Multi-instance registration is a challenging problem in computer vision and robotics,where multiple instances of an object need to be registered in a standard coordinate system.Pioneers followed a non-extensible one-s...Multi-instance registration is a challenging problem in computer vision and robotics,where multiple instances of an object need to be registered in a standard coordinate system.Pioneers followed a non-extensible one-shot framework,which prioritizes the registration of simple and isolated instances,often struggling to accurately register challenging or occluded instances.To address these challenges,we propose the first iterative framework for multi-instance 3D registration(MI-3DReg)in this work,termed instance-by-instance(IBI).It successively registers instances while systematically reducing outliers,starting from the easiest and progressing to more challenging ones.This enhances the likelihood of effectively registering instances that may have been initially overlooked,allowing for successful registration in subsequent iterations.Under the IBI framework,we further propose a sparse-to-dense correspondence-based multi-instance registration method(IBI-S2DC)to enhance the robustness of MI-3DReg.Experiments on both synthetic and real datasets have demonstrated the effectiveness of IBI and suggested the new state-of-the-art performance with IBI-S2DC,e.g.,our mean registration F1 score is 12.02%/12.35%higher than the existing state-of-the-art on the synthetic/real datasets.The source codes are available online at https://github.com/caoxy01/IBI.展开更多
目的探讨DNA分化抑制因子(inhibitor of DNA differentiation,Id)Id1/Id3在子宫内膜癌中的表达及对子宫内膜癌细胞增殖、侵袭、迁移及粘附等生物学行为的作用。方法 Western blot方法检测4例子宫内膜癌组织及相应的癌旁组织中的Id1/Id3...目的探讨DNA分化抑制因子(inhibitor of DNA differentiation,Id)Id1/Id3在子宫内膜癌中的表达及对子宫内膜癌细胞增殖、侵袭、迁移及粘附等生物学行为的作用。方法 Western blot方法检测4例子宫内膜癌组织及相应的癌旁组织中的Id1/Id3的表达;将子宫内膜癌RL-952和HEC-1-B两株细胞各分为未处理细胞组、空白病毒组、启动子病毒组和Id1/Id3双敲低组。通过qRT-PCR检测不同腺病毒载体感染细胞后MMP2、CXCR4和P21 mRNA表达量,Western blot检测MMP2、CXCR4、P21蛋白表达情况;通过MTT增殖试验、Transwell侵袭实验、细胞划痕实验和细胞粘附实验检测Id1/Id3表达改变后,对子宫内膜癌细胞增殖、侵袭、移行和粘附能力的影响。结果 Id1/Id3在子宫内膜癌组织中较癌旁组织表达增高(P<0.05);双敲低Id1/Id3,子宫内膜癌细胞中MMP2、CXCR4的mRNA水平和蛋白水平明显降低(P<0.05),P21的mRNA水平和蛋白水平则明显升高(P<0.05),RNAi组与其他3组细胞相比均有显著性差异;Id1/Id3双敲低组子宫内膜癌RL-952和HEC-1-B株细胞增殖能力、侵袭能力、迁移能力和粘附能力均抑制(P<0.05)。结论 Id1/Id3在子宫内膜癌患者组织中高表达,并可通过升调MMP2、CXCR4和降调P21的表达促进子宫内膜癌细胞增殖、侵袭、迁移及粘附作用,靶向Id1/Id3治疗可能成为预防和治疗子宫内膜癌的新方案。展开更多
基金supported in part by the National Natural Science Foundation of China(62372377).
文摘Multi-instance registration is a challenging problem in computer vision and robotics,where multiple instances of an object need to be registered in a standard coordinate system.Pioneers followed a non-extensible one-shot framework,which prioritizes the registration of simple and isolated instances,often struggling to accurately register challenging or occluded instances.To address these challenges,we propose the first iterative framework for multi-instance 3D registration(MI-3DReg)in this work,termed instance-by-instance(IBI).It successively registers instances while systematically reducing outliers,starting from the easiest and progressing to more challenging ones.This enhances the likelihood of effectively registering instances that may have been initially overlooked,allowing for successful registration in subsequent iterations.Under the IBI framework,we further propose a sparse-to-dense correspondence-based multi-instance registration method(IBI-S2DC)to enhance the robustness of MI-3DReg.Experiments on both synthetic and real datasets have demonstrated the effectiveness of IBI and suggested the new state-of-the-art performance with IBI-S2DC,e.g.,our mean registration F1 score is 12.02%/12.35%higher than the existing state-of-the-art on the synthetic/real datasets.The source codes are available online at https://github.com/caoxy01/IBI.
文摘目的探讨DNA分化抑制因子(inhibitor of DNA differentiation,Id)Id1/Id3在子宫内膜癌中的表达及对子宫内膜癌细胞增殖、侵袭、迁移及粘附等生物学行为的作用。方法 Western blot方法检测4例子宫内膜癌组织及相应的癌旁组织中的Id1/Id3的表达;将子宫内膜癌RL-952和HEC-1-B两株细胞各分为未处理细胞组、空白病毒组、启动子病毒组和Id1/Id3双敲低组。通过qRT-PCR检测不同腺病毒载体感染细胞后MMP2、CXCR4和P21 mRNA表达量,Western blot检测MMP2、CXCR4、P21蛋白表达情况;通过MTT增殖试验、Transwell侵袭实验、细胞划痕实验和细胞粘附实验检测Id1/Id3表达改变后,对子宫内膜癌细胞增殖、侵袭、移行和粘附能力的影响。结果 Id1/Id3在子宫内膜癌组织中较癌旁组织表达增高(P<0.05);双敲低Id1/Id3,子宫内膜癌细胞中MMP2、CXCR4的mRNA水平和蛋白水平明显降低(P<0.05),P21的mRNA水平和蛋白水平则明显升高(P<0.05),RNAi组与其他3组细胞相比均有显著性差异;Id1/Id3双敲低组子宫内膜癌RL-952和HEC-1-B株细胞增殖能力、侵袭能力、迁移能力和粘附能力均抑制(P<0.05)。结论 Id1/Id3在子宫内膜癌患者组织中高表达,并可通过升调MMP2、CXCR4和降调P21的表达促进子宫内膜癌细胞增殖、侵袭、迁移及粘附作用,靶向Id1/Id3治疗可能成为预防和治疗子宫内膜癌的新方案。
