类胰岛素生长因子1 (IGF-1)是一种单链多肽,通过自分泌和旁分泌的方式调节骨代谢,促进骨形成。大量研究已经证实,IGF-1与骨密度呈显著正相关,对骨代谢的调节起着至关重要的作用。本文将结合近年来的研究进展,围绕概述IGF-1与骨质疏松(OP...类胰岛素生长因子1 (IGF-1)是一种单链多肽,通过自分泌和旁分泌的方式调节骨代谢,促进骨形成。大量研究已经证实,IGF-1与骨密度呈显著正相关,对骨代谢的调节起着至关重要的作用。本文将结合近年来的研究进展,围绕概述IGF-1与骨质疏松(OP)的相关性、IGF-1影响骨密度的机制等方面对IGF-1与OP的相关性研究进展作一综述。Insulin-like growth factor 1 (IGF-1) is a single chain polypeptide that regulates bone metabolism and promotes bone formation through autocrine and paracrine pathways. A large number of studies have confirmed that IGF-1 is significantly positively correlated with bone mineral density and plays a crucial role in the regulation of bone metabolism. In this paper, based on the recent research progress, the correlation between IGF-1 and osteoporosis (OP) and the mechanism of IGF-1 affecting bone mineral density will be reviewed.展开更多
文摘类胰岛素生长因子1 (IGF-1)是一种单链多肽,通过自分泌和旁分泌的方式调节骨代谢,促进骨形成。大量研究已经证实,IGF-1与骨密度呈显著正相关,对骨代谢的调节起着至关重要的作用。本文将结合近年来的研究进展,围绕概述IGF-1与骨质疏松(OP)的相关性、IGF-1影响骨密度的机制等方面对IGF-1与OP的相关性研究进展作一综述。Insulin-like growth factor 1 (IGF-1) is a single chain polypeptide that regulates bone metabolism and promotes bone formation through autocrine and paracrine pathways. A large number of studies have confirmed that IGF-1 is significantly positively correlated with bone mineral density and plays a crucial role in the regulation of bone metabolism. In this paper, based on the recent research progress, the correlation between IGF-1 and osteoporosis (OP) and the mechanism of IGF-1 affecting bone mineral density will be reviewed.
