysis was used to identify risk factors affecting the prognosis of sepsis patients, and then a subject operating characteristic curve (ROC) was constructed to assess the predictive value of each indicator on the prognosis of sepsis patients. Results: A total of 127 patients were included, with 76 in the survival group and 51 in the non-survival group. Patients in the non-survival group were more likely to have chronic obstructive pulmonary disease, and had significantly higher MPV, MPVLR, APACHE II scores, SOFA scores and age compared to the survival group (P < 0.05). In contrast, peripheral blood lymphocyte counts in the survival group were significantly higher than that in the non-survival group (P < 0.05). Multivariate logistic regression analysis showed that MPVLR and APACHE II scores were independent risk factors for 28-day mortality in sepsis patients (P < 0.05). Receiver operating characteristic curve (ROC) curve analysis showed that the area under the curve (AUC) values for MPVLR, APACHE II scores, and their combination were 0.840, 0.800, and 0.885, respectively. Notably, the MPVLR combined with the APACHE II score showed the best predictive value, with an AUC of 0.824. It demonstrated excellent predictive performance, achieving a sensitivity of 94.6% and a specificity of 82.4%. Conclusion: APACHE II scores and MPVLR are independent risk factors for 28-day mortality in sepsis patients, and their combined use provides higher predictive value.展开更多
文摘目的:总结一例64岁II型糖尿病合并血栓性血小板减少性紫癜患者在院治疗调控血糖期间针对在血浆置换治疗过程中出现感染、内分泌代谢紊乱、出血、气体交换障碍等主要护理问题的护理要点,以期为相似案例提供借鉴。方法:就患者治疗全周期进行管理,以抢救生命、治疗疾病为重点,期间以控制管理基础疾病为基础,包括预防感染、血糖管理、症状护理、血浆置换护理、管道管理、心理护理等方面。结果:连续治疗10 d后患者生命体征暂时能够平稳,病情得到控制。结论:对患者生命治疗周期进行整体管控护理,针对基础慢性疾病合并疑难急症进行科学合理地护理,能迅速保障患者生命安全、提升治疗效率。Objective: To summarize the key points of nursing for a 64-year-old patient with type II diabetes mellitus complicated with thrombotic thrombocytopenic purpura during inpatient treatment for major nursing problems such as infection, endocrine and metabolic disorders, bleeding and gas exchange disorders during plasma exchange treatment, in order to provide reference for similar cases. Methods: The whole cycle of treatment was managed, focusing on life-saving and disease treatment, and the control and management of underlying diseases were the basis, including infection prevention, blood glucose management, symptom nursing, plasmapheresis nursing, pipeline management, and psychological nursing. Results: After 10 days of continuous treatment, the patient’s vital signs were temporarily stable and the condition was controlled. Conclusion: The overall control and nursing of the patient’s life cycle and the scientific and reasonable nursing for the underlying chronic diseases combined with intractable and urgent diseases can quickly ensure the life safety of patients and improve the treatment efficiency.
基金the Experimental Technology Research Project of Zhejiang University(SYB202138)National Natural Science Foundation of China(32000195)。
文摘With the approval of more and more genetically modified(GM)crops in our country,GM safety management has become more important.Transgenic detection is a major approach for transgenic safety management.Nevertheless,a convenient and visual technique with low equipment requirements and high sensitivity for the field detection of GM plants is still lacking.On the basis of the existing recombinase polymerase amplification(RPA)technique,we developed a multiplex RPA(multi-RPA)method that can simultaneously detect three transgenic elements,including the cauliflower mosaic virus 35S gene(CaMV35S)promoter,neomycin phosphotransferaseⅡgene(NptⅡ)and hygromycin B phosphotransferase gene(Hyg),thus improving the detection rate.Moreover,we coupled this multi-RPA technique with the CRISPR/Cas12a reporter system,which enabled the detection results to be clearly observed by naked eyes under ultraviolet(UV)light(254 nm;which could be achieved by a portable UV flashlight),therefore establishing a multi-RPA visual detection technique.Compared with the traditional test strip detection method,this multi-RPA-CRISPR/Cas12a technique has the higher specificity,higher sensitivity,wider application range and lower cost.Compared with other polymerase chain reaction(PCR)techniques,it also has the advantages of low equipment requirements and visualization,making it a potentially feasible method for the field detection of GM plants.
文摘Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular factors.Although the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).
基金supported by Fundamental Research Funds for the Central Universities(300102214908)Innovation Capability Support Program of Shaanxi(2022TD-07).
文摘To reduce the temperature diseases of asphalt pavement,improve the service quality of road and extend service life,the research of inorganic powders that reduce the temperature of asphalt pavements was systematically sorted out.The common types,physicochemical properties and application methods of inorganic powders were defined.The road performances of modified asphalt and its mixture were evaluated.The modification mechanism of inorganic powders in asphalt was analyzed.On this basis,the cooling effect and cooling mechanism of inorganic powders was revealed.The results indicate that inorganic powders are classified into hollow,porous,and energy conversion types.The high-temperature performance of inorganic powders modified asphalt and its mixture is significantly improved,while there is no significant change in low-temperature performance and water stability.The average increase in rutting resistance factor(G*/sin(δ))and dynamic stability is 40%–72%and 30%–50%,respectively.The modification mechanism of inorganic powders in asphalt is physical blending.The thermal conductivity of hollow and porous inorganic powders modified asphalt mixture decreases by 30.05%and 43.14%,respectively.The temperature of hollow,porous and energy conversion inorganic powders modified asphalt mixture at 5 cm decreases by 2.3 ℃–3.5 ℃,0.8 ℃–3.7 ℃and 4.1 ℃–4.7℃,respectively.Hollow and porous inorganic powders block heat conduction,while energy conversion inorganic powders achieve cooling through their functional properties.
基金Supported by the Universities Key Laboratory of System Modeling and Data Mining in Guizhou Province(Grant No.2023013)the National Natural Science Foundation of China(Grant No.12161013)the Science and Technology Program of Guizhou Province(Grant No.ZK[2023]025)。
文摘Semenov-Tian-Shansky has given the solution of the modified classical Yang-Baxter equation, which was called the modified r-matrix. Relevant studies have been extensive in recent times. In this paper, we introduce the concept and representations of modified RotaBaxter Hom-Lie algebras. We develop a cohomology of modified Rota-Baxter Hom-Lie algebras with coefficients in a suitable representation. As applications, we study formal deformations and abelian extensions of modified Rota-Baxter Hom-Lie algebras in terms of second cohomology groups.
基金supported by the National Natural Science Foundation of China(Nos.41975044,42371354,41801021,42101385)Open Fund of Hubei Luojia Laboratory(No.2201000043)the Fundamental Research Funds for National Universities,China University of Geosciences,Wuhan。
文摘As a crucial human activity,dam construction can profoundly impact the surface hydrology patterns.The Three Gorges Reservoir(TGR),as one of the largest hydraulic engineering projects in the world,has gained continuous attention for its eco-hydrological effects.However,further investigation is necessary to understand the runoff and social impacts of the TGR on the Upper Yangtze River.This study first employed a modified SWAT model to simulate runoff,compared scenarios with and without the TGR,and finally evaluated water supply and demand in the Upper Yangtze River.The results showed a significant increasing trend in the surface water area of the Upper Yangtze River from 2000-2020.The modified SWAT model performs well in simulating the runoff,with Nash-Sutcliffe Efficiency and Percent Bias improved by 0.04-0.30 and 2-31.90,respectively.Scenario simulation results revealed that the TGR reduced seasonal differences in runoff.During the flood season,the runoff volume at the Yichang Station in the scenario with the TGR is lower than in the scenario without the TGR,peaking at 4500 m3/s.Conversely,in the dry season,the runoff volume of the scenario with TGR is higher,with a maximum increase of 1500 m3/s.The region exhibiting the greatest runoff variations is the Yangtze River's main stem in the Three Gorges Reservoir region.Besides,the TGR notably alleviated the water supply-demand imbalance in Chongqing during the winter and spring seasons,with a maximum increase of 0.16 in the supplydemand index.This study can contribute significantly to understanding the natural and social impacts of the TGR from the perspective of hydrological and scenario simulation.
基金supported by Gansu Provincial Science and Technology Plan(23CXGA0195)Longnan Science and Technology Plan(2024CX03)。
文摘Graphene oxide nanomaterials are increasingly used in various fields due to their superior properties.In order to study the influence of graphene oxide additives on the performance of modified asphalt,in this study,graphene oxide modified asphalt was prepared and characteristics was studied including the high deformation resistance performance and the self-healing property of modified asphalt.Functional groups and morphology of graphene oxide modified asphalt were described by Fourier transform infrared spectroscopy.The high deformation resistance performance and self-healing effect of asphalt samples were obtained through dynamic slear rheometer(DSR)test.Results shows that graphene oxide dispersions improve the performance of asphalt relatively well compared to graphene oxide powder.There is no chemical reaction between graphene oxide and asphalt,but physical connection.The addition of graphene oxide improved the high deformation resistance of modified asphalt and expedited the self-healing ability of asphalt under fatigue load.
基金the National Key R&D Program of China(2022YFB3206000)the National Natural Science Foundation of China(U23A20487)+1 种基金Dr.Li Dak Sum&Yip Yio Chin Development Fund for Regenerative Medicine,Zhejiang Universitythe National Natural Science Foundation of China(61975172).
文摘近红外二区(the second near-infrared window,NIR-II,900~1880 nm)荧光成像具有信号背景比高、穿透深度大的优势,在生物医学领域具有广泛的应用前景。对NIR-II成像窗口的划分有利于优化成像过程,其中,NIRIIx(1400~1500 nm)成像窗口得益于其独特的水吸收,可以有效抑制散射背景,实现高对比度成像。文章通过仿真模拟和活体实验,系统评估了NIR-IIx窗口的成像潜力。为了更好地推进NIR-IIx荧光成像的临床转化,研究采用美国食品及药物管理局(FDA)批准的有机小分子染料吲哚菁绿(Indocyanine Green,ICG)作为荧光探针,利用其延伸至NIR-II的荧光发射拖尾,实现了高对比度和清晰度的小鼠血管和肠道的NIR-IIx成像。此外,研究还结合同样通过FDA认证的亚甲基蓝(Methylene Blue,MB),成功实现了高质量的NIR-II双通道成像,精准定位小鼠的血管和淋巴结。文章进一步挖掘了NIR-IIx在生物成像上的独特优势和临床应用的潜力,并为NIR-II荧光成像的临床转化提供了重要参考。
文摘目的:探讨外周血平均血小板体积/淋巴细胞计数(MPVLR)联合APACHE II评分对脓毒症患者预后的预测价值。方法:采用回顾性队列研究方法,选择该院2020年8月至2023年8月收治的符合脓毒症3.0诊断标准的患者。根据脓毒症患者的28 d预后情况分为生存组及死亡组。收集患者的临床资料及确诊脓毒症后24 h内血小板体积(MPV)、淋巴细胞(LYM)计数的最差值,并计算平均血小板体积/淋巴细胞计数(MPVLR)、APACHE II评分及SOFA评分。随后使用多因素Logistic回归分析,确定脓毒症患者预后的影响因素,再构建受试者工作特征曲线,评估各项指标对脓毒症患者预后的预测价值。结果:共纳入患者127例,生存组患者76例,死亡组患者51例。死亡组患者更易合并慢性阻塞性肺疾病,且平均血小板体积(MPV)、平均血小板体积/淋巴细胞计数(MPVLR)、APACHE II评分、SOFA评分、及年龄均高于生存组,且差异具有统计学意义(P Objective: To investigate the prognostic value of the mean platelet volume (MPV)-to-lymphocyte ratio (MPVLR) combined with the APACHE II score in predicting the outcomes of patients with sepsis. Methods: This retrospective study screened patients with sepsis who were hospitalized in our hospital, from August 2020 to August 2023 were included and categorized into the survival group and the non-survival group based on 28-day outcomes of sepsis patients. Clinical date and the worst of mean platelet volume (MPV), lymphocyte (LYM) count values within 24 hours of sepsis diagnosis were collected, MPVLR and APACHE II scores were calculated. Multifactorial logistic regression analysis was used to identify risk factors affecting the prognosis of sepsis patients, and then a subject operating characteristic curve (ROC) was constructed to assess the predictive value of each indicator on the prognosis of sepsis patients. Results: A total of 127 patients were included, with 76 in the survival group and 51 in the non-survival group. Patients in the non-survival group were more likely to have chronic obstructive pulmonary disease, and had significantly higher MPV, MPVLR, APACHE II scores, SOFA scores and age compared to the survival group (P < 0.05). In contrast, peripheral blood lymphocyte counts in the survival group were significantly higher than that in the non-survival group (P < 0.05). Multivariate logistic regression analysis showed that MPVLR and APACHE II scores were independent risk factors for 28-day mortality in sepsis patients (P < 0.05). Receiver operating characteristic curve (ROC) curve analysis showed that the area under the curve (AUC) values for MPVLR, APACHE II scores, and their combination were 0.840, 0.800, and 0.885, respectively. Notably, the MPVLR combined with the APACHE II score showed the best predictive value, with an AUC of 0.824. It demonstrated excellent predictive performance, achieving a sensitivity of 94.6% and a specificity of 82.4%. Conclusion: APACHE II scores and MPVLR are independent risk factors for 28-day mortality in sepsis patients, and their combined use provides higher predictive value.
