In response to the increasing demand for hadron therapy facilities,significant efforts have been directed toward enhancing the performance of high-gradient and high-transmission injectors for light ion beams.For carbo...In response to the increasing demand for hadron therapy facilities,significant efforts have been directed toward enhancing the performance of high-gradient and high-transmission injectors for light ion beams.For carbon ion irradiations,which offer greater radiobiological efficiency in tumor treatment,recent research has focused on developing high-production sources of fully stripped C^(6+)ions and highly compact,high-frequency RFQ cavities.This study explores the design possibilities of a carbon ion acceleration section using 750 MHz Interdigital H-mode Drift Tube Linacs(IH-DTLs)as a high-efficiency solution for accelerating ions in the 5-10 MeV per nucleon energy range.A particle-tracking routine based on the TRAVEL code was developed to design the acceleration line through a tailored KONUS-type configuration.Three design solutions were proposed and compared,exploring different alternatives regarding the use of a MEBT to match the output beam phase space of the RFQ to the optics of the line,as well as varying considerations for magnetic systems to focus the beam.Additionally,the compatibility of the proposed solutions with the existing design of the carbon ion bent-linac for hadron therapy was assessed.展开更多
[Objectives]To apply the novel induction heating(IH)technology for the extraction of Ophiopogon japonicus polysaccharide(OJPS),fully utilize the advantages of IH technology to improve the extraction yield of OJPS,and ...[Objectives]To apply the novel induction heating(IH)technology for the extraction of Ophiopogon japonicus polysaccharide(OJPS),fully utilize the advantages of IH technology to improve the extraction yield of OJPS,and compare it with traditional Chinese medicine polysaccharide extraction methods.[Methods]Using the polysaccharide extraction yield as the evaluation index,the IH extraction process for OJPS was optimized through an L_(9)(3^(4))orthogonal test,and systematic methodological validation was conducted.Finally,the process parameters and procedure for extracting OJPS using IH technology were optimized.[Results]The optimal extraction process was as follows:solid-liquid ratio of 1:55,extraction time of 75 min,and alcohol precipitation ratio of 1:4.The methodological investigation showed that OJPS had a good linear relationship in the range of 20-140μg/mL,with R^(2)=0.9993.The average recovery rate was 99.94%(RSD=1.32%).The RSD s for precision,repeatability,and stability were all less than 2%,indicating that the measurement method for OJPS extraction yield was excellent.The extraction yields of OJPS by reflux extraction,ultrasonic extraction,and IH extraction were 26.67%,40.70%,and 51.74%,respectively.[Conclusions]The novel IH extraction technology is stable and reliable,has a significant impact on the extraction yield of OJPS,and also improves the conversion rate of OJPS.It is expected to become an emerging technology and research direction for the extraction of Chinese medicine polysaccharides.展开更多
基金Project co-funded by European Union in the context of the precommercial public procurement of RD services managed by CDTI E.P.Eco-funded by the European Regional Development Fund(ERDF)as part of the project for the development of a Compact Linear Accelerator for Hadrontherapy,Exp.CPP 03/2023 AB(DCCPI/OCPI)。
文摘In response to the increasing demand for hadron therapy facilities,significant efforts have been directed toward enhancing the performance of high-gradient and high-transmission injectors for light ion beams.For carbon ion irradiations,which offer greater radiobiological efficiency in tumor treatment,recent research has focused on developing high-production sources of fully stripped C^(6+)ions and highly compact,high-frequency RFQ cavities.This study explores the design possibilities of a carbon ion acceleration section using 750 MHz Interdigital H-mode Drift Tube Linacs(IH-DTLs)as a high-efficiency solution for accelerating ions in the 5-10 MeV per nucleon energy range.A particle-tracking routine based on the TRAVEL code was developed to design the acceleration line through a tailored KONUS-type configuration.Three design solutions were proposed and compared,exploring different alternatives regarding the use of a MEBT to match the output beam phase space of the RFQ to the optics of the line,as well as varying considerations for magnetic systems to focus the beam.Additionally,the compatibility of the proposed solutions with the existing design of the carbon ion bent-linac for hadron therapy was assessed.
基金Supported by General Program of Natural Science Foundation of Jiangxi Province(20232BAB206169)Science and Technology Program of Jiangxi Administration of Traditional Chinese Medicine(2024B0037)+2 种基金Science and Technology Plan of Jiangxi Provincial Health Commission(202211411)Open Fund of Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine(TCM-201909)National College Students Innovation and Entrepreneurship Training Program(202110412041,202410410212,202510412017).
文摘[Objectives]To apply the novel induction heating(IH)technology for the extraction of Ophiopogon japonicus polysaccharide(OJPS),fully utilize the advantages of IH technology to improve the extraction yield of OJPS,and compare it with traditional Chinese medicine polysaccharide extraction methods.[Methods]Using the polysaccharide extraction yield as the evaluation index,the IH extraction process for OJPS was optimized through an L_(9)(3^(4))orthogonal test,and systematic methodological validation was conducted.Finally,the process parameters and procedure for extracting OJPS using IH technology were optimized.[Results]The optimal extraction process was as follows:solid-liquid ratio of 1:55,extraction time of 75 min,and alcohol precipitation ratio of 1:4.The methodological investigation showed that OJPS had a good linear relationship in the range of 20-140μg/mL,with R^(2)=0.9993.The average recovery rate was 99.94%(RSD=1.32%).The RSD s for precision,repeatability,and stability were all less than 2%,indicating that the measurement method for OJPS extraction yield was excellent.The extraction yields of OJPS by reflux extraction,ultrasonic extraction,and IH extraction were 26.67%,40.70%,and 51.74%,respectively.[Conclusions]The novel IH extraction technology is stable and reliable,has a significant impact on the extraction yield of OJPS,and also improves the conversion rate of OJPS.It is expected to become an emerging technology and research direction for the extraction of Chinese medicine polysaccharides.
